Article
Nutrition & Dietetics
Haoyue Cheng, Peihan Chi, Yan Zhuang, Xialidan Alifu, Haibo Zhou, Yiwen Qiu, Ye Huang, Libi Zhang, Diliyaer Ainiwan, Zhicheng Peng, Shuting Si, Hui Liu, Yunxian Yu
Summary: This study conducted Mendelian randomization (MR) analysis and found no causal relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in the three trimesters and the risk of preterm birth (PTB), premature rupture of membranes (PROM), and preterm premature rupture of membranes (PPROM).
Article
Obstetrics & Gynecology
Alexandra C. Sundermann, Tiara D. Aldridge, Katherine E. Hartmann, Sarah H. Jones, Eric S. Torstenson, Digna R. Velez Edwards
Summary: The study found no significant association between fibroids and preterm birth during pregnancy, even after accounting for confounding factors. This suggests that the presence of fibroids may not be a major risk factor for preterm birth as previously believed.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Obstetrics & Gynecology
Pierre Delorme, Elsa Lorthe, Jeanne Sibiude, Gilles Kayem
Summary: Studies on prelabour rupture of membranes (PROM) suggest that expectant management (EM) until 37 weeks of gestation in preterm PROM can reduce overall neonatal morbidity, while active management in term PROM may lead to a shorter birth interval without lowering neonatal infection rates. Induction methods using oxytocin, PGE2, or oral misoprostol have similar maternal and neonatal outcomes.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Jenny Wu, Anna E. Denoble, Jeffrey A. Kuller, Sarah K. Dotters-Katz
Summary: Studies comparing retention versus removal of cervical cerclage in women with PPROM showed potential prolongation of latency to delivery with retention, but also potential increase in maternal infectious morbidity. Limited evidence found no significant differences in neonatal outcomes, with most studies limited by retrospective nature and small sample sizes.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Article
Medicine, General & Internal
Han-Ying Chen, Kuan-Ying Huang, Yi-Heng Lin, Shin-Yu Lin, Chien-Nan Lee
Summary: This study aimed to investigate whether the antibiotics recommended by the current guidelines were sufficient to eradicate the majority of pathogens involved in PPROM. The results showed that the most suitable antibiotic therapy for PPROM in Taiwan was a combination of oral azithromycin 1g on admission, intravenous administration of a third-generation cephalosporin for 48 hours, followed by oral amoxicillin for five days. However, further randomized clinical trials with a larger study population are needed to evaluate the efficacy of this recommended antibiotic regimen.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ting-ting Lin, Chen Zhang, Lei Chen, Li Jin, Xian-hua Lin, Jie-xue Pan, Cindy-Lee Dennis, Ben W. Mol, He-feng Huang, Yan-ting Wu
Summary: A study in Shanghai found that non-infected pregnant women in their second trimester during COVID-19 lockdown had an increased risk of preterm birth. Additionally, pregnant women in their third trimester during the lockdown had a higher risk of premature rupture of membranes-induced preterm birth compared to those in the non-lockdown period.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nicholas R. Spencer, Enkhtuya Radnaa, Tuvshintugs Baljinnyam, Talar Kechichian, Ourlad Alzeus G. Tantengco, Elizabeth Bonney, Ananth Kumar Kammala, Samantha Sheller-Miller, Ramkumar Menon
Summary: This study developed a mouse model of ascending infection and inflammation associated with preterm birth. Clinically, these models can help understand the mechanism of infection-related preterm birth, determine intervention targets, or identify potential biomarkers for predicting high-risk pregnancy status early in pregnancy.
Article
Obstetrics & Gynecology
Martha B. Kole-White, Linda A. Nelson, Megan Lord, Phinnara Has, Erika F. Werner, Dwight J. Rouse, Erica J. Hardy
Summary: This study compared the impact of oral-only antibiotics treatment with intravenous antibiotics followed by oral antibiotics treatment on pregnancy latency in patients with preterm premature rupture of membranes. The results suggested that there was no significant difference in pregnancy latency between the oral-only antibiotics regimen and the standard regimen.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Alberto Muniz Rodriguez, Andrew Pastor, Nathan S. Fox
Summary: The study demonstrates that cerclage does not increase the risk of preterm premature rupture of membranes prior to 34 weeks compared to women at increased risk of preterm birth, likely due to underlying risk factors rather than the cerclage procedure itself.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Yiting Mao, Zhaonan Liu, Chen Zhang, Yinyu Wang, Yicong Meng, Lei Chen, Jianzhong Sheng, Yanting Wu, Hefeng Huang
Summary: The study suggests that advanced paternal age is associated with a higher risk of preterm birth and very early preterm birth, particularly with premature rupture of membranes and medically induced preterm birth. Furthermore, there seems to be a fetal sex-specific association between advanced paternal age and a higher risk of premature rupture of membranes preterm birth for male fetuses.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Michal Fishel Bartal, Lynda G. Ugwu, William A. Grobman, Jennifer L. Bailit, Uma M. Reddy, Ronald J. Wapner, Michael W. Varner, John M. Thorp, Steve N. Caritis, Mona Prasad, Alan T. N. Tita, George R. Saade, Dwight J. Rouse
Summary: The rate of preterm premature rupture of membranes (PROM) and the likelihood of composite maternal or neonatal morbidity after preterm PROM were similar for twin and singleton gestations in a large, diverse cohort.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Marion Rouzaire, Marion Corvaisier, Virginie Roumeau, Aurelien Mulliez, Feras Sendy, Amelie Delabaere, Denis Gallot
Summary: Factors predictive of short latency exceeding 48 h after PPROM include the need for tocolysis, a cervical length less than 25 mm at admission, and the existence of anamnios. Outpatient follow-up did not result in increased maternal morbidity or neonatal mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Maria Paola Bonasoni, Andrea Palicelli, Giulia Dalla Dea, Giuseppina Comitini, Paola Nardini, Loredana Vizzini, Giuseppe Russello, Marcellino Bardaro, Edoardo Carretto
Summary: Klebsiella pneumoniae infection leading to acute chorioamnionitis caused intrauterine fetal demise in a case presented here. The mother was admitted at 18 weeks + 1 day for threatened abortion, with IUFD occurring 11 days later. The correct treatment was initiated based on fetal microbiological results, leading to full patient recovery.
Article
Biochemistry & Molecular Biology
Bruna Ribeiro Andrade Ramos, Julia Abbade Tronco, Marcio Carvalho, Tainara Francini Felix, Patricia Pintor Reis, Juliano Coelho Silveira, Marcia Guimaraes Silva
Summary: This study compared the expression of miRNAs in sEV from peripheral blood between term and preterm pregnancies. It found that miR-612 expression was increased in the preterm group, while miR-1253, miR-1283, miR378e, and miR-579-3p were downregulated in the preterm premature rupture of membranes (PPROM) group. The study suggests that miRNAs in circulating sEV play a regulatory role in the pathogenesis of preterm labor (PTL) and PPROM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Tsuyoshi Murata, Hyo Kyozuka, Yuta Endo, Toma Fukuda, Shun Yasuda, Akiko Yamaguchi, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori
Summary: The study showed that pregnant women with uterine myomas have an increased incidence of preterm birth and preterm premature rupture of membranes. However, intrauterine infection in women with uterine myomas was not significantly associated with an increased incidence of preterm birth or preterm premature rupture of membranes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)