Article
Gastroenterology & Hepatology
Masau Sekiguchi, Marcus Westerberg, Anders Ekbom, Rolf Hultcrantz, Anna Forsberg
Summary: This study investigated lesion detection rates during colonoscopies and the associated factors. The results showed that, in addition to sufficient withdrawal time, antispasmodic use and acquiring skills enabling short insertion time may improve lesion detection.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Ipek Sapci, Xue Jia, James Wu, Emre Gorgun, David Liska, James Church, Scott R. Steele, Michael A. Valente
Summary: The time of day does not have a significant effect on the quality metrics of colonoscopy in patients undergoing screening. In our practice, colonoscopies meet and exceed all national quality benchmarks, regardless of the time of day they are performed.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Oncology
Yingshuang Zhu, Yanqin Huang, Yeting Hu, Yimin Fang, Xiangxing Kong, Qian Xiao, Jinjie He, Yunfeng Zhu, Qilong Li, Jinhuan Yang, Qi Dong, Mingjuan Jin, Meilin Wang, Kun Chen, Shu Zheng, Kefeng Ding
Summary: This study found that individuals with high-risk adenomas (at least one advanced adenoma or >= 3 nonadvanced adenomas) have an increased risk of subsequent CRC in the Chinese population, while those with 1 to 2 nonadvanced adenomas do not show significantly increased risk of CRC. These results provide valuable evidence for the current surveillance guidelines in China.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Kazuhiro Mizukami, Erina Fushimi, Ryota Sagami, Takashi Abe, Takao Sato, Shohei Terashi, Masahide Fukuda, Hidefumi Nishikiori, Takayuki Nagai, Masaaki Kodama, Kazunari Murakami
Summary: This study investigated the lesion-detection ability of an AI-equipped colonoscopy as an addition to colonoscopy screening. The results showed that the CADe group had a significantly higher adenoma detection rate compared to the conventional group, especially for non-expert endoscopists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Subin Chirayath, Janak Bahirwani, Parampreet Kaur, Noel Martins, Ronak Modi
Summary: The study found that quality measures of screening colonoscopies, such as CIR, CIT, and SWT, were negatively impacted during the COVID-19 period, likely due to the introduction of personal protective equipment. However, ADR remained similar, indicating that the clinical benefit of colonoscopies was not affected by the use of PPE.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Amanda J. Cross, Emma C. Robbins, Brian P. Saunders, Stephen W. Duffy, Kate Wooldrage
Summary: Higher adenoma detection rates (ADRs) in flexible sigmoidoscopy screening provide greater long-term protection against colorectal cancer (CRC) incidence and mortality.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sunil Gupta, Sergei Vosko, Neal Shahidi, Timothy O'Sullivan, Oliver Cronin, Anthony Whitfield, Rajiv Kurup, Mayenaaz Sidhu, Eric Y. T. Lee, Stephen J. Williams, Nicholas G. Burgess, Michael J. Bourke
Summary: This study investigated the prevalence, risk factors, and management of colorectal strictures following endoscopic resection of large nonpedunculated colorectal polyps. The results showed that most patients with an endoscopic resection (ER) defect size of 90% or greater developed strictures, with a significant proportion being severe and requiring early balloon dilation. In contrast, the risk of strictures was low for ER defects of 60%-89% and less than 60%.
Article
Gastroenterology & Hepatology
Liang Huang, Yue Hu, Shan Liu, Bo Jin, Bin Lu
Summary: A large-scale retrospective study found that factors such as patient age, gender, sedation, single examiner colonoscopy, and senior level endoscopists are strongly correlated with adenoma detection rate (ADR) in colonoscopy procedures. These multilevel factors play an important role in improving the quality of colonoscopy.
BMC GASTROENTEROLOGY
(2021)
Article
Oncology
Joaquin Cubiella, Antia Gonzalez, Raquel Almazan, Elena Rodriguez-Camacho, Raquel Zubizarreta, Isabel Pena-Rey Lorenzo
Summary: In a CRC screening program, the surgery rate and associated complications in patients with nonmalignant lesions are low, and are mainly related to age, gender, endoscopic findings, endoscopist's ADR, and hospital complexity.
Article
Oncology
Kenechukwu Chudy-Onwugaje, Wen-Yi Huang, L. Joseph Su, Mark P. Purdue, Christine C. Johnson, Lingxiao Wang, Hormuzd A. Katki, Kathryn Hughes Barry, Sonja I. Berndt
Summary: In this study, a beneficial role for both aspirin and ibuprofen in preventing advanced adenoma and curbing progression to recurrence and cancer among older adults was observed during long-term follow-up.
Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Gil Ho Lee, Joon Koo Kang, Sun Gyo Lim, Bumhee Park, Jae Bum Park, Sung Jae Shin, Jae Youn Cheong, Jin Hong Kim, Kee Myung Lee
Summary: The study found that the monthly number of endoscopic examinations increased toward the end of the year, but the gastric cancer detection rates were negatively associated with calendar month. This highlights the importance of policy guidelines to improve cancer screening programs.
Article
Gastroenterology & Hepatology
Zhiyu Dong, Junwen Wang, Ying Chen, Huihui Sun, Bo Li, Qiongmei Zhang, Kejing Sun, Zhenxiang Wang, Xue Qian, Tingting Zhan, Yuanxi Jiang, Shuchang Xu
Summary: This study found that Fridays and weekends have a negative impact on adenoma detection rate (ADR); ADR is significantly lower when colonoscopies are performed in the afternoon, while increasing procedure order leads to lower cecal intubation rate (CIR).
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2021)
Article
Multidisciplinary Sciences
Hery Djagat Purnomo, Cecilia Oktaria Permatadewi, Agung Prasetyo, Didik Indiarso, Suhartono, Hesti Triwahyu Hutami, Dik Puspasari, Devia Eka Listiana, Herna Rizkia Armatussolikha, Suryanto Setyo Priyadi, Sri Sadono, Silvina, Nurhayati, Samsudin, Ahnaf, Muhammad Hidayanto, Puriyanto Wahyu Nugroho, Nur Dian Rakhmawati, Agus Susanto, Mukti Setiawan, Mochamad Sonny
Summary: Colorectal cancer is a major public health problem in Indonesia, and CRC screening is expected to improve early diagnosis and reduce mortality rates. However, primary health care-based CRC screening has not yet been performed in Semarang, Indonesia. This study aimed to gather information about the prevalence, adenoma detection rate, and public compliance for CRC screening in this region. The results suggest that a primary care-based CRC screening program should be considered, along with public awareness education to increase colonoscopy compliance.
Article
Gastroenterology & Hepatology
Jeffrey Rebhun, Meredith Yellen, Yinglin Xia, Asim Shuja
Summary: This study aims to investigate the significance of the day of the work week on endoscopist performance, using ADR and proposed quality measures. The results showed that ADR on Friday was significantly lower than other days, and all days were independent predictors of increased ADR. Proposed quality indicators were well correlated with ADR, and CWT may have additional value as a quality metric.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Martin Buerger, Marko Weber, Iver Petersen, Andreas Stallmach, Carsten Schmidt
Summary: In this study, the use of improved narrow-band imaging (190-NBI) was associated with a lower adenoma detection rate (ADR) compared to high-definition white light colonoscopy (HD-WLC). However, this difference was only observed in inexperienced endoscopists. Therefore, more intensive training should be provided before implementing 190-NBI technology in daily clinical care.
Article
Gastroenterology & Hepatology
Martin Menendez Rodriguez, Natalia Garcia-Morales, Teresa Seoane Pillado, Jorge Garau Ramirez, Alba Traver Salvador, Yesica Hervas Jimenezf, Noel Pin Vieito, Luis Menendez Rodriguez, Joaquin Cubiella
Summary: Colorectal cancer is the second leading cause of cancer-related death worldwide, and the tumor stage at diagnosis is the main prognostic factor for survival. However, the participation rate in colorectal cancer screening programs is only around 50%. This study aimed to identify the perceived benefits and barriers of the population when participating in a colorectal cancer screening program using the faecal occult blood test. Through a case-control study with 408 participants, epidemiological and social variables associated with lifestyle and behavioral factors were analyzed based on the Health Belief Model. Descriptive analysis was conducted, and variables associated with adherence were identified through logistic regression.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Medicine, General & Internal
Lorenzo Cantarelli, Marta Carrillo Palau, Manuel Hernandez Guerra, Gloria Julia Nazco Casariego, Fernando Gutierrez Nicolas
Summary: The aim of this study was to determine the predictive potential of monitoring infliximab plasma levels for sustained clinical response and evaluate its usefulness in improving treatment efficacy and symptom control in patients with inflammatory bowel disease. The results confirmed the predictive potential of monitoring infliximab plasma levels as a strategy to evaluate sustained long-term clinical response. The study highlights the importance of introducing this monitoring into routine clinical practice to identify non-responders, optimize treatment, prevent relapse, and improve long-term therapy maintenance.
Article
Gastroenterology & Hepatology
Javier Crespo, Joaquin Cabezas, Antonio Aguilera, Marina Berenguer, Maria Buti, Xavier Forns, Federico Garcia, Javier Garcia-Samaniego, Manuel Hernandez-Guerra, Francisco Jorquera, Jeffrey Lazarus, Sabela Lens, Elisa Martro, Juan Antonio Pineda, Martin Prieto, Francisco Rodriguez-Frias, Manuel Rodriguez, Miguel Angel Serra, Juan Turnes, Raquel Dominguez-Hernandez, Miguel Angel Casado, Jose Luis Calleja
Summary: The Spanish Society of Digestive Pathology (SEPD), the Spanish Association for the Study of the Liver (AEEH), the Spanish Society of Infections and Clinical Microbiology (SEIMC) and its Viral Hepatitis Study Group (GEHEP), with the endorsement of the Alliance for the Elimination of Viral Hepatitis in Spain (AEHVE), have developed a document for comprehensive diagnosis of viral hepatitis (B, C, and D) from a single blood sample. They propose an algorithm to analyze the rest of the viruses, including viral load, when a positive result for viral hepatitis or HIV is found in the blood sample. They also recommend ruling out previous hepatitis A virus infection and determining the HIV serology. Automated alerts and epidemiological monitoring should be initiated in case of a positive result for any of the viruses.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Medicine, General & Internal
Guillermo Bosch, Merce Comas, Laia Domingo, Anna Guillen-Sola, Esther Duarte, Xavier Castells, Maria Sala
Summary: This study characterized dysphagia and its association with aspiration pneumonia and mortality in a tertiary hospital in Barcelona, Spain. The results showed that dysphagia was present in 2.4% of all hospital discharges and was more frequent in older patients and in men. The most common diagnoses associated with dysphagia were aspiration pneumonia (48.2%) and stroke (14%). Dysphagia was associated with a higher risk of aspiration pneumonia and increased mortality among hospitalized patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Ana Echarri, Jose L. Perez-Calle, Marta Calvo, Gema Molina, Monica Sierra-Ausin, Maria C. Morete-Perez, Noemi Mancenido, Belen Botella, Noelia Cano, Beatriz Castro, Daniel Martin-Rodriguez, Yolanda Sanchez-Ortega, Pilar Corsino, Mercedes Canas, Ana M. Lopez-Calleja, Pilar Nos, Javier Muniz
Summary: This study investigated the information habits of patients with inflammatory bowel disease (IBD) and the perceptions of both patients and professionals regarding a national website as an educational resource. The results showed that 80% of patients searched the internet for information on their disease, and most patients valued a website recommended by their professional, showing willingness to participate in online educational initiatives and provide feedback to improve its usefulness. Professionals believed that this type of website is the best supplementary information source for patients and prescribed it to a majority of patients, especially those who were newly diagnosed.
TELEMEDICINE AND E-HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Laia Bonjoch, Yasmin Soares de Lima, Marcos Diaz-Gay, Isabella Dotti, Jenifer Munoz, Leticia Moreira, Sabela Carballal, Teresa Ocana, Miriam Cuatrecasas, Oswaldo Ortiz, Antoni Castells, Maria Pellise, Francesc Balaguer, Azucena Salas, Ludmil B. B. Alexandrov, Sergi Castellvi-Bel
Summary: Serrated polyposis syndrome (SPS) is a common polyposis syndrome that increases the risk of colorectal cancer (CRC). A germline frameshift variant in the POLD1 gene was identified in an SPS patient with CRC. The variant also appeared in three other SPS-affected family members. Organoid models were generated to study the variant's impact, but no significant differences were observed compared to the control group. Further research is needed to understand the functional consequences of POLD1 alterations. This study provides the first organoid model for germline POLD1 variants, establishing a foundation for studying SPS, CRC, and other malignancies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Health Care Sciences & Services
Daniel G. Abietar, Laia Domingo, Laura Medina-Perucha, Nuria Saavedra, Anna Berenguera, Laia Lacueva, Marta Hurtado, Xavier Castells, Maria Sala
Summary: This study aimed to explore patients' and companions' perceptions, attitudes, and experiences of patient safety, taking into account contextual factors such as cultural background. The study found that good communication, a calm environment, and patient education were important factors. Different cultural backgrounds led to different attitudes towards patient safety. The findings of this study could enrich interventions in areas with diverse cultural backgrounds.
HEALTH EXPECTATIONS
(2023)
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Gastroenterology & Hepatology
Laila Aldars-Garcia, Ruben Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutierrez, Iago Rodriguez-Lago, Luis Fernandez-Salazar, Daniel Ceballos, Jose Manuel Benitez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, Maria Jose Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, Maria Esteve, Ruth de Francisco, Maria Jose Garcia, Ruben Frances, Ainhoa Rodriguez Pescador, Benito Velayos, Elena Guerra del Rio, Sandra Marin Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldan-Martin, Cristina Ramirez, Ancor Sanz-Garcia, Juan J. Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P. Gisbert, Maria Chaparro
Summary: This study investigates the metabolic differences in different subgroups of newly diagnosed treatment-naive IBD patients. The results indicate alterations in energy and amino acid metabolism in IBD patients, with an increased demand for ketone bodies. The differences in metabolites are more pronounced in Crohn's disease patients compared to ulcerative colitis patients, and in serum compared to urine. Cluster analysis identifies three distinct patient profiles with significant differences in clinical, anthropometric, and metabolomic variables.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Infectious Diseases
Olga. P. Nyssen, Pietro Pratesi, Miguel. A. Spinola, Laimas Jonaitis, Angeles Perez-Aisa, Dino Vaira, Ilaria Maria Saracino, Matteo Pavoni, Giulia Fiorini, Bojan Tepes, Dmitry. S. Bordin, Irina Voynovan, Angel Lanas, Samuel. J. Martinez-Dominguez, Enrique Alfaro, Luis Bujanda, Manuel Pabon-Carrasco, Luis Hernandez, Antonio Gasbarrini, Juozas Kupcinskas, Frode Lerang, Sinead. M. Smith, Oleksiy Gridnyev, Marcis Leja, Theodore Rokkas, Ricardo Marcos-Pinto, Antonio Mestrovic, Wojciech Marlicz, Vladimir Milivojevic, Halis Simsek, Lumir Kunovsky, Veronika Papp, Perminder. S. Phull, Marino Venerito, Lyudmila Boyanova, Doron Boltin, Yaron Niv, Tamara Matysiak-Budnik, Michael Doulberis, Daniela Dobru, Vincent Lamy, Lisette. G. Capelle, Emilijia Nikolovska Trpchevska, Leticia Moreira, Anna Cano-Catalia, Pablo Parra, Francis Megraud, Colm O'Morain, Guillermo. J. Ortega, Javier. P. Gisbert
Summary: The segmentation of patients into homogeneous groups can improve the effectiveness of eradication therapy. The study aims to determine the most important treatment strategies used in Europe and evaluate the effectiveness of first-line treatments based on year and country. The analysis found that the overall treatment effectiveness increased from 87% in 2013 to 93% in 2022, with the highest effectiveness achieved in 2022 using bismuth-quadruple therapy in Spain. Cluster analysis identified homogeneous treatment groups and assessed the effectiveness of different first-line treatments.
Meeting Abstract
Gastroenterology & Hepatology
M. Baldan-Martin, I. Lloro, M. Azkargorta, C. Ramirez, I. Soleto Fernandez, M. Orejudo, S. Garcia, J. Mercado, C. H. Gordillo, S. Riestra, M. Rivero, A. Gutierrez, I. Rodriguez-Lago, L. Fernandez-Salazar, D. Ceballos, J. M. Benitez, M. Aguas, I. Baston-Rey, F. Bermejo, M. J. Casanova, R. Lorente, Y. Ber, V. Royo, M. Esteve, F. Elortza, J. P. Gisbert, M. Chaparro
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Baldan-Martin, C. Rubin de Celix, M. Orejudo, L. Ortega, S. Fernandez-Tome, I. Soleto, C. Ramirez, R. Arroyo, P. Fernandez, C. Santander, J. A. Moreno-Monteagudo, M. J. Casanova, F. Casals, S. Casabona, I. Becerro, U. M. Marigorta, A. M. Aransay, D. Bernardo, M. Chaparro, J. P. Gisbert
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. F. Munoz Nunez, C. Rodriguez, J. P. Gisbert, S. Bernardo, J. Aparicio, I. Tagarro, F. Casellas
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
P. Perez Galindo, J. M. Benitez, C. Rubin de Celix, F. Mesonero, A. Castano Garcia, M. Vicuna, L. Bernal, F. Bertoletti, C. Ramirez Castro, M. Sanchez-Azofra, L. Sanchez-Delgado, A. Ponferrada, C. Tejido Sandoval, M. Capilla, V. Laredo de la Torre, M. T. Diz-Lois, C. Duenas Sadornil, N. Garcia-Morales, M. Gonzalez-Vivo, B. Lopez-Cauce, L. Melcarne, C. Calvino-Suarez, E. Lastiri Gonzalez, P. Ramirez de la Piscina, J. P. . Gisbert, I. Perez Martinez, B. Castro, A. Cousillas, M. Manosa, D. Carpio, M. Barreiro-de Acosta
JOURNAL OF CROHNS & COLITIS
(2023)
