Article
Gastroenterology & Hepatology
Meng-Ying Lin, Yung-Yeh Su, Yu-Ting Yu, Chien-Jui Huang, Bor-Shyang Sheu, Wei-Lun Chang
Summary: The red material obtained from EUS FNB contains a higher amount of tumor DNA and can be used as an alternative source for tumor DNA analysis.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Yuri Hanada, Stephen P. Pereira, Brian Pogue, Edward Maytin, Tayyaba Hasan, Bryan Linn, Tiffany Mangels-Dick, Kenneth K. Wang
Summary: This study evaluated the feasibility of EUS-guided verteporfin PDT in ablating nonresectable locally advanced pancreatic cancer (LAPC). Results showed promise for this minimally invasive ablative therapy in select patients, with visible tumor necrosis within 48 hours post-treatment. Patient enrollment and data collection are ongoing.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Dongwook Oh, Jae Hoon Lee, Tae Jun Song, Ki Byung Song, Dae Wook Hwang, Jin Hee Kim, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Summary: This study evaluated the efficacy and safety of a novel lumen-apposing metal stent (LAMS) in patients with postoperative pancreatic fluid collections (POPFCs). The results showed that EUS-guided transluminal drainage (EUS-TD) with the novel LAMS was technically feasible and effective for treating symptoms of POPFCs, with an acceptable adverse event rate.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mariola Marx, Toni Trosic-Ivanisevic, Fabrice Caillol, Nicolas Demartines, Alain Schoepfer, Christian Pesenti, Jean-Philippe Ratone, Maxime Robert, Marc Giovannini, Sebastien Godat
Summary: This article presents a preliminary clinical experience in treating pancreatic insulinomas <2 cm by EUS-RFA. The results show that EUS-RFA is feasible and effective in managing small neuroendocrine tumors of the pancreas with an acceptable safety profile. However, further evidence is needed to assess long-term survival and recurrence.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Nirav Thosani, Putao Cen, Julie Rowe, Sushovan Guha, Jennifer M. Bailey-Lundberg, Dimpal Bhakta, Prithvi Patil, Curtis J. Wray
Summary: The study aims to report the safety, feasibility, and outcomes of EUS-RFA in patients with advanced pancreatic adenocarcinoma. The results showed that EUS-RFA was safe and well-tolerated, and it improved the median survival in some patients. Further prospective trials are needed to understand the role of EUS-RFA in the overall management of PDAC.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Fausto Rosa, Mihai Rimbas, Gianenrico Rizzatti, Giuseppe Quero, Claudio Fiorillo, Michele Impagnatiello, Francesca D'Aversa, Guido Costamagna, Sergio Alfieri, Alberto Larghi
Summary: The study evaluated the safety and efficacy of preoperative endoscopic ultrasound guided fine needle tattooing (EUS-FNT) for detecting pancreatic neuroendocrine tumors (pNETs). Results showed that EUS-guided FNT is a safe and useful method to mark preoperatively small pNETs, with all identified tumors successfully tattooed in one session and no interference with specimen evaluation during pathological examination.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Chen Du, Ningli Chai, Enqiang Linghu, Huikai Li, Xiuxue Feng, Xiangdong Wang, Ping Tang
Summary: The diagnostic value of SpyGlass in diagnosing pancreatic cystic lesions (PCLs) appears to be similar to EUS-FNA in this study. There was no significant difference in diagnostic accuracy between the two methods when performed by experienced endoscopists.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Immunology
Robin D. Wright, Thais F. Bartelli, Seyda Baydogan, James Robert White, Michael P. Kim, Manoop S. Bhutani, Florencia Mcallister
Summary: In this feasibility study, the tumor microbiome (TM) of pancreatic adenocarcinoma was characterized using Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) biopsy and sequencing techniques. The results showed that it is possible to characterize the TM in biopsies with proper decontamination strategies and by comparing it to non-matched tumor.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Fred G. Karaisz, Osama O. Elkelany, Benjamin Davies, Gerard Lozanski, Somashekar G. Krishna
Summary: The morbidity associated with pancreatectomies limits surgical options for high-risk patients. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) offers a minimally invasive and potentially definitive means to treat pancreatic neoplasms. EUS-RFA may play a role in the treatment and palliation of non-surgical cases of pancreatic adenocarcinoma.
Review
Medicine, General & Internal
Jun Liang Teh, Anthony Yuen Bun Teoh
Summary: Endoscopic ultrasound guided-pancreatic duct drainage (EUS-PDD) is a technically challenging procedure for interventional endoscopists. It is most commonly indicated for patients with main pancreatic duct obstruction who have failed conventional endoscopic retrograde pancreatography (ERP) drainage or have surgically altered anatomy. EUS-PDD can be performed using either the EUS-rendezvous (EUS-RV) or the EUS-transmural drainage (TMD) techniques.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yen- Chen, Avijit Chatterjee, Robert Berger, Yonca Kanber, Jonathan Wyse, Eric Lam, Ian Gan, Manon Auger, Sana Kenshil, Jennifer Telford, Fergal Donnellan, James Quinlan, Gregory Lutzak, Fatma Alshamsi, Josee Parent, Kevin Waschke, Adel Alghamdi, Jeffrey Barkun, Peter Metrakos, Prosanto Chaudhury, Myriam Martel, Alastair Dorreen, Kristen Candido, Corey Miller, Viviane Adam, Alan Barkun, George Zogopoulos, Clarence Wong
Summary: In this study, EUS-FNB alone was found to be non-inferior to EUS-FNA+ROSE in the diagnosis of solid pancreatic lesions, with similar diagnostic accuracy for malignancy and excellent histological yield. EUS-FNB alone required fewer needle passes and shorter procedure time compared to EUS-FNA+ROSE, with comparable costs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoxuan Zheng, Haibin Yuan, Chuanjia Gu, Chi Yang, Fangfang Xie, Xueyan Zhang, Binkai Xu, Jiayuan Sun
Summary: This study evaluated the feasibility and safety of transbronchial cryoablation using a novel flexible cryoprobe in an in vivo porcine model. The results showed successful completion of all ablation procedures without major complications. The cryoablation zones were clearly visualized on CT and histopathological analysis revealed necrotic zones and vascular occlusion. This study suggests that bronchoscopic cryoablation may be a feasible and effective modality for the treatment of peripheral lung cancer.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Article
Oncology
Thanawin Wong, Tanawat Pattarapuntakul, Nisa Netinatsunton, Bancha Ovartlarnporn, Jaksin Sottisuporn, Naichaya Chamroonkul, Pimsiri Sripongpun, Sawangpong Jandee, Apichat Kaewdech, Siriboon Attasaranya, Teerha Piratvisuth
Summary: This study evaluated and compared the diagnostic yields of fine-needle aspiration (FNA) and fine-needle biopsy (FNB) using conventional FNA and Franseen needles in patients with solid pancreatic mass. The results showed that FNB using the Franseen needle had a higher diagnostic yield, fewer needle passes, and shorter total procedure time compared to FNA using the conventional FNA needle, without serious adverse events.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Pathology
Charlotte Vestrup Rift, David Scheie, Anders Toxvaerd, Bojan Kovacevic, Pia Klausen, Peter Vilmann, Carsten Palnaes Hansen, Eva Lobner Lund, Jane Preuss Hasselby
Summary: In the diagnosis of pancreatic cysts, TTNBs have higher sensitivity and specificity compared to cytology, particularly for mucinous cysts and high-risk cysts.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Joanne Lundy, Hugh Gao, William Berry, Samar Masoumi-Moghoddam, Brendan J. Jenkins, Daniel Croagh
Summary: This study investigated the potential of combining transcriptomic and mutation analysis with standard cytology to improve the accuracy of PDAC diagnosis and identified an effective diagnostic gene signature. KRAS mutation analysis significantly improved diagnostic accuracy to 91.3% in external validation sets and 91.6% in the validation cohort. Additionally, exploratory analysis suggested that KRAS mutant allele fraction may serve as a novel surrogate marker of tumor cellularity in snap-frozen EUS-FNA biopsies.
CLINICAL CANCER RESEARCH
(2021)
Article
Anesthesiology
Karin H. Wodack, Michael F. Graessler, Sarah A. Nishimoto, Christoph R. Behem, Hans O. Pinnschmidt, Mark A. Punke, M. Ignacio Monge-Garcia, Constantin J. C. Trepte, Daniel A. Reuter
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2019)
Article
Surgery
Christoph R. Behem, Michael F. Graessler, Hans O. Pinnschmidt, Anna Dupree, Harleen K. Sandhu, E. Sebastian Debus, Sabine H. Wipper, Constantin J. C. Trepte
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2019)
Article
Surgery
Fiona Rohlffs, Constantin Trepte, Krassi Ivancev, Nikolaos Tsilimparis, Vladimir Makaloski, E. Sebastian Debus, Tilo Koelbe
JOURNAL OF ENDOVASCULAR THERAPY
(2019)
Review
Pharmacology & Pharmacy
Gerald Kircheis, Stefan Lueth
Article
Medicine, General & Internal
Florian Hentschel, Stefan Lueth
Article
Surgery
Vladimir Makaloski, Fiona Rohlffs, Constantin Trepte, E. Sebastian Debus, Bent Ohlenschlaeger, Jurg Schmidli, Tilo Koelbel
JOURNAL OF ENDOVASCULAR THERAPY
(2019)
Article
Emergency Medicine
Katharina Grupp, Johannes Erbes, Annika Poppe, Karin Wodack, Andreas Gocht, Constantin Trepte, Jan Havel, Oliver Mann, Jakob R. Izbicki, Kai Bachmann
WORLD JOURNAL OF EMERGENCY SURGERY
(2019)
Article
Acoustics
Wilma Schierling, Sabine Wipper, Christoph R. Behem, Daniel C. Hinck, Constantin J. Trepte, Eike S. Debus, Karin Pfister
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Article
Anesthesiology
Sandra Funcke, Hans O. Pinnschmidt, Stefan Wesseler, Charlotte Brinkmann, Burkhard Beyer, Virginija Jazbutyte, Christoph R. Behem, Constantin Trepte, Rainer Nitzschke
ANESTHESIA AND ANALGESIA
(2020)
Review
Gastroenterology & Hepatology
Florian Hentschel, Till Bornscheuer, Stefan Lueth
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2019)
Article
Gastroenterology & Hepatology
Jan-Hendrik Bockmann, Marcel Grube, Vanessa Hamed, Johann von Felden, Johanna Landahl, Malte Wehmeyer, Katja Giersch, Michaela T. Hall, John M. Murray, Maura Dandri, Stefan Lueth, Ansgar W. Lohse, Marc Luetgehetmann, Julian Schulze Zur Wiesch
BMC GASTROENTEROLOGY
(2020)
Article
Surgery
B. E. Wellge, C. J. Trepte, C. Zoellner, J. R. Izbicki, M. Bockhorn
Article
Cardiac & Cardiovascular Systems
Josephina Haunschild, Konstantin von Aspern, Zara Khachatryan, Edoardo Bianchi, Till Friedheim, Sabine Wipper, Constantin J. Trepte, Susann Ossmann, Michael A. Borger, Christian D. Etz
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Gastroenterology & Hepatology
Florian Hentschel, Stefan Lueth
Article
Multidisciplinary Sciences
Christoph R. Behem, Till Friedheim, Sabine H. Wipper, Hans O. Pinnschmidt, Michael F. Graessler, Catharina Gaeth, Hannes Holthusen, Adina Rapp, Timo Suntrop, Josephina Haunschild, Christian D. Etz, Constantin J. C. Trepte
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)