Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Taylor Corsi, Michael A. Ciaramella, Nadia K. Palte, John P. Carlson, Saum A. Rahimi, William E. Beckerman
Summary: Sex differences have an impact on the outcomes of elective endovascular abdominal aortic aneurysm repair (EVAR), with lower 5-year survival and higher reintervention rates in female patients. Besides patient age and baseline health risk, there might be other factors contributing to greater surgical morbidity and mortality for women after elective EVAR.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Christopher A. Latz, Laura Boitano, Samuel Schwartz, Nicholas Swerdlow, Kirsten Dansey, Rens R. B. Varkevisser, Virendra Patel, Marc L. Schermerhorn
Summary: The 30 day mortality rates for elective open complex abdominal aortic aneurysm repair varied depending on the type of aneurysm, with open repair having nearly double the mortality odds compared to endovascular repair. Independent factors associated with death included BMI <18.5, more severe chronic kidney disease, more proximal extent of aneurysm, age, and history of advanced COPD.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Surgery
Kristian Smidfelt, Joakim Nordanstig, Axel Davidsson, Kristina Torngren, Marcus Langenskiold
Summary: Misdiagnosis is common in patients with rAAA, and is associated with a significantly higher risk of mortality. In patients undergoing surgical intervention, the mortality rate is slightly higher in misdiagnosed patients compared to correctly diagnosed patients.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Neuroimaging
D. Andrew Wilkinson, Badih J. Daou, Jeffrey L. Nadel, Neeraj Chaudhary, Joseph J. Gemmete, Byron Gregory Thompson, Aditya S. Pandey
Summary: The study evaluated the incidence of aneurysmal SAH in patients diagnosed with AAA using longitudinal claims data. Results showed a higher SAH rate in patients with AAA, with AAA being the strongest predictor for SAH even after adjusting for comorbidities. The study suggested that the common genetic and environmental risk factors for both diseases should be further investigated.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Herrero-Cervera, Carla Espinos-Estevez, Susana Martin-Vano, Alida Taberner-Cortes, Maria Aguilar-Ballester, Angela Vinue, Laura Piqueras, Sergio Martinez-Hervas, Herminia Gonzalez-Navarro
Summary: The study suggests a protective role of LIGHT in preventing VSMC trans-differentiation and maintaining their contractile characteristics. Loss of LIGHT exacerbates AAA severity and affects the gene expression of VSMCs.
Review
Cardiac & Cardiovascular Systems
Samuel Debono, Jennifer Nash, Andrew L. Tambyraja, David E. Newby, Rachael O. Forsythe
Summary: The management of abdominal aortic aneurysms has been rigorously examined, with traditional open surgical repair improving long-term outcomes but associated with significant morbidity and mortality. Endovascular aneurysm repair has reduced early complications but introduced unique issues like endoleaks. A need for postoperative imaging surveillance and re-intervention arises due to the risks associated with endoleak development, influencing the selection of repair mode for individual patients.
Article
Medicine, General & Internal
Natalia Niklas, Piotr Gutowski, Arkadiusz Kazimierczak, Pawel Rynio
Summary: The current stratification model of aneurysm rupture is inadequate in certain clinical cases. Our study reveals differences in wall structure between ruptured and unruptured aneurysms, with the AFL/ILT surface ratio potentially serving as a predictive factor for aneurysm rupture and symptom occurrence in AAA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Christian-Alexander Behrendt, Thea Kreutzburg, Jenny Kuchenbecker, Giuseppe Panuccio, Mark Dankhoff, Konstantinos Spanos, George Kouvelos, Sebastian Debus, Frederik Peters, Tilo Koelbel
Summary: This study aimed to determine sex-specific perioperative and long-term outcomes of patients who underwent abdominal aortic aneurysm repair. The results showed no significant differences in perioperative and long-term survival rates between sexes, but females were more likely to have pre-existing health issues and experience complications during the perioperative period.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Endocrinology & Metabolism
Zijia Huang, Huiling Su, Tiejun Zhang, Yuwen Li
Summary: Diabetes mellitus has a negative association with abdominal aortic aneurysm, but is also associated with poorer outcomes following AAA repair. Hypoglycemic medications may have a protective effect against AAA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Maja Carina Nackenhorst, Marvin Kapalla, Simon Weidle, Felix Kirchhoff, David Zschaepitz, Sabine Sieber, Christian Reeps, Hans-Henning Eckstein, Heike Schneider, Markus Thaler, Philipp Moog, Albert Busch, Nadja Sachs
Summary: This study investigates the histologic and serologic analyses of inflammatory and IgG4-positive abdominal aortic aneurysms (AAA), finding that the incidence of these subtypes is very low based on histologic and serum analyses. The degree of inflammation differs between the two subtypes, but no increased levels of IgG or IgG4 were found in the serologic analysis. Short-term operative outcomes were not different for both sub-cohorts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Julie Hogh, Michael Huy Cuong Pham, Andreas Dehlbaek Knudsen, Rebekka Faber Thudium, Marco Gelpi, Per Ejlstrup Sigvardsen, Andreas Fuchs, Jorgen Tobias Kuhl, Shoaib Afzal, Borge Gronne Nordestgaard, Thomas Benfield, Lars Kober, Jan Gerstoft, Klaus Fuglsang Kofoed, Susanne Dam Nielsen
Summary: This study found that people living with HIV have a significantly higher risk of aortic aneurysms compared to uninfected individuals, with HIV status independently associated with this condition. Among PLWH, factors like age, obesity, and hepatitis B co-infection are associated with a higher risk of aortic aneurysms. Increased attention to this condition in PLWH may be beneficial.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Julie Hogh, Michael Huy Cuong Pham, Andreas Dehlbaek Knudsen, Rebekka Faber Thudium, Marco Gelpi, Per Ejlstrup Sigvardsen, Andreas Fuchs, Jorgen Tobias Kuhl, Shoaib Afzal, Borge Gronne Nordestgaard, Thomas Benfield, Lars Kober, Jan Gerstoft, Klaus Fuglsang Kofoed, Susanne Dam Nielsen
Summary: This study found that people living with HIV have a significantly higher prevalence of aortic aneurysms compared to uninfected individuals, with HIV status being independently associated with aortic aneurysms. Among PLWH, age, obesity, and hepatitis B co-infection were identified as risk factors for aortic aneurysms. These findings suggest that increased attention to aortic aneurysms in PLWH may be beneficial.
EUROPEAN HEART JOURNAL
(2021)
Article
Physiology
Matthew L. Stone, Ashish K. Sharma, Yunge Zhao, Eric J. Charles, Mary E. Huerter, William F. Johnston, Irving L. Kron, Kevin R. Lynch, Victor E. Laubach
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Nicolas H. Pope, Morgan Salmon, William F. Johnston, Guanyi Lu, Christine L. Lau, Gilbert R. Upchurch, Gorav Ailawadi
ANNALS OF THORACIC SURGERY
(2015)
Letter
Cardiac & Cardiovascular Systems
William F. Johnston, Morgan Salmon, Nicolas H. Pope, Akshaya Meher, Gang Su, Matthew L. Stone, Guanyi Lu, Gary K. Owens, Gilbert R. Upchurch, Gorav Ailawadi
Article
Surgery
Amit Jain, Tanya F. Flohr, William F. Johnston, Margaret C. Tracci, Kenneth J. Cherry, Gilbert R. Upchurch, John A. Kern, Ravi K. Ghanta
JOURNAL OF VASCULAR SURGERY
(2016)
Article
Cardiac & Cardiovascular Systems
William F. Johnston, Morgan Salmon, Nicolas H. Pope, Akshaya Meher, Gang Su, Matthew L. Stone, Guanyi Lu, Gary K. Owens, Gilbert R. Upchurch, Gorav Ailawadi
Article
Gastroenterology & Hepatology
Joshua M. Judge, George J. Stukenborg, William F. Johnston, William H. Guilford, Craig L. Slingluff, Peter T. Hallowell
JOURNAL OF GASTROINTESTINAL SURGERY
(2014)
Article
Surgery
Guanyi Lu, Gang Su, Yunge Zhao, William F. Johnston, Nicholas E. Sherman, Emilie F. Rissman, Christine Lau, Gorav Ailawadi, Gilbert R. Upchurch
JOURNAL OF SURGICAL RESEARCH
(2014)
Article
Hematology
Morgan Salmon, Basil Schaheen, Michael Spinosa, William Montgomery, Nicolas H. Pope, John P. Davis, William F. Johnston, Ashish K. Sharma, Gary K. Owens, Juanita L. Merchant, Zendra E. Zehner, Gilbert R. Upchurch, Gorav Ailawadi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Surgery
J. Michael Cullen, Guanyi Lu, Alexander H. Shannon, Gang Su, Ashish Sharma, Morgan Salmon, Anna Z. Fashandi, Michael D. Spinosa, William G. Montgomery, W. Forrest Johnston, Gorav Ailawadi, Gilbert R. Upchurch
JOURNAL OF VASCULAR SURGERY
(2019)
Article
Multidisciplinary Sciences
Zachary Tyerman, Jolian Dahl, Alexander Shannon, W. Forrest Johnston, Nicholas H. Pope, Guanyi Lu, Gilbert R. Upchurch, Gorav Ailawadi, Morgan Salmon
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Multidisciplinary Sciences
Alexander H. Shannon, J. Michael Cullen, Jolian J. Dahl, Erik J. Scott, Zachary Tyerman, Michael D. Spinosa, William G. Montgomery, W. Forrest Johnston, Guanyi Lu, Morgan Salmon, Gorav Ailawadi, Gilbert R. Upchurch
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Surgery
Morgan Salmon, Robert B. Hawkins, Jolian Dahl, Erik Scott, Gorav Ailawadi
Summary: This study demonstrates that disruption of IL-1a exacerbates abdominal aortic aneurysms, while intervention targeting IL-1a can alleviate AAA formation.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Guillaume S. Chevrollier, Aaron L. Klinger, Heather J. Green, Mariella M. Gastanaduy, W. Forrest Johnston, Herschel D. Vargas, Brian R. Kann, Charles B. Whitlow, Jennifer L. Paruch
Summary: This study aimed to determine whether using liposomal bupivacaine in transversus abdominis plane blocks improves postoperative pain and reduces opioid use after colorectal surgery. The results showed that patients receiving liposomal bupivacaine blocks had lower maximum pain scores on the day of surgery, but no other differences were found in pain scores, morphine milligram equivalents used, or length of stay between the two groups. Therefore, the use of liposomal bupivacaine in transversus abdominis plane blocks for colon and rectal resections is not justified.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
W. Forrest Johnston, Caitlin Stafford, Todd D. Francone, Thomas E. Read, Peter W. Marcello, Patricia L. Roberts, Rocco Ricciardi
DISEASES OF THE COLON & RECTUM
(2017)