Article
Immunology
Nicolo de Pretis, Antonio Amodio, Giulia De Marchi, Eugenio Marconato, Rachele Ciccocioppo, Luca Frulloni
Summary: AIP is a fibroinflammatory disease of the pancreas, with type 1 associated with IgG4-related disease and type 2 associated with inflammatory bowel disease. While serum IgG4 elevation is a useful diagnostic tool for type 1 AIP, new biomarkers are needed for both type 1 and type 2 AIP.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Paulina Nunez, Noa Krugliak Cleveland, Rodrigo Quera, David T. Rubin
Summary: Endoscopic evaluation plays a crucial role in predicting disease activity and severity in inflammatory bowel diseases, with mucosal healing associated with improved clinical outcomes and incorporated into standard care. Therapeutic endoscopic options and surveillance strategies, including early detection of neoplasia, continue to advance with evolving technology and visualization techniques.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Genetics & Heredity
Jie Deng, Ziying Song, Xiaolan Li, Huiqing Shi, Shangqing Huang, Lijun Tang
Summary: This review focuses on the role of long non-coding RNAs (lncRNAs) in the pathogenesis, diagnosis, and therapy of acute pancreatitis (AP). Accumulating evidence has shown significant alterations in the expression of lncRNAs, which are involved in the mechanisms of AP such as premature trypsinogen activation, impaired autophagy, inflammatory response, and acinar cell death. Moreover, lncRNAs can be potential biomarkers for the diagnosis of AP and therapeutic targets for AP treatment.
FRONTIERS IN GENETICS
(2023)
Editorial Material
Immunology
Qinglong Wu, Kang Ning, Xiaoxiao Zhao, Feng Liao, Min Wang, Longgang Chang, Yanmin Liu, Jinmiao Chen, Ming Zhao, Zhangran Chen
Summary: Autoimmune diseases affect 5% to 8% of the global population and their pathogenesis remains unclear, posing a significant challenge to healthcare systems.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Surinder Singh Rana
Summary: This article summarizes the diagnostic and therapeutic role of EUS in acute pancreatitis, chronic pancreatitis, and autoimmune pancreatitis.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Nicolo de Pretis, Stefano Francesco Crino, Luca Frulloni
Summary: Autoimmune pancreatitis (AIP) is a disease that can be classified into two subtypes based on histology, with diagnosis achieved using the criteria of ICDC. Treatment with steroids is recommended for patients with typical imaging appearance, while differential diagnosis with pancreatic cancer is crucial for those with atypical imaging or mass-forming appearance. EUS-guided tissue acquisition is proposed for histological diagnosis, especially with the use of new needles for fine-needle biopsy (FNB).
Review
Radiology, Nuclear Medicine & Medical Imaging
Shinji Okaniwa
Summary: Diagnosis of autoimmune pancreatitis involves suspicion of AIP, identification of specific pancreatic manifestations in the acute phase, use of high-frequency transducers and elastography for differential diagnosis, monitoring changes post-steroid trial, and evaluation of other organ involvement in IgG4-related disease.
JOURNAL OF MEDICAL ULTRASONICS
(2021)
Review
Gastroenterology & Hepatology
Atsushi Kanno, Tetsurou Miwata, Hiroki Nagai, Eriko Ikeda, Kozue Ando, Yuki Kawasaki, Yamato Tada, Kensuke Yokoyama, Kiichi Tamada, Noriyoshi Fukushima, Alan Kawarai Lefor, Hironori Yamamoto
Summary: Endoscopic ultrasound-guided pancreatic sampling is effective for the histopathological diagnosis of autoimmune pancreatitis and can help distinguish between AIP and pancreatic cancer. Recent advancements in needle biopsy methodologies and technologies have improved the diagnostic efficacy of this technique. The guidance provided in this study is expected to further advance the histopathological diagnosis of AIP using EUS-guided pancreatic sampling.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
M. Alvaro Berbis, Jose Aneiros-Fernandez, F. Javier Mendoza Olivares, Enrique Nava, Antonio Luna
Summary: The use of artificial intelligence tools in diagnostic imaging holds great promise, especially in the field of deep learning analysis, potentially changing the way care is delivered in gastroenterology. This review aims to explore the role of neural networks in evaluating gastrointestinal conditions and how different models perform in critical tasks.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Seung Bae Yoon, Sung-Hoon Moon, Tae Jun Song, Jong Hyeok Kim, Myung-Hwan Kim
Summary: The diagnostic yield for AIP may be higher with FNB than with FNA, despite similar rates of histologic tissue procurement. Additionally, a 19G needle showed better diagnostic performance compared to a 22G needle.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Miroslav Vujasinovic, Sara Nikolic, Alina Gordon Achour, J. Matthias Lohr
Summary: This study found that micronutrient deficiencies, particularly in vitamin D and zinc, may be common in patients with autoimmune pancreatitis (AIP). Micronutrient deficiencies were associated with AIP relapse initially, but this association lost statistical significance after stratifying for AIP type 1 and adjusting for PEI and elevated IgG4 levels.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Lotte Boxhoorn, Robert C. Verdonk, Marc G. Besselink, Marja Boermeester, Thomas L. Bollen, Stefan A. W. Bouwense, Vincent C. Cappendijk, Wouter L. Curvers, Cornelis H. Dejong, Sven M. van Dijk, Hendrik M. van Dullemen, Casper H. J. van Eijck, Erwin J. M. van Geenen, Muhammed Hadithi, Wouter L. Hazen, Pieter Honkoop, Jeanin E. van Hooft, Maarten A. J. M. Jacobs, June E. C. Kievits, Marnix P. M. Kop, Eva Kouw, Sjoerd D. Kuiken, Michiel Ledeboer, Vincent B. Nieuwenhuijs, Lars E. Perk, Jan-Werner Poley, Rutger Quispel, Rogier J. J. de Ridder, Hjalmar C. van Santvoort, Christina J. Sperna Weiland, Martijn W. J. Stommel, Hester C. Timmerhuis, Ben J. Witteman, Devica S. Umans, Niels G. Venneman, Frank P. Vleggaar, Roy L. J. van Wanrooij, Marco J. Bruno, Paul Fockens, Rogier P. Voermans
Summary: In a multicentre prospective cohort study, patients with infected necrotising pancreatitis who underwent endoscopic drainage were compared. The results showed that LAMS did not reduce the need for necrosectomy and the rate of bleeding complications was similar.
Article
Gastroenterology & Hepatology
Sheng-Yu Zhang, Yun-Lu Feng, Long Zou, Xi Wu, Tao Guo, Qing-Wei Jiang, Qiang Wang, Ya-Min Lai, Shou-Jiang Tang, Ai-Ming Yang
Summary: This study demonstrated the differences in EUS features of newly diagnosed AIP, as well as the disparities in typical AIP and CP features between diffuse and focal AIP. The CP change level was found to be relatively limited in newly diagnosed AIP cases in both groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ana Dugic, Cristina Verdejo Gil, Claudia Mellenthin, Miroslav Vujasinovic, J-Matthias Lohr, Steffen Muehldorfer
Summary: This systematic review examines the clinical utility of various serum biomarkers in diagnosing AIP, distinguishing it from pancreatic cancer, and predicting disease course, steroid therapy response, and relapse. Several autoantibodies and biomarkers, in addition to IgG4, show potential for AIP diagnosis and differentiation from pancreatic cancer.
Article
Clinical Neurology
Avi Gadoth, Yahel Segal, Yael Paran, Orna Aizenstein, Yifat Alcalay
Summary: Non-antigen-specific assays, like immunofluorescence assay (IFA), can be useful in identifying antibodies not detected by commercial kits in the evaluation of autoimmune encephalitis. They can lead to changes in initial diagnosis, treatment modifications, and detection of suspected cancer cases.
JOURNAL OF NEUROLOGY
(2022)
