Article
Oncology
Yiming Liu, Yanqiao Ren, Sangluobu Ge, Bin Xiong, Guofeng Zhou, Gansheng Feng, Songlin Song, Chuansheng Zheng
Summary: The study evaluated the efficacy and safety of TACE in treating TN-HCC and R-HCC, with R-HCC patients showing better outcomes before PSM analysis but inferior results after PSM analysis. Risk signature analysis based on conditional inference tree can accurately predict recurrence and survival outcomes in both groups of patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiaohui Wang, Yu Yuan, Juncheng Wang, Zishan Liu, Minshan Chen, Qunfang Zhou, Zhongguo Zhou
Summary: This study compared the effects of preoperative TACE and postoperative TACE on patients with HCC larger than 5 cm, finding that patients who received preoperative TACE had better overall survival and recurrence-free survival outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Ho Chu, Dong I. L. Gwon, Gun Ha Kim, Jin Hyoung Kim, Gi-Young Ko, Ji Hoon Shin, Heung-Kyu Ko, Hyun-Ki Yoon
Summary: This retrospective study compared the safety and efficacy of balloon-occluded transarterial chemoembolization (B-TACE) and conventional TACE (C-TACE) in treating single hepatocellular carcinoma (HCC). The results showed that B-TACE had a higher initial complete response rate and longer time to local tumor progression for medium- to large-sized HCCs (> 3 cm) compared to C-TACE.
EUROPEAN RADIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Tengfei Si, Zhenlin Huang, Shirin Elizabeth Khorsandi, Yun Ma, Nigel Heaton
Summary: This study found that hepatic arterial infusion chemotherapy (HAIC) may be a more effective treatment for unresectable hepatocellular carcinoma (HCC) compared to transarterial chemoembolization (TACE). HAIC demonstrated significant improvements in overall survival (OS) and progression-free survival (PFS), particularly in patients with advanced portal vein tumor thrombus (PVTT).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Linbin Lu, Peichan Zheng, Zhixian Wu, Xiong Chen
Summary: This study analyzed the overall survival of patients with intermediate-stage HCC undergoing hepatic resection (HR) or transarterial chemoembolization (TACE). The results showed that HR was associated with improved overall survival, especially in patients with LDH levels higher than 192 U/L. Conversely, TACE may be more suitable for patients with LDH levels lower than or equal to 192 U/L.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
A. Bogdanovic, P. Bulajic, D. Masulovic, N. Bidzic, M. Zivanovic, D. Galun
Summary: The study compared short- and long-term outcomes of patients with huge HCC who underwent potentially curative LR or TACE, finding that LR group had higher overall survival rates both before and after propensity score matching. Total bilirubin and TACE treatment were identified as independent prognostic factors associated with long-term survival.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Ho Chu, Seng-Yong Chun, Jin Hyoung Kim, Pyeong Hwa Kim, Dong Il Gwon, Heung-Kyu Ko, Nayoung Kim
Summary: This study indicates that TACE may be effective for patients with HCC invading the hepatic vein or inferior vena cava. The predictive model can help identify candidates most likely to benefit from TACE.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Yu-Xing Chen, Jin-Xing Zhang, Chun-Gao Zhou, Jin Liu, Sheng Liu, Hai-Bin Shi, Qing-Quan Zu
Summary: This study compared the safety and efficacy of TACE-lenvatinib with TACE alone for unresectable HCC patients. The results showed that TACE-lenvatinib group achieved better tumor control, PFS, and OS compared to the TACE group.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Gastroenterology & Hepatology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Chih-Chieh Ko, Yi-Hsiang Huang, Chien-Wei Su, Rheun-Chuan Lee, Ping-Hsing Tsai, Ming-Chih Hou, Teh-Ia Huo
Summary: Tumor burden score (TBS) is a feasible new prognostic marker in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE), with higher TBS associated with factors such as vascular invasion and abnormal blood markers, leading to poorer overall survival rates.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Health Care Sciences & Services
Evgenia Kotsifa, Chrysovalantis Vergadis, Michael Vailas, Nikolaos Machairas, Stylianos Kykalos, Christos Damaskos, Nikolaos Garmpis, Georgios D. Lianos, Dimitrios Schizas
Summary: HCC is the most common primary liver malignancy associated with liver cirrhosis and chronic liver disease. Key risk factors for HCC development include viral infections, alcoholic liver disease, and nonalcoholic fatty liver disease. Treatment options for HCC depend on tumor burden, liver function, and patient's health status, with surgical resection, transplantation, ablation, TACE, and systemic therapy being potential strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Zhang, Lei Mu, Yiyue Ren, Tianan Jiang
Summary: A study using propensity score matching found no significant difference in long-term survival benefits between thermal ablation monotherapy and thermal ablation combined with transarterial chemoembolization in hepatocellular carcinoma patients.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Pei-Min Hsieh, Pojen Hsiao, Yaw-Sen Chen, Jen-Hao Yeh, Chao-Ming Hung, Hung-Yu Lin, Ching-Hou Ma, TaoQian Tang, Yu Wei Huang, Pin-Nan Cheng, Kun-Chou Hsieh, Kuang-Chun Hu, Ming-Jong Bair, Chih-Wen Lin
Summary: This retrospective study examined prognostic factors and therapeutic strategies for patients with single large hepatocellular carcinoma (HCC), and found that surgical resection was associated with higher overall survival (OS) and progression-free survival (PFS) rates compared to transarterial chemoembolization (TACE).
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Oncology
Di Zhu, Kun Ma, Wei Yang, Hai-Feng Zhou, Qi Shi, Jian-Wu Ren, Yu-Guan Xie, Sheng Liu, Hai-Bin Shi, Wei-Zhong Zhou
Summary: The study compared the efficacy and safety of TACE combined with apatinib and camrelizumab with TACE combined with apatinib in patients with unresectable HCC. The TACE + AC group showed significantly longer overall survival and progression-free survival compared to the TACE + A group, with similar safety profiles observed in both combination therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Biao Yang, Minlan Yuan, Ting Yang, Zhengyin Liao, Hao Wu
Summary: This retrospective study evaluates the clinical outcome of transcatheter arterial chemoembolization (TACE) and liver resection (LR) for hepatocellular carcinoma (HCC) in the caudate lobe. The results suggest that TACE may provide a longer overall survival (OS) compared to LR, particularly for patients with CNLC-IIb stage HCC.
Article
Oncology
Benoit Allignet, Pierre Pradat, Francoise Mornex, Floriane Izarn, Agnes Rode, Jean-Yves Mabrut, Kayvan Mohkam, Philippe Merle
Summary: This study compared the efficacy of TACE-hRT and SR in early single or paucinodular intrahepatic HCC patients. The results showed no significant difference in TTP between TACE-hRT and SR, but lower PFS and OS rates in the TACE-hRT group. Factors negatively impacting PFS and OS included age, alcohol-related liver disease, and total number of HCC nodules. Although TACE-hRT is an effective and safe treatment for patients at high risk of surgical complications, surgical resection remains the preferred option.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Ho Kim, Jae Kyung Jung, Hyo-Cheol Kim, Jin Wook Chung, Jin Woo Choi
Summary: The study aimed to determine the ideal size range of embolic agents in interventional oncology experiments using rat models of hepatocellular carcinoma. Fluorescent microparticles were administered to evaluate their distribution and tumor response rates. The 15-19 Rm embolic agents were found to be the most favorable for causing tumor necrosis without nontarget toxicity.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Min Woo Lee, Jeong Min Lee, Young Hwan Koh, Jin Wook Chung
KOREAN JOURNAL OF RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ijin Joo, Jeong Min Lee, Young Hwan Koh, Sang Hyun Choi, Sunyoung Lee, Jin Wook Chung
KOREAN JOURNAL OF RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
In Joon Lee, Ho Jong Chun, Jin Wook Chung
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyo-Cheol Kim, Shiro Miyayama, Jin Woo Choi, Gyoung Min Kim, Jin Wook Chung
Summary: Intra-arterial treatment is important for managing unresectable hepatocellular carcinoma, as a thorough understanding of tumor arterial supply allows for selective therapy. The inferior phrenic artery is the most common collateral artery that feeds the cancer, and it has a specific vascular anatomy. Techniques and catheters are used for catheterization of the artery depending on its origin sites.
Article
Biochemistry & Molecular Biology
Su Jong Yu, Jeong-Ju Yoo, Dong Ho Lee, Su Jin Kim, Eun Ju Cho, Se Hyung Kim, Jeong-Hoon Lee, Yoon Jun Kim, Jeong Min Lee, Jae Young Lee, Jung-Hwan Yoon
Summary: Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced MRI can detect early stages of hepatocellular carcinoma (HCC) in patients with cirrhosis, but its survival benefit is unknown. This retrospective cohort study found that intermittent replacement of ultrasonography (USG) with Gd-EOB-DTPA-enhanced MRI improved the clinical outcomes of cirrhosis patients, including overall survival and time to progression.
Article
Medicine, General & Internal
Eun Ju Cho, Goh Eun Chung, Jeong-Ju Yoo, Yuri Cho, Dong Wook Shin, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Su Jong Yu
Summary: This study aimed to investigate whether the association between alcohol consumption and hepatocellular carcinoma (HCC) risk differs by fasting serum glucose level and diabetes. The results showed that mild-to-moderate alcohol consumption increased the risk of HCC in all glycemic statuses, but the risk was highest in patients with diabetes.
Article
Medicine, General & Internal
Jeong-Ju Yoo, Man Young Park, Eun Ju Cho, Su Jong Yu, Sang Gyune Kim, Yoon Jun Kim, Young Seok Kim, Jung-Hwan Yoon
Summary: This study investigates the effect of smoking on the incidence of hepatocellular carcinoma (HCC) and cardiovascular disease (CVD) in patients with metabolic-associated fatty liver disease (MAFLD). The analysis of a Korean health screening database shows that smoking significantly increases the risk of HCC and CVD in MAFLD patients. Complete smoking cessation is highly recommended for individuals with MAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jihye Kim, Moon Haeng Hur, Seung Up Kim, Jin-Wook Kim, Dong Hyun Sinn, Hyun Woong Lee, Moon Young Kim, Jae Youn Cheong, Yong Jin Jung, Han Ah Lee, Young-Joo Jin, Jun Sik Yoon, Sung-Jae Park, Chang Hun Lee, In Hee Kim, June Sung Lee, Young Youn Cho, Hyung Joon Kim, Soo Young Park, Yeon Seok Seo, Hyunwoo Oh, Dae Won Jun, Mi Na Kim, Young Chang, Jae Young Jang, Sang Youn Hwang, Yoon Jun Kim
Summary: This study compared the effectiveness of entecavir and tenofovir disoproxil fumarate in preventing hepatocellular carcinoma among patients with chronic hepatitis B. The study found that the two antivirals had similar efficacy in preventing HCC and had comparable rates of other outcomes. However, the tenofovir disoproxil fumarate group had more side effects, leading to some patients needing to switch initial antiviral medications.
Editorial Material
Gastroenterology & Hepatology
Min Kyung Park, Yoon Jun Kim
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Cheol-Hyung Lee, Yun Bin Lee, Hyemi Moon, Jong-Won Chung, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Yoon Jun Kim, Juneyoung Lee, Jung-Hwan Yoon
Summary: This study investigated the associations between aspirin use and risks of hepatocellular carcinoma (HCC), liver-related mortality, and major bleeding in non-cirrhotic patients with chronic hepatitis B (CHB). The results showed that aspirin use was associated with reduced risks of HCC and liver-related death, without an increase in the risk of major bleeding, in patients with CHB and a higher metabolic risk factor burden.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Heechul Nam, Hyun Yang, Ho Soo Chun, Han Ah Lee, Joon Yeul Nam, Jeong Won Jang, Yeon Seok Seo, Do Young Kim, Yoon Jun Kim, Si Hyun Bae
Summary: The study aimed to identify prognostic factors, including pre-treatment low skeletal muscle mass (LSMM), for survival outcomes in patients with hepatocellular carcinoma (HCC) undergoing trans-arterial radioembolization (TARE).
Article
Medicine, General & Internal
Heejoon Jang, Su Jong Yu, Hong Ghi Lee, Tae Min Kim, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Kim
Summary: The optimal duration of prophylactic antiviral therapy in patients with resolved HBV receiving rituximab is unclear. This study found that there is no significant difference in HBV reactivation between the 6-month and 12-month prophylactic TDF groups after completion of rituximab-based chemotherapy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Surgery
Jiyoung Kim, Suk Kyun Hong, Jae-Yoon Kim, Jaewon Lee, Hyun Hwa Choi, Sola Lee, Su young Hong, Jeong-Moo Lee, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study investigated the prognosis of patients diagnosed with totally necrotic nodules upon explant hepatectomy after liver transplantation (LT) for hepatocellular carcinoma (HCC). The results showed that 3.0% of patients experienced HCC recurrence during a median follow-up of 84 months. The 5-year overall and recurrence-free survival rates were 92.8% and 92.2%, respectively. A maximum diameter of the totally necrotic nodules greater than 5 cm was identified as the only factor associated with tumor recurrence after LT.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2023)