Article
Medicine, General & Internal
Mesut Akarsu, Soner Onem, Zarni Htway, Ozan Cengiz, Suleyman Dolu, Leyla Iyilikci
Summary: Peutz-Jeghers syndrome is an autosomal dominant disorder characterized by multiple hamartomatous polyps in the small intestine. This case report describes the first double balloon enteroscopy during pregnancy for a patient with a history of intestinal resection due to the syndrome. Experienced endoscopists in expert centers should perform the procedure to manage the high-risk complications effectively.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2022)
Article
Oncology
Masaaki Yamamoto, Kazuya Iwamoto, Rei Suzuki, Yosuke Mukai, Tomohira Takeoka, Kei Asukai, Naoki Shinno, Hisashi Hara, Takashi Kanemura, Nozomu Nakai, Shinichiro Hasegawa, Keijiro Sugimura, Naotsugu Haraguchi, Junichi Nishimura, Hiroshi Wada, Hidenori Takahashi, Chu Matsuda, Masayoshi Yasui, Takeshi Omori, Hiroshi Miyata, Masayuki Ohue, Masaru Murata
Summary: Peutz-Jeghers syndrome is a rare genetic disorder characterized by gastrointestinal polyps and pigmentation. Laparoscopic-assisted disinvagination and polypectomy is a useful, minimally invasive treatment for PJS patients with multiple intussusceptions caused by small intestinal polyps.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Sergio Klimkowski, Mohamed Ibrahim, Juan J. Ibarra Rovira, Mohamed Elshikh, Sanaz Javadi, Albert R. Klekers, Abdelraham A. Abusaif, Ahmed W. Moawad, Kamran Ali, Khaled M. Elsayes
Summary: Peutz-Jeghers Syndrome is a hereditary syndrome defined by gastrointestinal hamartomatous polyps, mucocutaneous pigmentations, and elevated cancer risk mainly caused by mutations in the STK11 gene. Patients have a higher risk of malignancies compared to the general population, requiring regular imaging examinations to detect potential abnormalities in a timely manner.
Article
Gastroenterology & Hepatology
Kaoru Takabayashi, Naoki Hosoe, Motohiko Kato, Yukie Hayashi, Kosaku Nanki, Kayoko Fukuhara, Yohei Mikami, Shinta Mizuno, Tomohisa Sujino, Makoto Mutaguchi, Makoto Naganuma, Naohisa Yahagi, Haruhiko Ogata, Takanori Kanai
Summary: Assessing deep small bowel lesions (DSB) using balloon-assisted enteroscopy (BAE) is crucial for evaluating endoscopic mucosal healing in Crohn's disease patients even in remission. A high mpSES-CD score >5 at DSB is significantly correlated with relapse rate, while a pSES-CD score at the TI does not exhibit correlation with relapse rate.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Zhongsheng Cao, Weili Jin, Xueping Wu, Wensheng Pan
Summary: This study assessed the efficacy and safety of single-balloon enteroscopy (SBE) for the treatment of small bowel polyps in patients with Peutz-Jeghers syndrome (PJS). The results showed that SBE is effective and safe for resecting small bowel polyps in patients with PJS.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Genetics & Heredity
Yu-Liang Jiang, Xiao-Dong Xu, Bai-Rong Li, En-Da Yu, Zi-Ye Zhao, Hong Liu
Summary: Early diagnosis of Peutz-Jeghers syndrome (PJS) is crucial based on selective features in family history among family members and pathological information. The novel mutations also expand the STK11 variant spectrum.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Article
Gastroenterology & Hepatology
Masanao Nakamura, Tomonori Yano, Motohiro Esaki, Shiro Oka, Keigo Mitsui, Fumihito Hirai, Keisuke Kawasaki, Mitsuhiro Fujishiro, Takehiro Torisu, Shinji Tanaka, Katsuhiko Iwakiri, Masahiro Kishi, Takayuki Matsumoto, Hironori Yamamoto
Summary: This study compared the impact of the EN-580XP system and EN-580T system on pancreatic injury during endoscopy. The results showed that the EN-580XP system appeared to have a less harmful effect on the pancreas, with significantly lower rates of pancreatic hyperamylasemia and hyperlipasemia compared to the EN-580T system.
Review
Medicine, General & Internal
Anja Wagner, Stefan Aretz, Annika Auranen, Marco J. Bruno, Giulia M. Cavestro, Emma J. Crosbie, Anne Goverde, Anne Marie Jelsig, Andrew R. Latchford, Monique E. van Leerdam, Anna H. Lepisto, Marta Puzzono, Ingrid Winship, Veronica Zuber, Gabriela Moslein
Summary: Scientific data on the management of Peutz-Jeghers syndrome (PJS) is limited, necessitating more collaborative studies for better understanding of this rare condition. Current guidelines only cover gastrointestinal and pancreatic management, leaving other aspects in need of further research and discussion.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yu Sasaki, Yasuhiko Abe, Naoko Mizumoto, Eiki Nomura, Yoshiyuki Ueno
Summary: Eosinophilic gastroenteritis (EoGE) is a rare digestive disorder characterized by eosinophilic infiltration in the stomach and intestines. The endoscopic findings of EoGE in the small intestine are not well understood, but this literature review identified common findings such as redness, villous atrophy, erosion, ulceration, edema, and stenosis. These findings contribute to the development of EoGE practice.
Article
Medicine, General & Internal
Chtourou Rahma, Ben Kraiem Najoua, Zouari Mohamed, Mellouli Manel, Dghaies Rim, Ben Dhaou Mahdi, Sellami Boudawara Tahya, Mhiri Riadh
Summary: We report a case of a young girl with Peutz-Jeghers syndrome who had recurrent small bowel intussusceptions. Laparotomy exploration revealed multiple jejunal polyps leading to jejunojejunal intussusceptions, which were removed via mini enterotomies. Pathological examination confirmed Peutz-Jeghers polyps.
CLINICAL CASE REPORTS
(2022)
Article
Medicine, General & Internal
Junloong Chiew, Sekkapan Thannimalai Sambanthan, Hans Alexander Mahendran
Summary: Peutz-Jeghers syndrome (PJS) is a genetic disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin pigmentation. Patients with PJS have a high risk of complications such as intussusception. Surgical intervention is the main treatment for PJS patients with intussusception.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Gastroenterology & Hepatology
Luca Elli, Lucia Scaramella, Gian Eugenio Tontini, Matilde Topa, Dario Conte, Reena Sidhu, Emanuele Rondonotti, Roberto Penagini, Maurizio Vecchi
Summary: This study assessed the impact of videocapsule endoscopy (VCE) and double balloon enteroscopy (DBE) in patients with suspected small bowel bleeding (SSBB). DBE had a significantly higher diagnostic yield compared to VCE, but the concordance between the two procedures was generally suboptimal. Post-procedural hemoglobin values were significantly higher, and there were no differences in diagnostic yield, complications, or hemoglobin values between patients treated with direct oral anticoagulants (DOACs) and non-DOAC patients.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Surgery
Peng Wang, Yuxin Wang, Yuanhang Dong, Jiefang Guo, Hongyu Fu, Zhaoshen Li, Yiqi Du
Summary: This study retrospectively analyzed data from 1291 patients undergoing DBE procedures, finding that DBE has a high diagnostic value for small bowel diseases such as CD and small bowel tumors, and also demonstrates a high level of safety in therapeutic interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Lijuan Qian, Yijie Gu, Lu Zheng, Tingting Xia
Summary: In this study, the clinical data of 134 cases of CE and 109 cases of DBE were retrospectively analyzed. The results showed that DBE had a higher disease diagnostic rate and suspected intestinal bleeding rate than CE, but required a longer examination time, had a higher incidence of adverse reactions, and a lower examination tolerance than CE.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Hao Dang, Nik Dekkers, Saskia le Cessie, Jeanin E. van Hooft, Monique E. van Leerdam, Philip P. Oldenburg, Louis Flothuis, Jan W. Schoones, Alexandra M. J. Langers, James C. H. Hardwick, Jolein van der Kraan, Jurjen J. Boonstra
Summary: The cumulative incidence of colorectal cancer recurrence for patients with T1 CRC treated with local endoscopic resection only is 3.3%, with the majority of recurrences occurring within 72 months of follow-up.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ellis L. Eikenboom, Anne-Sophie van der Werf-'t Lam, Mar Rodriguez-Girondo, Christi J. Van Asperen, Winand N. M. Dinjens, Robert M. W. Hofstra, Monique E. Van Leerdam, Hans Morreau, Manon C. W. Spaander, Anja Wagner, Maartje Nielsen
Summary: This study investigates the effectiveness and cost of immunohistochemistry testing in Lynch syndrome patients and their relatives. The proportion of MMRd and MMR germline PV is influenced by age, completeness, and type of diagnostics, and complete diagnostics can explain almost all MMRd CRC, contributing to optimizing testing and surveillance.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Berbel L. M. Ykema, Lisanne S. Rigter, Manon C. W. Spaander, Leon M. G. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Evelien Dekker, Wieke H. M. Verbeek, Ernst J. Kuipers, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, Richard W. M. van der Maazen, Gerrit A. Meijer, Michael Schaapveld, Flora E. van Leeuwen, Beatriz Carvalho, Petur Snaebjornsson, Monique E. van Leerdam
Summary: The study evaluated clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in Hodgkin's lymphoma (HL) survivors who had undergone abdominal radiotherapy and/or procarbazine treatment. Colorectal neoplasia in HL survivors differs from average-risk controls, with AN primarily classified based on polyp size (>=10 mm) and longer follow-up between HL diagnosis and colonoscopy associated with a higher prevalence of AN.
DIGESTIVE ENDOSCOPY
(2022)
Article
Surgery
Mitchell L. S. Driessen, Leontien M. Sturms, Frank W. Bloemers, Henk Jan ten Duis, Michael J. R. Edwards, Dennis den Hartog, E. J. Kuipers, Peter A. Leenhouts, Martijn Poeze, Inger B. Schipper, Richard W. Spanjersberg, Klaus W. Wendt, Ralph J. de Wit, Stefan W. A. M. van Zutphen, Mariska A. C. de Jongh, Luke P. H. Leenen
Summary: The COVID-19 pandemic has had an adverse effect on the outcome of major trauma patients in the Netherlands. Fewer patients, especially those with less severe traumatic brain injuries, were admitted to the ICU during the peak period, resulting in increased mortality rates for this subgroup.
Article
Oncology
Josephina G. Kuiper, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings
Summary: The NCR-PHARMO GP cohort, consisting of 135,868 cancer patients, provides rich data on primary care management of cancer, enabling large-scale observational cancer research in the primary care setting. Patient-level linkage allows for long-term follow-up with ongoing annual updates.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
S. A. Nieuwenburg, M. C. Mommersteeg, L. M. M. Wolters, A. J. van Vuuren, N. Erler, M. P. Peppelenbosch, G. M. Fuhler, M. J. Bruno, E. J. Kuipers, M. C. W. Spaander
Summary: This study found that FIT can be used with high accuracy and sensitivity for the diagnosis of H. pylori, and is considered the most convenient test method. Non-invasive Hp-FIT test shows great promise for combined upper and lower gastrointestinal (pre-) cancerous screening. Further research should explore the clinical implications, benefits, and cost-effectiveness of this approach.
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Sulleman Moreea, Harinder Dhaliwal, Dana C. Moffatt, Krish Ragunath, Terry Ponich, Alan N. Barkun, Ernst J. Kuipers, Robert Bailey, Fergal Donnellan, David Wagner, Keith Sanborn, James Lau
Summary: The study evaluated the safety and effectiveness of Hemospray as a monotherapy for active peptic ulcer bleeding. Results showed that Hemospray was successfully administered in nearly all patients, with a high rate of hemostasis achieved. Recurrent bleeding was observed in a small percentage of patients, but no adverse events were attributed to the use of Hemospray.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Oncology
Emilie C. H. Breekveldt, Esther Toes-Zoutendijk, Manon C. W. Spaander, Hilliene J. van de Schootbrugge-Vandermeer, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian R. B. Ramakers, Evelien Dekker, Iris D. Nagtegaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The Dutch colorectal cancer (CRC) screening programme based on faecal immunochemical testing has shown a decrease in advanced-stage CRC incidence after its introduction in 2014. The incidence initially increased before screening but later decreased and remained below expected levels. These findings provide evidence for the effectiveness of the Dutch screening programme in reducing advanced-stage CRC incidence.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Dominique S. V. M. Clement, Monique E. van Leerdam, Soraya de Jong, Martin O. Weickert, John K. Ramage, Margot E. T. Tesselaar, Rajaventhan Srirajaskanthan
Summary: Neuroendocrine tumours (NETs) are rare tumours arising in the digestive system, mainly the small bowel or pancreas. This study aimed to describe the presence of sarcopenia at the time of diagnosis of stage IV NET in the digestive system and correlate it with survival. Sarcopenia was present in 69% of patients, and its presence in pancreatic NETs was associated with poorer survival.
Article
Gastroenterology & Hepatology
Esther Toes-Zoutendijk, Lucie de Jonge, Carola Adriana van Iersel, Manon C. W. Spaander, Anneke J. van Vuuren, Folkert van Kemenade, Christian R. Ramakers, Evelien Dekker, Iris D. Nagetaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The study assessed the impact of delayed invitation on screen-detected and interval colorectal cancers (CRC) in a FIT-based CRC screening program. Individual-level data from individuals who participated in 2017 and 2018 with a negative FIT and were eligible for screening in 2019 and 2020 were analyzed. The results showed that the first COVID-19 wave had a modest impact on screening yield, and a small proportion of FIT negatives had interval CRC, possibly due to an extended invitation interval.
Review
Surgery
Petra A. Custers, Barbara M. Geubels, Geerard L. Beets, Doenja M. J. Lambregts, Monique E. van Leerdam, Baukelien van Triest, Monique Maas
Summary: This review identified the heterogeneity in terminology, criteria, and features used to define a near-complete response. The differences may be related to therapeutic aims and strategies. A reproducible definition of near-complete response is necessary.
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Pieter Wisse, Nicole S. Erler, S. Y. D. Boer, Gijsbert Den Hartog, M. Oudkerk Pool, Jochim S. Terhaar Sive Droste, C. Verveer, Gerrit Meijer, Iris Lansdorp-Vogelaar, Ernst J. Kuipers, Evelien Dekker, Manon Spaander
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Oncology
Sonja Levy, Wieke H. M. Verbeek, Ferry A. L. M. Eskens, Jose G. van den Berg, Derk Jan A. de Groot, Monique E. van Leerdam, Margot E. T. Tesselaar
Summary: The study demonstrates that the combination of everolimus and cisplatin is an effective treatment option for advanced EP-NEC, especially in carefully selected patients. The treatment resulted in high disease control rate and overall response rate, with some patients experiencing durable responses.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
