Article
Multidisciplinary Sciences
Hye Gyo Chung, Jong-In Chang, Kwang Hyuk Lee, Joo Kyung Park, Kyu Taek Lee, Jong Kyun Lee
Summary: This study compared the diagnostic yield of EUS and ERCP-based tissue sampling in intrinsic biliary strictures, finding that EUS was more sensitive and accurate than ERCP, particularly in strictures located in the distal bile duct.
Article
Gastroenterology & Hepatology
Amy Tyberg, Avik Sarkar, Haroon M. Shahid, Sardar M. Shah-Khan, Monica Gaidhane, Alexa Simon, Ian A. Eisenberg, Michael Lajin, Petko Karagyozov, Kelvin Liao, Roohi Patel, Eric Zhao, Ma Guadalupe Martinez, Everson L. Artifon, Andre D. Lino, Giuseppe Vanella, Paolo G. Arcidiacono, Michel Kahaleh
Summary: Patients undergoing EUS-BD before hepatobiliary surgery require fewer repeat endoscopic interventions, have a shorter duration between endoscopy and surgical intervention, higher rates of surgical clinical success, and a shorter length of hospital stay after surgery.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Surgery
Christina J. Sperna Weiland, Evelien C. Verschoor, Alexander C. Poen, Xavier J. M. N. Smeets, Niels G. Venneman, Abha Bhalla, Ben J. M. Witteman, Hester C. Timmerhuis, Devica S. Umans, Jeanin E. van Hooft, Marco J. Bruno, P. Fockens, Robert C. Verdonk, Joost P. H. Drenth, Erwin J. M. van Geenen
Summary: Even with advanced imaging techniques, the presence of common bile duct sludge or stones can be missed during ERCP. Pre-procedural EUS or MRCP can reduce the proportion of unnecessary ERCPs. A shorter time interval between EUS or MRCP and ERCP increases the detection rate of suspected CBD stones during ERCP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Rao Saad Ali Khan, Laima Alam, Zoya Ali Khan, Uzair Ali Khan
Summary: This study evaluated the diagnostic accuracy of different imaging modalities in patients with partial biliary obstruction and no obvious cause. The results showed that EUS had the highest diagnostic accuracy compared to MRCP, especially in patients with intermediate risk of choledocholithiasis.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Surgery
Roberto Di Mitri, Michele Amata, Filippo Mocciaro, Elisabetta Conte, Ambra Bonaccorso, Barbara Scrivo, Daniela Scimeca
Summary: The study found that EUS-guided biliary drainage (EUS-BD) with Lumen Apposing Metal Stent (LAMS) is effective for jaundice palliation after ERCP failure but comes with significant adverse events. Maldeployment of LAMS remains a serious complication with fatal consequences if not promptly recognized and managed. Therefore, rescue therapy should be promptly applied especially in tertiary-care centers with highly skilled endoscopists, interventional radiologists, and dedicated surgeons.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Helena Gomez Facundo, Ruth Ribas Montoliu, Daniel Rolando Coronado Llanos, Gemma Sugranyes Naval, Erik Llacer Millan, Sandra Lopez Gordo, Judith Hermoso Bosch, Sergio Lopez Rodriguez, Montse Martin Baranera, Sergio Gonzalez Martinez
Summary: Early cholecystectomy performed seven days after resolution of MABP significantly reduces readmission rates for biliary events, without increasing the incidence of residual choledocholithiasis.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Anthony Yuen Bun Teoh, Betrand Napoleon, Rastislav Kunda, Paolo Giorgio Arcidiacono, Pradermchai Kongkam, Alberto Larghi, Schalk Van der Merwe, Jeremies Jacques, Romain Legros, Ratanachu-Ek Thawee, Payal Saxena, Maridi Aerts, Livia Archibugi, Shannon Melissa Chan, Fabien Fumex, Arthur J. Kaffes, Mark Tsz Wah Ma, Nouredin Messaoudi, Gianenrico Rizzatti, Kelvin Kwok Chai Ng, Enders Kwok Wai Ng, Philip Wai Yan Chiu
Summary: This study compared primary endoscopic ultrasound (EUS)-guided biliary drainage with endoscopic retrograde cholangiopancreatography (ERCP) for treating unresectable malignant distal biliary obstruction (MDBO). The results showed no significant difference in 1-year stent patency rates between the two procedures, but EUS-guided biliary drainage had higher technical success and shorter procedural time.
Article
Gastroenterology & Hepatology
Takeshi Ogura, Atsushi Okuda, Saori Ueno, Nobu Nishioka, Akira Miyano, Kazuya Ueshima, Yoshitaro Yamamoto, Kazuhide Higuchi
Summary: This study evaluated the technical feasibility and safety of using a 22-gauge needle and a new 0.018-inch guidewire for EUS-BD in patients with insufficient bile duct dilatation. The results showed that the technical success rate of using the 22-gauge needle and the new guidewire was comparable to that of using the 19-gauge needle and the conventional guidewire, even in cases of insufficient bile duct dilatation. The study suggests that further research with a larger sample size is needed to confirm these findings.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Surgery
Eric Bergeron, Theo Doyon, Thibaut Maniere, Etienne Desilets
Summary: In this study, RBE occurred in 28.5% of subjects at a median time of 34 days, with an incidence of 2.5% as early as 1 week. This suggests that cholecystectomy should be done preferably within 7 days after common bile duct clearance to prevent RBE and adverse outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Jiasu Li, Jian Tang, Feng Liu, Jun Fang
Summary: This meta-analysis suggests that EUS-CDS and EUS-HGS have similar technical and clinical success rates, but EUS-CDS has a slightly shorter procedure time and fewer early adverse events compared to EUS-HGS.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Pietro Fusaroli, Andrea Lisotti
Summary: ERCP combined with EUS is the preferred treatment for choledocholithiasis, with high success rates and reduced risk of complications.
MEDICINA-LITHUANIA
(2021)
Article
Surgery
C. Ginestet, F. Sanglier, V Hummel, A. Rouchaud, R. Legros, H. Lepetit, M. Dahan, P. Carrier, V Loustaud-Ratti, D. Sautereau, J. Albouys, J. Jacques, S. Geyl
Summary: This study compared the real-life efficacies of percutaneous transhepatic biliary drainage (PTBD) and endoscopic ultrasound-guided biliary drainage (EUS-BD) with electrocautery-enhanced lumen-apposing metal stent (EC-LAMS) in cases of ERCP failure for malignant biliary obstruction. The results showed that EUS-BD with EC-LAMS had higher clinical success rates, safety, cost-effectiveness, and overall survival compared to PTBD in this patient population.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Krupa, Robert Staron, Dorota Dulko, Natalia Lozinska, Alan R. Mackie, Neil M. Rigby, Adam Macierzanka, Aleksandra Markiewicz, Christian Jungnickel
Summary: The study determined that serum bilirubin is a good indicator of the type of biliary obstruction, able to differentiate between benign obstructions such as choledocholithiasis and malignant changes such as pancreatic neoplasms or cholangiocarcinoma. Additionally, it was shown that conjugated/unconjugated bile salts confirm the presence of an obstruction, with lower levels indicating increased possibilities of inflammation and neoplasms.
Article
Gastroenterology & Hepatology
Alessandro Fugazza, Carlo Fabbri, Roberto Di Mitri, Maria Chiara Petrone, Matteo Colombo, Luigi Cugia, Arnaldo Amato, Edoardo Forti, Cecilia Binda, Marcello Maida, Emanuele Sinagra, Alessandro Repici, Ilaria Tarantino, Andrea Anderloni
Summary: EUS-guided choledochoduodenostomy with a lumen-apposing metal stent is a viable alternative for patients with distal malignant biliary obstruction and failed ERCP, with acceptable rates of adverse events.
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Abdelhai Abdelqader, Michel Kahaleh
Summary: Pancreaticobiliary endotherapy continues to progress in the era of therapeutic endosonography. Endoscopic ultrasound-guided biliary and pancreatic duct drainage is increasingly becoming the preferred alternative when ERCP fails.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Angel Lanas, Jane M. Andrews, James Lau, Murat Toruner, Susan E. Bromley, Ian M. Gralnek
Summary: There is a need for better patient management and physician guidance in treating iron deficiency/iron-deficiency anemia (IDA) in patients who have experienced acute gastrointestinal bleeding (GIB). Published data on this subject are limited and disparate, and there is a lack of information on post-discharge outcomes such as persistent anemia and re-hospitalization. Acute GIB-related ID/IDA is a common condition that is likely underdiagnosed and undertreated. Further research is needed to establish evidence-based guidelines for iron therapies in these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Harry L. A. Janssen, Jinlin Hou, Tarik Asselah, Henry L. Y. Chan, Fabien Zoulim, Yasuhito Tanaka, Ewa Janczewska, Ronald G. Nahass, Stefan Bourgeois, Maria Buti, Pietro Lampertico, Oliver Lenz, Thierry Verbinnen, Joris Vandenbossche, Willem Talloen, Ronald Kalmeijer, Maria Beumont, Michael Biermer, Umesh Shukla
Summary: The study evaluated the efficacy and safety of JNJ-56136379 in patients with chronic hepatitis B. The results showed that JNJ-56136379+NA significantly reduced HBV DNA and HBV RNA levels, but had limited effects on HBsAg or HBeAg declines in HBeAg-positive patients. Overall, JNJ-56136379 did not demonstrate clear superiority over NA in terms of efficacy.
Article
Gastroenterology & Hepatology
Terry Cheuk-Fung Yip, Vincent Wai-Sun Wong, Mandy Sze -Man Lai, Jimmy Che-To Lai, Vicki Wing-Ki Hui, Lilian Yan Liang, Yee-Kit Tse, Henry Lik-Yuen Chan, Grace Lai -Hung Wong
Summary: We investigated the long-term incidence of hepatocellular carcinoma (HCC) and hepatic decompensation among chronic hepatitis B patients who have achieved hepatitis B surface antigen (HBsAg) seroclearance. The study found that the proportion of patients who developed HCC after HBsAg clearance was 1.1%, while the proportion of patients who developed hepatic decompensation was 1.3%. HBsAg clearance for over 7 years was associated with a reduced risk of hepatic decompensation but not HCC.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
James Y. W. Lau, Rui Li, Chen-huan Tan, Xiu-jing Sun, Hao-jun Song, Lan Li, Feng Ji, Bu-jiang Wang, Dong-tao Shi, Wai K. Leung, Imogen Hartley, Alan Moss, Karina Y. Y. Yu, Bing Y. Suen, Peng Li, Francis K. L. Chan
Summary: There is a clinically significant failure rate in current endoscopic methods for the control of acute nonvariceal bleeding. The role of over-the-scope clips (OTSCs) as the first treatment has not been defined. A multicenter, randomized controlled trial showed that compared to standard endoscopic hemostatic treatments, OTSCs can reduce the risk of further bleeding from nonvariceal upper gastrointestinal causes.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Tao Lyu, Ka Shing Cheung, Zijie Deng, Li Ni, Chuan Chen, Juan Wu, Wai K. Leung, Wai Kay Seto
Summary: Whole genome sequencing of Helicobacter pylori revealed potential novel genetic mutations associated with clarithromycin and levofloxacin resistance, including fliJ and cheA genes, which may improve predictive accuracy for targeted sequencing tests in the future.
Article
Gastroenterology & Hepatology
Fang Jiang, Chengsheng Ju, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wallis C. Y. Lau, Wai K. Leung
Summary: This study investigated the risk of hospitalization for upper gastrointestinal bleeding (UGIB) in patients who had received H. pylori eradication therapy and were newly started on warfarin or DOACs. The results showed that DOACs had a significantly lower risk of UGIB compared to warfarin in H. pylori-eradicated patients. Additionally, there was no significant difference in UGIB risk between H. pylori-eradicated and H. pylori-negative patients newly started on warfarin or DOACs.
Article
Biochemistry & Molecular Biology
Lui Ng, Ryan Wai-Yan Sin, David Him Cheung, Wai-Keung Leung, Abraham Tak-Ka Man, Oswens Siu-Hung Lo, Wai-Lun Law, Dominic Chi-Chung Foo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is increasing worldwide, and it is associated with colorectal polyps. This study aimed to investigate the potential of serum microRNAs (miRNAs) in identifying NAFLD in colorectal polyp patients. The results showed that a serum miRNA panel composed of four miRNA pairs significantly identified NAFLD in colorectal polyp patients, and its performance improved when patients with other concurrent metabolic disorders were removed from the analysis. The serum miRNA panel could be a potential diagnostic biomarker for screening NAFLD in colorectal polyp patients for early diagnosis and prevention of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Ka Luen Thomas Lui, Sze Hang Kevin Liu, Kathy Leung, Joseph T. Wu, Ann G. Zauber, Wai Keung Leung
Summary: The widespread adoption of computer-aided detection (CADe) in detecting colorectal polyps would result in shorter surveillance intervals for patients, particularly according to the US Multi-Society Task Force on Colorectal Cancer (USMSTF) guideline. Based on simulation, CADe application would lead to approximately 19.1% and 1.9% of patients requiring shorter surveillance intervals, as recommended by the USMSTF and European Society of Gastrointestinal Endoscopy (ESGE) guidelines, respectively. Specifically, all or 2.7% of patients initially scheduled for 3-5 years of surveillance would have their intervals shortened to 3 years, according to the USMSTF guideline.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kenneth W. W. Lin, Rajneesh Kumar, Feng Shen, Henry L. -Y. Chan, Grace L. -H. Wong, Rahul Kumar, Wan Cheng Chow, Su Lin, Vincent W. -S. Wong, Jian-Gao Fan, George B. -B. Goh
Summary: The prevalence of concomitant chronic hepatitis B (CHB) and hepatic steatosis (HS) is increasing in Asia. Non-invasive tests (NITs) have good accuracy in predicting fibrosis degree in patients with concomitant CHB and HS.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Claudia Wing-Kwan Wu, Rashid Nok-Shun Lui, Vincent Wai-Sun Wong, Tsz-Fai Yam, Terry Cheuk-Fung Yip, Ken Liu, Jimmy Che-To Lai, Yee-Kit Tse, Tony Shu-Kam Mok, Henry Lik-Yuen Chan, Kelvin Kwok-Chai Ng, Grace Lai-Hung Wong, Stephen Lam Chan
Summary: The study successfully validated the efficacy of the Baveno VII criteria in predicting high-risk varices in patients with hepatocellular carcinoma, providing a non-invasive method for assessing the risk of variceal bleeding and hepatic decompensation.
Article
Gastroenterology & Hepatology
Xinrong Zhang, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Wei-Xuan Leow, Lilian Yan Liang, Lee-Ling Lim, Guanlin Li, Luqman Ibrahim, Huapeng Lin, Jimmy Che To Lai, Angel Mei-Ling Chim, Henry Lik Yuen Chan, Alice Pik-Shan Kong, Wah Kheong Chan, Vincent Wai-Sun Wong
Summary: The study aimed to investigate whether automated fibrosis score calculation and electronic reminder messages could increase the detection of advanced liver disease in patients with type 2 diabetes. The results showed that in the intervention group using automated fibrosis score calculation and electronic reminders, 33.3% of patients received appropriate care, compared to only 3.1% in the control group.
Review
Biochemistry & Molecular Biology
Ho-Yu Ng, Wai K. Leung, Ka-Shing Cheung
Summary: Despite the global decline in prevalence, efforts are needed to optimize H. pylori treatment regimens due to increasing antibiotic resistance. Advancements in sequencing technology have helped broaden our understanding of molecular mechanisms behind resistance and facilitated testing of antibiotic susceptibility. Establishing routine antibiotic susceptibility surveillance programs and enforcing antibiotic stewardship are important for managing H. pylori in a sustainable manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Feifei Zhang, Fang Jiang, Lingling Wang, Yijun Chen, Wenxue Zhang, Anni Zhou, Shutian Zhang, Wai K. Leung
Summary: This population-based retrospective cohort study aimed to determine whether H. pylori eradication therapy reduces the risk of colorectal cancer (CRC). The results showed that the risk of CRC was initially higher in H. pylori-infected subjects but gradually decreased over time and became lower than the general population after 10 years of H. pylori eradication, particularly for rectal cancer.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Yunhao Li, Fang Jiang, Chun Ying Wu, Wai K. Leung
Summary: This updated meta-analysis reveals that up to 26% of individuals in Asia have preneoplastic gastric lesions. There has been a significant decline in the prevalence of IM over the past 50 years in Asia, while the prevalence of CAG has remained stable. The rates of CAG and IM vary significantly among different regions, and Helicobacter pylori infection is associated with CAG and IM.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Fang Jiang, Yan Kiu Li, Boqing Chen, Chengsheng Ju, Chuan-Guo Guo, Ka Shing Cheung, Wallis C. Lau, Wai Keung Leung
