Review
Nutrition & Dietetics
Amritpal Dhaliwal, Jonathan Quinlan, Kellie Overthrow, Carolyn Greig, Janet M. Lord, Matthew J. Armstrong, Sheldon C. Cooper
Summary: Sarcopenia, commonly seen in patients with inflammatory bowel disease, has a significant impact on the management of IBD, affecting quality of life, prognosis, and treatment. Research is ongoing to develop interventions to counteract sarcopenia in various chronic inflammatory diseases.
Review
Gastroenterology & Hepatology
Maitreyi Raman, Vidya Rajagopalan, Sandeep Kaur, Raylene A. Reimer, Christopher Ma, Subrata Ghosh, Jeff Vallance
Summary: This article provides an overview of the effects of physical activity on the onset and course of inflammatory bowel disease, as well as patient-reported outcomes and quality of life. While physical activity has shown positive effects on several outcome measures, there is currently a lack of standard guidelines.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Microbiology
Gina L. Guzzo, Murthy N. Mittinty, Bastien Llamas, Jane M. Andrews, Laura S. Weyrich
Summary: It is known that the bacterial gut microbiome is altered in inflammatory bowel disease (IBD), but the role of eukaryotic microorganisms in IBD is less understood. This study characterized the eukaryotic microbial communities in IBD patients and found higher prevalence of fungi and lower prevalence of protozoa compared to healthy individuals. Disease state, age, and BMI were associated with the prevalence and abundance of these eukaryotes. The study also found that the eukaryotic gut microbiome varied over time in IBD patients who received fecal transplants. The findings suggest that future studies should consider including eukaryotic microbes when characterizing the gut microbiome in IBD.
Review
Gastroenterology & Hepatology
Tilemachos Koutouratsas, Anastassios Philippou, George Kolios, Michael Koutsilieris, Maria Gazouli
Summary: The gut microbiome may be related to the pathogenesis of inflammatory bowel diseases, and the effects of physical exercise on the gut microbiome may be beneficial for certain patients with IBD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Chun-Han Lo, Hamed Khalili, Mingyang Song, Paul Lochhead, Kristin E. Burke, James M. Richter, Edward L. Giovannucci, Andrew T. Chan, Ashwin N. Ananthakrishnan
Summary: The study found that adhering to a healthy lifestyle can reduce mortality risk in patients with inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Factors such as never smoking, maintaining a healthy weight, engaging in physical activity, following a balanced diet, and moderate alcohol consumption were all associated with decreased mortality in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura Tasson, Fabiana Zingone, Brigida Barberio, Romina Valentini, Pamela Ballotta, Alexander C. Ford, Marco Scarpa, Imerio Angriman, Matteo Fassan, Edoardo Savarino
Summary: The study found that fatigue is common in IBD patients, and abnormal CRP, sarcopenia, and severe anxiety are factors independently associated with severe fatigue.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Chung Sang Tse, Aricca D. Van Citters, Brittany Ricci, Noah Z. Freundlich, Moses Lee, Samir A. Shah, Gil Y. Melmed, Corey A. Siegel, Welmoed K. van Deen
Summary: Patients with inflammatory bowel disease (IBD) prioritize goals related to symptoms/disease activity and clinical course/management. They are less concerned about psychosocial/quality of life and medication. Patients' demographics, IBD characteristics, and health care utilisation patterns can predict specific types of concerns/goals.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jonathan Blackwell, Sonia Saxena, Irene Petersen, Matthew Hotopf, Hanna Creese, Alex Bottle, Christopher Alexakis, Richard C. Pollok
Summary: Depression alone is not associated with subsequent development of IBD, but when accompanied by GI symptoms, it may indicate a risk for IBD.
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Aldukhayel Abdulrhman, Adil Alsweed, May Rashed Alotaibi, Abdullah Yousef Aldakhil, Shahad Fahad Alahmadi, Saud Musallum Albishri, Nurah Ibrahem Alhmed
Summary: This study aimed to summarize the prevalence of renal stones in patients with inflammatory bowel disease (IBD) and evaluate the risk factors and differences in urinary profile between IBD patients and healthy controls. The overall prevalence of renal stones in patients with IBD was comparable to the general population. Patients with Chron's disease had a higher prevalence of urolithiasis compared to Ulcerative colitis.
Review
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Giuseppina Liguori, Massimo Galli
Summary: Vaccination is crucial in managing patients with inflammatory bowel disease (IBD), yet vaccination rates are low due to lack of awareness among healthcare providers and patients. Current evidence-based recommendations for vaccines and prevention of infectious diseases in IBD patients should be widely promoted and implemented.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa. Recent studies have shown the involvement of RNA modifications in the specific pathogenesis of IBD. RNA modification-targeting reagents have shown promising outcomes in treating colitis. Understanding RNA modifications in IBD could contribute to early diagnosis, disease monitoring, and innovative therapeutic approaches.
Article
Infectious Diseases
Puo-Hsien Le, Cheng-Tang Chiu, Pai-Jui Yeh, Yu-Bin Pan, Cheng-Hsun Chiu
Summary: This study retrospectively evaluated the role of Clostridium innocuum (CI) infection in patients with inflammatory bowel disease (IBD). The results showed that CI infection may lead to poorer clinical remission in ulcerative colitis, which should be considered in the treatment approach.
JOURNAL OF INFECTION
(2022)
Review
Medicine, General & Internal
Elizabeth A. A. Spencer, Manasi Agrawal, Tine Jess
Summary: This article reviews the available predictors of outcomes in IBD patient and emphasizes the importance of global collaborative efforts and tools to support the clinical use of these prognostication tools.
FRONTIERS IN MEDICINE
(2022)