Review
Pathology
Lin Yuan, Tsung-Teh Wu, Lizhi Zhang
Summary: Microscopic colitis (MC) is a chronic inflammatory disease of the colon characterized by chronic, watery, nonbloody diarrhea and normal or almost normal endoscopic findings. Two main subtypes of MC, lymphocytic colitis (LC) and collagenous colitis (CC), are identified through microscopic examination on colon biopsy. The pathogenesis of MC is still unclear, but it has been associated with various risk factors and other diseases such as celiac disease, inflammatory bowel disease, and medication use. This paper aims to provide a systematic introduction to the clinicopathologic features of MC, focusing on unusual features and associations with other conditions.
Review
Medicine, General & Internal
Emese Mihaly, Arpad Patai, Zsolt Tulassay
Summary: Microscopic colitis (MC) is increasingly recognized, but there are still many unanswered questions regarding its pathogenesis, diagnosis, and therapy. The relationship between microbiome changes, different subtypes of the disease, and the effectiveness of treatments like budesonide and biologics remain unclear, highlighting the need for further research in the future.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Murtaza Shabbir Hussain, Harika Balagoni, Sankalp Dwivedi, Marc Piper
Summary: The association between microscopic colitis (MC) and inflammatory bowel disease (IBD) is uncertain and infrequently reported in the literature. A unique case is presented here, where a patient initially diagnosed with IBD was later found to have MC on histology after reappearance of diarrhea months later. Common pathophysiologic mechanisms, such as tumor necrosis factor a and T helper type 1 cells, may explain the relationship between MC and IBD. A prompt biopsy should be taken during endoscopy if suspicious for MC, in order to decrease the duration of patient's symptoms and save healthcare costs.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Hamed Khalili, Jordan E. Axelrad, Bjorn Roelstraete, Ola Olen, Mauro D'Amato, Jonas F. Ludvigsson
Summary: The study reveals that gastrointestinal infections are associated with an increased risk of microscopic colitis, especially Clostridioides difficile. The association between gastrointestinal infections and risk of MC is stronger for the collagenous subtype.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Amnon Sonnenberg, Robert M. Genta
Summary: The study revealed transitions between LC and CC in MC patients, as well as between MC and IBD. Gastroenterologists should consider underlying phenotype changes as a possible explanation for treatment failure in patients with either disease.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Ahmed Almradi, Alexandra C. Istl, Mei Lucy Yang, Katherine A. Fleshner, Claire E. Parker, Leonardo Guizzetti, Christopher Ma, Siddharth Singh, Vipul Jairath
Summary: The study found that preoperative anti-TNF therapy in patients with Crohn's disease undergoing elective surgery was associated with increased odds of postoperative infection, while it did not significantly affect total complications. In patients with ulcerative colitis undergoing elective surgery, preoperative anti-TNF therapy did not show significant associations with either infectious or total complications.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ondrej Fabian, Lukas Bajer
Summary: Advances in diagnostics and treatment strategies for inflammatory bowel diseases have led to the establishment of new therapeutic goals. Achieving endoscopic remission is desired, but a significant proportion of patients in remission still show microscopic disease activity. Histological evaluation has shown better predictive value for clinical complications, but validated scoring indices are currently lacking.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)