Article
Gastroenterology & Hepatology
Sarina Schwarz, Michel Hornschuch, Christian Pox, Ulrike Haug
Summary: This study investigated the incidence of colorectal cancer (CRC) after screening colonoscopy, stratified by tumor location, age, and sex. The results showed that the incidence of CRC increases with age, and women have a higher proportion of proximal CRC compared to men. Additionally, delaying the repeat colonoscopy may result in higher CRC detection rates.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2023)
Article
Oncology
Liang Wang, Markus D. Knudsen, Chun-Han Lo, Kai Wang, Mingming He, Georgios Polychronidis, Dong Hang, Xiaosheng He, Rong Zhong, Kana Wu, Andrew T. Chan, Shuji Ogino, Edward L. Giovannucci, Mingyang Song
Summary: Adherence to a healthy lifestyle after polypectomy may help reduce the incidence and mortality of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Jung Ah Lee, Yoosoo Chang, Yejin Kim, Dong-Il Park, Soo-Kyung Park, Hye Yin Park, Jaewoo Koh, Soo-Jin Lee, Seungho Ryu
Summary: This study evaluated the effect of colonoscopy screening on all-cause and CRC mortality in individuals under 45 years old and those 45 years and older. The results showed that colonoscopy screening was associated with a lower risk of all-cause mortality in both age groups, and significantly reduced CRC mortality in individuals aged 45 years and older. Therefore, more rigorous confirmatory studies are needed to validate the benefits of early screening in reducing mortality.
CANCER RESEARCH AND TREATMENT
(2023)
Review
Gastroenterology & Hepatology
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
Summary: In the era of widespread uptake of screening colonoscopy, CRC incidence rates decreased by up to 50% in older age groups in the USA, despite adverse trends in CRC risk factors and increasing CRC incidence at younger ages. However, first results from a randomized trial suggest rather modest effects of screening colonoscopy. The apparent discrepancy between real-world and trial evidence can be explained by factors such as limited screening adherence, widespread uptake of colonoscopy outside the screening offers, and the inclusion of prevalent, non-preventable CRC cases in reported numbers of incident cases. Alternative interpretations of screening endoscopy trial results accounting for prevalence bias are in line with trends in countries offering CRC screening, and should encourage more widespread implementation and uptake of effective CRC screening.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Szu-Min Peng, Wen-Feng Hsu, Ying-Wei Wang, Li-Ju Lin, Amy Ming-Fang Yen, Li-Sheng Chen, Yi-Chia Lee, Ming-Shiang Wu, Tony Hsiu-Hsi Chen, Han-Mo Chiu
Summary: A study in the Taiwanese Colorectal Cancer Screening Program found that subjects with negative colonoscopy after positive FIT who received subsequent FIT screening had a significantly lower risk of incident CRC, suggesting that scheduling subsequent FIT is important in reducing the risk of missed neoplasms and incident CRC in a national FIT screening program.
Letter
Medicine, General & Internal
Kelvin Yan, Tao Ren
Summary: The author comments on an article discussing the use of Epstein-Barr virus DNA or antibodies as a biomarker for the diagnosis of nasopharyngeal carcinoma. They point out the high number needed to screen in order to detect a case of cancer and estimate the number needed to screen to prevent one death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Elizabeth A. Kobe, Brian A. Sullivan, Xuejun Qin, Thomas S. Redding, Elizabeth R. Hauser, Ashton N. Madison, Cameron Miller, Jimmy T. Efird, Ziad F. Gellad, David Weiss, Kellie J. Sims, Christina D. Williams, David A. Lieberman, Dawn Provenzale
Summary: This study aims to describe adverse events during follow-up in a colonoscopy screening program and identify factors associated with increased risk. The results suggest that long-term programmatic screening and surveillance are safe, but serious cardiopulmonary events are the most common major events.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Xu, Mirza S. Khan, Thomas Z. Li, Riqiang Gao, James G. Terry, Yuankai Huo, Thomas A. Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A. Landman, Kim L. Sandler
Summary: This study evaluated the added value of CT-based AI-derived body composition measurements in predicting the risk of lung cancer incidence, lung cancer death, cardiovascular disease death, and all-cause mortality. The results showed that these measurements improved the risk prediction for lung cancer death, CVD death, and all-cause mortality, but not for lung cancer incidence.
Article
Medicine, General & Internal
Deborah A. Fisher, Nicole Princic, Lesley-Ann Miller-Wilson, Kathleen Wilson, A. Mark Fendrick, Paul Limburg
Summary: This study compared the use of CRC screening tests before and after the availability of the multitarget stool DNA (mt-sDNA) test, finding an increase in the proportion of individuals up to date with CRC screening between 2011 and 2019, but remained suboptimal. There were no substantial changes in the use of colonoscopy or FIT, with an increase in adoption of mt-sDNA and a decrease in the use of FOBT observed during the study period.
Article
Public, Environmental & Occupational Health
Hee-Soon Juon, Alicia Hong, Marcella Pimpinelli, Madhuwani Rojulpote, Russell McIntire, Julie A. Barta
Summary: The study examined the relationship between occupational exposures and lung cancer diagnosis, finding that African-Americans had higher odds of lung cancer diagnosis than White individuals, especially when exposed to asbestos and silica. Effective public health prevention programs are needed, particularly for minorities who may face disproportionately greater occupational exposures due to socioeconomic constructs and barriers.
PREVENTIVE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Luca Benazzato, Manuel Zorzi, Giulio Antonelli, Stefano Guzzinati, Cesare Hassan, Alberto Fantin
Summary: In an organized screening program in Italy, post-colonoscopy adverse events were rare but not negligible. The most frequent event was post-polypectomy bleeding, especially after resection of large (>= 20mm) and proximal lesions.
Article
Multidisciplinary Sciences
Jin Hwa Park, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Suk-Kyun Yang, Jeong-Sik Byeon
Summary: This study analyzed the clinical outcomes of colonoscopic polypectomy and surveillance colonoscopies in patients with at least 10 polyps. The results showed that with an increasing number of surveillance colonoscopies, the number of detected polyps and the procedure time decreased. Colorectal cancer detected during surveillance colonoscopies was successfully treated by polypectomy. This suggests that colonoscopic polypectomy and repeat surveillance colonoscopies are clinically effective, efficient, and safe.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
D. E. F. W. M. van Toledo, J. E. G. IJspeert, M. C. W. Spaander, I. D. Nagtegaal, M. E. van Leerdam, I. Lansdorp-Vogelaar, E. Dekker
Summary: By analyzing the results of colonoscopy, it was found that the simultaneous presence of high-risk serrated polyps and high-risk adenomas, or the presence of only high-risk serrated polyps, is associated with an increased risk of metachronous colorectal cancer.
Article
Surgery
Maria S. Altieri, Hannah Thompson, Aurora Pryor, Jie Yang, Chencan Zhu, Mark Talamini, Jill Genua
Summary: The study found that younger patients have shown an increasing trend in undergoing colorectal resections for cancer in recent years, with a yearly increase of up to 6%. It is recommended to consider new screening initiation guidelines and increase awareness among clinicians and the general public.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Economics
Sophie Guthmuller, Vincenzo Carrieri, Ansgar Wuebker
Summary: This study explores the effects of Organized Screening Programs (OSPs) on breast cancer screening, incidence, and mortality by combining data from regional OSPs in Europe with survey data and population-based cancer registries. The findings suggest that OSPs on average increase mammography by 25 percentage points, increase breast cancer incidence by 16% five years after implementation, and reduce breast cancer mortality by about 10% ten years after.
JOURNAL OF HEALTH ECONOMICS
(2023)
Review
Gastroenterology & Hepatology
Seifeldin Hakim, Srinivas Ramireddy, Mitual Amin, Souheil Gebara, Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Gastroenterology & Hepatology
Mitchell S. Cappell, Mihajlo Gjeorgjievski, Molly Orosey
DIGESTIVE DISEASES AND SCIENCES
(2019)
Article
Gastroenterology & Hepatology
Amy Le, Mitual Amin, Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2019)
Review
Gastroenterology & Hepatology
Mitchell S. Cappell, Stavros Nicholas Stavropoulos, David Friedel
DIGESTIVE DISEASES AND SCIENCES
(2020)
Article
Education & Educational Research
Zaid Imam, Mitchell S. Cappell
BMC MEDICAL EDUCATION
(2019)
Article
Gastroenterology & Hepatology
Seifeldin Hakim, Andrew M. Aneese, Ahmed Edhi, Christienne Shams, Treta Purohit, Michael E. Cannon, Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2020)
Editorial Material
Gastroenterology & Hepatology
Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2020)
Review
Medicine, General & Internal
Inayat Gill, Ahmed Iqbal Edhi, Mitchell S. Cappell
Letter
Gastroenterology & Hepatology
Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Inayat Gill, Aciel Ahmed Shaheen, Ahmed Iqbal Edhi, Mitual Amin, Ketan Rana, Mitchell S. Cappell
Summary: Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, and has been linked to protein-losing enteropathy (PLE) and severe COVID-19 infection. A novel case of collagenous duodenitis (CD) associated with PLE is reported, along with a proposed mechanism for CD causing PLE and an association of PLE with COVID-19 attributed to immunosuppression.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Letter
Gastroenterology & Hepatology
Mitchell S. Cappell
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Mitchell S. Cappell
Summary: This study reports the revolutionary reorganization of an academic gastroenterology division in metropolitan Detroit during the COVID-19 pandemic surge, showing significant changes in patient care and medical education to address the increasing number of infected patients and minimize the risks of transmission.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Inayat Gill, Ahmed Edhi, Mitual Amin, Mitchell S. Cappell
Summary: This case report highlights the severe manifestations of esophageal candidial and cytomegaloviral infections in an AIDS patient. The infections can recur years after treatment, and cytomegaloviral esophageal ulcers can mimic pseudo-diverticula. Limited literature exists on the association between cytomegalovirus and esophageal pseudo-diverticula.
CASE REPORTS IN GASTROINTESTINAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Christienne Shams, Seifeldin Hakim, Mitual Amin, Mitchell S. Cappell
CASE REPORTS IN GASTROINTESTINAL MEDICINE
(2018)
Article
Medicine, General & Internal
Seifeldin Hakim, Francisco Davila, Mitual Amin, Ismail Hader, Mitchell S. Cappell
CASE REPORTS IN MEDICINE
(2018)