Article
Peripheral Vascular Disease
Hanna Remde, Christina Pamporaki, Marcus Quinkler, Svenja Nolting, Aleksander Prejbisz, Henri J. L. M. Timmers, Jimmy Masjkur, Carmina T. Fuss, Martin Fassnacht, Graeme Eisenhofer, Timo Deutschbein
Summary: This study aimed to evaluate the diagnostic outcome of CST in patients with moderate NMN elevations, showing high sensitivity and specificity in diagnosing PPGL.
Article
Immunology
Ilesh Jani, Trevor F. Peter
Summary: Testing programs for SARS-CoV-2 have relied on PCR laboratory tests and rapid antigen assays, but their limitations in cost and accessibility have contributed to inequity in COVID-19 testing. Low-cost point-of-care nucleic acid tests have the potential to address these issues and improve pandemic preparedness, as well as strengthen primary healthcare services.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Jerome R. Lechien, Michael F. Vaezi, Walter W. Chan, Jacqueline E. Allen, Petros D. Karkos, Sven Saussez, Kenneth W. Altman, Milan R. Amin, Tareck Ayad, Maria R. Barillari, Peter C. Belafsky, Joel H. Blumin, Nikki Johnston, Francois Bobin, Matthew Broadhurst, Fabio P. Ceccon, Christian Calvo-Henriquez, Young-Gyu Eun, Carlos M. Chiesa-Estomba, Lise Crevier-Buchman, John O. Clarke, Giovanni Dapri, Claudia A. Eckley, Camille Finck, P. Marco Fisichella, Abdul-Latif Hamdan, Stephane Hans, Kathy Huet, Rui Imamura, Blair A. Jobe, Toshitaka Hoppo, Lance P. Maron, Vinciane Muls, Ashli K. O'Rourke, Paulo S. Perazzo, Gregory Postma, Vyas M. N. Prasad, Marc Remacle, Geraldo D. Sant'Anna, Robert T. Sataloff, Edoardo V. Savarino, Antonio Schindler, Nora Siupsinskiene, Ping-Huei Tseng, Craig H. Zalvan, Karol Zelenik, Bernard Fraysse, Jonathan M. Bock, Lee M. Akst, Thomas L. Carroll
Summary: The objective of this work was to propose a global definition and diagnostic approach of laryngopharyngeal reflux (LPR) through an international consensus group, in order to guide primary care and specialist physicians in the management of LPR.
Article
Surgery
Karla Bernardi, Lauren Hawley, Vivian L. Wang, Anahita D. Jalilvand, Kelly R. Haisley, Kyle A. Perry
Summary: This retrospective cohort study evaluated 353 patients who underwent laparoscopic fundoplication (LF) for GERD between 2011 and 2017. The results showed that 16% of patients developed GERD-like symptoms after the surgery, and only 9% of these patients had recurrent pathologic acid reflux.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Letter
Medicine, General & Internal
Peter Bogaty, Paul K. Drain
Summary: The author raises important questions regarding rapid diagnostic testing for SARS-CoV-2, including the impact of vaccination on quarantine requirements and the duration of positive results from nucleic acid amplification tests.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Paul K. Drain
Summary: This passage discusses the key points of rapid diagnostic testing for SARS-CoV-2, including the authorized testing methods, the target population, and the timing and handling of test results.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Otorhinolaryngology
Jerome R. Lechien, Francois Bobin, Vinciane Muls, Francois Mouawad, Didier Dequanter, Mihaela Horoi, Marie-Paule Thill, Alexandra Rodriguez Ruiz, Sven Saussez
Summary: This study assessed the evolution of symptoms and findings of LPR patients according to the type of reflux, and found that non-acid and mixed LPR respond similarly to treatment as acid LPR. However, treatment for non-acid or mixed LPR requires specific medication to cover non-acid proximal reflux events.
CLINICAL OTOLARYNGOLOGY
(2021)
Editorial Material
Critical Care Medicine
Lucas G. Axiotakis, Necati Enver, Claire L. Keating, Michael J. Pitman
Summary: Inhaled antibiotics, such as ALIS, are effective in treating chronic lung infections, but may cause laryngeal toxicity, highlighting the need for better understanding of toxicity mechanisms and coordinated care for patients receiving such treatments.
Review
Immunology
Marloes A. H. M. Michels, Elena B. Volokhina, Nicole C. A. J. van de Kar, Lambertus P. W. J. van den Heuvel
Summary: This review addresses the challenges of diagnosing nephritic factors (NeFs), autoantibodies that promote the activity of complement cascade enzymes. NeFs are associated with rare complement-mediated kidney disorders and stabilizing complement convertase complexes. However, measuring NeFs for diagnosis remains difficult, limiting our understanding of their clinical associations. The review discusses the diseases associated with NeFs, the mechanisms of different NeF types, laboratory methods for detection, and efforts for standardization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Soichiro Matsuda, Mototsugu Kato, Yuko Sakakibara, Hiroshige Hamada, Yoshihiro Sasaki, Hideki Mori, Yuichiro Hirai, Shuji Inoue, Tatsuya Toyokawa, Takashi Kagaya, Toshio Kuwai, Naoki Esaka, Haruhiro Yamashita, Noriko Watanabe, Mio Matsumoto, Hiroyuki Fujii, Mamiko Demura, Kimitoshi Kubo, Katsuhiro Mabe, Naohiko Harada
Summary: This study demonstrates that administering vonoprazan once every second day is an effective alternative to proton pump inhibitors in the maintenance treatment of erosive GERD.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Sabrina J. Layne, Zachary S. Lorsch, Amit Patel
Summary: In the current clinical practice, patient symptoms and traditional findings from endoscopy, manometry, and reflux monitoring guide the care of patients with suspected GERD. However, novel metrics and techniques acquired from or performed at these procedures are of great interest as they have the potential to enhance the evaluation and management of these patients.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Medicine, General & Internal
Mitsushige Sugimoto, Masaki Murata, Eri Iwata, Naoyoshi Nagata, Takao Itoi, Takashi Kawai
Summary: In a Japanese population positive for H. pylori, eradication therapy was associated with reflux esophagitis in around 10% of patients. Symptoms of reflux esophagitis may improve throughout the 12 months after successful eradication therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
Matthew R. R. Naunheim, Molly N. N. Huston, Neil Bhattacharyya
Summary: Inhaled corticosteroids (ICS) are associated with voice changes. This study aimed to determine the strength of the association between ICS use and a diagnosis of dysphonia made by an otolaryngologist, and to investigate if inhaler particle type or medication type influenced this risk.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Katie Yoganathan, Alexander Stevenson, Awais Tahir, Ross Sadler, Aleksandar Radunovic, Naveed Malek
Summary: Myasthenia gravis (MG) and congenital myasthenic syndromes (CMS) are disorders with autoimmune or genetic and neurophysiological basis. Single-fibre EMG has the highest sensitivity and positive anti-acetylcholine receptor antibodies have the highest specificity. Newer testing strategies, such as ocular vestibular-evoked myogenic potentials and next-generation sequencing, require further research to assess their sensitivity and specificity.
JOURNAL OF NEUROLOGY
(2022)
Review
Chemistry, Analytical
Olena Filchakova, Dina Dossym, Aisha Ilyas, Tamila Kuanysheva, Altynay Abdizhamil, Rostislav Bukasov
Summary: More than six billion tests for COVID-19 have been conducted worldwide. This article emphasizes the importance of testing for the SARS-CoV-2 virus and corresponding human antibodies, not only for medical diagnosis and treatment, but also for economic and social activities. The review discusses the parameters of these tests and compares different detection methods. While RT-PCR remains the gold standard, there is a need for alternative methods that are less expensive and more accessible.