Review
Gastroenterology & Hepatology
William D. Chey, Jana G. Hashash, Laura Manning, Lin Chang
Summary: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that affects quality of life. The latest clinical practice update recommends dietary modifications, such as the low-FODMAP diet, as the primary treatment for IBS symptoms. Best practice advice includes involving patients who are insightful and motivated in dietary changes, avoiding restrictive diets for patients who are poor candidates, highlighting the benefits of soluble fiber and the low-FODMAP diet, and following a three-phase approach for the low-FODMAP diet. The efficacy of a gluten-free diet for IBS is uncertain and there is limited evidence to support the routine use of biomarkers in clinical practice.
Article
Nutrition & Dietetics
Martyna Wiecek, Paulina Panufnik, Magdalena Kaniewska, Konrad Lewandowski, Grazyna Rydzewska
Summary: The study found that in patients in remission of IBD, a low-FODMAP diet intervention is effective in reducing IBS-like symptoms, regardless of the presence of bacterial overgrowth.
Article
Nutrition & Dietetics
Samira Rastgoo, Nasser Ebrahimi-Daryani, Shahram Agah, Sara Karimi, Mohammad Taher, Bahram Rashidkhani, Ehsan Hejazi, Fatemeh Mohseni, Mina Ahmadzadeh, Amir Sadeghi, Azita Hekmatdoost
Summary: The study demonstrated the superiority of adding glutamine supplementation to a low FODMAP diet in alleviating IBS symptoms, while also confirming the beneficial effects of a low FODMAP diet in IBS management through a randomized controlled trial.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Katerina Belogianni, Paul Townsend Seed, Miranda Clare Elizabeth Lomer
Summary: A validated questionnaire has been developed to assess knowledge, attitudes, and practices in the dietary management of IBS. The questionnaire was refined through feedback and psychometric testing, resulting in a final version with 46 items. It was found to have good reliability and validity.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Jongsung Hahn, Jeongwon Choi, Min Jung Chang
Summary: This meta-analysis revealed that a low fermentable oligo-, di-, monosaccharides, and polyols diet (LFD) has a moderate reduction effect on the symptom severity and a slight improvement effect on the quality of life of irritable bowel syndrome (IBS) patients, as well as a significant improvement in stool habits.
Review
Pharmacology & Pharmacy
Chao-Rong Xie, Bin Tang, Yun-Zhou Shi, Wen-Yan Peng, Kun Ye, Qing-Feng Tao, Shu-Guang Yu, Hui Zheng, Min Chen
Summary: This study evaluated the most effective approaches for managing irritable bowel syndrome (IBS) by analyzing different combinations and components of probiotics or a low FODMAP diet. The results showed that Lactobacillus was the most effective component for relieving IBS symptoms, while Bifidobacterium and Bacillus were potentially effective and require further verification.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Sanna Nybacka, Stine Storsrud, Helen M. Lindqvist, Hans Tornblom, Magnus Simren, Anna Winkvist
Summary: The study found subtle differences in FODMAP intake among IBS patients with different subtypes, with the association between IBS symptoms and FODMAP intake being most prominent in unsubtyped IBS patients. However, patients intolerant to certain FODMAPs may have already reduced their intake, requiring future cohort or experimental studies for further investigation.
Review
Pediatrics
Elvira Ingrid Levy, Charlotte De Geyter, Abdelhalim Ouald Chaib, Berthold Albert Aman, Badriul Hegar, Yvan Vandenplas
Summary: There are limited randomized controlled trials on managing pediatric IBS, with most intervention trials targeting changes to the gastrointestinal microbiome. Heterogeneity in study designs and outcomes make it difficult to formulate recommendations. Insufficient evidence exists to recommend therapeutic interventions in pediatric IBS, despite the association with dysbiosis. More prospective trials are needed.
Article
Cell Biology
Hadar Bootz-Maoz, Ayelet Pearl, Ehud Melzer, Stephen Malnick, Efrat Sharon, Yifat Bennet, Rotem Tsentsarevsky, Shlomi Abuchatzera, Sivan Amidror, Elana Aretz, Shalhevet Azriel, Chen Gam Ze Letova, Maria Naama, Irit Shoval, Orly Yaron, Sarit Karako-Lampert, Shai Bel, Nissan Yissachar
Summary: Changes in microbiome composition are associated with human diseases, and finding causative connections between specific microbial taxa and their impact on the host tissues is crucial for clinical translation. This study infuses gut organ cultures with microbiota samples from therapy-naive patients with IBS under a low-FODMAP diet and identifies a diet-sensitive pathobiont that disrupts gut barrier functions. The findings support the potential feasibility of microbiome-based therapies in IBS.
Article
Gastroenterology & Hepatology
Daniel So, Chu K. Yao, Zaid S. Ardalan, Phoebe A. Thwaites, Kourosh Kalantar-Zadeh, Peter R. Gibson, Jane G. Muir
Summary: Concomitant supplementation of fibers during a low FODMAP diet did not alter symptomatic response in patients with IBS but augmented stool bulk and normalized low stool water content and slow transit.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Anne-Sophie van Lanen, Angelika de Bree, Arno Greyling
Summary: The low-FODMAP diet is effective in reducing symptoms severity and improving quality of life in patients with irritable bowel syndrome, regardless of age, intervention duration, and IBS subtype. Future research should focus on the long-term effects of such diets on nutritional adequacy and the gut microbiome.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Maria Ines Pinto-Sanchez, Andrea Nardelli, Rajka Borojevic, Giada De Palma, Natalia Causada Calo, Justin McCarville, Alberto Caminero, Daniel Basra, Alexa Mordhorst, Ekatherina Ignatova, Suzanne Hansen, Melanie Uhde, Gary L. Norman, Joseph A. Murray, Edgardo Smecuol, David Armstrong, Julio C. Bai, Detlef Schuppan, Stephen M. Collins, Armin Alaedini, Paul Moayyedi, Elena F. Verdu, Premysl Bercik
Summary: Patients with antigliadin IgG and IgA in IBS showed improvement in symptoms, particularly diarrhea, on a gluten-free diet. The presence of these antibodies was associated with overall reductions in symptoms, with improvements in pain and mental health. Larger studies are needed to validate these findings.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
Ionela-Daniela Morariu, Liliana Avasilcai, Madalina Vieriu, Vasile Valeriu Lupu, Branco-Adrian Morariu, Ancuta Lupu, Paula-Cristina Morariu, Oana-Lelia Pop, Iuliana Magalena Starcea, Laura Trandafir
Summary: Irritable bowel syndrome is a common gastrointestinal disease that causes various symptoms such as bloating, abdominal pain, and diarrhea. A low-FODMAP diet has been shown to effectively reduce these symptoms and improve the quality of life for patients with irritable bowel syndrome.
Article
Gastroenterology & Hepatology
Uday C. Ghoshal, Uzma Mustafa, Subhra K. Mukhopadhyay
Summary: A novel FODMAP meal challenge test (FMCT) was developed in this study, which can predict the response of IBS patients to a low-FODMAP diet.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Ameen Eetemadi, Ilias Tagkopoulos
Summary: This study identified two types of IBS patients based on gut microbiome data - those who respond well to a low-FODMAP diet and those who would benefit from dietary supplementation. Microbiome data can predict patient response to the low-FODMAP diet.
CLINICAL NUTRITION
(2021)
