Article
Oncology
Pierina Navarria, Federico Pessina, Giuseppe Minniti, Ciro Franzese, Beatrice Marini, Giuseppe D'agostino, Marco Badalamenti, Luca Raspagliesi, Giacomo Reggiori, Francesca Lobefalo, Laura Fariselli, Davide Franceschini, Luisa Bellu, Elena Clerici, Valentina Pinzi, Marta Scorsetti
Summary: Around 2-15% of primary renal cell carcinoma patients will develop brain metastases. The prognosis of brain metastatic RCC patients is poor and determining the optimal local therapeutic approach is a challenge. A retrospective multi-institutional study was conducted to assess the efficacy of local treatments and identify prognostic factors. The study confirmed the efficacy and safety of SRS/HSRS and found that patients with specific characteristics had a better outcome.
Article
Urology & Nephrology
Aravind Cherukuri, Khodor I. Abou-Daya, Raad Chowdhury, Rajil B. Mehta, Sundaram Hariharan, Parmjeet Randhawa, David M. Rothstein
Summary: Borderline rejection in renal transplantation is associated with decreased allograft survival. Identifying patients with early borderline rejection at risk for poor outcomes is important for timely intervention.
KIDNEY INTERNATIONAL
(2023)
Review
Oncology
Yu-Wei Chen, Brian Rini, Kathryn E. Beckermann
Summary: This review summarizes ongoing efforts in drug development in clear cell renal cell carcinoma (ccRCC), focusing on novel targets and treatment methods. While immunotherapy-based combinations have shown significant efficacy improvement in frontline treatment, there is still a need for new therapies to address non-responsive or resistant patients.
Review
Oncology
Julien Pierrard, Thais Tison, Guillaume Grisay, Emmanuel Seront
Summary: In the past decade, significant progress has been made in the treatment of renal cell carcinoma with the development and use of various drugs. However, the management of brain metastases in RCC patients remains challenging. Local intervention and systemic therapies have limitations in treating cerebral lesions.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Urology & Nephrology
Laura Bukavina, Karim Bensalah, Freddie Bray, Maria Carlo, Ben Challacombe, Jose A. Karam, Wassim Kassouf, Thomas Mitchell, Rodolfo Montironi, Tim O'Brien, Valeria Panebianco, Ghislaine Scelo, Brian Shuch, Hein van Poppel, Christopher D. Blosser, Sarah P. Psutka
Summary: The incidence and mortality rates of kidney cancer vary significantly globally, with variations across time, geography, and sex. Hypertension, obesity, and smoking are the most well-established risk factors. Recent advances in genetic characterization have improved our understanding of the mutations that predispose individuals to kidney cancer.
Article
Cell Biology
Aravind Cherukuri, Alan D. Salama, Rajil Mehta, Kanishka Mohib, Leting Zheng, Ciara Magee, Mark Harber, Hans Stauss, Richard J. Baker, Amit Tevar, Douglas Landsittel, Fadi G. Lakkis, Sundaram Hariharan, David M. Rothstein
Summary: The study found that the T1B IL-10/TNF-α ratio 3 months after transplantation is an effective biomarker for predicting renal allograft rejection and patient clinical course, helping to identify high-risk patients early, guide treatment, and improve graft survival.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Samuel Swearson, Aseel O. Rataan, Steven Eliason, Brad A. Amendt, Yousef Zakharia, Aliasger K. Salem, Thai Ho, Youcef M. Rustum
Summary: This study quantitated the expression levels of miR-17, -19a, -34a, -155, and -210 in different types of renal cell carcinoma cell lines and primary kidney tumors. The results showed that miR-17 and -19a were expressed at lower levels, while miR-34a, miR-155, and miR-210 were expressed at higher levels. In ccRCC cell lines with sarcomatoid differentiation, miR-34a was expressed higher than miR-210, -155, -17, and -19a. More samples are needed to confirm the statistical significance of the differences in miR expression levels in tumor biopsies. Previous studies have shown that miR-210, miR-155, and HIFs are druggable targets, and downregulation of these miRs may be a novel strategy for the treatment of advanced ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Aisheng Dong, Qing Yang, Meimian Hua, Chao Cheng, Changjing Zuo
Summary: This study describes the findings of FAPI PET/CT in renal tumors, including a case of lipid-poor renal angiomyolipoma and a case of high-grade clear cell renal cell carcinoma. Both tumors showed intense FAPI uptake, indicating that lipid-poor renal angiomyolipoma should be considered in the differential diagnosis of FAPI-avid renal tumors.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aron Bartha, Zsuzsanna Darula, Gyoengyi Munkacsy, Eva Klement, Peter Nyirady, Balazs Gyorffy
Summary: This research used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear cell renal cell carcinoma (ccRCC). Top genes over-expressed in ccRCC were identified using transcriptomic data of patients with malignant and normal tissue samples. Protein level analysis and mass spectrometry further validated the differential protein abundance of these genes. A minimal panel of proteins highly specific for ccRCC tissues was identified using transcriptomic and proteomic data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Evgenia Efthymiou, Georgios Velonakis, Georgios Charalampopoulos, Argyro Mazioti, Elias Brountzos, Nikolaos Kelekis, Dimitrios Filippiadis
Summary: This study evaluates the performance of RENAL and mRENAL scores in predicting oncological outcomes in patients with T1 renal cell carcinomas treated with microwave ablation. The results show that both RENAL and mRENAL scores have significant prognostic ability in predicting progression in renal cancer.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Oncology
Gennady Bratslavsky, Stephanie Gleicher, Joseph M. Jacob, Thomas H. Sanford, Oleg Shapiro, Dimitra Bourboulia, Laurie M. Gay, Julie Andrea Elvin, Jo-Anne Vergilio, James Suh, Shakti Ramkissoon, Eric Allan Severson, Jonathan Keith Killian, Alexa Betzig Schrock, Jon H. Chung, Vincent A. Miller, Mehdi Mollapour, Jeffrey S. Ross
Summary: The study found that genomic alteration patterns in collecting duct carcinoma (CDC) and renal medullary carcinoma (RMC) differ significantly from clear cell renal cell carcinoma (CCRCC). Targeted therapies for CDC and RMC appear limited, with rare opportunities to target alterations in receptor tyrosine kinase and MTOR pathways. Similarly, the low TMB and absence of MSI-High status in CDC and RMC suggest resistance to immunotherapies.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Fenfang Zhou, Dexin Shen, Yaoyi Xiong, Songtao Cheng, Huimin Xu, Gang Wang, Kaiyu Qian, Lingao Ju, Xinhua Zhang
Summary: CTHRC1 expression is elevated in KIRP and KIRC, associated with tumor stage, histology, lymph node metastasis, and clinical prognosis in KIRP, as well as tumor grade, stage, nodal metastasis, and survival prognosis; it is also positively related to various tumor-infiltrating immune cells in KIRP and KIRC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Correia de Sousa, Etienne Delangre, Miranda Turkal, Michelangelo Foti, Monika Gjorgjieva
Summary: The endoplasmic reticulum plays crucial roles in protein production, metabolism homeostasis, and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and its normal functions are compromised. In renal cancer cells, the activation of endoplasmic reticulum stress pathway is exploited to promote cell survival through rewiring of metabolism, activation of stress responses, autophagy, and inhibition of cell death. However, a certain threshold of endoplasmic reticulum stress activation is required to shift the response from pro-survival to pro-apoptotic outcome. The therapeutic potential of targeting endoplasmic reticulum stress in renal cancer is still poorly understood and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nicholas H. Chakiryan, Youngchul Kim, Anders Berglund, Andrew Chang, Gregory J. Kimmel, Ali Hajiran, Jonathan Nguyen, Carlos Moran-Segura, Daryoush Saeed-Vafa, Esther N. Katende, Neale Lopez-Blanco, Jad Chahoud, Phillip Rappold, Philippe E. Spiess, Michelle Fournier, Daniel Jeong, Liang Wang, Jamie K. Teer, Jasreman Dhillon, Fengshen Kuo, Abraham Ari Hakimi, Philipp M. Altrock, James J. Mule, Brandon J. Manley
Summary: In clear cell renal cell carcinoma (ccRCC), the clustering of CD163+M2 like TAMs into the stromal compartment at the tumor-stroma interface is associated with poor clinical outcomes and CD8+T cell terminal exhaustion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Michael Staehler, Michael Stoeckle, Daniel C. Christoph, Arnulf Stenzl, Karin Potthoff, Marc-Oliver Grimm, Dunja Klein, Johanna Harde, Fabian Bruning, Peter J. Goebell, Marinela Augustin, Frederik Roos, Iris Benz-Rud, Norbert Marschner, Viktor Gruenwald
Summary: The MARC-2 trial investigated clinical outcomes in metastatic renal cell carcinoma patients treated with everolimus after failure of VEGFR-TKI therapy, finding that patients aged >=65 years and patients with BMI >25 kg/m2 benefited most, with no new safety signals emerging.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Urology & Nephrology
Michael D. Staehler, Dena J. Battle, Cristiane D. Bergerot, Sumanta Kumar Pal, David F. Penson
Summary: The study investigated the financial impact of COVID-19 on renal cell carcinoma (RCC) patients from 14 countries, with findings highlighting patients' financial concerns and anxiety levels.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Michael Staehler, Dena Battle, Sumanta Kumar Pal, Cristiane Decat Bergerot
Summary: During the COVID-19 crisis, many renal cell carcinoma patients expressed concerns, but the majority still preferred to continue treatment and monitoring. Some patients had high levels of anxiety, but they remained unwilling to defer treatment.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
L. M. Mittlmeier, M. Unterrainer, S. Rodler, A. Todica, N. L. Albert, C. Burgard, C. C. Cyran, W. G. Kunz, J. Ricke, P. Bartenstein, C. G. Stief, H. Ilhan, M. Staehler
Summary: This study compared the efficacy of F-18-PSMA-1007 PET imaging and CT for treatment response assessment in mRCC patients undergoing TKI or CI therapy. The results suggest that F-18-PSMA-1007 PET may provide a more precise assessment of patient response to systemic treatment compared to CT.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Annabel Spek, Anno Graser, Jozefina Casuscelli, Bernadett Szabados, Severin Rodler, Julian Marcon, Christian Stief, Michael Staehler
Summary: The study aimed to evaluate the role of DCE-CT as a predictor of long-term outcomes in mRCC patients receiving antiangiogenic treatment. It was found that using a 50% reduction in blood flow as a cut-off at follow-up could identify patients with favorable long-term outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Michael Staehler, S. Rodler, M. Schott, J. Casuscelli, C. Stief, A. Spek, B. Schlenker
Summary: The use of Hemopatch(R) in partial nephrectomy resulted in lower blood loss and shorter surgery time compared to conventional methods, with minimal impact on renal function. Complexity of the procedure may influence the choice of surgical approach, and Hemopatch(R) could be beneficial for complex surgeries.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena M. Mittlmeier, Andrei Todica, Franz-Josef Gildehaus, Marcus Unterrainer, Leonie Beyer, Matthias Brendel, Nathalie L. Albert, Stephan T. Ledderose, Franziska J. Vettermann, Melanie Schott, Severin Rodler, Julian Marcon, Harun Ilhan, Clemens C. Cyran, Christian G. Stief, Michael Staehler, Peter Bartenstein
Summary: Ga-68-EMP-100 PET/CT imaging in mRCC patients demonstrates distinctly elevated uptake with high individual differences, including both c-MET-positive and c-MET-negative lesions, warranting further studies on its clinical use as a biomarker.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Infectious Diseases
Jan-Niclas Mumm, Stephan Ledderose, Andreas Ostermann, Martina Rudelius, Johannes C. Hellmuth, Max Muenchhoff, Dieter Munker, Clemens Scherer, Yannic Volz, Benedikt Ebner, Clemens Giessen-Jung, Christopher Lampert, Theresa Vilsmaier, Stephanie Schneider, Madeleine Gapp, Katrin Milger-Kneidinger, Jurgen Behr, Michael Von Bergwelt-Baildon, Oliver T. Keppler, Christian Stief, Giuseppe Magistro, Michael Staehler, Severin Rodler
Summary: This study found high expression of ACE-2 receptor protein in the urinary system, and stable shedding of SARS-CoV-2 RNA in urine. Although viral RNA was detected in a small number of patients' urine samples, the study does not support a relevant route of virus transmission through urine.
Article
Oncology
Severin Rodler, Melanie Goetz, Jan-Niclas Mumm, Alexander Buchner, Annabel Graser, Jozefina Casuscelli, Christian Stief, Christoph Fuerweger, Alexander Muacevic, Michael Staehler
Summary: This study evaluates the safety and efficacy of robotic radiosurgery (RRS) for the treatment of lung metastases in patients with metastatic renal cell carcinoma (RCC). The results demonstrate that RRS is a safe and effective treatment option, with favorable survival rates in this patient group. Future research may focus on combining RRS with systemic treatment.
Article
Pathology
Franziska Erlmeier, Benedict Bruecher, Christine Stoehr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Stroebel, Frank Becker, Christian Wuelfing, Peter Barth, Michael Stoeckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stephan Macher-Goeppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C. Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Arndt Hartmann, Yvonne Mondorf, Philipp Ivanyi, Marie Mikuteit, Sandra Steffens
Summary: This study investigated the expression of c-Met in papillary RCC and its association with prognosis, and the results showed that c-Met expression is not a prognostic marker for overall survival in pRCC.
Article
Multidisciplinary Sciences
Robert J. Motzer, Jean-Francois Martini, Xinmeng J. Mu, Michael Staehler, Daniel J. George, Olga Valota, Xun Lin, Hardev S. Pandha, Keith A. Ching, Alain Ravaud
Summary: This study performed comprehensive genomic and transcriptomic analysis on tumor samples from high-risk renal cell carcinoma patients, identifying specific gene expression signatures and potential therapeutic targets. The results highlight the importance of immune response and tumor environment in adjuvant therapy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Yannic Volz, Johanna Troost, Lennert Eismann, Friedrich Jokisch, Gerald Bastian Schulz, Boris Schlenker, Alexander Kretschmer, Michael Staehler, Stefan Boeck, Raphaela Waidelich, Alexander Buchner, Christian G. Stief, Severin Rodler
Summary: This study explores predictive factors for high fear of cancer recurrence (FCR) in patients undergoing surgery for genitourinary cancer. The results indicate a decrease in FCR after surgery, with sociodemographic factors such as age, gender, employment, and education influencing FCR levels, while tumor-related factors have a less prominent role.
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Biochemistry & Molecular Biology
Vinh Ngoc Bui, Lena M. Unterrainer, Matthias Brendel, Sophie C. Kunte, Adrien Holzgreve, Fabian Allmendinger, Peter Bartenstein, Frederick Klauschen, Marcus Unterrainer, Michael Staehler, Stephan Ledderose
Summary: In this study, the expression pattern of PSMA in different subtypes of renal cell carcinoma was investigated. The results showed that PSMA expression was strongest in ccRCC and cpRCC, supporting the use of PSMA-targeted theranostic approaches in these subtypes.
Article
Oncology
Stefanie Zschaebitz, Franziska Erlmeier, Christine Stoehr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Stroebel, Frank Becker, Christian Wuelfing, Peter Barth, Michael Stoeckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stephan Macher-Goeppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C. Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Yvonne Mondorf, Arndt Hartmann, Philipp Ivanyi, Sandra Steffens
Summary: This study analyzed the expression of PSMA in papillary RCC (pRCC) type 1 and type 2, and evaluated the potential of PSMA-targeted imaging and treatment in pRCC. The results showed that PSMA staining was positive in a small percentage of type 1 pRCC samples, while no PSMA expression was detected in type 2 pRCC samples in this large cohort. These findings suggest limited expression of PSMA in pRCC, and further analysis in this subtype is not encouraged based on current clinical evaluation of PSMA expression in RCC.
Article
Medicine, General & Internal
Michael Staehler, Tina Schuler, Annabel Spek, Severin Rodler, Alexander Tamalunas, Christoph Fuerweger, Alexander Muacevic
Summary: This study compared the outcomes of patients who received single fraction RRS with those who underwent open partial nephrectomy (OPN). The results showed that RRS is a viable alternative to OPN in patients unfit for surgery, with comparable oncological and functional outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)