Article
Immunology
Hongyi Yuan, Shufei Wei, Zongtao Ren, Feng Li, Bin Liu, Rui Liu, Xiaoyu Zhang
Summary: The expression of KLHL21 is significantly reduced in bladder carcinoma tissues and cell lines, and lower expression of KLHL21 is associated with poorer overall survival. Over-expression of KLHL21 inhibits the proliferation, migration and invasion of bladder carcinoma cells, while knockdown of KLHL21 accelerates these processes. KLHL21 negatively regulates the activation of the NF-KB signaling pathway and down-stream molecules involved in cell survival, death, and migration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Luyao Ma, Wanying Zeng, Zhiyi Tan, Rui Wang, Yi Yang, Shubin Lin, Feng Li, Shuai Wang
Summary: Through studying an experimental colitis mouse model, it was found that the increased systemic exposure of metronidazole in patients with inflammatory bowel diseases might be related to the downregulation of CYP2A5, which is regulated by the inflammatory factor NF-KB. The regulatory effect of colitis on CYP2A5 depends mainly on the disease itself, rather than the inflammatory compound, DSS.
MOLECULAR PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Reza Zinatizadeh, Bettina Schock, Ghanbar Mahmoodi Chalbatani, Peyman Kheirandish Zarandi, Seyed Amir Jalali, Seyed Rouhollah Miri
Summary: The NF-kB transcription factor family plays a critical role in controlling important regulatory gene expression in the cellular environment, impacting processes such as immunity, inflammation, cell death, and proliferation. Understanding NF-kB function can help in the development of treatments for rare and widespread diseases.
Article
Biochemistry & Molecular Biology
Jionghuang Chen, Kexiong Qiao, Chaolei Zhang, Xinyang Zhou, Qian Du, Yuezhen Deng, Liping Cao
Summary: NF-KB signaling is active in pancreatic cancer and plays a crucial role in its progression. This study demonstrates that VRK2 regulates TNFa/NF-KB signaling by interacting with IKKss and activating the pathway. VRK2 overexpression promotes the growth of pancreatic cancer cells and organoids. Inhibition of IKKss abolishes the promotive effect of VRK2. These findings suggest that VRK2 may serve as a potential therapeutic target for pancreatic cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xian-sheng Meng, Xi Luo, Yi Zheng, Tian-jiao Li, Yong-rui Bao, Shuai Wang, Jia-peng Leng
Summary: The consumption of flavonoid-rich fructus aurantii extracts (FAE) shows potential in the prevention and treatment of colitis-associated cancer (CAC) due to its anti-inflammatory and anti-cancer properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Menghui Xu, Ruhao Zhuo, Shengxiang Tao, Yaxu Liang, Chunru Liu, Qingyang Liu, Tian Wang, Xiang Zhong
Summary: This study found that lipopolysaccharide activates the NOD1/NF-κ B pathway through altering m(6)A RNA methylation, promoting the production of inflammatory cytokines and leading to liver inflammation and damage.
Article
Agriculture, Multidisciplinary
Xinyue Yang, Qing Wang, Xinghai Zhang, Lingling Li, Xingyue Cao, Li Zhou, Yefei Huang, Guixiang Sun, Yansu Chen
Summary: Purple yam polyphenol extracts (PYPE) can improve ulcerative colitis and inhibit colitis-related colorectal cancer in mice models by exerting anti-inflammatory and anticancer effects, suggesting it as a potential preventive strategy against UC and CAC.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yuanyuan Tao, Wendao You
Summary: This study reveals that high expression of USP4 in gastric cancer is associated with poor prognosis, and it mediates gastric cancer cell growth through regulating the PRL-3/NF-KB signaling pathway. The findings suggest that USP4 may serve as a novel therapeutic target for gastric cancer.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Medicine, Research & Experimental
Tao Zheng, Zhengjun Lin, Guangyao Jiang, Hongxuan Chen, Yaocheng Yang, Xiangbin Zeng
Summary: Breast cancer is the most prevalent cancer in females, with metastatic bone disease being a major complication. Pogostone has been found to inhibit osteoclast differentiation and bone resorption, as well as suppress invasion and migration of breast cancer cells. These findings suggest that pogostone could be a potential drug for the treatment of breast cancer-associated bone metastasis.
Article
Endocrinology & Metabolism
Tingyou Zhang, Xiaojuan Wang, Shanshan Deng, Lin Zhou, Xiaowen Sun, Ruizhan Tong, Lin Xu, Ran Li, Xiaorong Yang, Fang Chen, Ning Li
Summary: The miR-301a/NF-KB pathway plays an important role in DOX resistance in breast cancer, and overexpression of miR-301a increases drug resistance in breast cancer cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Zetian Gao, Qiubo Zhang, Hang Chen, Jiayi Chen, Jingyu Kang, Hang Yu, Yufei Song, Xie Zhang
Summary: In this study, we found that TNFR2 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and is associated with aggressive clinicopathologic characteristics and poor outcomes. Overexpression of TNFR2 promotes proliferation, migration, and invasion of PDAC cells through activation of the NF-KB signaling pathway. TNFR2 may serve as a potential therapeutic target for PDAC.
Article
Immunology
Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Samaneh Arab, Fatemeh Forouzanfar, Mitra Yadollahi, Samira Asgharzade
Summary: COVID-19 is a global pandemic with significant morbidity and mortality, and there is currently no approved drug available to eradicate the virus. Research suggests that dysregulation of inflammation pathways may be a key factor in COVID-19 complications, with non-coding RNAs (miRNAs) playing crucial roles in regulating this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Guang-Yu Zhong, Jia-Nan Tan, Jing Huang, Sheng-Ning Zhou, Jin-Hao Yu, Lin Zhong, Dong Hou, Shi-Lin Zhi, Jin-Tao Zeng, Hong-Ming Li, Chu-Lian Zheng, Bin Yang, Fang-Hai Han
Summary: This study revealed that LINC01537 promotes gastric cancer metastasis and tumorigenesis by stabilizing RIPK4 and enhancing the NF-kB signaling pathway expression.
Article
Plant Sciences
Gaoxiang Shi, Jinrong Kong, Yunlai Wang, Zihua Xuan, Fan Xu
Summary: Licorice has anti-inflammatory and immunomodulatory effects by affecting the protein expression of TLR4/MyD88/NF-KB, improving the integrity of the intestinal mucosal barrier. It also reverses the imbalance in Th17/Treg cell differentiation and influences the expression of ROR-yt and Foxp3. Licorice has a significant impact on the diversity of gut microbiota, improving the composition of dominant species and increasing the amount of beneficial bacteria.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
