Review
Medicine, General & Internal
Yasutaka Ishii, Masahiro Serikawa, Tomofumi Tsuboi, Ryota Kawamura, Ken Tsushima, Shinya Nakamura, Tetsuro Hirano, Ayami Fukiage, Takeshi Mori, Juri Ikemoto, Yusuke Kiyoshita, Sho Saeki, Yosuke Tamura, Sayaka Miyamoto, Kazuaki Chayama
Summary: Endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) play important roles in the diagnosis of pancreatic cancer. EUS has higher sensitivity for detecting small pancreatic cancer, while ERCP is essential for evaluating pancreatic duct stricture.
Article
Surgery
Chan Hyuk Park, Moon Jae Chung, Da Hae Park, Seonjeong Min, Se Woo Park
Summary: Fatty pancreas is a significant risk factor for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). Clinicians need to be aware of the risk of fatty pancreas for the development of PEP prior to performing ERCP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Igor Braga Ribeiro, Epifanio Silvino do Monte Junior, Antonio Afonso Miranda Neto, Igor Mendonca Proenca, Diogo Turiani Hourneaux de Moura, Mauricio Kazuyoshi Minata, Edson Ide, Marcos Eduardo Lera dos Santos, Gustavo de Oliveira Luz, Sergio Eiji Matuguma, Spencer Cheng, Renato Baracat, Eduardo Guimaraes Hourneaux de Moura
Summary: PEP is a feared and potentially fatal complication, with up to 30% occurrence in high-risk patients. Despite debates, further research is needed to fully understand the effectiveness of preventive measures.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Surgery
Chan Hyuk Park, Se Woo Park, Min Jae Yang, Sung Hoon Moon, Da Hae Park
Summary: A risk prediction model for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) was developed and validated, with the high-risk group showing a significantly higher risk of PEP development compared to the low- or intermediate-risk groups under the post-ERCP model.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Hiroaki Sakai, Naoto Iwai, Junichi Sakagami, Takashi Okuda, Tomoya Ohara, Chie Hattori, Masashi Taniguchi, Kohei Oka, Tasuku Hara, Toshifumi Tsuji, Toshiyuki Komaki, Keizo Kagawa, Osamu Dohi, Hiroaki Yasuda, Hideyuki Konishi, Yoshito Itoh
Summary: The effectiveness of low-dose rectal diclofenac in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) was investigated in this study. The results showed that low-dose rectal diclofenac did not reduce the incidence and severity of PEP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Koichi Fujita, Shujiro Yazumi, Hisakazu Matsumoto, Masanori Asada, Hiroko Nebiki, Kazuya Matsumoto, Toru Maruo, Mamoru Takenaka, Takeshi Tomoda, Takumi Onoyama, Akira Kurita, Toshiharu Ueki, Toshiro Katayama, Takashi Kawamura, Hirofumi Kawamoto
Summary: This study evaluated the incidence and severity of adverse events (AEs) in biliary endoscopic retrograde cholangiopancreatography (ERCP), and identified risk factors and preventive measures for post-ERCP pancreatitis (PEP). The overall incidence of AEs was 10.1%, with a mortality rate of 0.08%. Prophylactic pancreatic stenting and epinephrine spraying were found to prevent PEP effectively.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Mamoru Takenaka, Makoto Hosono, Madan M. Rehani, Yasutaka Chiba, Rei Ishikawa, Ayana Okamoto, Tomohiro Yamazaki, Atsushi Nakai, Shunsuke Omoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Shiro Hayashi, Tsutomu Nishida, Masatoshi Kudo
Summary: This study compared radiation exposure in endoscopic ultrasound-guided drainage (EUS-D) and endoscopic retrograde cholangiopancreatography drainage (ERCP-D), finding that despite shorter procedure time, EUS-D had significantly higher radiation doses than ERCP-D.
DIGESTIVE ENDOSCOPY
(2022)
Article
Surgery
Tae Young Park, Hyun Kang, Geun Joo Choi, Hyoung-Chul Oh
Summary: This study analyzed 12 studies and found that aggressive hydration can significantly reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, the effect of aggressive hydration is not significant in high-risk populations and patients with moderate-severe pancreatitis, suggesting the need for further research.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Medicine, General & Internal
Kazunori Nakaoka, Eizaburo Ohno, Naoto Kawabe, Teiji Kuzuya, Kohei Funasaka, Yoshihito Nakagawa, Mitsuo Nagasaka, Takuya Ishikawa, Ayako Watanabe, Takumi Tochio, Ryoji Miyahara, Tomoyuki Shibata, Hiroki Kawashima, Senju Hashimoto, Yoshiki Hirooka
Summary: Pancreatic ductal adenocarcinoma (PDAC) can be treated with surgery, chemotherapy, and radiotherapy. However, surgery is currently the only curative treatment, and early detection of smaller tumors is critical for better prognosis. Imaging features and genetic tests play important roles in the accurate diagnosis of early-stage PDAC.
Article
Gastroenterology & Hepatology
Min Jae Yang, Jae Chul Hwang, Dakeun Lee, Young Bae Kim, Byung Moo Yoo, Jin Hong Kim
Summary: This study evaluated the factors associated with a positive cancer diagnosis from transpapillary biliary forceps biopsy (TBFB) and found that bile duct cancer, intraductal growing type, and five or more tissue samples were significant predictors of positive TBFB results. Increasing the number of tissue samples by five or more led to higher sensitivity in patients with bile duct cancer with the periductal infiltrating type.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Yunxiao Lyu, Shenjian Ye, Bin Wang
Summary: This retrospective analysis showed that delayed ERCP performed > 72 h after admission has economic and safety outcomes similar to those of early ERCP for patients with concurrent ABP and non-severe AC.
Article
Gastroenterology & Hepatology
Mikael Parhiala, Camilla Nojgaard, Andreas Bartholdy, Anne Waage, Povilas Ignatavicius, Trond Engjom, Georg Dimcevski, Ingrid Kvale Nordaas, Evangelos Kalaitzakis, Asbjorn M. Drewes, Amer Hadi, Soren S. Olesen, Jakob L. Poulsen, Johanna Laukkarinen, Scandinavian Baltic Pancreatic Club
Summary: This study aimed to determine the frequency of endoscopic procedures (EP) in chronic pancreatitis (CP) patients and analyze their pain and quality of life (QoL) after the procedures. The study found that 20% of CP patients underwent EP, and these patients had higher QoL scores and improved symptoms. Patients who had pancreatic stenting had similar pain patterns to the reference population.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
Yong-Gang He, Jing Li, Xue-Hui Peng, Jing Wu, Ming-Xun Xie, Yi-Chen Tang, Lu Zheng, Xiao-Bing Huang
Summary: The study retrospectively analyzed the treatment outcomes of 162 patients with pancreatic pseudocysts, finding that sequential therapy with combined ENPD and ERPD is safe and effective in managing these patients.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, General & Internal
Jian-Han Lai, Keng-Han Lee, Chen-Wang Chang, Ming-Jen Chen, Ching-Chung Lin
Summary: This study compared the predictive factors and reliability of computed tomography (CT) and endoscopic ultrasonography (EUS) in patients with pancreatic mass lesions, as well as the diagnostic accuracy of EUS-guided fine needle aspiration (FNA) or fine needle biopsy (FNB) in patients with chronic pancreatitis (CP). The results showed that EUS had superior diagnostic accuracy compared to CT. Hypoattenuation pattern or vessel invasion on CT and pancreatic duct dilatation or distal pancreatic atrophy on EUS were significant predictive factors. The study concluded that EUS imaging is a reliable modality for evaluating pancreatic lesions in patients with CP.
Article
Medicine, General & Internal
Juri Ikemoto, Masahiro Serikawa, Keiji Hanada, Noriaki Eguchi, Tamito Sasaki, Yoshifumi Fujimoto, Shinichiro Sugiyama, Atsushi Yamaguchi, Bunjiro Noma, Michihiro Kamigaki, Tomoyuki Minami, Akihito Okazaki, Masanobu Yukutake, Yasutaka Ishii, Teruo Mouri, Akinori Shimizu, Tomofumi Tsuboi, Koji Arihiro, Kazuaki Chayama
Summary: Early diagnosis of PDAC is crucial for improving prognosis, with 70% of patients being asymptomatic. EUS is the most sensitive for detecting small PDAC, with MRI showing the highest positivity rate for main pancreatic duct stenosis. ERCP-associated pancreatic juice cytology has a sensitivity of 84% for preoperative pathological diagnosis.
Letter
Gastroenterology & Hepatology
Gregory A. Cote, Haley Nitchie, B. Joseph Elmunzer, Richard S. Kwon, Field F. Willingham, Sachin Wani, Daniel Mullady, Amitabh Chak, Vikesh Singh, Adam Slivka, Shyam Varadarajulu, Martin Freeman, Srinivas Gaddam, Priya Jamidar, Paul Tarnasky, Lydia Foster, Peter B. Cotton
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Shaurya Prakash, B. Joseph Elmunzer, Erin M. Forster, Gregory A. Cote, Robert A. Moran
Summary: Based on limited observational data, in expert hands, EDGE has a high rate of technical success and an acceptable rate of adverse events. As a novel procedure, many knowledge gaps need to be addressed to inform the design of meaningful comparative studies and guide informed consent.
Article
Gastroenterology & Hepatology
Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh K. Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T. Barbu, Haq Nawaz, Silvia C. Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J. Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Peter J. Lee, Somashekar Krishna, Luis F. Lara, Samuel Han, Bechien U. Wu, Georgios Papachristou
Summary: This study aims to evaluate the performance of the Pancreatitis Activity Scoring System (PASS) in a global patient cohort and investigate the predictive accuracy and distinct trajectories of a modified PASS. The results suggest that the modified PASS performs well in predicting disease severity and exhibits distinct trajectories between severity subgroups.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Kaveh Sharzehi, Gregory A. Cote
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Bradford Chong, Gregory A. Cote
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Dhiraj Yadav, David C. Whitcomb, Gong Tang, Adam Slivka, Melena Bellin
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Pedram Paragomi, Georgios I. Papachristou, Kwonho Jeong, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh K. Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T. Barbu, Haq Nawaz, Silvia C. Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J. Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Peter J. Lee, Phil A. Hart, Darwin L. Conwell, Frederico G. S. Toledo, Dhiraj Yadav
Summary: This study examined the impact of pre-existing diabetes mellitus on the severity of acute pancreatitis and found that pre-existing diabetes mellitus itself is not a risk factor for severe acute pancreatitis.
Article
Gastroenterology & Hepatology
Nikhil R. Thiruvengadam, Abdul Kouanda, Anita Kalluri, Douglas Schaubel, Monica Saumoy, Kimberly Forde, Jun Song, Alec Faggen, Brenton G. Davis, Kenechukwu Chudy Onwugaje, Gregory Cote, Mustafa A. Arain, Michael L. Kochman
Summary: This study aimed to determine the value of PAN-PROMISE in independently defining ERCP-related morbidity. The results showed that a substantial number of patients experience significant morbidity after ERCP despite not developing PEP or other adverse events. Further research is needed to better understand the reasons behind this increase in symptoms and find interventions to reduce the symptom burden post-ERCP.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Dongni Fu, Brandon M. Blobner, Phil J. Greer, Robert Lafyatis, Melena D. Bellin, David C. Whitcomb
Article
Gastroenterology & Hepatology
Vikesh K. Singh, David C. Whitcomb, Peter A. Banks, Samer AlKaade, Michelle A. Anderson, Stephen T. Amann, Randall E. Brand, Darwin L. Conwell, Gregory A. Cote, Timothy B. Gardner, Andres Gelrud, Nalini Guda, Christopher E. Forsmark, Michele Lewis, Stuart Sherman, Thiruvengadam Muniraj, Joseph Romagnuolo, Xiaoqing Tan, Gong Tang, Bimaljit S. Sandhu, Adam Slivka, C. Mel Wilcox, Dhiraj Yadav
Summary: In a well-defined North American cohort, it was found that approximately 70.7% of patients with chronic pancreatitis had a history of acute pancreatitis, with the majority occurring more than 5 years prior to the diagnosis of chronic pancreatitis. Patients with multiple episodes of acute pancreatitis were diagnosed with chronic pancreatitis an average of 5 years earlier compared to those with only one episode.
Article
Gastroenterology & Hepatology
Nikhil R. Thiruvengadam, Gregory A. Cote, Shashank Gupta, Medora Rodrigues, Yecheskel Schneider, Mustafa A. Arain, Pejman Solaimani, Steve Serrao, Michael L. Kochman, Monica Saumoy
Summary: This study aimed to evaluate the cost-effectiveness requirements of computer-aided detection (CAD) in colorectal cancer (CRC) screening/surveillance and its impact on adenoma detection by endoscopists with different ADRs. The findings showed that CAD significantly improved ADR and reduced CRC incidence and mortality. Therefore, in clinical implementation, CAD needs to improve ADR to at least 30% or have a cost of less than $579 per colonoscopy to be cost-effective.
Article
Gastroenterology & Hepatology
Gregory A. Cote, Valerie Durkalski-Mauldin, April Williams, Haley Nitchie, Jose Serrano, Dhiraj Yadav, S. H. A. R. P. Consortium SHARP Consortium
Summary: Using the SHARP trial as an example, this article discusses the rationale and key aspects of study design for clinical trials of endoscopic therapy in acute pancreatitis. The challenges in recruitment and strategies used by the SHARP team are highlighted, providing valuable insights for investigators planning similar trials. The development of evidence-based treatments will facilitate physicians in recommending effective treatments for pancreatitis.
Article
Gastroenterology & Hepatology
Peter J. Lee, Ali Lahooti, Stacey Culp, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Ila Lahooti, Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin Traian Babu, Haq Nawaz, Silvia Cristina Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Luis Lara, Samuel Han, Georgios I. Papachristou
Summary: This study aimed to determine the adjusted effects of body mass index (BMI) and alcoholic etiology on the risk of multisystem organ failure (MSOF) in patients with acute pancreatitis (AP). The results showed that alcoholic etiology was independently associated with increased risk of MSOF compared to non-alcohol etiologies, and obese men (but not women) were more susceptible to MSOF.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Stephen J. D. O'Keefe, Toby Graham, Gregory A. Cote, David C. Whitcomb, Anna Evans, Devavrata Soni
Summary: This randomized controlled trial indicates that in patients with severe acute pancreatitis, enteral feeding through endoscopic-assisted DJ tube placement is more effective and safer than NG feeding. The risk of feeding failure is higher in the NG group.
TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Phil A. Hart, Dana K. Andersen, Erica Lyons, Gregory A. Cote, Zobeida Cruz-Monserrate, Robert H. Dworkin, B. Joseph Elmunzer, Evan L. Fogel, Christopher E. Forsmark, Ian Gilron, Megan Golden, Aysegul Gozu, Lindsay McNair, Stephen J. Pandol, Emily R. Perito, Anna Evans Phillips, Jennifer A. Rabbitts, David C. Whitcomb, John A. Windsor, Dhiraj Yadav, Tonya M. Palermo
Summary: Recurrent acute pancreatitis and chronic pancreatitis are high-morbidity diseases with no current therapies for reversing or delaying disease progression. Clinical trials are needed to address this important gap. A conference sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases discussed the current gaps and opportunities in patient-focused trials for pancreatitis.