Article
Gastroenterology & Hepatology
Meng Wei, Wei-Bo Cao, Ru-Dong Zhao, Dan-Ping Sun, Yi-Ze Liang, Ya-Di Huang, Ze-Wei Cheng, Jun Ouyang, Wen-Shuo Yang, Wen-Bin Yu
Summary: Elevated bile acids after sleeve gastrectomy (SG) induce the expression of FGF15 in the distal ileum by activating their receptor FXR. Furthermore, the promoted FGF15 partly mediates the improving effects of SG on hepatic glucose metabolism.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Multidisciplinary Sciences
Yeshong Park, Young Suk Park, Sangjun Lee, So Hyun Kang, Eunju Lee, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung-Ho Kim
Summary: The study compared the short-term outcomes of single-port, reduced-port, and conventional laparoscopic sleeve gastrectomy, suggesting that single-port and reduced-port approaches could be alternative choices for selected patients. Although there was a slight difference in remission of dyslipidemia, this difference disappeared after matching. Further studies are necessary to establish standardized guidelines for single-port sleeve gastrectomy.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Yuanyuan Zhai, Wenling Zhou, Xu Yan, Yuan Qiao, Lingling Guan, Zhichun Zhang, Hao Liu, Jizhi Jiang, Jiang Liu, Liang Peng
Summary: This study investigated the effect of AS-IV on NAFLD and explored the involvement of intestinal flora. AS-IV treatment alleviated diet-induced metabolic impairments, particularly hepatic steatosis. The changes in intestinal flora and BAs were found to play an essential role in the remission of hepatic steatosis by AS-IV.
Article
Multidisciplinary Sciences
Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mohamed A. Marie, Ahmed Rabiee, Mona Youssry Helmy, Mohamed Sabry Tourky, Mohamed Gamal Qassem, Hossam El-Din Shaaban, Mohamed D. Sarhan
Summary: Independent predictors of complete remission of T2DM after LSG were younger age, shorter duration, single oral antidiabetic, lower HOMA-IR, and higher C-peptide. The combined marker of young age, short duration of DM, and low HOMA-IR had a sensitivity of 93% and specificity of 82% in predicting complete remission.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Kadir Yildirim, Ilhan Karabicak, Esra Kayahan Ulu, Recep Aktimur, Mahmut Fikret Gursel, Zafer Malazgirt
Summary: This study aimed to investigate the correlation between improvements in hepatosteatosis and biochemical parameters, especially Neutrophil-lymphocyte ratio (NLR), and ultrasonographic findings one year after laparoscopic sleeve gastrectomy. The results showed a significant improvement in hepatosteatosis and a decrease in NLR one year after the surgery. However, no correlation was found between the decrease in NLR and the improvement in hepatosteatosis.
Article
Biochemistry & Molecular Biology
Gabriela Moreira Soares, Luana Emanuelly Sinhori Lopes, Sandra Lucinei Balbo, Carine Marmentini, Gabriela Alves Bronczek, Mirian Ayumi Kurauti, Maria Lucia Bonfleur, Licio Augusto Velloso, Everardo Magalhaes Carneiro, Antonio Carlos Boschero, Jose Maria Costa Jr
Summary: Sleeve gastrectomy (SG) normalizes metabolic homeostasis and insulin sensitivity in obese individuals, possibly through increased insulin clearance mediated by enhanced liver IDE expression. However, IDE activity does not appear to be affected by SG surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Emma Rose McGlone, Matthieu Siebert, Marian Dore, David C. D. Hope, Iona Davies, Bryn Owen, Bernard Khoo, Rob Goldin, Dave Carling, Stephen Bloom, Maude Le Gall, Tricia M-M. Tan
Summary: The study investigated the effects of sleeve gastrectomy on weight-independent improvements in liver steatosis in mice with diet-induced obesity. It was found that VSG not only improves liver fat content but also enhances insulin and glucagon sensitivity.
LIVER INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Fu Chen, Bingyang Liu
Summary: This study aimed to investigate the effects of sleeve gastrectomy (SG) on hypercholesterolemia and hepatic cholesterol accumulation in a type 2 diabetes mellitus (T2DM) rat model. The results showed that SG partially alleviated hypercholesterolemia and hepatic cholesterol accumulation by inhibiting hepatic de novo cholesterogenesis.
Article
Surgery
Guillermo Borjas, Nestor Sanchez, Ali Urdaneta, Andres Maldonado, Eduardo Ramos
Summary: This study compared the short-term outcomes of magnet-assisted reduced-port gastric sleeve (RPSG-MA) and conventional laparoscopic sleeve gastrectomy (CLSG), and found that the RPSG-MA group had shorter hospital stay than the CLSG group, with similar operative time and complication rates.
Article
Gastroenterology & Hepatology
Matthew Barron, Hailey Hayes, Deemantha G. Fernando, Aron M. Geurts, Tammy L. Kindel
Summary: In this study, a global GLP-1R knockout rat model was developed to investigate the role of GLP-1R in weight loss and metabolic disease improvement after sleeve gastrectomy. The results showed that loss of the GLP-1R resulted in increased adiposity, insulin resistance, and severe steatosis, indicating a critical role of GLP-1R in these aspects. However, the metabolic efficacy of sleeve gastrectomy in terms of body weight, glucose tolerance, and fatty liver disease improvement was not significantly affected by GLP-1R knockout, suggesting a GLP-1R-independent mechanism in certain outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Endocrinology & Metabolism
Rachel Ben-Haroush Schyr, Abbas Al-Kurd, Botros Moalem, Anna Permyakova, Hadar Israeli, Aya Bardugo, Yhara Arad, Liron Hefetz, Michael Bergel, Arnon Haran, Shahar Azar, Itia Magenheim, Joseph Tam, Ronit Grinbaum, Danny Ben-Zvi
Summary: Direct measurements of glucose and insulin in the blood entering and leaving the liver show that VSG affects glucose and insulin metabolism through mechanisms independent of weight loss and diet. Insulin levels were elevated in the portal vein, and hepatic insulin clearance was elevated in VSG-operated mice. Hepatic expression of genes associated with insulin clearance was upregulated.
Article
Endocrinology & Metabolism
Esraa Altawil, Hadeel Alkofide, Husam Alamri, Noura Alhassan, Hamad Saud S. Alsubaie, Awadh Alqahtani, Omar Alobaid
Summary: This study revealed a potential association between higher levels of parathyroid hormone post-bariatric surgery and vitamin D deficiency and lower calcium levels, despite recommended supplementation. The importance of routine testing for hyperparathyroidism both before and after bariatric surgery was emphasized.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Weilun Meng, Ronggang Peng, Lei Du, Yixing Zheng, Diya Liu, Shen Qu, Yawei Xu, Yi Zhang
Summary: This study investigated the impact of weight loss after laparoscopic sleeve gastrectomy (LSG) on cardiac structural and functional remodeling in obese Chinese. The results showed that weight loss after LSG effectively improved cardiac structural abnormalities in obese Chinese, but did not improve cardiac function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M. Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D. Moore, Li Yang, Wendong Huang
Summary: The study suggests that vertical sleeve gastrectomy (VSG) achieves its metabolic benefits by reducing intestinal bile acids and fat absorption levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
