Review
Biochemistry & Molecular Biology
Maxime De Rudder, Alexandra Dili, Peter Staerkel, Isabelle A. Leclercq
Summary: Liver sinusoidal endothelial cells (LSEC) play unique roles in liver sinusoids and liver regeneration, but there are still many unanswered questions about their specific functions and interactions with other liver cells during different phases. Understanding the complex relationship between LSEC and liver regeneration is crucial for developing strategies to prevent small for size syndrome after extended hepatectomy or small liver transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Amelia J. Hessheimer, Jordi Vengohechea, Lilia Martinez de la Maza, Javier Munoz, Marina Vendrell, Josep Marti Sanahuja, Alba Torroella, Farah Adel Al Shwely, Francisco Riquelme, Cesar Munoz, Rocio Garcia, Pilar Taura, Constantino Fondevila
Summary: This study conducted hepatic resections in a pig model and found that extended major hepatectomy led to immediate changes in portal pressure, causing liver cell injury, but these effects were significantly improved with somatostatin therapy.
Article
Biotechnology & Applied Microbiology
Zeyuan Li, Bo Peng, Shilian Chen, Jiaping Li, Kai Hu, Lijuan Liao, Qiuli Xie, Mei Yao, Lixing Liang, Stephen Tomlinson, Guandou Yuan, Songqing He
Summary: This study compared the different mechanisms of liver regeneration and injury between partial hepatectomy (pHx) and extended hepatectomy (eHx) using transcriptome and metabolome analysis. The results showed that eHx caused more severe liver injury and lower survival rates compared to pHx. Analysis of differentially expressed genes (DEGs) and differentially produced metabolites (DPMs) suggested that cholesterol metabolism and insulin resistance pathways might be important for liver regeneration and mouse survival post-PHx and -eHx.
Article
Biochemistry & Molecular Biology
Xin Yan, Ji-Hua Shi, Jian-Feng Xue, Wen-Zhi Guo, Bin Li, Shui-Jun Zhang
Summary: The study revealed that blocking the PD-1/PD-L1 pathway can enhance small-for-size liver regeneration by inducing M1 macrophage polarization, while M2 macrophage polarization and upregulation of PD-L1 expression can lead to compromised liver regeneration.
Article
Cell & Tissue Engineering
Sandra Nickel, Sebastian Vlaic, Madlen Christ, Kristin Schubert, Reinhard Henschler, Franziska Tautenhahn, Caroline Burger, Hagen Kuehne, Silvio Erler, Andreas Roth, Christiane Wild, Janine Brach, Seddik Hammad, Claudia Gittel, Manja Baunack, Undine Lange, Johannes Broschewitz, Peggy Stock, Isabella Metelmann, Michael Bartels, Uta-Carolin Pietsch, Sebastian Kraemer, Uwe Eichfeld, Martin von Bergen, Steven Dooley, Hans-Michael Tautenhahn, Bruno Christ
Summary: Research has shown that transplantation of mesenchymal stromal cells can alleviate surgery-induced hepatocellular stress and epithelial-mesenchymal transition, improving epithelial integrity and facilitating regeneration.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Surgery
Tetsuji Wakabayashi, Kuniya Tanaka, Toshimitsu Shiozawa, Yuki Takahashi, Mikiko Tanabe, Kenichi Matsuo
Summary: ALPPS and LDLT using small-for-size grafts show similar hypertrophy ratios and histological features for FLR, suggesting a similar hepatic regenerative process.
Article
Multidisciplinary Sciences
Jan Bednarsch, Zoltan Czigany, Sven H. Loosen, Lara Heij, Lorenz Ruckgaber, Henning Maes, Jan-Pit Krause, Matthias Reen, Beata Toteva, Theresa Vosdellen, Philipp Bruners, Sven Arke Lang, Tom Florian Ulmer, Christoph Roderburg, Tom Luedde, Ulf Peter Neumann
Summary: The study aimed to evaluate the impact of rifaximin on liver function, regeneration, and volumetric recovery in patients undergoing major hepatectomy, but it was prematurely terminated due to the unlikelihood of reaching a significant primary endpoint. Rifaximin did not show significant effects on postoperative liver function, volume regeneration, or surgical complications.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sinan Efe Yazici, Mustafa Emre Gedik, Can Berk Leblebici, Kemal Kosemehmetoglu, Gurcan Gunaydin, Ahmet Bulent Dogrul
Summary: In this study, the researchers investigated the mechanisms of liver regeneration and found that Vegf, endocan, endostatin, and eEF2K play important roles in the process of liver regeneration after partial hepatectomy. Specifically, endocan may serve as a useful biomarker for clinical prognosis.
MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Luke D. Rothermel, Benjamin D. Powers, Margaret M. Byrne, Kevin McCarthy, Jason W. Denbo, Jasmina Ehab, Jason B. Fleming, Daniel A. Anaya
Summary: Background Parenchyma-sparing (PS) liver resection is recommended for liver tumors, and the value-based differences between PS approaches and more extended resections are still unclear.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Mingfei Han, Xian Liu, Wen Zhang, Mengnan Wang, Wenjing Bu, Cheng Chang, Miao Yu, Yingxing Li, Chunyan Tian, Xiaoming Yang, Yunping Zhu, Fuchu He
Summary: TSMiner is an analytical tool that can capture dynamic regulatory events from time-series gene expression profiles, demonstrating superior sensitivity and accuracy compared to existing methods. When applied to a mouse liver regeneration dataset, TSMiner identified numerous transcriptional activators and repressors, revealing temporal dynamics of key biological processes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Lucia Calthorpe, Nikdokht Rashidian, Andrea Benedetti Cacciaguerra, Patricia C. Conroy, Taizo Hibi, Mohammad Abu Hilal, Daniel Hoffman, Keon Min Park, Jaeyun Wang, Mohamed Abdelgadir Adam, Adnan Alseidi
Summary: This study compared different criteria for post-hepatectomy liver failure (PHLF) and evaluated the association between International Study Group of Liver Surgery (ISGLS) PHLF and the Comprehensive Complication Index (CCI) and 90-day mortality. The results showed that the ISGLS criteria best predicted 90-day mortality. Patients with ISGLS grade C had an increased risk of CCI>40 and 90-day mortality.
Article
Oncology
Zhengqing Lei, Nuo Cheng, Anfeng Si, Pinghua Yang, Guangmeng Guo, Weihu Ma, Qiushi Yu, Xuan Wang, Zhangjun Cheng
Summary: A nomogram was developed to predict grade B/C post-hepatectomy liver failure in HCC patients undergoing major hepatectomy, showing more accurate ability than conventional scoring models like MELD and ALBI scores.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Dilmurodjon Eshmuminov, Debora J. Studer, Victor Lopez Lopez, Marcel A. Schneider, Jan Lerut, Mary Lo, Linda Sher, Thomas J. Musholt, Oana Lozan, Nabila Bouzakri, Carlo Sposito, Rosalba Miceli, Shoma Barat, David Morris, Helga Oehler, Teresa Schreckenbach, Peri Husen, Charles B. Rosen, Gregory J. Gores, Toshihiko Masui, Tan-To Cheung, Corina Kim-Fuchs, Aurel Perren, Philipp Dutkowski, Henrik Petrowsky, Espen Thiis-Evensen, Pal-Dag Line, Michal Grat, Stefano Partelli, Massimo Falconi, Lulu Tanno, Ricardo Robles-Campos, Vincenzo Mazzaferro, Pierre-Alain Clavien, Kuno Lehmann
Summary: This multicenter study compares the outcomes of liver resection (LR) and liver transplantation (LT) in patients with neuroendocrine liver metastasis (NELM). The results suggest that LT provides a survival benefit over LR, but adherence to selection criteria is important.
Article
Cell Biology
Daniela Lenggenhager, Jonas Grossmann, Jerome Gouttenoire, Christine Sempoux, Achim Weber
Summary: Immunohistochemistry for HEV ORF2 protein is a useful tool for tissue-based diagnosis of hepatitis E. However, we report an unexpected immunoreactivity of the HEV ORF2 antibody to CMV proteins. The staining pattern of CMV-infected cells is limited to the nucleus, in contrast to the cytoplasmic and occasional canalicular positivity observed in hepatitis E.
Article
Surgery
Dominique Lisa Birrer, Ekaterina Kachaylo, Eva Breuer, Michael Linecker, Philipp Kron, Udo Ungethuem, Catherine Hagedorn, Regula Steiner, Carola Kalin, Lucia Bautista Borrego, Jean-Francois Dufour, Michelangelo Foti, Thorsten Hornemann, Pierre-Alain Clavien, Bostjan Humar
Summary: Surgical liver failure (SLF) is the most common cause of death after liver surgery, but its etiology remains unclear. This study found that early SLF is related to portal hyperafflux, resulting in hypoxia and downregulation of lipid oxidation activities. Stimulation of lipid oxidation with low-dose ITPP and L-carnitine can reduce SLF risks.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cell Biology
Simon Haefliger, Juergen Hench, Colm J. O'Rourke, Nathalie Meyer-Schaller, Sarp Uzun, Joan Saldarriaga, Achim Weber, Luca Mazzucchelli, Philip Jermann, Stephan Frank, Jesper B. Andersen, Luigi Terracciano, Christine Sempoux, Matthias S. Matter
Summary: This study analyzed the genetic and epigenetic alterations of hepatocellular adenomas (HCA) with atypical morphological features, and found differences with hepatocellular carcinoma (HCC) or HCA without atypical morphology. Therefore, targeted sequencing and/or combined methylation/copy number profiling should be performed to differentiate between HCC and HCA when diagnosis is difficult.
Article
Oncology
Lilian Roth, Dilmurodjon Eshmuminov, Linda Russo, Felix Laminger, Friedrich Kober, Sebastian Roka, Kuno Lehmann
Summary: This study aimed to assess the sensitivity and specificity of blood and serum markers after CRS/HIPEC. It found that HIPEC alters the diagnostic sensitivity and specificity of these markers, with PCT identified as a highly specific marker for diagnosing infectious complications after CRS/HIPEC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Roessler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Kuno Lehmann
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Dilmurodjon Eshmuminov, Botirjon Aminjonov, Russell F. Palm, Giuseppe Malleo, Ryan K. Schmocker, Raef Abdallah, Changhoon Yoo, Walid L. Shaib, Marcel Andre Schneider, Elena Rangelova, Yoo Jin Choi, Hongbeom Kim, J. Bart Rose, Sameer Patel, Gregory C. Wilson, Sarah Maloney, Lea Timmermann, Klaus Sahora, Fabian Rossler, Victor Lopez-Lopez, Emanuel Boyer, Laura Maggino, Thomas Malinka, Jeong Youp Park, Matthew H. G. Katz, Laura Prakash, Syed A. Ahmad, Scott Helton, Jin-Young Jang, Sarah E. Hoffe, Roberto Salvia, Julien Taieb, Jin He, Pierre-Alain Clavien, Ulrike Held, Kuno Lehmann
Summary: Pancreatic cancer often presents as locally advanced or borderline resectable. It is currently unclear which chemotherapy is preferred for patients in these categories. This study found that initial treatment with FOLFIRINOX appears to provide a survival benefit for patients that are ultimately unresectable, compared to gemcitabine-based chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Rahel Stiefel, Kuno Lehmann, Thomas Winder, Alexander R. Siebenhuener
Summary: This study aimed to analyze the outcomes of GEP-NETs treatment and compare them with the latest treatment recommendations. The results showed that treatment steps and stages of GEP-NETs were related to survival rates. Surgery was commonly used in both early and advanced stages, while the use of Somatostatine-Agonist as a drug treatment was also common.
Article
Endocrinology & Metabolism
Alessa Fischer, Simon Kloos, Umberto Maccio, Juliane Friemel, Hanna Remde, Martin Fassnacht, Christina Pamporaki, Graeme Eisenhofer, Henri J. L. M. Timmers, Mercedes Robledo, Stephanie M. J. Fliedner, Katharina Wang, Julian Maurer, Astrid Reul, Kathrin Zitzmann, Nicole Bechmann, Gintare Zygiene, Susan Richter, Constanze Hantel, Diana Vetter, Kuno Lehmann, Hermine Mohr, Natalia S. Pellegata, Martin Ullrich, Jens Pietzsch, Christian G. Ziegler, Stefan R. Bornstein, Matthias Kroiss, Martin Reincke, Karel Pacak, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: This study investigated the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs. It also evaluated SSTR-based therapies in metastatic PPGLs. The results showed that SSTR2 expression was associated with SDHB/SDHx mutations and metastatic disease. Somatostatin receptor-based therapies had a high disease control rate in metastatic PPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Harriet Louise Walker, Shahi Ghani, Christoph Kuemmerli, Christian Andreas Nebiker, Beat Peter Muller, Dimitri Aristotle Raptis, Sebastian Manuel Staubli
Summary: ChatGPT-4 is an AI chatbot that can answer complex questions and may become the new standard for accessing medical information. This study assessed the reliability of medical information provided by ChatGPT and found that it is comparable in quality to existing internet information.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Multidisciplinary Sciences
Keyue Sun, Daniela Bochicchio, Pierre-Alain Clavien, Philipp Dutkowski, Bostjan Humar
Summary: Uterine transplantation is a new approach for treating absolute uterine factor infertility, which has shown success in animal models and led to pregnancy in clinical practice. Continuous optimization of the procedure is still needed.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Medicine, General & Internal
Ladina Vonzun, Romana Brun, Nora Gadient-Limani, Marcel Andre Schneider, Theresia Reding, Rolf Graf, Perparim Limani, Nicole Ochsenbein-Kolble
Summary: This prospective cohort study aimed to generate reference values for serum pancreatic stone protein (PSP) in pregnancy and compare them to the values of the general healthy population. The PSP values in healthy pregnant women (4-12 ng/mL) were within the range of the reference values of the general healthy population (8-16 ng/mL).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Alessa Fischer, Umberto Maccio, Katharina Wang, Juliane Friemel, Martina A. Broglie Daeppen, Diana Vetter, Kuno Lehmann, Astrid Reul, Mercedes Robledo, Constanze Hantel, Nicole Bechmann, Karel Pacak, Kathrin Zitzmann, Christoph J. Auernhammer, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: In pheochromocytomas and paragangliomas, hypoxia upregulates the expression of PD-L1 and HIF-2 alpha, promoting tumor progression and immune microenvironment alterations. Head and neck paragangliomas undergoing embolization show significantly higher expression levels of PD-L1 and HIF-2 alpha, suggesting that targeted treatment using HIF-2 alpha and checkpoint inhibitors may be beneficial.
Review
Medicine, General & Internal
Franz von Stauffenberg, Inga Hegemann, Rahel Schwotzer, Kuno Lehmann, Jeannette Widmer
Summary: This study evaluated therapy strategies for symptomatic abdominal haemophilic pseudotumours and found that primary surgical resection can be considered as the first-line treatment, with preoperative embolisation as a bridging therapy before surgery. Diagnostic biopsy and percutaneous drainage should be avoided to prevent complications.
SWISS MEDICAL WEEKLY
(2023)