Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Yue-Yuan Li, Wen-Ting Lu, Jian-Xiang Liu, Li-Hong Wu, Meng Chen, Hong-Mei Jiao
Summary: This study aimed to evaluate the esophageal motility characteristics of patients with EGJOO and identify valuable parameters for confirming the diagnosis. The results showed that based on CCv4.0, patients with EGJOO had more severe esophagogastric junction dysfunction and were implicated in the proximal esophagus. Additionally, several parameters were supportive for confirming the diagnosis of EGJOO.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Songfeng Chen, Xiangbin Xing, Xun Hou, Qianjun Zhuang, Niandi Tan, Yi Cui, Jinhui Wang, Mengyu Zhang, Shixian Hu, Yinglian Xiao
Summary: This study identified differentially expressed proteins and potential pathways associated with achalasia. The study revealed specific protein alterations related to immunity, inflammation, infection, and neurodegeneration pathways in both serum and muscle samples of achalasia patients. Different protein clusters were also observed between different types of achalasia, indicating potential molecular pathways associated with different disease stages.
GASTROENTEROLOGY REPORT
(2023)
Article
Gastroenterology & Hepatology
Anand S. Jain, Chaitanya Allamneni, Meredith Kline, Raj Dalsania, Marie Godiers, Steven Keilin, Shanthi Srinivasan, Ravinder Mittal
Summary: This study examined the relationship between distensibility index (DI) and integrated relaxation pressure (IRP), and their correlations with dysphagia symptoms in patients with achalasia and esophagogastric junction outflow obstruction (EGJOO). The study found that DI is not correlated with HRM EGJ measurements and has the strongest effect on dysphagia severity.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Melissa Nelson, Xi Zhang, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: Mast cells play a major role in allergic disorders such as eosinophilic esophagitis, causing clinical manifestations and potential neurodegeneration in the esophagus. Their release of proinflammatory and cytotoxic mediators could impact esophageal muscle contraction and enteric neurons, contributing to conditions like achalasia.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dhyanesh A. Patel, James Goss, Muhammad Hayat, Claudio Tombazzi, Rishi D. Naik, James C. Slaughter, Muhammad Aslam, Shabnam Sarker, Tina Higginbotham, Michael F. Vaezi
Summary: This study investigates the association between chronic opioid use and motility disorders of the esophagogastric junction and esophageal body peristalsis. The results demonstrate that opioid users are more likely to experience dysphagia and be diagnosed with spastic disorders. Additionally, opioid users have a higher symptom burden in the long term compared to non-opioid users.
Article
Gastroenterology & Hepatology
Daniela Jodorkovsky, Danny Wong, Ryan Din, Daniel R. Sikavi, Darren J. H. Lee, Jennifer X. Cai, Wai-Kit Lo, Walter W. Chan
Summary: This study found that EGJOO patients with abnormal EBM are more likely to experience esophageal symptoms, indicating that abnormal EBM may impact the clinical presentation of EGJOO.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Surgery
Wei Zhao, Bin Wang, Lingyun Zhang, Zhongqing Zheng, Xin Chen, Chunshan Zhao, Bangmao Wang, Hong Jin, Lili Zhang
Summary: Smooth muscle fibrosis is common in the lower part of the esophagus in patients with achalasia, and it is positively correlated with the severity of symptoms two years after per-oral endoscopic myotomy (POEM). The fibrosis may be related to eosinophil infiltration and TGF-beta 1.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Shahin Ayazi, Katrin Schwameis, Ping Zheng, Kirsten Newhams, Brittney M. Myers, Andrew D. Grubic, Toshitaka Hoppo, Blair A. Jobe
Summary: This study evaluated the impact of MSA on the lower esophageal sphincter (LES) and esophageal body using high resolution impedance manometry. The findings showed that MSA improved LES characteristics without affecting esophageal peristaltic progression and bolus clearance.
Review
Gastroenterology & Hepatology
Benjamin D. Rogers, C. Prakash Gyawali
Summary: The esophagogastric junction (EGJ) is a complex barrier between the thoracic and abdominal luminal gut compartments, relaxation and muscle abnormalities at EGJ may lead to achalasia and gastroesophageal reflux disease. High resolution manometry (HRM) is the current gold standard for assessing EGJ morphology and function, with newer metrics and tests providing more comprehensive evaluation of EGJ functionality and morphology.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Oncology
Yasufumi Koterazawa, Manabu Ohashi, Masaru Hayami, Rie Makuuchi, Satoshi Ida, Koshi Kumagai, Takeshi Sano, Souya Nunobe
Summary: To ensure a pathologically negative proximal margin (PM) in gastric cancer with esophageal invasion or esophagogastric junction cancer, the esophagus should be transected beyond the gross boundary of invasion. However, there are no established recommendations for the length of esophageal resection in these cases.
Article
Surgery
Matthias Paireder, Ivan Kristo, Reza Asari, Gerd Jomrich, Johannes Steindl, Erwin Rieder, Sebastian F. Schoppmann
Summary: After undergoing LES-EST treatment, patients with GERD and IEM showed significant improvement in health-related quality of life, but the normalization or significant improvement of esophageal acid exposure was limited.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Food Science & Technology
Pengxu Wei
Summary: This article focuses on the treatment methods and effects of botulinum toxin injection for UES dysfunction. The research suggests that the entire UES should be targeted for injection rather than just the cricopharyngeal muscle. The article also discusses the therapeutic mechanisms of botulinum toxin and the strengths and weaknesses of guiding techniques.
Article
Chemistry, Applied
Nantaporn Promdam, Pissared Khuituan, Pharkphoom Panichayupakaranant
Summary: Standardized [6]-gingerol extracts were prepared using alternative green solvents and showed significant inhibitory effects on mouse ileal contractions and lower esophageal sphincter contractions, indicating their potential as nutraceuticals for alleviating nausea and vomiting.
Article
Physiology
Guy Elisha, Sourav Halder, Dustin A. A. Carlson, Peter J. J. Kahrilas, John E. E. Pandolfino, Neelesh A. A. Patankar
Summary: Plotting P-CSA hysteresis loops in the esophagus can provide insights into its motor function. FLIP can measure pressure and cross-sectional area during secondary peristalsis. The loops show a horizontal shape with phases similar to cardiovascular analyses, and this study aims to explain the phases within the esophageal body.
FRONTIERS IN PHYSIOLOGY
(2023)