Article
Immunology
Xiao-Lin Yan, Xiao-Chen Liu, Yu-Ni Zhang, Ting-Ting Du, Qing Ai, Xiong Gao, Jing-Li Yang, Lei Bao, Lu-Quan Li
Summary: This study found that succinate plays an important role in the pathogenesis and severity of necrotizing enterocolitis, and the activation of the HIF-1α signaling pathway may lead to disease progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Cheng Guo, Fang-Xiong Ye, Yong-Hong Jian, Chun-Hua Liu, Zhi-Hui Tu, Ding-Ping Yang
Summary: The study demonstrated the significant role of miR-214-5p in sepsis-related AKI, showing its potential as a therapeutic candidate by activating AMPK to protect the kidneys from inflammation and oxidative stress.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Food Science & Technology
Li Li, Jionghao Chen, Haoming Sun, Qiang Niu, Yan Zhao, Xiaojun Yang, Qingzhu Sun
Summary: This study found that Orm2 deficiency exacerbates HFD-induced gut microbiota disturbance and intestinal inflammation, providing a novel insight into the therapeutic strategy of obesity focusing on complex bacterial flora rather than single probiotic administration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qi-Hai Wang, Shu Pan, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qingcheng Mao, Jian Zuo
Summary: This study found that rheumatoid arthritis conditions can increase the oral absorption of MTX, and this is related to changes in MTX absorption-related transporters in the intestines. Additionally, glycolysis-driven high energy metabolism can increase the absorption of MTX in rheumatic subjects, leading to exacerbated toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Robert J. Motzer, Toni K. Choueiri, David F. McDermott, Thomas Powles, Yann-Alexandre Vano, Saurabh Gupta, Jin Yao, Celine Han, Ron Ammar, Simon Papillon-Cavanagh, Shruti S. Saggi, M. Brent McHenry, Petra Ross-Macdonald, Megan Wind-Rotolo
Summary: The study found that biomarkers previously associated with immune checkpoint inhibitor-containing regimens were not predictive for survival in RCC patients treated with nivolumab plus ipilimumab. However, gene expression analysis revealed an association between an inflammatory response and progression-free survival in patients receiving this treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Longxian Lv, Xiaoyuan Bian, Liya Yang, Jiafeng Xia, Xianwan Jiang, Wenrui Wu, Shuting Wang, Qiangqiang Wang, Lanjuan Li
Summary: Ketogenic diet worsens DSS-induced colitis in mice by increasing inflammation, disrupting the intestinal barrier, and modulating gut microbiota and metabolism.
Article
Endocrinology & Metabolism
Xiao-Yan Huang, Ji-Xiong Chen, Yi Ren, Li-Chun Fan, Wei Xiang, Xiao-Jie He
Summary: This study found that miR-122-enriched exosomes promote adipogenesis by regulating the VDR/SREBF1 axis. Inhibition of miR-122 can alleviate obesity.
Article
Cell Biology
Lisa Perruzza, Francesco Strati, Matteo Raneri, Hai Li, Giorgio Gargari, Tanja Rezzonico-Jost, Martina Palatella, Ivo Kwee, Diego Morone, Frauke Seehusen, Paolo Sonego, Claudio Donati, Pietro Franceschi, Andrew J. Macpherson, Simone Guglielmetti, Victor Greiff, Fabio Grassi
Summary: This study demonstrates that hydrolysis of extracellular ATP by apyrase results in amplification of the SIgA repertoire, influencing the distribution of bacteria and gene expression in the intestinal epithelium in mice. Apyrase-induced SIgA improves intestinal homeostasis, attenuating barrier impairment and susceptibility to infection.
Article
Cell Biology
Stefan Teufel, Petra Koeckemann, Christine Fabritius, Lena Wolff, Jessica Bertrand, Thomas Pap, Christine Hartmann
Summary: Agonists and antagonists of the canonical Wnt signaling pathway have an impact on rheumatoid arthritis, primarily modifying bone loss and soft-tissue inflammation. WNT9a levels are elevated in the pannus tissue of RA patients, suggesting a specific role in TNF-triggered RA.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Mariana Charleaux de Ponte, Vanessa Gerolde Cardoso, Guilherme Lopes Goncalves, Juliana Martins Costa-Pessoa, Maria Oliveira-Souza
Summary: Compared to the sham group, renal ischemia-reperfusion significantly increased plasma creatinine, urea, and albuminuria levels, while decreasing Nphs1 mRNA expression and nephrin and WT1 protein staining. Tubular injury was also observed with increased Havcr1 and Mki67 mRNA expression and reduced megalin staining. This study suggests that early diabetes could exacerbate renal ischemia-reperfusion-induced acute kidney injury by enhancing renal dysfunction, inflammation, and profibrotic responses.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
Lu-Ping Tang, Wei-Hao Li, Yi-Lei Liu, Jian-Chi Lun, Yong-Ming He
Summary: The study illustrates that heat stress can impact the intestines of chickens, leading to decreased immunity and increased susceptibility to bacterial infections, while also increasing the risk of intestinal inflammatory damage.
Article
Cardiac & Cardiovascular Systems
Yutian Li, Shan Deng, Xiaohong Wang, Wei Huang, Jing Chen, Nathan Robbins, Xingjiang Mu, Kobina Essandoh, Tianqing Peng, Anil G. Jegga, Jack Rubinstein, David E. Adams, Yigang Wang, Jiangtong Peng, Guo-Chang Fan
Summary: This study utilizing a global Sectm1a-knockout mouse model revealed that Sectm1a deficiency leads to increased accumulation of inflammatory macrophages in the heart, worsening cardiac injury in response to inflammatory stimuli. By modulating LXR alpha signaling in macrophages, Sectm1a was identified as a novel regulator of inflammation-induced cardiac dysfunction, suggesting its potential as a therapeutic target for resolving inflammation and associated cardiac dysfunction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Lichao Yang, Guotao Wu, Qiang Wu, Liangxin Peng, Lianwen Yuan
Summary: This study found that METTL3 overexpression aggravates cellular inflammation in inflammatory bowel diseases and is involved in the NF-kappa B signaling pathway.
CELL DEATH DISCOVERY
(2022)
Article
Immunology
Ying Li, Han Ma, Liang Xue, Huizhen Chen, Rui Pang, Yanyan Shang, Juan Luo, Xinqiang Xie, Jumei Zhang, Yu Ding, Moutong Chen, Juan Wang, Qingping Wu
Summary: The study found that severe paronychia is associated with a higher abundance of anaerobic microorganisms such as Parvimona, Prevotella, and Peptoniphilus, while Lactobacillus decreases as the disease progresses. Co-occurring network analysis suggested that disturbance of dermic microbiome and reduction of antagonism by Lactobacillus against anaerobic pathogens may worsen inflammation in paronychia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)