Article
Medicine, General & Internal
Serkan Bilgin, Ahmet Kayali, Adnan Yamanoglu, Huseyin Acar, Zeynep Karakaya, Firdevs Topal, Elif Saritas Yuksel, Fatih Esad Topal
Summary: In patients with dysphagia and normal CM, over 40% were completely asymptomatic at follow-up, while less than half reported significant symptoms, with the remaining responders admitting to moderate to mild symptoms.
Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Engineering, Environmental
Wenjin Zhang, Yiling Yang, Yuchuan Wang, Teng Fei, Yu Wang, Chenghui Sun, Siping Pang
Summary: 1-Trinitromethyl-3,4,5-trinitropyrazole (3), with super-high density and good thermal stability, was successfully synthesized. The intermolecular interactions of compound 3 were carefully studied, suggesting its potential as a replacement for ammonium perchlorate and ammonium dinitramide in solid propellants.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Surgery
Federica Riccio, Mario Costantini, Renato Salvador
Summary: Accurate diagnosis is crucial for successful treatment of achalasia, with barium swallow, upper endoscopy, and high-resolution manometry providing essential information about anatomy, absence of other diseases, and type of achalasia. Prognostic value is also found in high-resolution manometry, with best treatment results obtained in type II achalasia according to the Chicago classification. Additional imaging tests such as abdominal CT scanning and endoscopic ultrasound may be necessary if malignancy is suspected.
WORLD JOURNAL OF SURGERY
(2022)
Review
Pharmacology & Pharmacy
Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Nathalie Rommel, Jan Tack, Tim Vanuytsel
Summary: Esophageal hypomotility, particularly ineffective esophageal motility according to the Chicago criteria, is a common motility disorder diagnosed on high resolution manometry. Most patients present with GERD symptoms or dysphagia. Prokinetic agents are commonly prescribed but their beneficial effects are limited to certain drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Chemistry, Physical
Jizhe Song, Mengtao Sun
Summary: This study investigates a twisted bilayer borophene (TBB) with a twist angle of 21.79 degrees on a Ag(111) film. The large cell size of the 21.79 degrees TBB creates favorable conditions for the short-range disordered phonon liquid state, leading to a decrease in thermal conductivity and excellent ZT values.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Computer Science, Artificial Intelligence
Wenjun Kou, Dustin A. Carlson, Alexandra J. Baumann, Erica N. Donnan, Jacob M. Schauer, Mozziyar Etemadi, John E. Pandolfino
Summary: This study developed an automatic diagnosis platform using machine learning and artificial intelligence to accurately identify esophageal motility disorders. The platform achieved high accuracy in diagnosing these disorders by utilizing a combination of deep-learning models and feature-based models, along with a model selection and balancing strategy.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Ryusei Nishi, Haruka Amitani, Kazumasa Hamada, Takamasa Fukumoto, Ryuichi Kato, Takako Yamamoto, Yuuki Fuku, Kenichiro Sagiyama, Akihiro Asakawa
Summary: Idiopathic achalasia is a rare esophageal disorder characterized by progressive dysphagia and high lower esophageal sphincter pressure. This case report highlights the importance of considering achalasia when patients present with persistent symptoms, even if initially excluded. Medication is not a definitive treatment, and surgical intervention may be necessary for recovery. The psychosomatic approach can also be beneficial in managing symptoms.
Article
Gastroenterology & Hepatology
Natalya C. B. Dias, Fernando A. M. Herbella, Leonardo M. Del Grande, Marco G. Patti
Summary: This study evaluated the role of the transdiaphragmatic pressure gradient (TPG) and lower esophageal sphincter (LES) dysfunction in the pathogenesis of gastroesophageal reflux disease (GERD). The results showed that abdominal pressure and TPG were higher in GERD-positive patients, while LES resting pressure was not different between groups. Relative LES pressure (LES retention pressure) was able to predict the presence and severity of GERD. The study concluded that TPG plays an important role in the pathophysiology of GERD, and the relative LES pressure is a reliable indicator for GERD.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Gastroenterology & Hepatology
Mentore Ribolsi, Matteo Ghisa, Edoardo Savarino
Summary: The article discusses investigations conducted using conventional manometry and high-resolution manometry (HRM) to explore the field of esophageal motility and understand the potential link between motor features and gastroesophageal reflux disease (GERD) pathogenesis. HRM studies have provided insights into the esophageal motor function in patients with various esophageal disorders, as well as the correlation between reduced esophageal motility, disruption of the esophagogastric junction, and gastroesophageal reflux burden.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Matteo Ghisa, Brigida Barberio, Elisa Marabotto, Nicola de Bortoli, Edoardo Savarino
Summary: Esophageal motor abnormalities are common in patients with eosinophilic esophagitis (EoE) and may contribute to symptoms. Eosinophils influence esophageal motility, and some motility abnormalities can be improved after medical treatment.
DIGESTIVE AND LIVER DISEASE
(2022)
