Article
Immunology
Ruiyan Chen, Ying Li, Xiaodong Chen, Jianhui Chen, Jie Song, Xiaoqiao Yang, Lifang Ye, Zizhong Wu, Peng Xie, Qiong Zhong, Runshi Yang, Jiachuan Wu
Summary: Helicobacter pylori infection can induce gastropathy, and the presence of DupA gene in certain strains may be associated with erosive gastritis but not gastric cancer. This finding is important for understanding the pathogenesis of H. pylori and for the prevention and treatment of erosive gastritis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Oncology
Qiang Zhou, Yu Fu, Lijia Wen, Yu Deng, Junhong Chen, Kai Liu
Summary: This meta-analysis revealed significant associations between XPD gene polymorphisms rs13181 and rs1799793 with hepatocellular carcinoma risk, particularly in the Chinese population. However, the variants of these genes were not found to be related to gastric cancer risk.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Multidisciplinary Sciences
Tomosuke Mukoyama, Shingo Kanaji, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study aimed to investigate the risk factors and severity of delayed gastric emptying (DGE) after gastrectomy. Female sex, diabetes, and distal gastric tumors were identified as independent risk factors for DGE. The DGE group had a longer hospital stay compared to the non-DGE group, and most DGE cases occurred after 1 week following surgery.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Biochemistry & Molecular Biology
Natalia Landeros, Alejandro H. Corvalan, Maher Musleh, Luis A. Quinones, Nelson M. Varela, Patricio Gonzalez-Hormazabal
Summary: This study identified seven novel associations and replicated one previously described in Caucasian population, providing insights into the understanding of miRNA genetic polymorphisms in gastric cancer pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yan Pu, Xu Wen, Zhangjun Jia, Yu Xie, Changxing Luan, Youjia Yu, Feng Chen, Peng Chen, Ding Li, Yan Sun, Jian Zhao, Haiqin Lv
Summary: Gastric cancer ranks second in incidence among all malignancies in China, posing a significant threat to human health. This study identified a significant association between the EFNA1 rs4971066 polymorphism and reduced susceptibility to gastric cancer development through the analysis of tagSNPs in GC related genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Yingxi Chen, Nan Hu, Linda Liao, Kai Yu, Xiao-Ou Shu, Wei Zheng, Jian-Min Yuan, Woon-Puay Koh, You-Lin Qiao, Jin-Hu Fan, Sanford M. Dawsey, Neal D. Freedman, Philip R. Taylor, Alisa M. Goldstein, Christian C. Abnet
Summary: Blood type has been associated with the risk of gastric cancer, and this study reveals a significant association between blood type and the risk of ESCC. Blood type B and AB were found to have a higher risk for ESCC compared to type O. The study also highlights the association of blood type with gastric noncardia adenocarcinoma, providing important evidence for further understanding the mechanisms of action.
Article
Pathology
Peidong Ni, Gang Wang, Yuanhang Wang, Kanghui Liu, Wangwang Chen, Jian Xiao, Hao Fan, Xiang Ma, Zengliang Li, Kuan Shen, Zekuan Xu, Li Yang
Summary: This study investigates the associations of five polymorphisms in the lncRNA MIF-AS1 with the risk and prognosis of gastric cancer (GC). The results show that rs17004044 variant of MIF-AS1 is associated with increased predisposition and poor prognosis in GC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Genetics & Heredity
Qi Liu, Danyan Li, Yunkai Dai, Yunzhan Zhang, Shaoyang Lan, Qi Luo, Jintong Ye, Xu Chen, Peiwu Li, Weijing Chen, Ruliu Li, Ling Hu
Summary: This study aimed to investigate the relationship between miR-146a, miR-196a2, miR-149, miR-499, and miR-27a gene single nucleotide polymorphisms (SNPs) and their expressions with pathological changes in gastric mucosa, and to further analyze the interactions between SNPs and Hp. The results showed that miR-196a2 rs11614913 and miR-27a rs895819 may affect the genetic susceptibility to gastric precancerous lesions (GPL) or gastric cancer (GC). The up-regulation of miR-499, miR-196a2, and miR-27a expression caused by Hp infection may be an important mechanism of gastric carcinogenesis.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Kwei-Jing Chen, Ming-Hong Hsieh, Yen-You Lin, Michael Yuan-Chien Chen, Ming-Yu Lien, Shun-Fa Yang, Chih-Hsin Tang
Summary: Oral cancer is a common cancer in Taiwanese males, and elevated levels of visfatin, a pro-inflammatory adipocytokine, have been found in oral squamous cell carcinoma (OSCC) patients. This study investigated the effects of visfatin gene polymorphisms and carcinogenic lifestyle factors on the risk of developing OSCC, as well as their associations with prognostic factors. The results show that certain visfatin gene polymorphisms and lifestyle factors may be associated with the development and prognosis of OSCC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Oncology
Ming-Han Ren, Xing-Si Qi, Yu-Ning Chu, Ya-Nan Yu, Yun-Qing Chen, Peng Zhang, Tao Mao, Zi-Bin Tian
Summary: Depth of invasion and lymphovascular invasion were strongly associated with lymph node metastasis in ulcerative early gastric cancer. Endoscopic resection may be applicable for undifferentiated mucosal ulcerative early gastric cancer < 30 mm in size, but further investigation is needed to evaluate its safety.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan Yang, Daofeng Dai, Wen Jin, Yingying Huang, Yingzi Zhang, Yiran Chen, Wankun Wang, Wu Lin, Xiangliu Chen, Jing Zhang, Haohao Wang, Haibin Zhang, Lisong Teng
Summary: This study compared the microbial composition and metabolites of proximal and distal gastric cancers, and discussed the correlation between microbiota and metabolites. The results may reveal the different mechanisms underlying the occurrence and development of proximal and distal gastric cancers, and provide a basis for future treatments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yihan Cui, Wenjin Wang, Peipei Luo, Yun Feng, Chen Mi, Ai Jia
Summary: This study found that SP4 gene polymorphisms are associated with gastric cancer risk, and specific genotypes may reduce the risk of gastric cancer.
Article
Oncology
Xianglong Duan, Liang Shan, Shuai Shi, Boyu Xu, Xin Chen, Jinqin Di, Bopeng Chen, Xiaoqing Li, Sida Liu, Yuhe Wang, Wei Yang
Summary: This study found that GBAP1 gene variants contribute to reduced risk of gastric cancer in the Chinese Han population, particularly gastric adenocarcinoma. Interestingly, the contribution of GBAP1 variants to GC susceptibility was associated with age, sex, BMI, smoking and drinking.
Article
Toxicology
Kuan Shen, Kanghui Liu, Yuanhang Wang, Peidong Ni, Jian Xiao, Fan Hao, Xinyi Zhou, Zekuan Xu, Li Yang
Summary: This study found that MSLN plays a cancer-promoting role in gastric cancer. Additionally, rs3764247 and rs3764246 were associated with a reduced risk of gastric cancer. It was also observed that rs3764247 was closely related to T stage, vascular infiltration, and HER2 expression. Furthermore, patients with rs3764247 CC genotype had poorer survival compared to patients with AA + AC genotype.
ARCHIVES OF TOXICOLOGY
(2022)
