Review
Gastroenterology & Hepatology
Mohamed G. Shiha, Imran Aziz
Summary: Patients with irritable bowel syndrome commonly have various extraintestinal complaints, such as anxiety, depression, and fibromyalgia. The presence of comorbidities poses a diagnostic and therapeutic challenge, leading to unnecessary investigations and interventions, including surgery. Shared pathophysiological mechanisms and potential management strategies are discussed in this review.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Psychology, Clinical
Rei Monden, Judith G. M. Rosmalen, Klaas J. Wardenaar, Francis Creed
Summary: This prospective population-based study assessed the predictors of new onsets of irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), and fibromyalgia (FM). The study found that syndrome-specific predictors were more common than shared ones. The study also revealed a close relationship between IBS and FM, which requires further research.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zahid Ijaz Tarar, Umer Farooq, Ahmad Nawaz, Mustafa Gandhi, Yezaz A. Ghouri, Asmeen Bhatt, Brooks D. Cash
Summary: The study found a significant correlation between IBS and fibromyalgia and chronic fatigue syndrome (CFS), with higher prevalence rates in IBS patients compared to the general adult population without IBS. Different subtypes of IBS, age, gender, and race were identified as predictors for increased odds of fibromyalgia and CFS.
Article
Psychology, Clinical
Kenneth S. Kendler, Judith G. M. Rosmalen, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
Summary: By examining the genetic risk patterns, this study clarifies the etiology of functional somatic disorders (FSD). Patients with fibromyalgia (FM) have elevated genetic risk for various disorders including pain syndromes, internalizing disorders, autoimmune disorders, and sleep disorders. In contrast, major depression (MD) and rheumatoid arthritis (RA) have more restricted genetic risk profiles. This study suggests that FSD arise from a distinctive pattern of genetic liability for a diversity of psychiatric, autoimmune, pain, sleep, and functional somatic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
M. Peters, I Mikeltadze, H. Karro, M. Saare, Andres Metspalu, Andres Metspalu, Mari Nelis, Lili Milani, Georgi Hudjashov, Tonu Esko, A. Salumets, R. Magi, T. Laisk
Summary: Despite overlapping symptoms, endometriosis and IBS have different significantly associated comorbidities, related to the organ systems primarily involved in the index diagnosis.
HUMAN REPRODUCTION
(2022)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Medicine, General & Internal
Katsiaryna Vashkevich, Kathryn Janiuk, Nasim Maleki
Summary: This study found that irritable bowel syndrome (IBS) is significantly associated with anxiety disorders, especially in chronic pain patients with comorbid alcohol use disorders. These findings suggest that GI problems resulting from chronic alcohol use may play a key role in the comorbidity of anxiety disorders, chronic pain, and alcohol use disorders. Addressing GI problems in IBS patients with alcohol use disorders may help manage alcohol use disorders and recovery more effectively.
FRONTIERS IN MEDICINE
(2023)
Review
Psychiatry
Zarmina Islam, Adrijana D'Silva, Maitreyi Raman, Yasmin Nasser
Summary: Irritable bowel syndrome and fibromyalgia have similar pathophysiologic mechanisms and co-diagnosed patients experience more severe symptoms and decreased quality of life. Mind-body interventions, especially cognitive behavioral therapy and yoga, can improve patient-reported outcomes in both conditions individually.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Varvara A. A. Ryabkova, Natalia Y. Y. Gavrilova, Alina A. A. Poletaeva, Alexander I. I. Pukhalenko, Irina A. A. Koshkina, Leonid P. P. Churilov, Yehuda Shoenfeld
Summary: Recent studies suggest that antibody-mediated autoimmune mechanisms may play a role in fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), specifically in relation to G protein-coupled receptors. However, the full extent of the natural antibody network and its implications in these disorders has not been fully explored.
Article
Endocrinology & Metabolism
Nina Groven, Solveig Klaebo Reitan, Egil Andreas Fors, Ismail Cuneyt Guzey
Summary: The study revealed associations between kynurenine metabolism and Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM), as well as characteristic symptoms such as fatigue and pain. These findings may position kynurenine metabolites as a target for future treatment and prevention of these conditions.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Michael Camilleri, Guy Boeckxstaens
Summary: This article evaluates the evidence that targeted pathophysiological mechanisms and customized treatments can be an alternative approach to treating patients with irritable bowel syndrome (IBS). The authors conducted a literature review on the mechanisms and treatments of IBS, identifying various noninvasive clinical tests that can assess the underlying mechanisms responsible for symptom generation. These mechanisms include rectal evacuation disorders, abnormal transit, visceral hypersensitivity or hypervigilance, bile acid diarrhea, sugar intolerances, barrier dysfunction, the microbiome, immune activation, and chemicals released by these mechanisms. The authors also recognized the basic molecular mechanisms contributing to these pathophysiologies, offering opportunities for interventions with medications targeted at specific food components, receptors, and potentially the microbiome. Although the evidence supporting interventions for each mechanism varies, the current state-of-the-art allows for a shift from symptom-based treatment to individualized treatment guided by pathophysiology and clinically identified biomarkers.
Article
Health Care Sciences & Services
Tingting Zhao, Yiming Zhang, Joochul Lee, Angela R. Starkweather, Erin E. Young, Xiaomei Cong
Summary: This study found that certain genetic polymorphisms are associated with the risk and symptoms of irritable bowel syndrome, including abdominal pain, sleep disturbance, and fatigue. These findings contribute to the understanding of how genetic variations influence the development and changes of IBS symptoms over time.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Steven E. Schutzer, Tao Liu, Chia-Feng Tsai, Vladislav A. Petyuk, Athena A. Schepmoes, Yi-Ting Wang, Karl K. Weitz, Jonas Bergquist, Richard D. Smith, Benjamin H. Natelson
Summary: This study suggests that ME/CFS and fibromyalgia may not be distinct entities based on the proteome profile of cerebrospinal fluid.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Paula Ma Rodriguez-Castillejo, Cesar Fernandez-de-las-Penas, Francisco Alburquerque-Sendin, Daiana P. Rodrigues-de-Souza
Summary: The comorbidity between FM and IBS is not considered in the eligibility criteria of clinical trials evaluating physical therapy. Improvements in the selection criteria are necessary to avoid selection bias in clinical trials involving FM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigates the role of corticotropin-releasing factor receptor type II (CRFR2) mechanisms in bladder hyperalgesia. The findings demonstrate the association between CRFR2-related mechanisms and bladder hypersensitivity, supporting the therapeutic value of these agents in the treatment of painful bladder disorders.
