Journal
GASTROENTEROLOGIA Y HEPATOLOGIA
Volume 35, Issue 6, Pages 411-420Publisher
ELSEVIER DOYMA SL
DOI: 10.1016/j.gastrohep.2012.01.017
Keywords
Bone mineral density; Fractures; Chronic cholestasis; Primary biliary cirrhosis; Vitamin D; Bisphosphonates
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Osteoporosis is a common complication of chronic liver disease, especially in the final stages. This entity is more critical in liver transplant recipients, when bone loss accelerates during the immediate postoperative period. The main mechanism involved in the development of osteoporosis in liver disease is deficient bone formation due to the harmful effects of substances such as bilirubin and bile acids or the toxic effect of alcohol or iron on osteoblasts. To prevent and treat osteoporosis, good nutrition and calcium and vitamin D supplementation are required. There are no specific recommendations on drug treatment but bisphosphonates are effective in increasing bone mass in patients with chronic cholestasis and have a good safety profile. (c) 2012 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.
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