Review
Medicine, Research & Experimental
Reem Hamdy A. Mohammed, Mahmoud Essam, Ismail Anwar, Hany Shehab, Mohamed El Komy
Summary: Biologic drugs target specific cytokine signaling pathways to treat autoimmune diseases. Despite their generally safe profiles, paradoxical reactions have been reported in some cases. This study presents a case of infliximab-induced psoriasis vulgaris in a patient with Crohn's disease. Discontinuing infliximab and introducing low-dose steroids and methotrexate successfully controlled both the psoriasis and bowel condition.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Zhijie Lv, Xiaoqi Zhang, Li Wu
Summary: Infliximab-induced seizures are rare in Crohn's disease patients and the mechanism remains unclear. Before and during treatment with infliximab, neurological assessment and tight clinical monitoring should be conducted in patients with pre-existing seizure disorders.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Ping Xia, Yan-Hong Li, Zhong Liu, Xu Zhang, Qian Jiang, Xiao-Yong Zhou, Wei Su
Summary: Paradoxical psoriasis induced by tumor necrosis factor alpha antagonists presents with significant pustular lesions and may have a protracted and complicated clinical course. Cases with moderate-to-high anti-nuclear antibody titers may be at risk for this condition and extensive pustular presentation could indicate a poor prognosis refractory to therapy.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Allergy
Patrick Baum, Sudha Visvanathan, Sandra Garcet, Janine Roy, Ramona Schmid, Sebastian Bossert, Benjamin Lang, Herve Bachelez, Robert Bissonnette, Christian Thoma, James G. Krueger
Summary: This study revealed that the IL-36 pathway plays a significant role in the pathogenesis of generalized pustular psoriasis. Treatment with spesolimab, an anti-IL-36 receptor antibody, resulted in rapid improvement of skin and pustular symptoms in patients with GPP. The treatment also modulated dysregulated molecular pathways associated with GPP and PPP, leading to improved clinical outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Dermatology
Li Yan Lim, Hazel H. H. Oon
Summary: Generalised pustular psoriasis (GPP) is a rare and severe form of psoriasis characterized by visible sterile primary pustules on non-acral skin. This article reviews the gastrointestinal (GI) and liver disorders associated with GPP. GPP is often accompanied by extracutaneous manifestations such as neutrophilic cholangitis and abnormal liver function tests. There is a possible genetic relationship between GPP and conditions like hepatocellular carcinoma and inflammatory bowel disease.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Summary: Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. This study found that NPPP shows more pronounced T helper 1-mediated inflammation, while PPPP exhibits stronger neutrophil-associated activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Dermatology
Ronak Miladi, Alireza Janbakhsh, Arefeh Babazadeh, Zeinab Aryanian, Soheil Ebrahimpour, Mohammad Barary, Terence T. Sio, Uwe Wollina, Mohamad Goldust, Zeinab Mohseni Afshar
Summary: This case report highlights the potential cutaneous manifestation of COVID-19, which should be considered by clinicians as part of the differential diagnoses. Ten case reports/series investigating psoriasis flare-ups following SARS-CoV-2 infection were included after thorough search of PubMed, SCOPUS, and ISI Web of Science databases.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Yueying, Feng Jing, Feng Qi, Shen Jun
Summary: A magnetic resonance enterography-based model was constructed in this study to predict the risk of loss of response to infliximab (IFX) in bio-naive patients with Crohn's disease (CD), providing an effective tool for the early estimation of treatment response before biological intervention.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Bilgin Karaalioglu, Fatih Yildirim, Melek Yalcin Mutlu, Gamze Akkuzu, Duygu Sevinc Ozgur, Cemal Bes
Summary: Palmoplantar pustular psoriasis (PPP) is a rare form of psoriasis that primarily affects the palms and soles. Treatment with hydroxychloroquine (HQ), a commonly used antimalarial drug, can potentially induce or exacerbate PPP.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Nutrition & Dietetics
Wuli Tang, Gang Xie, Junlin Li, Wei Tan, Rongqi Yi, Ling Yang, Lingqin Zhang, Jiaxing Deng, Yue Zhang, Kang Li
Summary: This study investigated the relationship between body composition parameters and disease severity in Crohn's disease (CD) patients treated with infliximab (IFX). The results showed significant differences in subcutaneous adiposity index (SAI), visceral adiposity index (VAI), and skeletal muscle mass index (SMI) among patients with different disease activity statuses. SMI was identified as a reliable indicator of disease activity status.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Yizhong Wang, Xuefeng Gao, Xinyue Zhang, Fangfei Xiao, Hui Hu, Xiaolu Li, Fang Dong, Mingming Sun, Yongmei Xiao, Ting Ge, Dan Li, Guangjun Yu, Zhanju Liu, Ting Zhang
Summary: The study revealed that pediatric CD patients have gut microbial dysbiosis and altered metabolism after IFX therapy, which is related to treatment outcomes. The effects of IFX treatment may be mediated by enriching bacteria taxa that produce SCFAs and BSH, thereby inhibiting inflammation and restoring bile acid metabolism. Some fecal bacteria and metabolites may serve as predictors of IFX therapy outcomes for pediatric CD patients.
Article
Dermatology
Kanika Kamal, Grant J. Riew, Baraa Hijaz, Simon M. Helfgott, Alvaro C. Laga, Vinod E. Nambudiri
Summary: "Generalized pustular psoriasis (GPP)" is a type of pustular psoriasis characterized by recurring or persistent outbreaks of primary sterile pustules on non-acral areas. These eruptions can occur with or without systemic inflammation. Various factors, such as medications, stress, and viral infection, have been identified as potential triggers for GPP flares. While some cases have reported GPP-like eruptions in individuals with coronavirus disease 2019 (COVID-19) infection, few have examined the relationship between infection and biologic use in the development of GPP. In this case, we present the history and management of a 45-year-old male patient with a previous diagnosis of spondyloarthropathy treated with a tumor necrosis factor-& alpha; inhibitor who recently experienced a new, spreading pustular rash following COVID-19 infection.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuyan Li, Yan Ma, Hongling Sun, Zijun Ni, Shurong Hu, Yan Chen, Meijuan Lan
Summary: This study investigated the adherence to Infliximab (IFX) among Chinese Crohn's disease patients and evaluated the association between medication belief and adherence. The results showed that medication concerns may be a predictive factor of adherence, and by enhancing knowledge and relieving concerns, patients' adherence to IFX can be increased.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Dermatology
Jorg C. Prinz, Siew Eng Choon, Christopher E. M. Griffiths, Joseph F. Merola, Akimichi Morita, Darren M. Ashcroft, Manuelle Viguier
Summary: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory skin disease with acute episodes of pustule formation. Understanding the epidemiology and clinical data of GPP is challenging due to its rarity. This review article provides an overview of GPP prevalence estimates in key demographics, genetic mutations associated with the disease, incidence of comorbidities, mortality rate, and causes of death.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
So Yoon Choi, Yiyoung Kwon, Sujin Choi, So Mi Lee, Byung-Ho Choe, Ben Kang
Summary: This study investigated whether infliximab (IFX) trough levels are associated with transmural healing in pediatric patients with Crohn's disease (CD) after 1-year treatment. The results showed that IFX trough levels were associated with endoscopic healing but not with transmural healing in pediatric patients with CD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Elena Cerrillo, Belen Beltran, Salvador Pous, Ana Echarri, Jose Carlos Gallego, Marisa Iborra, Jose Pamies, Pilar Nos
INFLAMMATORY BOWEL DISEASES
(2015)
Article
Gastroenterology & Hepatology
Jos C. Gallego, Ana Porta, Maria C. Pardo, Cristina Fernandez
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose C. Gallego, Ana I. Echarri, Ana Porta, Virginia Ollero
EUROPEAN JOURNAL OF RADIOLOGY
(2011)
Meeting Abstract
Gastroenterology & Hepatology
E. Cerrillo, B. Beltran, A. Echarri, J. C. Gallego, J. Pamies, M. L. Martinez, M. Iborra, G. Bastida, B. Laiz, P. Nos
JOURNAL OF CROHNS & COLITIS
(2014)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose C. Gallegos, Carlos de Joe, Ana Echarri, Ignacio Lopez-de-Ullibarri
AMERICAN JOURNAL OF ROENTGENOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Amado Cabana, J. C. Gallego Ojea, M. Felez Carballada
Summary: This study investigates the relationship between the shape of time-intensity curve on dynamic gadolinium-enhanced MRI and the type of ovarian tumor (benign, borderline, or malignant) classified as indeterminate based on ultrasonography, aiming to enable accurate pre-surgical diagnosis. Significant associations were found between the curve types and the lesion types, indicating that dynamic contrast-enhanced MRI can be useful for classifying indeterminate ovarian tumors as benign, borderline, or malignant.
Review
Radiology, Nuclear Medicine & Medical Imaging
Jose C. Gallego, Ana Echarri
INSIGHTS INTO IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose C. Gallego, Ana Echarri
Article
Radiology, Nuclear Medicine & Medical Imaging
J. C. Gallego Ojea, A. I. Echarri Piudo, A. Porta Vila
Meeting Abstract
Gastroenterology & Hepatology
Ana Echarri, Jose C. Gallego, Virginia Ollero, Ana Porta, Javier A. Castro
Article
Clinical Neurology
JC Gallego
