Article
Oncology
Alexandre Augusto Ferreira Bafutto, Osvaldo Antonio Prado Castro, Daniel Kendi Fukuhara, Wilson Rodrigues de Freitas Jr, Caio de Carvalho Zanon, Laura Lopes Claro, Marineide Carvalho, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Paulo Kassab
Summary: This study aimed to investigate the lymph node distribution in patients with background remnant gastric cancer (RGC). The results showed that the incidence of lymph node involvement was highest at Station 19, 11p, 3, 4sb, and 7. Dissection of Station 3, 4sb, and 4sa is crucial for surgical treatment with curative purposes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Honghu Wang, Hao Qi, Xiaofang Liu, Ziming Gao, Iko Hidasa, Ailixier Aikebaier, Kai Li
Summary: For patients with remnant gastric cancer (RGC), the lymph node ratio (NR) is more accurate than pN staging in predicting prognosis, along with tumor size and lymphovascular invasion being significant factors. When the retrieved lymph node (RLN) count is 15, NR serves as an important and independent prognostic index for RGC, providing a more accurate prediction of patient outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sung Eun Oh, Min-Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Ji Yeong An
Summary: This retrospective study evaluated the impact of meso-jejunal lymph node (MJLN) metastasis on survival in patients with remnant gastric cancer (RGC). The results showed that MJLN metastasis had a negative effect on patient survival and could be considered as an independent prognostic factor.
Article
Oncology
Xiaoliang Jin, Wei Wu, Jing Zhao, Shuang Song, Chunli Zhang, Wenyong Sun, Bin Lv
Summary: Recent studies have shown that the prognosis of signet ring cell carcinoma (SRCC) is related to staging. In early cases, SRCC had a similar lymph node metastasis (LNM) rate to differentiated gastric carcinoma (DC) but significantly lower than undifferentiated carcinoma (UDC). Tumor size, infiltration depth, pathological type, and mixed type were identified as risk factors for LNM in early cases.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kazuki Kano, Takanobu Yamada, Kouji Yamamoto, Keisuke Komori, Hayato Watanabe, Kosuke Takahashi, Yukio Maezawa, Hirohito Fujikawa, Masakatsu Numata, Toru Aoyama, Hiroshi Tamagawa, Haruhiko Cho, Norio Yukawa, Takaki Yoshikawa, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Takashi Oshima
Summary: The lymph node ratio (LNR) and log odds of positive LNs (LODDS) were found to be independent risk factors for recurrence-free survival (RFS) and overall survival (OS) in patients with remnant gastric cancer (RGC). Even in patients with a small number of harvested LNs, LNR remains a significant prognostic indicator.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xianjuan Shen, Shan Kong, Shuo Ma, Lei Shen, Ming Zheng, Shiyi Qin, Jing Qi, Qiuhong Wang, Xiaopeng Cui, Shaoqing Ju
Summary: The circRNA hsa_circ_0000437 was found to play a significant role in gastric cancer progression, promoting cell proliferation, migration, invasion, and apoptosis resistance. It was also found to induce lymph node metastasis through the HSPA2-ERK signaling pathway. Clinical data showed that hsa_circ_0000437 was enriched in the serum of gastric cancer patients and was associated with lymph node metastasis. These findings suggest that hsa_circ_0000437 may serve as a potential biomarker for lymph node metastasis in gastric cancer patients.
Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Alexandre Moraes Bestetti, Diogo Turiani Hourneaux de Moura, Igor Mendonca Proenca, Epifanio Silvino do Monte Junior, Igor Braga Ribeiro, Joao Guilherme Ribeiro Jordao Sasso, Angelo So Taa Kum, Sergio A. Sanchez-Luna, Wanderley Marques Bernardo, Eduardo Guimaraes Hourneaux de Moura
Summary: Endoscopic resection (ER) and surgery are both safe and effective treatments for early gastric cancer patients, with ER associated with lower rates of adverse events and shorter hospital stay. However, ER has lower complete resection rates and higher recurrence rates compared to surgery, although overall survival and cancer-specific survival are similar between the two approaches.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yu Mei, Shuo Wang, Tienan Feng, Min Yan, Fei Yuan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: The study established a nomogram for predicting lymph node metastasis in early gastric cancer, with age, tumor size, submucosal invasion, histological subtype, and HER2 positivity identified as independent risk factors. The model showed good performance in both internal and external validation, with the prediction model providing a higher net benefit for guiding treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Adrienne B. Shannon, Richard J. Straker, Luke Keele, Douglas L. Fraker, Robert E. Roses, John T. Miura, Giorgos C. Karakousis
Summary: The study found that in patients with gastric adenocarcinoma receiving neoadjuvant chemotherapy, retrieving at least 23 nodes during gastrectomy may improve the 5-year overall survival rate. Therefore, it is important to maintain adequate lymph node retrieval postoperatively for better prognostic prediction.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Cell Biology
Xinying Guo, Jie Gu, Anwei Xue, Shushu Song, Bo Liu, Xiaodong Gao, Jianxin Gu, Lei Chang, Yuanyuan Ruan
Summary: Endoscopic surgery is commonly used for EGC treatment, but LNM remains a significant risk factor for relapse. The study found that GNE expression is down-regulated in EGC patients with LNM. Combining GNE expression with other predictive factors can improve the accuracy of LNM prediction in EGC patients.
Article
Pathology
Seokhwi Kim, Won Jung Bae, Ji Mi Ahn, Jin-Hyung Heo, Kyoung-Mee Kim, Kyeong Woon Choi, Chang Ohk Sung, Dakeun Lee
Summary: The study identified unique miRNA expression profiles that can predict metastasis in intramucosal carcinomas (IMCs), with most miRNAs showing stepwise increased or decreased expression. A machine-learning algorithm could distinguish metastatic IMC from nonmetastatic IMC, and gene ontology and pathway analysis revealed enrichment of key signaling pathways. Furthermore, immunohistochemical staining indicated differential expression of pathway components between metastatic and nonmetastatic IMC.
Article
Oncology
Keiichiro Kumamoto, Takashi Tasaki, Koji Ohnishi, Michihiko Shibata, Shohei Shimajiri, Masaru Harada, Yoshihiro Komohara, Toshiyuki Nakayama
Summary: The activation of immune cells in regional lymph nodes is associated with lymphocyte infiltration in primary cancer tissues, impacting cancer-specific survival in patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Dam Lee, Haengdueng Jeong, Bo Ram Hwang, Byeong Min Yu, Yejin Cho, Ki Teak Nam, Hyunki Kim, Yong Chan Lee
Summary: Strains of Helicobacter pylori positive for CagA may contribute to the development of gastric cancer through the induction of CK2 activation and CK28 degradation. The downregulation of CK28 and subsequent activation of AKT and Snail signaling pathways may play a crucial role in the epithelial-to-mesenchymal transition (EMT) in gastric cancer. CK2 could be a potential molecular target for the treatment of H. pylori-infected gastric cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Gastroenterology & Hepatology
Yeon Seung Chung, Youngsic Jeon, Jeong Eun Yoo, Taek Chung, Hyang Joo Ryu, Hyunki Kim, Hyungjin Rhee, Young Nyun Park
Summary: In this study, a method was developed to differentiate intrahepatic cholangiocarcinomas (iCCAs) from adenocarcinomas originating from extrahepatic organs adjacent to the liver. The combination of albumin mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) staining for filamin-A and cytokeratin 19 (CK19) showed better diagnostic performance than albumin ISH alone. The newly developed iCCA-score consisting of these three markers can accurately differentiate iCCA from extrahepatic adenocarcinomas.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Jung Yong Hong, Hee Jin Cho, Kum-Hee Yun, Young Han Lee, Seung Hyun Kim, Wooyeol Baek, Sang Kyum Kim, Yurimi Lee, Yoon-La Choi, Minsuk Kwon, Hyo Song Kim, Jeeyun Lee
Summary: This study investigated the molecular determinants of pazopanib response in refractory soft tissue sarcoma patients. It identified CDK4 amplification as a predictor of poor response and shorter progression-free survival. Additionally, the combination of pazopanib and durvalumab showed efficacy in patients with high immune/stromal cell infiltration and increased CD19 expression.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Ki Cheong Park, Jung Min Kim, Sang Yong Kim, Seok-Mo Kim, Jin Hong Lim, Min Ki Kim, Sungsoon Fang, Yonjung Kim, Gordon. B. B. Mills, Sung Hoon Noh, Jae-Ho Cheong
Summary: In this study, the role of PGC1 alpha in regulating cancer cell viability under metabolic and genotoxic stress was investigated. The findings suggest that PGC1 alpha is a key regulator of anti-apoptosis in metabolic and genotoxic stress-resistant cells, and it may serve as a potential therapeutic target for refractory cancers.
Article
Oncology
Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Hyoung-Il Kim, Woo Jin Hyung, Yoo Min Kim
Summary: This study aimed to identify the clinical features of chylous ascites and evaluate the treatment outcomes. Results showed that patients with chylous ascites had a longer length of hospital stay, and low body mass index, surgical resection extent were associated with the occurrence of chylous ascites. Adequate initial treatment for chylous ascites after radical gastrectomy for gastric cancer can be achieved with a fat-controlled diet and medication.
JOURNAL OF GASTRIC CANCER
(2023)
Review
Pathology
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So -Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
Summary: The first edition of 'A Standardized Pathology Report for Gastric Cancer' was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. This second edition consists of standard data elements and conditional data elements, including basic pathologic findings and items necessary for predicting the prognosis of GC patients. Other factors relevant to adjuvant therapy are classified as conditional data elements. The standardized pathology report will be helpful for GC diagnosis and facilitate collaborative studies.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Khean-Lee Goh, Yeong Yeh Lee, Alex Hwong-Ruey Leow, Raja Affendi Raja Ali, Shiaw Hooi Ho, Sanjiv Mahadeva, Rosaida Hj Mohd Said, Raman Muthukaruppan Chettiar, Hoi Poh Tee
Summary: There are misconceptions in Malaysian clinical practice regarding the appropriate diagnostic method and treatment strategies for Helicobacter pylori infection. To address this, an expert panel of nine key opinion leaders in gastroenterology developed a set of consensus statements relevant to the Malaysian healthcare practice. The panel achieved consensus in three areas of H. pylori infection management: indications for testing, diagnosis, and treatment. They proposed 19 consensus statements, which can serve as a guide for physicians across various healthcare settings in Malaysia.
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Ainaa Almardhiyah Abd Rashid, Lydiatul Shima Ashari, Nor Hamizah Shafiee, Raja Affendi Raja Ali, Lee Yeong Yeh, Mohd Razif Shahril, Hamid Jan Jan Mohamed
Summary: A study in Malaysia found that the processed diet pattern, characterized by a high intake of confectionaries and fast foods, was associated with an increased risk of colorectal cancer. Further research is needed to understand the impact of different dietary patterns on the gut microbiota associated with colorectal cancer, in order to develop prevention measures through lifestyle changes.
Article
Fisheries
Yun Hui Kim, Bo Yeon Kim, Yong Soo Choi, Kwang Sik Lee, Byung Rae Jin
Summary: Feeding honeybees with a heat-killed pathogen cocktail can induce transgenerational immune responses, as shown by the upregulation of vitellogenin and defensin-1 in nurse bees. The Toll signaling pathway and the expression of defensin-1 were also upregulated upon ingestion of the pathogen cocktail. Furthermore, the introduction of the cocktail resulted in increased resistance to pathogen infection in worker larvae.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Surgery
Naruhiko Ikoma, Travis Grotz, Hirofumi Kawakubo, Hyoung-Il Kim, Satoru Matsuda, Yuki Hirata, Atsushi Nakao, Loretta A. Williams, Xin Shelley Wang, Tito Mendoza, Xuemei Wang, Brian D. Badgwell, Paul F. Mansfield, Woo-Jin Hyung, Vivian E. Strong, Yuko Kitagawa
Summary: This study aims to evaluate the impact of minimally invasive proximal gastrectomy (MIPG) on postoperative quality of life in patients with proximal gastric and gastroesophageal junction (P/GEJ) cancers. The study will compare the differences in postoperative appetite level, reflux condition, and quality of life between MIPG and minimally invasive total gastrectomy (MITG). A total of 60 patients are expected to be recruited, and the surgical procedures and anti-reflux techniques will be chosen based on patients' or surgeons' preferences. Assessments include appetite level, body weight, biochemical markers, and quality of life questionnaires. The expected outcome of this study is to establish the benefits and safety of MIPG.
Article
Multidisciplinary Sciences
Chang Min Lee, Sungsoo Park, Sung Hyun Park, Ki-Yoon Kim, Minah Cho, Yoo Min Kim, Woo Jin Hyung, Hyoung-Il Kim
Summary: A comparison between laparoscopic gastrectomy using ALIs and robotic gastrectomy was conducted, revealing that laparoscopic gastrectomy using ALIs showed similar perioperative outcomes and a shorter operation time compared to robotic gastrectomy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ja Ho Koo, Myeongjee Lee, Eun Hwa Kim, Hyung Jung Oh, Joon Seok Lim, Woo Jin Hyung, Hong In Yoon, Inkyung Jung, Yong Eun Chung
Summary: This retrospective study investigated the impact of repetitive exposure to intravenous iodinated contrast media on long-term renal function in patients who underwent curative surgery for gastric cancer. The study found that the frequency of CT scans using ICM slightly increased the odds of developing chronic kidney disease.
SCIENTIFIC REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Suhana Ahmad, Lidawani Lambuk, Naveed Ahmed, Ali Mussa, Vincent Tee, Ros Akmal Mohd Idris, Nur Fazimah Sahran, Yean Yean Chan, Rosline Hassan, Yeong Yeh Lee, Rohimah Mohamud
Summary: Nab-paclitaxel demonstrates good efficacy and safety in the treatment of metastatic gastric cancer, providing better disease response and longer survival.
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
