Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Yunsuk Choi, Yoo Kyung Jeong, Lan Jeong Ju, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, SuJin Koh, Young Joo Min, Eui-Kyu Noh, Jae-Cheol Jo
Summary: Osteoporosis is a progressive skeletal disease affecting millions worldwide, currently treated with drugs that have severe side effects. Cell replacement therapy using mesenchymal stem cells may be a future treatment strategy. This study found that LIGHT can enhance osteogenesis of hBM-MSCs, possibly through WNT/β-catenin pathway activation.
Review
Immunology
Cong-wen Yang, Ru-dong Chen, Qing-run Zhu, Shi-jie Han, Ming-jie Kuang
Summary: This study aimed to evaluate the effectiveness of umbilical cord mesenchymal stromal cells (UC-MSCs) in patients with COVID-19. The meta-analysis results showed that UC-MSCs can reduce mortality in COVID-19 patients and there is no significant correlation between adverse events and UC-MSC treatment. Additionally, treatment with UC-MSCs was found to suppress inflammation and improve pulmonary symptoms. Therefore, UC-MSCs hold promise as a safe and effective treatment for COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ekaterina Semenova, Mariusz P. Grudniak, Eugeniusz K. Machaj, Katarzyna Bocian, Magdalena Chroscinska-Krawczyk, Marzena Trochonowicz, Igor M. Stepaniec, Magdalena Murzyn, Karolina E. Zagorska, Dariusz Boruczkowski, Tomasz J. Kolanowski, Tomasz Oldak, Natalia Rozwadowska
Summary: The study compared MSCs from three different regions of the umbilical cord and found that WJ-MSCs have high and stable proliferation potential and phenotype, making them a preferable source for medical applications.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Genetics & Heredity
Qiwei Liu, Junhui Zhang, Yong Tang, Yuanyuan Ma, Zhigang Xue, Jinjuan Wang
Summary: Huc-MSCs can restore fertility in aging and chemotherapy-damaged mice by rescuing ovarian function and reconstructing the fallopian tubes and uterus.
CURRENT GENE THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yanxia Fu, Jun Li, Ziyu Zhang, Fangli Ren, Yinyin Wang, Huihui Jia, Jihe Liu, Zhijie Chang
Summary: Exosomes derived from human umbilical cord MSCs (HUMSCs) have immunoregulatory functions in rheumatoid arthritis, reducing swelling and inflammation levels, and restoring the balance between Th17 and Treg cells.
Article
Cell & Tissue Engineering
Lei Shi, You Zheng, Zhi Cheng, Ningfei Ji, Changming Niu, Yan Wang, Tingrong Huang, Ruyou Li, Mao Huang, Xiaolin Chen, Lei Shu, Mingjing Wu, Kaili Deng, Jing Wei, Xueli Wang, Yang Cao, Jiaxin Yan, Ganzhu Feng
Summary: This study investigated the long-term safety and efficacy of hUC-MSCs therapy in severe COVID-19 patients. The results showed that hUC-MSCs transplantation was a safe approach in the long term and had a positive effect on postinfection sequelae in COVID-19 survivors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Youshu Lin, Hongwei Wang, Cuibao Jiang, Chen Chen, Danpeng Shen, Fan Xie, Hongpeng Zhang, Jie Yang, Hao Wang
Summary: The study found that human umbilical cord mesenchymal stem cells (hUC-MSCs) had a significant therapeutic effect on psoriasis in a mouse model. Higher concentrations of hUC-MSCs showed the best therapeutic effect.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Ciara Shortiss, Linda Howard, Siobhan S. McMahon
Summary: Spinal cord injury is a devastating trauma that can lead to permanent disability and chronic issues, presenting a significant socioeconomic burden. Regenerative medicine aims to overcome injury and restore function through gene therapy and tissue engineering. Combining biomaterials and lentiviral vectors has been shown to be more effective in promoting repair and function restoration post SCI.
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Cell Biology
Serena Barachini, Marina Montali, Francesca M. Panvini, Vittoria Carnicelli, Gian Luca Gatti, Nicola Piolanti, Enrico Bonicoli, Michelangelo Scaglione, Gabriele Buda, Paolo D. Parchi
Summary: Mesangiogenic progenitor cells (MPCs) isolated from human bone marrow mononuclear cells have the ability to differentiate into mesenchymal stromal cells while retaining endothelial differentiative potential. Their power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential, particularly in musculoskeletal tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Tiago L. Laundos, Francisco Vasques-Novoa, Rita N. Gomes, Vasco Sampaio-Pinto, Pedro Cruz, Helder Cruz, Jorge M. Santos, Rita N. Barcia, Perpetua Pinto-do-O, Diana S. Nascimento
Summary: Research indicates that mesenchymal stem cells derived from the umbilical cord show strong potential in treating myocardial infarction by improving cardiac function and limiting adverse cardiac remodeling. While some variability was found among donors, these cell products exhibited similar functionality and transcriptome characteristics in in vitro experiments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ravena P. do Nascimento, Livia B. de Jesus, Markley S. Oliveira-Junior, Aurea M. Almeida, Eduardo L. T. Moreira, Bruno D. Paredes, Jorge M. David, Bruno S. F. Souza, Maria de Fatima D. Costa, Arthur M. Butt, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The study found that Agathisflavone can protect injured spinal cord tissue and exhibit therapeutic effects in a rat model of acute spinal cord injury. It also promotes neurogenesis and increases the expression of neurotrophins while reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Haijun Hu, Houqing Long, Zhenxiao Ren, Tianhua Liu, Jinghui Xu, Fan Xiao
Summary: This study investigated the therapeutic mechanism of pain caused by spinal cord injury (SCI) through local injection of human umbilical cord mesenchymal stem cells (HU-MSCs) at the site of injury. The results showed that HU-MSCs injection could alleviate neuropathic pain and promote motor function recovery.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell & Tissue Engineering
Qing Hua, Yong Zhang, Hongjuan Li, Haoran Li, Ranran Jin, Li Li, Yuancui Xiang, Meng Tian, Jingjing Wang, Lei Sun, Yali Wang
Summary: This study demonstrates that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) can repair damaged endometrium through trans-differentiation, immunomodulatory capacities, and NF-kappa B signaling, suggesting their potential value for the treatment of intrauterine adhesions (IUAs).
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Chuan He, Chao Yang, Qiang Zeng, Zhigang Liu, Fangfang Wang, Qiang Chen, Ting Liu
Summary: Umbilical cord-derived MSCs cultured in different media showed the general characteristics of MSCs. HGF, ANG-1, and TGF-beta 1 secretion by MSCs in the MCL was higher than in the other media, while PGE2 secretion was lower in the MCL. MSCs in the MCL inhibited IFN-gamma and TNF-alpha more effectively. MSC treatment promoted recovery of peripheral blood cells, increased Treg ratio and VEGF level, and significantly improved bone marrow.
STEM CELL RESEARCH & THERAPY
(2023)