Article
Oncology
Zhu Liu, Lian-Lian Hong, Jin-Sen Zheng, Zhe-Nan Ling, Zhi-Long Zhang, Ya-Nan Qi, Xin-Yu Zhang, Tian-Yu Zhu, Jiu-Li Wang, Jing Han, Xiang-Liu Chen, Qi-Ming Yu, Shi Wang, Pei Li, Zhi-Qiang Ling
Summary: This study provides the first integrative genomic and transcriptomic profiles of primary gastric linitis plastica (GLP), a distinct subtype of gastric cancer. Dysfunction in the Hippo pathway and mutations in genes such as MUC6 and CDH1 are key characteristics of GLP. Additionally, GLP exhibits high immunodeficiency and low AMPK pathway activity. Up-regulation of PI3K-AKT pathway-related genes, IGF2BP3 and MUC16, is associated with PI3K-AKT pathway activity in GLP.
Article
Medicine, Research & Experimental
Mara Fornasarig, Alessandra Capuano, Stefania Maiero, Eliana Pivetta, Vincenzo Canzonieri, Claudio Belluco, Maurizio Mongiat, Renato Cannizzaro, Paola Spessotto
Summary: This study found abnormal changes in vasculature in patients with Linitis plastica (LP) using probe-based Confocal Laser Endomicroscopy (pCLE). The abnormal features included vessel enlargement, tortuosity, and leakage associated with the affected submucosal layer. This provides a new endoscopic approach and strategy for diagnosing LP.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Adil Ayub, Buria Naeem, Alexander Perez, Douglas Tyler, Suzanne Klimberg
Summary: This study utilized a national database to investigate the clinical characteristics, treatment modalities, and outcomes of gastric linitis plastica (LP). The findings showed that surgical resection and chemotherapy were associated with improved survival, while advanced-stage disease and lack of surgical resection and chemotherapy were associated with increased risk of death.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Yang Han, Yi Xuan, Xiaowen Liu, Hui Zhu, Meng Zhang, Dazhi Xu, Yanong Wang, Hong Cai
Summary: This study suggests that an observed tumor size greater than 8 cm may serve as a critical value for distinguishing the prognosis of Borrmann III and IV gastric cancer. It is proposed as a quantitative diagnostic criterion for gastric linitis plastica regardless of Borrmann type.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xinhua Chen, Yunfei Zhi, Zhousheng Lin, Jinyuan Ma, Weiming Mou, Jiang Yu
Summary: A study identified 342 eligible patients with gastric linitis plastica (GLP) and developed nomograms to predict individualized prognosis, finding that chemotherapy and radiotherapy might improve 1- and 3-year overall survival and cancer-specific survival, but not 5-year cancer-specific survival.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ryutaro Takada, Kosuke Minaga, Akane Hara, Yasuo Otsuka, Shunsuke Omoto, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Hajime Honjo, Shigenaga Matsui, Takaaki Chikugo, Tomohiro Watanabe, Masatoshi Kudo
Summary: EUS-FNA biopsy showed a diagnostic ability of 76.9% in patients with negative endoscopic biopsy findings for GLP, contributing to diagnosis in 18.5% of cases without adverse events. The absence of superficial ulcerations was identified as a predictor of false-negative endoscopic biopsy findings in patients with GLP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Stephanie Morgant, Pascal Artru, Ammar Oudjit, Nelson Lourenco, Arnaud Pasquer, Thomas Walter, Jean-Marc Gornet, Alexandre Rouquette, Catherine Brezault, Romain Coriat
Summary: The study evaluated the performance of EUS in linitis plastica and found similar sensitivity and specificity compared to classical gastric cancer, indicating a broader potential use of EUS in preoperative settings.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Antoine Assaf, Benoit Terris, Lola-Jade Palmieri, Alexandre Rouquette, Frederic Beuvon, Anna Pellat, Einas Abou Ali, Claire Ginestet, Arthur Belle, Dr Marion Dhooge, Catherine Brezault, Rachel Hallit, Anthony Dohan, Stanislas Chaussade, Romain Coriat, Maximilien Barret
Summary: Gastric linitis plastica (GLP) is a type of gastric adenocarcinoma with a poor prognosis. The infiltrating nature of this tumor leads to low diagnostic yield from superficial mucosal biopsies. This study investigated the role of endoscopic ultrasound-fine needle biopsy (EUS-FNB) in diagnosing GLP. The results showed that EUS-FNB had a sensitivity of 90% in diagnosing GLP in patients with suspected disease and normal mucosal biopsies, and it was also helpful in diagnosing other serious conditions.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Mei, Xijia Feng, Tienan Feng, Min Yan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: This retrospective study examined the role of adjuvant chemotherapy (ACT) in patients with pT2N0M0 gastric cancer who underwent radical resection. The study found that ACT was associated with higher 5-year overall survival and disease-specific survival rates. Patients with pT2N0M0 gastric cancer, regardless of high-risk factors, may be suitable for ACT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ryosuke Sato, Kazuyuki Matsumoto, Hiromitsu Kanzaki, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Koichiro Tsutsumi, Shigeru Horiguchi, Hironari Kato
Summary: This case report highlights the usefulness of EUS-FNB in detecting GLP when endoscopic biopsy results are negative. It also suggests the possibility of autoimmune pancreatitis (AIP) coexisting with GLP as a paraneoplastic syndrome.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qian Zhao, Hui Dong, Aisheng Dong, Changjing Zuo
Summary: We present a case of rectal linitis plastica secondary to prostate adenocarcinoma, and describe the MRI, Ga-68-PSMA-11 PET/CT, and PET/MRI findings. The rectal linitis plastica was the initial manifestation of the prostate adenocarcinoma, with the rectum being the sole site of metastasis. Imaging showed circumferential thickening of the rectal wall on MRI, and intense Ga-68-PSMA-11 uptake on PET/CT and PET/MRI. Familiarity with these imaging features can aid in the recognition of this rare condition.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tin-Lok Wong, Jia-Jian Loh, Shixun Lu, Helen H. N. Yan, Hoi Cheong Siu, Ren Xi, Dessy Chan, Max J. F. Kam, Lei Zhou, Man Tong, John A. Copland, Leilei Chen, Jing-Ping Yun, Suet Yi Leung, Stephanie Ma
Summary: By establishing 5FU+CDDP resistant organoid lines from gastric cancer patients, this study reveals that JAK/STAT signaling and its downstream target ADAR1 are upregulated, and ADAR1 contributes to chemoresistance and self-renewal through RNA editing. The study also finds hyper-edited lipid metabolism genes in the resistant lines, and ADAR1-mediated editing on SCD1 promotes lipid droplet formation, alleviating chemotherapy-induced ER stress and enhancing self-renewal. Inhibition of SCD1 reverses chemoresistance and reduces tumor-initiating cell frequency, and higher levels of ADAR1 and SCD1 or a high SCD1 editing/ADAR1 mRNA signature predict worse prognosis.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Medicine, General & Internal
Usman Iqbal Aujla, Sadia Jabbar, Muhammad Atique
Summary: Gastric linitis plastica is a highly aggressive malignancy with poor prognosis. Timely and accurate diagnosis is crucial for its effective management. This case report highlights the role of endoscopic ultrasound fine needle aspiration (EUS-FNA) in establishing a diagnosis in challenging cases where routine endoscopy is inconclusive.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2022)
Article
Oncology
Jin Huang, Guofeng Zhao, Qiu Peng, Xin Yi, Liyan Ji, Jing Li, Pansong Li, Yanfang Guan, Jie Ge, Ling Chen, Runzhe Chen, Xin Hu, Won-Chul Lee, Alexandre Reuben, P. Andrew Futreal, Xuefeng Xia, Jian Ma, Jianjun Zhang, Zihua Chen
Summary: By performing whole-exome sequencing and T-cell receptor sequencing, researchers discovered that gastric linitis plastica (LP) exhibits high genomic and TCR heterogeneity, as well as suppressed T-cell infiltration. These findings may explain the frequent recurrence and poor therapeutic response of this disease.
MOLECULAR ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Shanjun Tan, Qiulin Zhuang, Zhige Zhang, Shuhao Li, Jiahao Xu, Junjie Wang, Yanni Zhang, Qiulei Xi, Qingyang Meng, Yi Jiang, Guohao Wu
Summary: This study investigated the link between postoperative loss of skeletal muscle mass and survival following gastric cancer surgery, finding that patients with postoperative skeletal muscle index loss >= 5% had poorer overall survival and disease-free survival. Further research is needed to determine whether stabilizing or enhancing skeletal muscle mass after surgery improves survival outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Oncology
Leonardo Solaini, Maria Bencivenga, Alessia D'ignazio, Marco Milone, Elisabetta Marino, Stefano De Pascale, Fausto Rosa, Michele Sacco, Uberto Fumagalli Romario, Luigina Graziosi, Giovanni De Palma, Daniele Marrelli, Paolo Morgagni, Giorgio Ercolani
Summary: This study aimed to investigate the benefits of staging laparoscopy for gastric cancer patients. The results showed that tumor type, tumor location, and staging could provide additional diagnostic information for patients undergoing laparoscopic surgery. The study concluded that staging laparoscopy is a useful tool to guide the most appropriate treatment strategy for gastric cancer patients.
Article
Oncology
Leonardo Solaini, Maria Bencivenga, Fausto Rosa, Alessia D'ignazio, Elisabetta Marino, Silvia Ministrini, Silvia Sofia, Michele Sacco, Gianni Mura, Emanuele Rausa, Marco De Prizio, Luigina Graziosi, Maurizio Degiuli, Guido Alberto Massimo Tiberio, Sergio Alfieri, Daniele Marrelli, Paolo Morgagni, Giorgio Ercolani
Summary: The coronavirus pandemic had a significant impact on the diagnosis and treatment of gastric cancer in nine Italian research centers. The number of advanced or metastatic cases increased after the spread of SARS-CoV-2 infection, particularly after the full lockdown periods. During the pandemic, shorter timeframes were required to complete the diagnostic work-up or refer patients to the best treatment option once they were referred to the centers.
Article
Surgery
Gian Luca Baiocchi, Simone Giacopuzzi, Giovanni Vittimberga, Stefano De Pascale, Elisabetta Pastorelli, Roberta Gelmini, Jacopo Vigano, Luigina Graziosi, Alessio Vagliasindi, Fausto Rosa, Francesca Steccanella, Paolo Demartini, Rossella Reddavid, Mattia Berselli, Ugo Elmore, Uberto Fumagalli Romario, Maurizio Degiuli, Paolo Morgagni, Daniele Marrelli, Domenico D'Ugo, Riccardo Rosati, Giovanni De Manzoni
Summary: Gastrectomy for gastric cancer in Western countries still has high rates of morbidity and mortality. In 2015, the EGCA launched a project to establish a list and definitions of post-operative complications specific for gastrectomy. This study investigated 386 cases of post-operative complications in Italy, with non-surgical infections and anastomotic leaks being the most frequent complications.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Fausto Rosa, Marcello Covino, Andrea Russo, Sara Salini, Raffaele Forino, Davide Della Polla, Pietro Fransvea, Giuseppe Quero, Claudio Fiorillo, Antonio La Greca, Gabriele Sganga, Antonio Gasbarrini, Francesco Franceschi, Sergio Alfieri
Summary: In a prospective observational cohort study, the frailty status of patients at the emergency department admission was evaluated for predicting in-hospital death risk stratification for those needing urgent cholecystectomy. Frailty and open surgery were found to be independent predictors of major complications. The evaluation of functional status in the emergency department could predict the risk of major complications and the need for open surgical approach in elderly patients undergoing urgent cholecystectomy.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Giuseppe Quero, Giuseppe Massimiani, Chiara Lucinato, Claudio Fiorillo, Roberta Menghi, Vito Laterza, Carlo A. Schena, Davide De Sio, Fausto Rosa, Valerio Papa, Antonio P. Tortorelli, Vincenzo Tondolo, Sergio Alfieri
Summary: This study evaluates the clinical significance of the novel ISGPS definition of PPAP. The results indicate that PPAP occurrence increases the risk of more severe complications, delayed gastric emptying, and post-operative pancreatic fistula. Soft pancreatic texture and a Wirsung diameter <3 mm are identified as prognostic factors for PPAP onset, while a pancreatic duct <= 3 mm significantly influences a more severe course of PPAP.
Review
Oncology
Shigeki Kusamura, Dario Baratti, Michele De Simone, Enrico Maria Pasqual, Luca Ansaloni, Daniele Marrelli, Manuela Robella, Fabio Accarpio, Mario Valle, Stefano Scaringi, Daniele Biacchi, Carmen Palopoli, Sergio Gazzanelli, Marcello Guaglio, Marcello Deraco
Summary: Diffuse malignant peritoneal mesothelioma (DMPM) is a rare cancer that originates in the peritoneum and has a poor prognosis. Cytoreductive surgery and HIPEC are currently the standard treatments, but selecting suitable patients and managing the perioperative period is challenging.
Editorial Material
Oncology
Valentina Ghirardi, Anna Fagotti, Luca Ansaloni, Mario Valle, Franco Roviello, Lorena Sorrentino, Fabio Accarpio, Gianluca Baiocchi, Lorenzo Piccini, Michele De Simone, Federico Coccolini, Mario Visaloco, Stefano Bacchetti, Giovanni Scambia, Daniele Marrelli
Summary: More than two thirds of ovarian cancer patients are diagnosed at an advanced stage. The standard treatment consists of surgery and chemotherapy. The use of cytoreductive surgery as the primary treatment is debated, and multiple factors need to be considered in the treatment decision-making process.
Article
Oncology
Giuseppe Quero, Claudio Fiorillo, Giuseppe Massimiani, Chiara Lucinato, Roberta Menghi, Fabio Longo, Vito Laterza, Carlo Alberto Schena, Davide De Sio, Fausto Rosa, Valerio Papa, Antonio Pio Tortorelli, Vincenzo Tondolo, Sergio Alfieri
Summary: This study examines the potential impact of post-pancreatectomy acute pancreatitis (PPAP) on long-term outcomes after pancreaticoduodenectomy (PD). The occurrence of PPAP is associated with a worse post-operative clinical course, but there is no significant difference in overall survival between patients with and without PPAP. However, patients with PPAP may have worse disease-free survival compared to those without PPAP, although the difference is not statistically significant.
Editorial Material
Gastroenterology & Hepatology
Fausto Rosa, Marcello Covino, Carlo Alberto Schena, Giuseppe Quero, Francesco Franceschi, Gabriele Sganga, Sergio Alfieri
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Carlo Alberto Schena, Vito Laterza, Davide De Sio, Giuseppe Quero, Claudio Fiorillo, Gayani Gunawardena, Antonia Strippoli, Vincenzo Tondolo, Nicola de'Angelis, Sergio Alfieri, Fausto Rosa
Summary: Staging laparoscopy plays a crucial role in the management of gastric cancer by increasing the rate of promptly diagnosed peritoneal metastases, reducing unnecessary laparotomies, and modifying the initial treatment strategy for gastric cancer.
Review
Oncology
Luigi Marano, Ludovico Carbone, Gianmario Edoardo Poto, Valeria Restaino, Stefania Angela Piccioni, Luigi Verre, Franco Roviello, Daniele Marrelli
Summary: Despite its decreasing incidence, gastric cancer remains an important global healthcare problem. Neoadjuvant chemotherapy has been recommended for gastric cancer in Europe and has potential benefits in downstaging the tumor and improving survival. The collection of at least twenty-five lymph nodes after neoadjuvant therapy can reduce the likelihood of recurrence.
Review
Oncology
Antonio Sommariva, Mario Valle, Roberta Gelmini, Marco Tonello, Fabio Carboni, Giovanni De Manzoni, Lorena Sorrentino, Enrico Maria Pasqual, Stefano Bacchetti, Cinzia Sassaroli, Andrea Di Giorgio, Massimo Framarini, Daniele Marrelli, Francesco Casella, Orietta Federici
Summary: This retrospective study presents the experience of the Italian Peritoneal Surface Malignancies Oncoteam with laparoscopic cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), showing the feasibility and safety of this approach and its favorable outcomes in selected patients.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
