Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Infectious Diseases
Yang-Kun Wang, Jun-Ling Zhou, Nian-Long Meng, Chao-Ya Zhu, Su-Nan Wang, Xiao-Dong Chen
Summary: This study investigates the occurrence and development of gastric mucosal atrophy due to Helicobacter pylori (Hp) infection, focusing on the histomorphological features. The results show that Hp infection disrupts the proliferation of stem cells in the gastric mucosa, leading to abnormal propagation of cells and disrupted differentiation, ultimately resulting in glandular atrophy. The findings provide a reliable pathological basis for precise treatment and controlling the development of gastric cancer.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Article
Multidisciplinary Sciences
Masaaki Kodama, Kazuhiro Mizukami, Yuka Hirashita, Tadayoshi Okimoto, Yasuhiro Wada, Masahide Fukuda, Sotaro Ozaka, Yoko Kudo, Kanako Ito, Ryo Ogawa, Kazuhisa Okamoto, Kensuke Fukuda, Kazunari Murakami
Summary: Although the prognosis of undifferentiated gastric cancer (UGC) diagnosed after Helicobacter pylori eradication (HPE) is poor, the characteristics of post-HPE UGC have not been well evaluated due to its low incidence. Female sex and absent follow-up were significant independent risk factors for post-HPE UGC.
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Biochemistry & Molecular Biology
Ryoko Nagata, Hiroki Sato, Shoji Takenaka, Junji Yokoyama, Shuji Terai, Hitomi Mimuro, Yuichiro Noiri
Summary: This study compared the genetic relatedness between gastric and oral Helicobacter pylori in Japanese patients with early gastric cancer through multilocus sequence typing analysis. The results showed that oral and gastric H. pylori have different genotypes, indicating that they belong to different strains. It is necessary to establish a culture method to investigate whether oral H. pylori acts as the source of gastric infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Qun Zhang, Ying Ni, Xiaofei Zhi, Jiwei Wang, Zheng Li, Jie Tang, Linjun Wang, Weizhi Wang, Zekuan Xu
Summary: In patients with gastric cancer infected with H. pylori, the expression of APRIL was upregulated and promoted the proliferation, migration, invasion, viability, and metastasis of GC cells through miR-145. Furthermore, APRIL induced gastric tumorigenicity by activating the NF-kappa B pathway. These findings lay the groundwork for a more in-depth analysis of APRIL in gastric cancer risk and prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Infection with H. pylori triggers a robust cellular response in the host, potentially leading to gastric cancer. The regulation of cellular processes through ubiquitinylation mechanisms influences various pathologies including cancer, yet the exact impact of H. pylori on this process remains unclear.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Ophthalmology
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki
Summary: This study conducted a Mendelian randomization analysis to assess the causal association between genetically predicted glycemic traits and the risk of primary open-angle glaucoma (POAG). The results did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Hasegawa, Haruyuki Takaki, Hiroshi Kodama, Keitaro Matsuo, Takashi Yamanaka, Atsuhiro Nakatsuka, Motoshi Takao, Hideo Gobara, Sadao Hayashi, Yoshitaka Inaba, Koichiro Yamakado
Summary: The purpose of this study was to explore the impact of ablative margin depicted by CT immediately after RF ablation on reducing LTP for CRC lung metastases. A retrospective study was conducted on 70 patients who underwent RF ablation for CRC lung metastases. The results indicated that an ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Rheumatology
Yu Toyoda, Masahiro Nakatochi, Akiyoshi Nakayama, Yusuke Kawamura, Hirofumi Nakaoka, Kenji Wakai, Keitaro Matsuo, Hirotaka Matsuo
Article
Endocrinology & Metabolism
Takuya Sakashita, Yasuyuki Nakamura, Yoichi Sutoh, Atsushi Shimizu, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Naoyuki Takashima, Aya Kadota, Katsuyuki Miura, Yoshikuni Kita, Hiroaki Ikezaki, Jun Otonari, Keitaro Tanaka, Chisato Shimanoe, Teruhide Koyama, Isao Watanabe, Sadao Suzuki, Hiroko Nakagawa-Senda, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Kiyonori Kuriki, Sakurako Katsuura-Kamano, Takeshi Watanabe, Shiroh Tanoue, Chihaya Koriyama, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Masahiro Nakatochi, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo
Summary: This study investigates the association between HbA1c and blood glucose levels and their corresponding genetic loci in a non-diabetic Japanese population. The study identifies KCNQ1 and TMC6 loci as being associated with HbA1c levels, but no replication is found for the loci associated with blood glucose levels. Furthermore, the variant rs2299620 in KCNQ1 shows heterogeneity in its effect on HbA1c levels based on BMI grouping.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Oncology
Shimon Kurasawa, Takahiro Imaizumi, Shoichi Maruyama, Keitaro Tanaka, Yoko Kubo, Mako Nagayoshi, Hiroaki Ikezaki, Sadao Suzuki, Teruhide Koyama, Chihaya Koriyama, Aya Kadota, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Kenji Wakai, Keitaro Matsuo
Summary: The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. This study aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in a Japanese cohort. The findings suggest a U-shaped relationship between eGFR and cancer incidence, with both moderate low and high eGFRs associated with higher cancer incidence. Only high eGFR was associated with cancer mortality, and kidney dysfunction enhanced the cancer risk from smoking.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Daisaku Nishimoto, Keiichi Shimatani, Toshiro Takezaki, Hiroaki Ikezaki, Masayuki Murata, Megumi Hara, Yuichiro Nishida, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Takahiro Otani, Sadao Suzuki, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai
Summary: The study evaluated the population-based impact of smoking, drinking, and genetic factors on low HDL-C levels using data from the J-MICC Study. The findings showed that smoking, drinking, and certain genetic variants were associated with HDL-C levels, but there was no significant gene-environment interaction. The population-based impact of the genetic factor CETP rs3764261 was higher than that of smoking and lower than that of drinking.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Kenji Takeuchi, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Yuriko N. Koyanagi, Keitaro Matsuo, Haruo Mikami, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
Summary: In Japanese adults, stress-coping strategies are related to all-cause mortality. Three coping strategies (emotional expression, emotional support-seeking, and disengagement) were associated with lower mortality in women. Emotional expression, problem-solving, and positive reappraisal were associated with lower mortality in men, but the relationship depended on the follow-up period. There was evidence of sex differences in the relationship between emotional support-seeking and all-cause mortality.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Yoshiaki Usui, Hidemi Ito, Kota Katanoda, Tomohiro Matsuda, Yoshinobu Maeda, Keitaro Matsuo
Summary: The introduction of rituximab has led to a decline in mortality rates of non-Hodgkin lymphoma in both Japan and the United States, despite an increase in incidence. However, the trends in mortality rates have differed between the two countries, with the mortality rate declining continuously in the United States but stopping in Japan.
Article
Oncology
Yukihiro Sugimoto, Yuriko N. Koyanagi, Yukino Kawakatsu, Isao Oze, Yukari Taniyama, Yumiko Kasugai, Tsutomu Tanaka, Tetsuya Abe, Masahiro Tajika, Yasuhiro Shimizu, Hidemi Ito, Kenji Wakai, Keitaro Matsuo
Summary: Alcohol is metabolized to acetaldehyde and acetate through the actions of alcohol dehydrogenase and aldehyde dehydrogenase. The ADH1B rs1229984 polymorphism is associated with drinking habits and the risk of esophageal cancer. Mediation analysis showed that this genetic variant increases the risk of esophageal cancer by affecting alcohol metabolism and drinking intensity.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Daisaku Nishimoto, Rie Ibusuki, Ippei Shimoshikiryo, Kenichi Shibuya, Shiroh Tanoue, Chihaya Koriyama, Toshiro Takezaki, Isao Oze, Hidemi Ito, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Yudai Tamada, Yuichiro Nishida, Chisato Shimanoe, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Satomi Tomida, Kiyonori Kuriki, Naoko Miyagawa, Keiko Kondo, Kokichi Arisawa, Takeshi Watanabe, Hiroaki Ikezaki, Jun Otonari, Kenji Wakai, Keitaro Matsuo
Summary: This Japanese cohort study examined the association between awareness of limiting food intake and all-cause mortality risk. The results showed that women with awareness of limiting fat intake had a significantly lower mortality risk, while awareness of limiting energy or sweets intake was not related to mortality risk reduction.
JOURNAL OF EPIDEMIOLOGY
(2023)
