Review
Oncology
Qixin Liu, Ziheng Peng, Liangfang Shen, Lin Shen
Summary: Ki-67 overexpression is associated with poor overall survival rates in melanoma patients, but not correlated with PFS and RFS rates. Ki-67 expression levels are associated with tumor thickness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Ana R. Flores, Alexandra Rema, Joao R. Mesquita, Marian Taulescu, Fernanda Seixas, Fatima Gartner, Irina Amorim
Summary: This study evaluated the expression of vimentin and Ki-67 proliferative index in canine gastric carcinomas and found that they have potential for providing prognostic information in these cases.
VETERINARY PATHOLOGY
(2022)
Article
Medicine, General & Internal
Yu Meng, Quan Quan, Fenfen Zhang, Yao Liu, Siling Ren, Xiaoling Mu
Summary: This study investigated the prognostic value of the Ki-67 index in endometrial stromal sarcoma and identified a cut-off value of 35% for predicting recurrence. High Ki-67 index and ovarian preservation were significantly associated with shorter progress free survival. The Ki-67 index could serve as a useful prognostic marker in endometrial stromal sarcoma.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Jianwei Xie, YaJun Zhao, Yanbing Zhou, Qingliang He, Hankun Hao, Xiantu Qiu, Gang Zhao, Yanchang Xu, Fangqin Xue, Jinping Chen, Guoqiang Su, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: The study focused on the long-term outcomes of patients with grade 3 gastric neuroendocrine carcinoma (GNEC) who underwent curative surgery, finding that combining carcinoembryonic antigen (CEA) levels and Ki-67 index can predict patient prognosis. A nomogram was constructed to predict patient survival, showing that the combination of Ki-67 status and AJCC 8th stage performed better in predicting prognosis than the AJCC 8th stage alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xueyan Jiang, Haodong Jia, Zhongyuan Zhang, Chao Wei, Chuanbin Wang, Jiangning Dong
Summary: This study evaluates the feasibility of using apparent diffusion coefficient (ADC) values combined with texture analysis (TA) to predict the expression levels of Ki-67 and p53 in endometrial carcinoma (EC) patients before surgery. The results show that ADC values combined with TA provide accurate predictions of Ki-67 and p53 expression levels, and have high auxiliary diagnostic value for clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Diming Wang, Wei Ye, Qingming Shi
Summary: The study revealed a correlation between the Ki-67 expression level and tumor staging, chemotherapy response, and survival prognosis in patients with advanced lung squamous cell carcinoma. High Ki-67 expression was associated with shorter overall survival and progression-free survival, serving as an independent prognostic biomarker.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Medicine, General & Internal
Mu-Yao Tsai, Ping-Chia Chiang, Chien-Hsu Chen, Ming-Tse Sung, Shun-Chen Huang, Jau-Ling Suen, Eing-Mei Tsai, Po-Hui Chiang
Summary: PD-L1 and Ki-67 expression rates in UTUC patients were 16.7% and 48.0%, respectively, significantly associated with pathological T stage and tumor necrosis. Positive PD-L1 expression with CPS >= 10 was a stronger independent prognostic factor for worse cancer-specific survival in UTUC patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Wei Han, Yi-Zhu Wu, Xiao-Yu Zhao, Zhen-Hua Gong, Guo-Liang Shen
Summary: Elevated expressions of MCM2-6 and MCM10 were significantly associated with melanoma and worse prognosis; GSEA revealed involvement of hallmark pathways like mTORC1 signaling, G2M checkpoint, E2F targets, and mitotic spindle; Potential correlations were found between MCM expression and immune cell infiltration in melanoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Laura S. Mertens, Francesco Claps, Roman Mayr, Peter J. Bostrom, Shahrokh F. Shariat, Ellen C. Zwarthoff, Joost L. Boormans, Cheno Abas, Geert J. L. H. van Leenders, Stefanie Goetz, Katrin Hippe, Simone Bertz, Yann Neuzillet, Joyce Sanders, Annegien Broeks, Dennis Peters, Michiel S. van der Heijden, Michael A. S. Jewett, Robert Stoehr, Alexandre R. Zlotta, Markus Eckstein, Yanish Soorojebally, Deric K. E. van der Schoot, Bernd Wullich, Maximilian Burger, Wolfgang Otto, Francois Radvanyi, Nanour Sirab, Damien Pouessel, Theo H. van der Kwast, Arndt Hartmann, Yair Lotan, Yves Allory, Tahlita C. M. Zuiverloon, Bas W. G. van Rhijn
Summary: This study analyzed the expression of FGFR3 gene mutation, p53, and Ki-67 in patients with invasive bladder cancer and evaluated their prognostic value. The results showed that FGFR3 gene mutation was associated with lower tumor stage, lower tumor grade, no lymph node metastasis, and longer disease-specific survival. In contrast, abnormal expression of p53 and Ki-67 was only associated with higher tumor stage and G3 grade tumors. Multivariable analysis showed that besides tumor stage, lympho-vascular invasion, and lymph node stage, FGFR3 gene mutation status was a significant predictor of patient prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Pathology
Ji-Seon Jeong, Kyung-Ja Cho, Hee Jin Lee, Jin Roh, Yoon Se Lee, Joon Seon Song
Summary: This study used immunohistochemistry to evaluate the expression of p53 and Ki-67 in oral and laryngeal epithelial lesions, and developed a scoring system and predictive model to differentiate different types of epithelial lesions.
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Article
Oncology
Chung-Man Moon, Yun Young Lee, Doo-Young Kim, Woong Yoon, Byung Hyun Baek, Jae-Hyun Park, Suk-Hee Heo, Sang-Soo Shin, Seul Kee Kim
Summary: This study aimed to predict the expression of Ki-67 proliferative index and p53 tumor suppressor protein in meningioma patients using preoperative multiparametric magnetic resonance imaging (mpMRI)-based clinical-radiomic analysis combined with machine learning (ML) algorithms. The results showed that larger tumor volumes, irregular tumor margin, and unclear tumor-brain interface were independently associated with high Ki-67 expression, while the presence of necrosis and the dural tail sign were independently associated with positive p53 expression. A model combining clinical and radiological features yielded better performance, providing a novel non-invasive strategy for assessing cell proliferation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Richard A. Carr, Domenico Mesiano, Cynthia Heffron, Teodora Radonic, James Wiggins, Simon Tso, Rishi Agrawal, Elaine Cheung, David N. Slater, Linda Nichols, Paul Craig
Summary: Clinical features and staining patterns of p16, p53, Ki-67, and EVG can be used to distinguish between keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC).
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-meng Zhao, Shuang-shuang Xie, Jian Wang, Ya-min Zhang, Wen-Cui Li, Zhao-Xiang Ye, Wen Shen
Summary: This study aimed to develop a CT model to predict Ki-67 expression in HCC and evaluate the added value of radiomics. The CR model combining clinical and CE-CT features showed good performance in predicting Ki-67 expression. However, radiomics did not provide additional value.
BMC MEDICAL IMAGING
(2023)
Article
Gastroenterology & Hepatology
Li-Ting Mao, Wei-Cui Chen, Jian-Ye Lu, Han-Liang Zhang, Yong-Song Ye, Yu Zhang, Bo Liu, Wei-Wei Deng, Xian Liu
Summary: The study found that the quantitative parameters based on DLSDCT can distinguish the expression status of Ki-67 in gastric cancer. These spectral parameters may have potential clinical applications in evaluating Ki-67 expression.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)