The case for immunomodulatory approaches in treating HSV encephalitis

TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain

(2014) L. N. Sorensen et al.   JOURNAL OF IMMUNOLOGY

Prolonged Microglial Cell Activation and Lymphocyte Infiltration following Experimental Herpes Encephalitis

(2014) C. P. Marques et al.   JOURNAL OF IMMUNOLOGY

Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus

(2012) Regina Gonzalez-Dosal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

Controlling systems of nucleic acid sensing-TLRs restrict homeostatic inflammation

(2012) Ryutaro Fukui et al.   EXPERIMENTAL CELL RESEARCH

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

(2012) Christian K Holm et al.   NATURE IMMUNOLOGY

Modulation of Experimental Herpes Encephalitis-Associated Neurotoxicity through Sulforaphane Treatment

(2012) Scott J. Schachtele et al.   PLoS One

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors affecting herpes simplex virus reactivation from the explanted mouse brain

(2012) Hui-Wen Yao et al.   VIROLOGY

Long-Term Therapy with Intravenous Immunoglobulin is Beneficial in Patients with Autoimmune Diseases

(2011) Gisele Zandman-Goddard et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Systemic responses during local viral infections: type I IFNs sound the alarm

(2011) Carolina B López et al.   CURRENT OPINION IN IMMUNOLOGY

Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells

(2011) Julie R. Boiko et al.   CYTOKINE

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive oxygen species drive herpes simplex virus (HSV)-1-induced proinflammatory cytokine production by murine microglia

(2011) Shuxian Hu et al.   Journal of Neuroinflammation

Role of Specific Innate Immune Responses in Herpes Simplex Virus Infection of the Central Nervous System

(2011) J. P. Wang et al.   JOURNAL OF VIROLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Oral Acyclovir Suppression and Neurodevelopment after Neonatal Herpes

(2011) David W. Kimberlin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensing herpes: more than toll

(2011) Jesper Melchjorsen   REVIEWS IN MEDICAL VIROLOGY

Innate immune sensing of DNA viruses

(2011) Vijay A.K. Rathinam et al.   VIROLOGY

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

(2011) Sang-Uk Seo et al.   PLoS Pathogens

Passively Administered Pooled Human Immunoglobulins Exert IL-10 Dependent Anti-Inflammatory Effects that Protect against Fatal HSV Encephalitis

(2011) Chandran Ramakrishna et al.   PLoS Pathogens

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6

(2011) Regina Gonzalez-Dosal et al.   PLoS Pathogens

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Toll-Like Receptor (TLR) 2 and TLR9 Expressed in Trigeminal Ganglia are Critical to Viral Control During Herpes Simplex Virus 1 Infection

(2010) Graciela Kunrath Lima et al.   AMERICAN JOURNAL OF PATHOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Antiviral Instruction of Bone Marrow Leukocytes during Respiratory Viral Infections

(2010) Tamar Hermesh et al.   Cell Host & Microbe

Antibody-mediated modulation of immune responses

(2010) Falk Nimmerjahn et al.   IMMUNOLOGICAL REVIEWS

Chronic Active Herpes Simplex Type 2 Encephalitis in an Asymptomatic Immunocompetent Child

(2010) William D. Brown et al.   JOURNAL OF CHILD NEUROLOGY

Plasma exchange and intravenous immunoglobulins: Mechanism of action in immune-mediated neuropathies

(2010) Helmar C. Lehmann et al.   JOURNAL OF NEUROIMMUNOLOGY

Herpes simplex virus induces neural oxidative damage via microglial cell Toll-like receptor-2

(2010) Scott J Schachtele et al.   Journal of Neuroinflammation

Subacute herpes simplex encephalitis presenting as relapsing encephalitis

(2010) Nils Peters et al.   JOURNAL OF NEUROLOGY

Brainstem encephalitis: an unusual presentation of herpes simplex virus infection

(2010) Daniel Livorsi et al.   JOURNAL OF NEUROLOGY

Concomitant Use of Acyclovir and Intravenous Immunoglobulin Rescues an Immunocompromised Child With Disseminated Varicella Caused Multiple Organ Failure

(2010) Ying-Chun Lu et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Intravenous immunoglobulin therapy prevents development of autoimmune encephalomyelitis and suppresses activation of matrix metalloproteinases

(2010) Naoko Niimi et al.   NEUROPATHOLOGY

Chronic Cortical and Subcortical Pathology with Associated Neurological Deficits Ensuing Experimental Herpes Encephalitis

(2009) Anibal G. Armien et al.   BRAIN PATHOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Intravenous immunoglobulins - understanding properties and mechanisms

(2009) A. Durandy et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Prognostic value of cerebrospinal fluid cytokine changes in herpes simplex virus encephalitis

(2009) Satoshi Kamei et al.   CYTOKINE

Intravenous immunoglobulin-based immunotherapy: an arsenal of possibilities for patients and science

(2009) Beatrix Kotlan et al.   Immunotherapy

Mechanisms Employed by Herpes Simplex Virus 1 to Inhibit the Interferon Response

(2009) Patrick Paladino et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?

(2009) Christopher D. Conrady et al.   JOURNAL OF NEUROIMMUNOLOGY

Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitis

(2009) Anders Hjalmarsson et al.   JOURNAL OF NEUROLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Innate and Adaptive Immune Responses to Herpes Simplex Virus

(2009) Tracy Chew et al.   Viruses-Basel

Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]

(2008) Francisco Martinez-Torres et al.   BMC Neurology

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

(2008) Tobias Haas et al.   IMMUNITY

Ly6c+“inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis

(2008) Daniel R. Getts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice Is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis

(2008) P. Lundberg et al.   JOURNAL OF VIROLOGY

Modulation of the cellular immune system by intravenous immunoglobulin

(2008) Thanyalak Tha-In et al.   TRENDS IN IMMUNOLOGY