Current work and future possibilities for the management of severe influenza: using immunomodulatory agents that target the host response

Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza

(2014) L. M. Alleva et al.   JOURNAL OF IMMUNOLOGY

Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK

(2014) K. P. Y. Hui et al.   JOURNAL OF IMMUNOLOGY

Peroxisome Proliferator–Activated Receptors γ Coactivator–1α

(2010) Elliott D. Crouser   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High mobility group box-1 recognition: The beginning of a RAGEless era?

(2010) Filipe Branco-Madeira et al.   EMBO Molecular Medicine

Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design

(2010) Takeshi Ichinohe   Expert Review of Vaccines

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

(2010) B Huang et al.   GENE THERAPY

Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones

(2010) Felix M. Wensveen et al.   IMMUNITY

Original Article: Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice

(2010) Carson E. Moseley et al.   Influenza and Other Respiratory Viruses

Tangeretin Reduces Ultraviolet B (UVB)-Induced Cyclooxygenase-2 Expression in Mouse Epidermal Cells by Blocking Mitogen-Activated Protein Kinase (MAPK) Activation and Reactive Oxygen Species (ROS) Generation

(2010) Ji Hye Yoon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages

(2010) Vera Francisco et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Role for IL-15 in the Migration of Effector CD8 T Cells to the Lung Airways following Influenza Infection

(2010) K. C. Verbist et al.   JOURNAL OF IMMUNOLOGY

H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response

(2010) D. Viemann et al.   JOURNAL OF IMMUNOLOGY

Effectiveness of Antiviral Treatment in Human Influenza A(H5N1) Infections: Analysis of a Global Patient Registry

(2010) Wiku Adisasmito et al.   JOURNAL OF INFECTIOUS DISEASES

18β-Glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice

(2010) H. Sasaki et al.   JOURNAL OF PERIODONTAL RESEARCH

Peroxisome Proliferator-Activated Receptor   Agonism Prevents Renal Damage and the Oxidative Stress and Inflammatory Processes Affecting the Brains of Stroke-Prone Rats

(2010) P. Gelosa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

(2010) C. Cilloniz et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism

(2010) D. Marchant et al.   JOURNAL OF VIROLOGY

Structured regulation of inflammation during respiratory viral infection

(2010) Tracy Hussell et al.   LANCET INFECTIOUS DISEASES

Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages

(2010) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression

(2010) Lina Wang et al.   NEUROSCIENCE LETTERS

Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients

(2010) Vidya A. Arankalle et al.   PLoS One

PPAR-γ Activation As an Anti-inflammatory Therapy for Respiratory Virus Infections

(2010) Josep Bassaganya-Riera et al.   VIRAL IMMUNOLOGY

Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus

(2009) Gülsah Gabriel et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10cells - the involvement of rapidly activated kinases and caspases

(2009) Yow-Jiun Jeng et al.   BMC CANCER

Using Complementary and Alternative Medicines to Target the Host Response during Severe Influenza

(2009) Lisa M. Alleva et al.   Evidence-based Complementary and Alternative Medicine

Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: why they are needed and how they might work

(2009) David S. Fedson   Influenza and Other Respiratory Viruses

Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication

(2009) E. Kamau et al.   JOURNAL OF GENERAL VIROLOGY

HMGB1 Enhances the Proinflammatory Activity of Lipopolysaccharide by Promoting the Phosphorylation of MAPK p38 through Receptor for Advanced Glycation End Products

(2009) Y.-H. Qin et al.   JOURNAL OF IMMUNOLOGY

Eosinophils Oxidize Damage-Associated Molecular Pattern Molecules Derived from Stressed Cells

(2009) R. Lotfi et al.   JOURNAL OF IMMUNOLOGY

Rosiglitazone Modulates the Innate Immune Response toPlasmodium falciparumInfection and Improves Outcome in Experimental Cerebral Malaria

(2009) Lena Serghides et al.   JOURNAL OF INFECTIOUS DISEASES

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Glycyrrhizin Prevents 7-Ketocholesterol Toxicity Against Differentiated PC12 Cells by Suppressing Mitochondrial Membrane Permeability Change

(2009) Doo Eung Kim et al.   NEUROCHEMICAL RESEARCH

Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor γ-dependent mechanism

(2009) Tamami Haraguchi et al.   NEUROSCIENCE LETTERS

Anti-inflammatory mechanisms of resveratrol in activated HMC-1 cells: Pivotal roles of NF-κB and MAPK

(2009) Ok-Hwa Kang et al.   PHARMACOLOGICAL RESEARCH

Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages

(2009) Suki M. Y. Lee et al.   PLoS One

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

(2009) J. R. Aldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR-α) IN THE REGULATION OF INFLAMMATION IN MACROPHAGES

(2009) Concetta Crisafulli et al.   SHOCK

Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia

(2009) Marieke A.D van Zoelen et al.   VIROLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes

(2009) Cristian Cillóniz et al.   PLoS Pathogens

Anti-Inflammatory and Proresolving Lipid Mediators

(2008) Charles N. Serhan et al.   Annual Review of Pathology-Mechanisms of Disease

Toll-like receptor-mediated activation of neutrophils by influenza A virus

(2008) J. P. Wang et al.   BLOOD

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor γ and nuclear factor-κB in macrophages

(2008) Brian M. Necela et al.   IMMUNOLOGY

Hyperinduction of Cyclooxygenase‐2–Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection

(2008) Suki M. Y. Lee et al.   JOURNAL OF INFECTIOUS DISEASES

Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor–κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors

(2008) Hironori Takei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Confronting an influenza pandemic with inexpensive generic agents: can it be done?

(2008) David S Fedson   LANCET INFECTIOUS DISEASES

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens

Antiviral effects ofGlycyrrhiza species

(2007) Cristina Fiore et al.   PHYTOTHERAPY RESEARCH