Article
Gastroenterology & Hepatology
Sumeet K. Asrani, Marwan S. Ghabril, Alexander Kuo, Raphael B. Merriman, Timothy Morgan, Neehar D. Parikh, Nadia Ovchinsky, Fasiha Kanwal, Michael L. Volk, Chanda Ho, Marina Serper, Shivang Mehta, Vatche Agopian, Roniel Cabrera, Victoria Chernyak, Hashem B. El-Serag, Julie Heimbach, George N. Ioannou, David Kaplan, Jorge Marrero, Neil Mehta, Amit Singal, Riad Salem, Tamar Taddei, Anne M. Walling, Elliot B. Tapper
Summary: The American Association for the Study of Liver Diseases (AASLD) Practice Metrics Committee developed a standardized set of process-based measures and patient-reported outcomes (PROs) for hepatocellular carcinoma (HCC) care to bridge the gap between guideline recommendations and measurable processes and outcomes for this high-risk population.
Article
Gastroenterology & Hepatology
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the fourth most common cancer among men in South Korea. The revised Korean guidelines integrate the most up-to-date research findings and expert opinions, providing useful advice and guidance for the clinical management of HCC.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joong-Won Park
Summary: This article introduces the incidence of hepatocellular carcinoma (HCC) worldwide and in South Korea, where the prevalence of chronic hepatitis B infection is high. The authors also discuss the latest clinical management guidelines and emphasize their role in guiding diagnosis and treatment.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi-Ran Li, Xiao-Yan Meng, Rui-Qing Zong, Fei-Xiang Wu
Summary: The study explored the value of serum procalcitonin levels in predicting post-hepatectomy liver failure, revealing a significant association between elevated procalcitonin level and higher PHLF rate, lower 30-day survival, and poor short-term postoperative outcomes. Other significant risk factors for PHLF included portal hypertension, portal blocking time, and blood transfusion. Elevated procalcitonin level was also highly associated with postoperative sepsis, ICU admission, 30-day mortality, and 3-month mortality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Ashish Manne, Madhuri Mulekar, Daisy Escobar, Pranitha Prodduturvar, Yazan Fahmawi, Phillip Henderson, Osama Abdul-Rahim, Zeiad Hussain, Spencer Liles, Annabelle Fonseca, John Harrison Howard, Wadad Mneimneh, Robert Gilbert, Omar Alkharabsheh, Sachin Pai, Zachary B. White, Cindy Nelson, Moh'd Khushman
Summary: This study investigated the adherence rate to AASLD 2018 guidelines in HCC patients and its impact on patient survival. The overall adherence rate was found to be 83%, and nonadherence to AASLD 2018 guidelines was associated with better survival in patients with BCLC Stage D.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Orthopedics
Jacqueline A. Osborne, Rachel Botkin, Cristina Colon-Semenza, Tamara R. DeAngelis, Oscar G. Gallardo, Heidi Kosakowski, Justin Martello, Sujata Pradhan, Miriam Rafferty, Janet L. Readinger, Abigail L. Whitt, Terry D. Ellis
Summary: A clinical practice guideline on Parkinson disease was developed by an American Physical Therapy Association volunteer guideline development group. The guideline was based on systematic reviews of current scientific and clinical information.
Article
Orthopedics
Lori A. Michener, Jill Heitzman, Laurel D. Abbruzzese, Salvador L. Bondoc, Kristin Bowne, Phillip Troy Henning, Heidi Kosakowski, Brian G. Leggin, Ann M. Lucado, Amee L. Seitz
Summary: A clinical practice guideline on glenohumeral joint osteoarthritis was developed by a volunteer guideline development group consisting of physical therapists, an occupational therapist, and a physician from the American Physical Therapy Association (APTA). The guideline is based on systematic reviews and accepted approaches for physical therapist management of this condition. It is also available in Spanish.
Article
Gastroenterology & Hepatology
Claudia Maccali, Aline L. Chagas, Ilka Boin, Emilio Quinonez, Sebastian Marciano, Mario Vilatoba, Adriana Varon, Margarita Anders, Sergio Hoyos Duque, Agnaldo S. Lima, Josemaria Menendez, Martin Padilla-Machaca, Jaime Poniachik, Rodrigo Zapata, Martin Maraschio, Ricardo Chong Menendez, Linda Munoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martin Fauda, Simone R. Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrian Gadano, Jose H. Parente Garcia, Claudia Megumi Tani, Luiz Augusto Carneiro D'Albuquerque, Flair J. Carrilho, Marcelo Silva, Federico Pinero
Summary: This study evaluated the post-recurrence survival (PRS) of HCC patients after liver transplantation, finding that early recurrence, sorafenib therapy, and surgery/TACE treatment were associated with improved survival rates. Any treatment, sorafenib therapy, and surgery/TACE treatment all significantly improved PRS.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Francesca Garuti, Andrea Neri, Francesca Avanzato, Annagiulia Gramenzi, Davide Rampoldi, Paola Rucci, Fabio Farinati, Edoardo G. Giannini, Fabio Piscaglia, Gian Ludovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Giuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco G. Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Maurizia R. Brunetto, Franco Trevisani
Summary: In Italy, over the last 15 years, there has been a gradual increase in age of HCC patients, a rise in non-viral cases, and improvements in clinical management. Different treatment methods have shown positive outcomes, leading to an overall increase in survival rates.
LIVER INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Marina Serper, Neehar D. Parikh, Grace Thiele, Nadia Ovchinsky, Shivang Mehta, Alexander Kuo, Chanda Ho, Fasiha Kanwal, Michael Volk, Sumeet K. Asrani, Marwan S. Ghabril, John R. Lake, Raphael B. Merriman, Timothy R. Morgan, Elliot B. Tapper
Summary: HCC is a major cause of mortality in patients with advanced liver disease and is associated with significant morbidity. The evaluation of patient-reported outcomes (PROs) in HCC is lacking in systematic assessment. A review of studies found that poor PROs were associated with worse prognosis in HCC patients, although some patients had better PROs compared to those with cirrhosis. Treatment methods were found to have an impact on symptom burden, but further research is needed for more specific effects.
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Review
Oncology
Eirini I. Rigopoulou, George N. Dalekos
Summary: AILDs patients have a lower risk of developing HCC compared to other liver diseases, but still face an increased risk, influenced mainly by factors such as cirrhosis, age, gender, alcohol consumption, and treatment response. Personalized HCC risk prediction offers a significant advantage for patients at high and/or medium risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Sang Hyun Choi, Jae Ho Byun, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin
Summary: The purpose of this study was to evaluate and compare the diagnostic performance of Liver Imaging Reporting and Data System (LI-RADS) v2018 for hepatocellular carcinoma (HCC) <= 3.0 cm on gadoxetic acid-enhanced MRI according to the etiology of cirrhosis. The sensitivity of LI-RADS for diagnosing HCC <= 3.0 cm was significantly lower in the alcoholic liver cirrhosis (ALC) group than in the hepatitis B virus-related cirrhosis (HBV) group.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ruifang Wang, Xiaobo Hu, Xiaorui Liu, Lu Bai, Junsheng Gu, Qinggang Li
Summary: Liver hepatocellular carcinoma (LIHC) is a major cause of cancer-related death worldwide. This study analyzed LIHC samples from TCGA, identified differentially expressed genes related to cell division and DNA replication, constructed a lncRNAs-miRNAs-mRNAs network, and identified biomarkers significantly associated with LIHC prognosis.
Article
Gastroenterology & Hepatology
Jae Hyon Park, Young Nyun Park, Myeong-Jin Kim, Mi-Suk Park, Jin-Young Choi, Yong Eun Chung, Hyungjin Rhee
Summary: This retrospective study analyzed patients who underwent resection for hepatocellular carcinoma (HCC) between January 2014 and December 2019. The results showed a strong association between fatty liver disease and metabolic syndrome with steatotic and steatohepatitic HCCs.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Alessandro Vitale, Gianluca Svegliati-Baroni, Alessio Ortolani, Monica Cucco, Giulio Dalla Riva, Edoardo G. Giannini, Fabio Piscaglia, Gianludovico Rapaccini, Mariella Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Giuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Antonio Gasbarrini, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Filippo Oliveri, Filippo Pelizzaro, Rafael Ramirez Morales, Umberto Cillo, Franco Trevisani, Luca Miele, Giulio Marchesini, Fabio Farinati
Summary: This study compared patients with MAFLD and non-MAFLD who had hepatocellular carcinoma (HCC) in Italy. It found that the proportion of MAFLD in HCC patients was increasing over time and is expected to surpass non-MAFLD in the future. Despite a later cancer stage at diagnosis, MAFLD HCC patients had a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Article
Virology
Luigia Trabace, Lorenzo Pace, Maria Grazia Morgese, Isabel Bianca Santo, Domenico Galante, Stefania Schiavone, Dora Cipolletta, Anna Maria Rosa, Pierluigi Reveglia, Antonio Parisi, Paolo Tucci, Giovanni Pepe, Rodolfo Sacco, Maria Pia Foschino Barbaro, Gaetano Corso, Antonio Fasanella
Summary: The Delta variant has raised concerns about its ability to evade SARS-CoV-2 vaccines. This study evaluated the neutralizing response of 172 Italian healthcare workers three months after receiving the Comirnaty vaccine. The results showed that the vaccine provides sustained neutralizing antibody activity against the Alpha variant, but it is less effective against the Gamma and even less against the Delta variants.
Article
Gastroenterology & Hepatology
Angelo Zullo, Bastianello Germana, Ermenegildo Galliani, Andrea Iori, Giovanni de Pretis, Guido Manfredi, Elisabetta Buscarini, Mario Ciuffi, Orazio Ignomirelli, Fabio Farinati, Edoardo Savarino, Paolo Pallini, Luisa Milan, Rita Conigliaro, Giuseppe Grande, Renato Cannizzaro, Stefania Maiero, Antonio Pisani, Stefania Marangi, Raffaele Manta, Olivia Morelli, Sergio Peralta, Alessia La Mantia, Matteo Rossano Buonocore, Kareem Khalal, Cesare Hassan, Fabio Monica
Summary: This study evaluated the accuracy of EndoFaster(R) device in ruling out gastric mucosal atrophy and found that it had a high negative predictive value in excluding atrophic gastritis, reducing the need for gastric biopsies.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Clinical Neurology
Federica Garri, Francesco Paolo Russo, Tommaso Carrer, Luca Weis, Francesca Pistonesi, Michele Mainardi, Michele Sandre, Edoardo Savarino, Fabio Farinati, Francesca Del Sorbo, Paola Soliveri, Daniela Calandrella, Roberta Biundo, Miryam Carecchio, Anna Lena Zecchinelli, Gianni Pezzoli, Angelo Antonini
Summary: This study retrospectively analyzed the usage of LCIG in 79 patients with Parkinson's disease and found that it has a relatively satisfactory long-term safety profile and efficacy, with a low rate of discontinuation. Peristomal complications may be a predictor of longer duration of therapy.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Maria Guarino, Valentina Cossiga, Mario Capasso, Chiara Mazzarelli, Filippo Pelizzaro, Rodolfo Sacco, Francesco Paolo Russo, Alessandro Vitale, Franco Trevisani, Giuseppe Cabibbo
Summary: The COVID-19 outbreak has significantly impacted healthcare systems worldwide, particularly for patients with hepatocellular carcinoma (HCC). Reshaping clinical practice is necessary to ensure patient care and safety. Due to the pandemic measures, HCC surveillance has decreased and care for HCC patients has been rearranged.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Daryl Ramai, Smit S. Deliwala, Saurabh Chandan, Janice Lester, Jameel Singh, Jayanta Samanta, Sara di Nunzio, Fabio Perversi, Francesca Cappellini, Aashni Shah, Michele Ghidini, Rodolfo Sacco, Antonio Facciorusso, Luca Giacomelli
Summary: Porphyria is a metabolic condition that can lead to liver cancer. Our study found that patients with porphyria are at an increased risk of developing primary liver malignancy. Therefore, routine surveillance should be conducted to detect liver cancer early in these patients.
Article
Gastroenterology & Hepatology
Angelo Zullo, Bastianello Germana, Ermenegildo Galliani, Andrea Iori, Giovanni de Pretis, Guido Manfredi, Elisabetta Buscarini, Mario Ciuffi, Orazio Ignomirelli, Fabio Farinati, Edoardo Savarino, Paolo Pallini, Luisa Milan, Rita Conigliaro, Giuseppe Grande, Renato Cannizzaro, Stefania Maiero, Antonio Pisani, Stefania Marangi, Raffaele Manta, Olivia Morelli, Sergio Peralta, La Mantia Alessia, Matteo Rossano Buonocore, Fabio Monica
Summary: This study aimed to assess the accuracy of different versions of the EndoFaster device operating with different amounts of gastric juice. The results showed that the device version operating with 3 ml of gastric juice had a high accuracy in excluding H. pylori infection, and was not affected by medication or previous treatment.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Surgery
Simone Famularo, Matteo Donadon, Federica Cipriani, Federico Fazio, Francesco Ardito, Maurizio Iaria, Pasquale Perri, Simone Conci, Tommaso Dominioni, Quirino Lai, Giuliano La Barba, Stefan Patauner, Sarah Molfino, Paola Germani, Giuseppe Zimmitti, Enrico Pinotti, Matteo Zanello, Luca Fumagalli, Cecilia Ferrari, Maurizio Romano, Antonella Delvecchio, Maria Grazia Valsecchi, Adelmo Antonucci, Fabio Piscaglia, Fabio Farinati, Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Riccardo Memeo, Giacomo Zanus, Guido Griseri, Marco Chiarelli, Elio Jovine, Mauro Zago, Moh'd Abu Hilal, Paola Tarchi, Gian Luca Baiocchi, Antonio Frena, Giorgio Ercolani, Massimo Rossi, Marcello Maestri, Andrea Ruzzenente, Gian Luca Grazi, Raffaele Dalla Valle, Fabrizio Romano, Felice Giuliante, Alessandro Ferrero, Luca Aldrighetti, Davide P. Bernasconi, Guido Torzilli
Summary: This study aimed to create a machine learning predictive model to allocate patients with recurrent hepatocellular carcinoma (HCC) to their best potential treatment based on their specific characteristics. An individualized algorithm for treatment allocation was developed using factors such as age, cirrhosis, number and size of recurrent nodules, extrahepatic spread, and time to recurrence. The algorithm provides recommendations for the best potential treatment according to patients' profiles.
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study revealed the presence of neuronal dysfunction and reactive gliosis in the duodenum of patients with Parkinson's disease, suggesting that the enteric nervous system is involved in the pathophysiology of the disease.
MOVEMENT DISORDERS
(2023)
Article
Oncology
Luca Ielasi, Francesco Tovoli, Matteo Tonnini, Bernardo Stefanini, Raffaella Tortora, Giulia Magini, Rodolfo Sacco, Tiziana Pressiani, Franco Trevisani, Ingrid Garajova, Fabio Piscaglia, Alessandro Granito
Summary: This study aimed to evaluate the prognostic role of different sites of metastases in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. The results showed that lymph nodes and lung metastases were associated with worse survival rates and treatment response, while bone and adrenal gland metastases did not significantly impact prognosis. Therefore, targeted treatment strategies should be considered for different metastatic sites.
Review
Biochemistry & Molecular Biology
Filippo Pelizzaro, Fabio Farinati, Franco Trevisani
Summary: In recent years, immune checkpoint inhibitors (ICIs) have significantly improved the treatment of hepatocellular carcinoma (HCC). The combination of atezolizumab and bevacizumab has become the standard frontline treatment for advanced stage HCC. However, not all patients benefit from immunotherapy, and identifying predictive biomarkers for response or resistance is crucial for optimal treatment selection. This review aims to summarize available data on tumor and clinical features associated with response or resistance to immunotherapies in HCC.
Article
Endocrinology & Metabolism
S. Censi, S. Carducci, G. Zoppini, A. Toffalini, V. Tonelli, J. Manso, C. Sabbadin, F. Galuppini, G. Pennelli, I. Piva, S. Barollo, L. Bertazza, V. Pilotto, D. Basso, B. Fabris, S. Bernardi, F. Farinati, C. Scaroni, C. Mian
Summary: This study investigated whether autoimmune atrophic gastritis (AAG) and chronic hypergastrinemia are associated with increased calcitonin (Ct) levels. The results showed that high gastrin levels in patients with AAG do not explain hypercalcitonemia, regardless of the presence of autoimmune thyroiditis (AT). Therefore, further diagnostic evaluation is necessary to rule out medullary thyroid cancer (MTC) in patients with high Ct levels and AAG.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Medicine, General & Internal
Elisa Pinto, Filippo Pelizzaro, Fabio Farinati, Francesco Paolo Russo
Summary: Hepatocellular carcinoma (HCC) is a common liver malignancy, and angiogenesis plays a crucial role in its development and progression. Deregulated angiogenic pathways have been identified as therapeutic targets in HCC. Locoregional and systemic treatments aim to disrupt tumor blood supply, but this may induce neoangiogenesis and tumor recurrence. Currently available tyrosine kinase inhibitors and monoclonal antibodies primarily target angiogenic pathways for HCC treatment.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study investigated the alterations of alpha-synuclein and glial responses in duodenum biopsies of Parkinson's disease (PD) patients. The findings provide evidence of synuclein pathology and gliosis in the duodenum of PD patients, including early cases, suggesting the important role of the gut in PD pathogenesis.
MOVEMENT DISORDERS
(2023)