Journal
FUTURE ONCOLOGY
Volume 8, Issue 6, Pages 723-730Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.12.52
Keywords
cancer; IncRNA; miRNA; STAT3
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Funding
- China Natural Science Foundation [81072078, 81101915, 81101901]
- National High Technology Research and Development Program 863 [2012AA02A508]
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STAT3 signaling has been linked to the development of various cancers and is widely recognized as a critical molecular target for cancer therapy. ncRNAs, especially miRNAs and IncRNAs, are acting as promising biomarkers and therapy targets implicated in tumor pathogenesis. This review focuses on the most up-to-date knowledge of miRNAs and IncRNAs, and their involvement with STAT3 signaling. The important miRNAs involved in the STAT3 pathway are summarized in a complex interaction network. The IncRNAs' potential for targeting STAT3 at post-transcriptional level was predicted based upon IncRNA-mRNA interaction. The current and potential STAT3-targeted therapeutics are also discussed.
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