☆ 4.4 Article

Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose

FUTURE ONCOLOGY (2012)

Journal

FUTURE ONCOLOGY

Volume 8, Issue 9, Pages 1157-1165

Publisher

FUTURE MEDICINE LTD

DOI: 10.2217/FON.12.93

Keywords

cell lines; electronic nose; machine olfaction; olfactory detection; prostate cancer; volatile organic compounds

Categories

Oncology

Funding

University of Eastern Finland
Tampere University Hospital [9M070, 9M048, 9N035]
Elna Kaarina Savolainen's Cancer Research Fund
Tampere Tuberculosis Foundation

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Abstract

Aim: To determine whether an electronic nose can differentiate cultured nonmalignant and malignant prostatic cells from each other and whether the smell print is secreted to the surrounding medium. Materials & methods: Prostatic nonmalignant (EP-156T and controls) and malignant (LNCaP) cell lines, as well as conditioned and unconditioned media, were collected. The smell prints of the samples were analyzed by a ChemPro (R) 100 electronic nose device. The data were normalized and dimension reduction was conducted. The samples were classified and misclassification rates were calculated. Results: The electronic nose differentiated the nonmalignant and malignant cell lines from each other, achieving misclassification rates of 2.9-3.6%. Cells did not differ from the conditioned medium but differed from the unconditioned medium (misclassification rates: 0.0-25.6%). Conclusion: Malignant and nonmalignant prostatic cell lines have distinct smell prints. Prostatic cancer cells seem to modify the smell print of their medium.

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