Journal
FUTURE ONCOLOGY
Volume 8, Issue 4, Pages 403-414Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FON.12.22
Keywords
angiogenesis; bevacizumab; breast cancer; clinical trial; lymphangiogenesis
Categories
Funding
- NCI NIH HHS [R01 CA160688] Funding Source: Medline
- NICHD NIH HHS [K12HD055881, K12 HD055881] Funding Source: Medline
Ask authors/readers for more resources
Breast cancer is a major health concern for many women, but despite the current standard therapies, many women still die of metastatic disease. Angiogenesis has been evaluated as a possible target for therapy and bevacizumab (Avastin (R), Genentech/Roche, CA, USA), a monoclonal antibody against VEGF-A, has been developed to target this. Current clinical trials utilizing bevacizumab have shown an increase in progression-free survival, but this has not translated to an increase in overall survival in breast cancer patients. In this article, we summarize the currently published trials utilizing bevacizumab in the treatment of breast cancer and describe various methods of measuring angiogenesis In vitro and In vivo. We also describe the related process of lymphangiogenesis, as this may contribute to the mechanism of cancer progression and may be a potential target for therapy in the future. Understanding these processes may help us develop new treatments for breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available