Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer

Metformin, diet and breast cancer: An avenue for chemoprevention

(2011) Paola Muti et al.   CELL CYCLE

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

(2011) Irina N. Alimova et al.   CELL CYCLE

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

(2011) Bolin Liu et al.   CELL CYCLE

Genetic polymorphisms in diabetes: Influence on therapy with oral antidiabetics

(2010) Una Glamočlija et al.   ACTA PHARMACEUTICA

Defining the pathway to insulin-like growth factor system targeting in cancer

(2010) Steven A. Rosenzweig et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

(2010) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells

(2010) Scott A. Shell et al.   CELL CYCLE

Drug Transporters and Imatinib Treatment: Implications for Clinical Practice

(2010) K. Eechoute et al.   CLINICAL CANCER RESEARCH

Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

(2010) J. Zha et al.   CLINICAL CANCER RESEARCH

Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

(2010) E. Rozengurt et al.   CLINICAL CANCER RESEARCH

Metabolic Syndrome, Central Obesity and Insulin Resistance are Associated with Adverse Pathological Features in Postmenopausal Breast Cancer

(2010) L.A. Healy et al.   CLINICAL ONCOLOGY

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

Clearance of the high intestinal 18F-FDG uptake associated with metformin after stopping the drug

(2010) Tamer Özülker et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer

(2010) Robert G. Maki   JOURNAL OF CLINICAL ONCOLOGY

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

(2010) Junyu Ning et al.   MOLECULAR ENDOCRINOLOGY

AMP-activated protein kinase and cancer

(2009) W. Wang et al.   Acta Physiologica

The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy

(2009) A. Vazquez-Martin et al.   ANNALS OF ONCOLOGY

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology

(2009) B. Martin-Castillo et al.   ANNALS OF ONCOLOGY

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

(2009) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

The association of metabolic syndrome with triple-negative breast cancer

(2009) B. Maiti et al.   BREAST CANCER RESEARCH AND TREATMENT

Is it Time to Test Metformin in Breast Cancer Clinical Trials?

(2009) M. Cazzaniga et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb®)

(2009) Alejandro Vázquez-Martín et al.   Clinical & Translational Oncology

New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes

(2009) G. Libby et al.   DIABETES CARE

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin in chemically-induced mammary carcinogenesis in rats

(2009) B. Bojkova et al.   NEOPLASMA

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome

(2008) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

(2008) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Insulin-Lowering Effects of Metformin in Women with Early Breast Cancer

(2008) Pamela J. Goodwin et al.   Clinical Breast Cancer

Impact of a Mixed Strength and Endurance Exercise Intervention on Insulin Levels in Breast Cancer Survivors

(2008) Jennifer A. Ligibel et al.   JOURNAL OF CLINICAL ONCOLOGY

LKB1; linking cell structure and tumor suppression

(2008) A F Hezel et al.   ONCOGENE

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer

(2008) P. D. Ryan et al.   ONCOLOGIST

Ovulatory Response to Treatment of Polycystic Ovary Syndrome Is Associated with a Polymorphism in theSTK11Gene

(2007) Richard S. Legro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM