Article
Oncology
Sang Il Kim, Joo Hee Yoon, Soo Young Hur
Summary: The study revealed high expression of MIS/AMHRII in endometrial cancer and showed that MIS/AMH treatment inhibits the growth of MIS/AMH receptor-expressing tumor cells through regulation of autophagy, apoptosis, and cell cycle pathways, as well as inhibition of Wnt signaling pathways. This suggests that MIS/AMH functions as a tumor suppressor and may be an effective therapeutic agent in endometrial cancer.
Review
Endocrinology & Metabolism
Nathalie di Clemente, Chrystele Racine, Alice Pierre, Joelle Taieb
Summary: Anti-Mullerian hormone (AMH) plays a significant role in regulating folliculogenesis and serves as a reliable marker for ovarian reserve. It is also involved in the pathogenesis of conditions like polycystic ovary syndrome (PCOS) and primary ovarian failure.
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Article
Obstetrics & Gynecology
Horace Roman, Isabella Chanavaz-Lacheray, Oana Mircea, Benoit Berby, Lise Dehan, Sophia Braund, Eric Verspyck, Lucian Puscasiu
Summary: The study examined the association between large ovarian endometriomas and high pre-operative AMH concentrations in 332 women with endometriosis. Results showed that women with cysts measuring over 6 cm had significantly increased AMH concentrations, regardless of age or presence of bilateral endometriomas. Surgeons and patients should take into consideration the impact of large endometriomas on AMH levels when planning surgery and post-operative conception.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Juan Feng, Wen-Wen Ma, Hui-Xia Li, Xiu-Ying Pei, Shou-Long Deng, Hua Jia, Wen-Zhi Ma
Summary: This study demonstrates that melatonin (Mel) can serve as an adjuvant to protect young female cancer patients from premature ovarian insufficiency (POI) induced by Cyclophosphaty-45mide (Cyc) chemotherapy. Melatonin treatment maintains ovarian hormone levels and inhibits the mitochondrial apoptotic pathway to prevent follicle loss. This has important implications for preserving fertility in cancer patients undergoing chemotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
C. Lapuente, M. Faya, P. G. Blanco, M. Grisolia-Romero, C. Marchetti, C. Gobello
Summary: The objectives of this study were to report the AMH serum concentrations in female cats at different developmental stages, establish the relationship between serum AMH and age or estrous cycle, and correlate the total number of ovarian follicle types with AMH in adult queens. The results showed that neonatal females had lower AMH serum concentrations than males, and AMH levels increased from neonatal to prepubertal and postpubertal stages. Age was inversely correlated with AMH, and AMH concentrations were lower in females in the follicular phase compared to anestrus females. Small antral follicles had a high correlation with AMH concentrations. It was concluded that AMH can serve as an indirect marker for assessing ovarian follicle size and functionality, and age and pubertal state should be considered when evaluating AMH concentrations in cats.
Review
Obstetrics & Gynecology
Richard A. Anderson, David Cameron, Florian Clatot, Isabelle Demeestere, Matteo Lambertini, Scott M. Nelson, Fedro Peccatori
Summary: Female patients undergoing anticancer treatment are at risk of adverse ovarian outcomes, and AMH can be used as a biomarker to assess ovarian reserve and POI. Chemotherapy or radiotherapy consistently led to reduced/undetectable AMH levels, but partial recovery was observed during follow-up. Oligo/amenorrhea was associated with post-treatment AMH decline, suggesting impending POI. Long-term follow-up of pediatric patients showed significantly lower AMH levels compared to control groups. AMH can identify the damaging effect of cancer treatments on ovarian function, but further studies are needed to determine its diagnostic and predictive value.
HUMAN REPRODUCTION UPDATE
(2022)
Review
Endocrinology & Metabolism
Rivak Punchoo, Sachin Bhoora
Summary: AMH is a glycoprotein synthesized by the testes and ovaries, commonly assayed by ELISA or automated immunoassay formats with variation between methods. Standardization efforts have been made to harmonize results and establish consensus medical cut-off points for AMH, but further improvements are needed to address issues of standard reference materials and procedures.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Renee M. G. Verdiesen, Carla H. van Gils, Rebecca K. Stellato, W. M. Monique Verschuren, Frank J. M. Broekmans, Annelien C. de Kat, Yvonne T. van der Schouw, N. Charlotte Onland-Moret
Summary: The study found that baseline age-specific AMH levels were not associated with overall cancer risk, but there may be an increased risk of breast cancer in women under 40. Analysis of age-related AMH trajectories suggested that women diagnosed with cancer had higher AMH levels at a younger age and declined faster compared to those who were not diagnosed with cancer, although there was no actual evidence for differences in trajectories.
Article
Multidisciplinary Sciences
Kaitlin N. Hart, William A. Stocker, Nicholas G. Nagykery, Kelly L. Walton, Craig A. Harrison, Patricia K. Donahoe, David Pepin, Thomas B. Thompson
Summary: This study elucidates the molecular mechanism of how anti-Mullerian hormone (AMH) binds to its receptor AMHR2, highlighting key interaction points that contribute to specificity and providing insights for the design of agonists, antagonists, or antibody therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
S. J. Huang, L. Purevsuren, F. Jin, Y. P. Zhang, C. Y. Liang, M. Q. Zhu, F. Wang, C. L. Jia, Z. H. Wei
Summary: The study elucidated the role of AMH in regulating ovarian follicle development in laying hens by measuring expression of relevant genes and treating hens with AMH. Results showed changes in gene expressions post-follicular selection and significant effects on ovarian morphology and hormone levels after AMH injection.
Review
Endocrinology & Metabolism
Akira Iwase, Yuko Hasegawa, Yumiko Tsukui, Mio Kobayashi, Hikaru Hiraishi, Tomoko Nakazato, Yoshikazu Kitahara
Summary: Anti-Mullerian hormone (AMH) is an indirect indicator of ovarian reserve and fertility. It is used to test the number of remaining follicles. A decline in AMH suggests a decrease in follicles, while polycystic ovary syndrome patients often have elevated AMH levels. AMH varies with folliculogenesis and changes in the follicle cohort, which play a crucial role in ovarian activity throughout a woman's lifetime.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Richard A. Anderson, Tom W. Kelsey, Anne Perdrix, Nathalie Olympios, Orianne Duhamel, Matteo Lambertini, Florian Clatot
Summary: This study investigated the value of anti-mullerian hormone (AMH) as a serum biomarker for predicting loss of ovarian function after chemotherapy in premenopausal women with early breast cancer (eBC). The results showed that AMH can accurately diagnose ovarian dysfunction after chemotherapy, and early analysis of AMH can accurately identify women who will not recover ovarian function.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Xiangyun Zong, Yang Yu, Wenhu Chen, Weiwei Zong, Hongjian Yang, Xuan Chen
Summary: This study analyzed the changes in anti-Mullerian hormone (AMH) levels and the factors influencing ovarian function in breast cancer patients before and after chemotherapy. The results showed that age, menarche age, baseline AMH level, and GnRHa application are the most important independent factors for the protection and recovery of ovarian reserve in premenopausal women with breast cancer.
Article
Endocrinology & Metabolism
Ghazal Mansouri, Maryam Safinataj, Armita Shahesmaeili, Leila Allahqoli, Hamid Salehiniya, Ibrahim Alkatout
Summary: This study evaluated the effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cysts. The results showed that the surgery reduced serum AMH levels and the number of cauterizations used, cyst type, and bilaterality had a significant impact on postoperative AMH levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
