New insights into the interaction of Mycobacterium tuberculosis and human macrophages

Mycobacterial Lipopeptides Elicit CD4+ CTLs in Mycobacterium tuberculosis-Infected Humans

(2014) M. Bastian et al.   JOURNAL OF IMMUNOLOGY

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’

(2013) Nawal Salahuddin et al.   BMC INFECTIOUS DISEASES

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

(2013) Chung-Yu Chen et al.   CELL BIOLOGY AND TOXICOLOGY

Autophagy as an immune effector against tuberculosis

(2013) Steven B Bradfute et al.   CURRENT OPINION IN MICROBIOLOGY

CD40 ligand and interferon-γ induce an antimicrobial response againstMycobacterium tuberculosisin human monocytes

(2013) Georgiana M. Klug-Micu et al.   IMMUNOLOGY

Dormant Mycobacterium tuberculosis Fails To Block Phagosome Maturation and Shows Unexpected Capacity To Stimulate Specific Human T Lymphocytes

(2013) S. Mariotti et al.   JOURNAL OF IMMUNOLOGY

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

The Mycobacterium tuberculosis regulatory network and hypoxia

(2013) James E. Galagan et al.   NATURE

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

(2013) Crystal M. Darby et al.   PLoS One

Mycobacterium Tuberculosis—Associated Immune Reconstitution Syndrome in Solid-Organ Transplant Recipients

(2013) Hsin-Yun Sun et al.   TRANSPLANTATION

Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection

(2013) Nasiema Allie et al.   Scientific Reports

Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis

(2013) Akhirunnesa Mily et al.   BMC Pulmonary Medicine

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity

(2013) Jim Sun et al.   PLoS Pathogens

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

Efferocytosis Is an Innate Antibacterial Mechanism

(2012) Constance J. Martin et al.   Cell Host & Microbe

Hypoxia Triggers the Expression of Human   Defensin 2 and Antimicrobial Activity against Mycobacterium tuberculosis in Human Macrophages

(2012) D. Nickel et al.   JOURNAL OF IMMUNOLOGY

Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages

(2012) H. Bruns et al.   JOURNAL OF IMMUNOLOGY

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

Redox homeostasis in mycobacteria: the key to tuberculosis control?

(2011) Ashwani Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A mycolic acid–specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection

(2011) Damien J. Montamat-Sicotte et al.   JOURNAL OF CLINICAL INVESTIGATION

High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

(2011) Adrian R Martineau et al.   LANCET

A phagocyte dilemma...

(2011) Adrian J Thrasher et al.   NATURE IMMUNOLOGY

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

(2011) Jacinta Bustamante et al.   NATURE IMMUNOLOGY

Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans

(2011) Katherine Y. King et al.   PLoS One

Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

(2011) D. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Low Oxygen on Macrophage Response to Leishmania Infection

(2011) A. Degrossoli et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

Vitamin D Is Required for IFN- -Mediated Antimicrobial Activity of Human Macrophages

(2011) M. Fabri et al.   Science Translational Medicine

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

(2010) Dhiraj Kumar et al.   CELL

Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis

(2010) C Ridruechai et al.   GENES AND IMMUNITY

A Short Polypeptide from the Herpes Simplex Virus Type 2 ICP10 Gene Can Induce Antigen Aggregation and Autophagosomal Degradation for Enhanced Immune Presentation

(2010) Xinping Fu et al.   HUMAN GENE THERAPY

LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature

(2010) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

(2010) Sudha B. Singh et al.   NATURE CELL BIOLOGY

The many roles of NOX2 NADPH oxidase-derived ROS in immunity

(2010) Grace Y. Lam et al.   Seminars in Immunopathology

The Type I NADH Dehydrogenase of Mycobacterium tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-α-Mediated Host Cell Apoptosis

(2010) Jessica L. Miller et al.   PLoS Pathogens

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

Vitamin D as Supplementary Treatment for Tuberculosis

(2009) Christian Wejse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

Anti-TNF immunotherapy reduces CD8+ T cell–mediated antimicrobial activity against Mycobacterium tuberculosis in humans

(2009) Heiko Bruns et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

(2009) Edward Thorp et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses

(2009) Philip T. Liu et al.   PLoS One

Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

(2009) Christopher D. Intemann et al.   PLoS Pathogens

Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells

(2008) Audrey Sirvent et al.   BIOLOGY OF THE CELL

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

(2008) Debasis Biswas et al.   BMC IMMUNOLOGY

Molecular Mechanisms of Host-Pathogen Interactions and their Potential for the Discovery of New Drug Targets

(2008) Volker Briken   CURRENT DRUG TARGETS