Article
Biochemistry & Molecular Biology
Wenjie Yang, Yang Li, Diana Boraschi
Summary: Plastic pollution is a global problem that poses risks to the environment and human health. Discarded plastic degrades into microplastics (MPs) in the environment, which can interact with microorganisms and biomolecules. These interactions can modify the characteristics of microbes and biomolecules, potentially affecting the immune response and leading to risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Jie Zhang, Junaid Zafar, Jinrong Kong, Fei Wang, Xuehua Shao, Ruonan Zhang, Rui Pang, Hanhong Xu, Xiaoxia Xu, Fengliang Jin
Summary: This study investigates the immune response of Spodoptera frugiperda to Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection, identifying Toll, IMD, and apoptosis pathways as primary immune responses. The study also discovers that AcMNPV induces differential expression of microRNAs (miRNAs) in the host, which negatively regulate the host's antiviral immune genes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Microbiology
Melene A. Alakavuklar, Aretha Fiebig, Sean Crosson
Summary: The cell envelope is a multilayered structure that protects bacterial cells from the outside world. The Brucella genus differs from commonly studied gram-negative bacteria in terms of its envelope structure and regulation, making it an ideal comparative model for studying the gram-negative envelope.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luis A. Arteaga-Blanco, Dumith Chequer Bou-Habib
Summary: The nanosized EVs released by cells play a crucial role in intercellular communication, regulating cellular homeostasis and potentially spreading pathogen-derived molecules. Studying EVs shed by human macrophages can provide insights into modulating host immune responses and developing innovative therapeutic strategies against infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
G. Forn-Cuni, L. Welvaarts, F. M. Stel, C. J. van den Hondel, M. Arentshorst, A. F. J. Ram, A. H. Meijer
Summary: The activation of antifungal autophagy response improves host survival against drug-resistant Aspergillus infections, but only in the presence of phagocytes. This finding suggests that stimulating the autophagy process may be a promising approach for developing therapies against invasive Aspergillosis.
Review
Biochemistry & Molecular Biology
Quanhui Yan, Xiaodi Liu, Yawei Sun, Weijun Zeng, Yuwan Li, Feifan Zhao, Keke Wu, Shuangqi Fan, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: This review summarizes recent advances in autophagy, apoptosis, and innate immunity induced by swine enteric coronavirus (SeCoV) infection, emphasizing their relationship with viral replication and signaling pathway alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Muhammad Nadeem Abbas, Saima Kausar, Bibi Asma, Wenhao Ran, Jingui Li, Zini Lin, Tiejun Li, Hongjuan Cui
Summary: The interaction between bacteria and insects has widespread implications due to their global distribution. It can directly impact human health as insects serve as disease vectors, and also have economic consequences. Moreover, it is linked to high mortality rates in economically important insects, resulting in significant economic losses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Katie Nightingale, Martin Potts, Leah M. Hunter, Ceri A. Fielding, Cassie M. Zerbe, Alice Fletcher-Etherington, Luis Nobre, Eddie C. Y. Wang, Blair L. Strang, Jack W. Houghton, Robin Antrobus, Nicolas M. Suarez, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, Michael P. Weekes
Summary: In this study, we identified a previously unknown mechanism by which a viral protein degrades the host protein SLFN11, and showed that SLFN11 has inhibitory effects on HCMV infection. This research provides an important resource for studying antiviral immunity and viral immune evasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Aitor Elizalde-Bielsa, Beatriz Aragon-Aranda, Maite Loperena-Barber, Miriam Salvador-Bescos, Ignacio Moriyon, Amaia Zuniga-Ripa, Raquel Conde-Alvarez
Summary: Brucellosis is a zoonotic disease caused by Gram-negative bacteria of the genus Brucella, which can cause long-lasting infections. The use of mice as in vivo models for investigating bacterial virulence is limited due to ethical and practical considerations. Galleria mellonella larvae have been increasingly used as an alternative model, showing lower mortality and delayed death upon Brucella infection compared to mice.
MICROBIAL PATHOGENESIS
(2023)
Review
Immunology
Ioannis Eleftherianos, Ghada Tafesh-Edwards, Amr Mohamed
Summary: Recent studies have shown that insect tissues and organs play a crucial role in the natural infection routes of parasites and microbial pathogens. This article summarizes the different types of parasites that infect insects through distinct routes and examines the relationship between infection routes and insect immune response. The findings suggest that understanding the association between infection routes and insect host defense can help in designing strategies for managing agricultural pests and disease vectors.
IMMUNOLOGY LETTERS
(2022)
Article
Cell Biology
Yuta Tachibana, Emi Hashizaki, Miwa Sasai, Masahiro Yamamoto
Summary: Using in vivo CRISPR screen technology, this study explored the requirements of secreted and non-secreted virulence factors in Toxoplasma in immune-deficient hosts. It identified several genes encoding non-secreted proteins, such as ROP5, ROP18, GRA12, and GRA45, as well as GRA72, which plays a role in GRA17/GRA23 localization, and UF-Mylation-related genes as interferon-y (IFN-y)-dependent virulence genes. This study demonstrates that host genetics can complement in vivo CRISPR screens to identify genes encoding IFN-y-dependent secreted and non-secreted virulence factors in Toxoplasma.
Article
Microbiology
Mark Deehan, Weiwei Lin, Benjamin Blum, Andrew Emili, Horacio Frydman
Summary: Autophagy is an intracellular degradation pathway involved in innate immunity. Pathogenic bacteria have evolved several mechanisms to escape degradation or exploit autophagy to acquire host nutrients. In the case of endosymbionts, which often have commensal or mutualistic interactions with the host, autophagy is not well characterized. We utilized tissue-specific autophagy mutants to determine if Wolbachia, a vertically transmitted obligate endosymbiont of Drosophila melanogaster, is regulated by autophagy in somatic and germ line cell types. Our analysis revealed core autophagy proteins Atg1 and Atg8 and a selective autophagy-specific protein Ref(2)p negatively regulate Wolbachia in the hub, a male gonad somatic cell type. Furthermore, we determined that the Wolbachia effector protein, CifB, modulates autophagy-Wolbachia interactions, identifying a new host-related pathway which these bacterial proteins interact with. In the female germ line, the cell type necessary for inheritance of Wolbachia through vertical transmission, we discovered that bulk autophagy mediated by Atg1 and Atg8 positively regulates Wolbachia density, whereas Ref(2)p had no effect. Global metabolomics of fly ovaries deficient in germ line autophagy revealed reduced lipid and carbon metabolism, implicating metabolites from these pathways as positive regulators of Wolbachia. Our work provides further understanding of how autophagy affects bacteria in a cell type-dependent manner. Autophagy is a eukaryotic intracellular degradation pathway which can act as an innate immune response to eliminate pathogens. Conversely, pathogens can evolve proteins which modulate the autophagy pathway to subvert degradation and establish an infection. Wolbachia, a vertically transmitted obligate endosymbiont which infects up to 40% of insect species, is negatively regulated by autophagy in whole animals, but the specific molecular mechanism and tissue which govern this interaction remain unknown. Our studies use cell type-specific autophagy mutants to reveal that Wolbachia is negatively regulated by selective autophagy in the soma, while nonselective autophagy positively regulates Wolbachia in the female germ line. These data provide evidence that cell type can drive different basal autophagy programs which modulate intracellular microbes differently. Additionally, we identified that the Wolbachia effector CifB acts in the selective autophagy pathway to aid in intracellular bacterial survival, providing a new function for CifB beyond its previously identified role in reproductive manipulation.
Review
Biochemistry & Molecular Biology
Eleanor K. P. Marshall, Marc S. Dionne
Summary: Fruit fly Drosophila melanogaster has emerged as an important model for studying host-pathogen interactions, particularly in the context of mycobacterial infections. Studies using Drosophila have identified key factors involved in controlling or resisting mycobacterial infections, laying the groundwork for further research into the interaction between host and pathogen factors. The development of genetic tools for manipulating mycobacterial genomes holds promise for more detailed investigations using the fruit fly model, although its full potential has yet to be fully realized.
MOLECULAR MICROBIOLOGY
(2022)
Review
Microbiology
Lauren W. W. Stranahan, Angela M. M. Arenas-Gamboa
Summary: Brucella is a facultatively intracellular bacterial pathogen that can evade the immune system and persist chronically within host cells. B. canis and B. ovis, despite being rough lipopolysaccharide phenotypes, exhibit full virulence in natural hosts and are able to manipulate the host immune response. Compensations for their roughness include alterations to outer membrane proteins, potentially enhancing stealth and allowing for longer periods of undetected persistence.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Yun Zhao, Vilma Arce-Gorvel, Raquel Conde-Alvarez, Ignacio Moriyon, Jean-Pierre Gorvel
MICROBES AND INFECTION
(2018)
Article
Immunology
Yun Zhao, Sean Hanniffy, Vilma Arce-Gorvel, Raquel Conde-Alvarez, SangKon Oh, Ignacio Moriyon, Sylvie Memet, Jean-Pierre Gorvel
Article
Cell Biology
Camille Wagner, Johnny Bonnardel, Clement Da Silva, Liesbet Martens, Jean-Pierre Gorvel, Hugues Lelouard
CELLULAR IMMUNOLOGY
(2018)
Review
Cell Biology
Leticia S. Guidolin, Vilma Arce-Gorvel, Andres E. Ciocchini, Diego J. Comerci, Jean-Pierre Gorvel
CELLULAR MICROBIOLOGY
(2018)
Article
Microbiology
Raquel Conde-Alvarez, Leyre Palacios-Chaves, Yolanda Gil-Ramirez, Miriam Salvador-Bescos, Marina Barcena-Varela, Beatriz Aragon-Aranda, Estrella Martinez-Gomez, Amaia Zuniga-Ripa, Maria J. de Miguel, Toby Leigh Bartholomew, Sean Hanniffy, Maria-Jesus Grillo, Miguel Angel Vences-Guzman, Jose A. Bengoechea, Vilma Arce-Gorvel, Jean-Pierre Gorvel, Ignacio Moriyon, Maite Iriarte
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Cell Biology
Thomas Moest, Weidong Zhao, Yaya Zhao, Jan Moritz Schussler, Wen Yan, Jean-Pierre Gorvel, Stephane Meresse
CELLULAR MICROBIOLOGY
(2018)
Article
Immunology
Cristina Gutierrez-Jimenez, Lisiena Hysenaj, Alejandro Alfaro-Alarcon, Ricardo Mora-Cartin, Vilma Arce-Gorvel, Edgardo Moreno, Jean Pierre Gorvel, Elias Barquero-Calvo
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Cell Biology
Karellen B. Garcia-Mendez, Soledad M. Hielpos, Pedro F. Soler-Llorens, Vilma Arce-Gorvel, Christine Hale, Jean-Pierre Gorvel, David O'Callaghan, Anne Keriel
CELLULAR MICROBIOLOGY
(2019)
Review
Infectious Diseases
Clea Melenotte, Michel Drancourt, Jean Pierre Gorvel, Jean Louis Mege, Didier Raoult
MEDECINE ET MALADIES INFECTIEUSES
(2019)
Article
Immunology
Matthieu Million, Maxime Gaudin, Clea Melenotte, Lionel Chasson, Sophie Edouard, Constance Verdonk, Elsa Prudent, Bernard Amphoux, Stephane Meresse, Richard Dorent, Hubert Lepidi, Bernard La Scola, Jean-Pierre Gorvel, Christelle Desnues, Didier Raoult
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Clara Degos, Lisiena Hysenaj, Gabriela Gonzalez-Espinoza, Vilma Arce-Gorvel, Aurelie Gagnaire, Alexia Papadopoulos, Karina Alejandra Pasquevich, Stephane Meresse, Juliana Cassataro, Sylvie Memet, Jean-Pierre Gorvel
CELLULAR MICROBIOLOGY
(2020)
Review
Microbiology
Clea Melenotte, Soraya Mezouar, Jean-Louis Mege, Jean-Pierre Gorvel, Guido Kroemer, Didier Raoult
CRITICAL REVIEWS IN MICROBIOLOGY
(2020)
Article
Cell Biology
Lucrecia Alberdi, Alexandra Vergnes, Jean-Baptiste Manneville, Dumizulu L. Tembo, Ziyan Fang, Yaya Zhao, Nina Schroeder, Audrey Dumont, Margaux Lagier, Patricia Bassereau, Lorena Redondo-Morata, Jean-Pierre Gorvel, Stephane Meresse
JOURNAL OF CELL SCIENCE
(2020)
Article
Cell Biology
Camille Wagner, Johnny Bonnardel, Clement Da Silva, Lionel Spinelli, Cynthia Arroyo Portilla, Julie Tomas, Margaux Lagier, Lionel Chasson, Marion Masse, Marc Dalod, Alexandre Chollat-Namy, Jean-Pierre Gorvel, Hugues Lelouard
Article
Microbiology
Fernando Chimal-Cazares, Gabriela Hernandez-Martinez, Sabino Pacheco, Miguel A. Ares, Jorge Soria-Bustos, Manuel Sanchez-Gutierrez, Jeannett A. Izquierdo-Vega, Jose Antonio Ibarra, Jorge A. Gonzalez-Y-Merchand, Jean-Pierre Gorvel, Stephane Meresse, Miguel A. De la Cruz
FRONTIERS IN MICROBIOLOGY
(2020)