Journal
FUTURE MICROBIOLOGY
Volume 8, Issue 3, Pages 387-401Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/FMB.12.149
Keywords
antibiotics; antimicrobial agents; aptamers; biosensors; hygiene monitoring; multidrug resistance; pathogens; riboswitches
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Funding
- Scientific and Technological Council of Turkey (TUBITAK) [BIDEB-2232]
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Discovery of alternative sources of antimicrobial agents are essential in the ongoing battle against microbial pathogens. Legislative and scientific challenges considerably hinder the discovery and use of new antimicrobial drugs, and new approaches are in urgent demand. On the other hand, rapid, specific and sensitive detection of airborne pathogens is becoming increasingly critical for public health. In this respect affinity oligonucleotides, aptamers, provide unique opportunities for the development of nanotechnological solutions for such medical applications. In recent years, aptamers specifically recognizing microbial cells and viruses showed great potential in a range of analytical and therapeutic applications. This article describes the significant advances in the development of aptamers targeting specific pathogens. Therapeutic application of aptamers as neutralizing agents demonstrates great potential as a future source of antimicrobial agent.
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