Article
Microbiology
Juan Dominguez, Ana I. Mendes, Ana R. Pacheco, Maria J. Peixoto, Jorge Pedrosa, Alexandra G. Fraga
Summary: Buruli Ulcer is a common infectious skin disease that can cause severe disfigurement and disability if not treated in a timely manner. The standard antibiotic regimen for treatment has limitations, leading researchers to explore new drug candidates. This study found that statins have the potential to be effective in treating Buruli Ulcer.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
B. G. O. Tchan, S. Ngazoa-Kakou, N. Aka, N. K. B. Apia, N. Hammoudi, M. Drancourt, J. Saad
Summary: We describe a new targeted sequencing approach that characterizes the PPE gene to disclose the simultaneous presence of different variants of a single pathogenic microorganism. This has direct implications on understanding pathogen diversity and natural history and therapeutic implications when dealing with obligate and opportunistic pathogens. By establishing a comprehensive database and utilizing PPE gene sequencing, the identification and typing of clinical M. ulcerans strains can be done more efficiently.
MICROBIOLOGY SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Laxmi Dhungel, Mark Eric Benbow, Heather Rose Jordan
Summary: Buruli ulcer, caused by Mycobacterium ulcerans, is a challenging necrotizing skin disease in West Africa due to unknown transmission modes and occurrence in remote areas. A One Health approach is needed to advance understanding of transmission and design management strategies. Understanding bacterial ecology, environmental niches, and the role of mycolactone is crucial in preventing and responding to this mysterious disease.
Article
Microbiology
Elizabeth Gyamfi, Charles A. Narh, Charles Quaye, Adiza Abbass, Bartholomew Dzudzor, Lydia Mosi
Summary: Secondary microbial infections were identified in BU lesions, with Staphylococci spp and Bacilli spp being the predominant bacteria, especially in BU patients who had not yet received antibiotic treatment. Clarithromycin and amikacin were found to be effective in treating secondary infection, although there was high resistance to streptomycin among the secondary bacteria isolates.
Article
Public, Environmental & Occupational Health
Philippe Bahadoran, Nassim Hammoudi, Alice Gaudart, Jamal Saad, Yoan Di Filippo, Michel Drancourt, Raymond Ruimy
Summary: This report describes a case of Buruli ulcer in a peri-urban area in Cote d'Ivoire, confirmed by whole genome sequencing to be caused by a Mycobacterium ulcerans genotype not previously reported in Cote d'Ivoire.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Biology
Koen Vandelannoote, Andrew H. Buultjens, Jessica L. Porter, Anita Velink, John R. Wallace, Kim R. Blasdell, Michael Dunn, Victoria Boyd, Janet A. M. Fyfe, Ee Laine Tay, Paul D. R. Johnson, Saras M. Windecker, Nick Golding, Timothy P. Stinear
Summary: This study establishes a model based on possum excreta surveillance that can effectively predict the occurrence of human BU cases and guide public health interventions.
Editorial Material
Public, Environmental & Occupational Health
Chiara Sepulcri, Antonio Di Biagio, Stefania Tutino, Umberto Valente, Ramona Barbieri, Anna Marchese, Matteo Bassetti
Summary: A case of Buruli ulcer in a Caucasian male returning from Madagascar was described, potentially the first reported case of Mycobacterium ulcerans infection in Madagascar.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Microbiology
Elizabeth Gyamfi, Magdalene Amerl Dogbe, Charles Quaye, Abel Adjet Affouda, Edwin Kyei-Baffour, Daisy Awuku-Asante, Mabel Sarpong-Duah, Lydia Mosi
Summary: This study aimed to identify genetic differences among Mycobacterium ulcerans strains between two Buruli ulcer endemic countries, Ghana and Cote d'Ivoire. The study found different genotypes among clinical and environmental samples, with clinical isolates showing more heterogeneity. Genotype D was found to be prominent in both clinical and environmental samples, suggesting possible transmission of M. ulcerans from the environment to humans.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Marc Jacobsen, Jonathan Kofi Adjei, Wilfred Aniagyei, Ernest Adankwah, Julia Seyfarth, Ertan Mayatepek, Daniel Antwi-Berko, Samuel Asamoah Sakyi, Alexander Y. Debrah, Linda Batsa Debrah, Dorcas O. Owusu, Richard O. Phillips
Summary: Immune-based diagnosis of Buruli ulcer disease (BUD) in children is challenging due to cross-reactivity between mycobacteria. Responses of T-cell IFN gamma/TNF alpha against Mycobacterium (M.) ulcerans and M. tuberculosis were different in children with BUD and TB, with only ratios discriminating the study groups efficiently.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Microbiology
Louisa Warryn, Gerd Pluschke
Summary: Acid-oxidizing solutions (AOSs) are effective in killing pathogenic bacteria and can potentially assist in the treatment of Buruli ulcer. In resource-poor settings, where secondary infections are common, topical application of AOSs can help prevent infections and control secondary infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Brodie Tweedale, Fiona P. Collier, Nilakshi Waidyatillake, Eugene Athan, Daniel O'Brien
Summary: Mycobacterium ulcerans disease is effectively treated with eight-weeks antibiotic therapy, but this prolonged regimen may cause significant toxicities. This study investigated the duration of antibiotic treatment required for negative cultures and examined the influence of patient characteristics on this outcome.
Article
Infectious Diseases
Takumi Fujimori, Hideharu Hagiya, Koji Iio, Osamu Yamasaki, Yuji Miyamoto, Yoshihiko Hoshino, Ayaka Kakehi, Mami Okura, Hiroshi Minabe, Yukika Yokoyama, Fumio Otsuka, Akihito Higashikage
Summary: This article reports a case of Buruli ulcer associated with M. ulcerans subsp. shinshuense in Japan, highlighting the importance of accurate diagnosis and calling for more clinical cases to investigate its epidemiology and clinical characteristics.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Yamin Gao, H. M. Adnan Hameed, Yang Liu, Lingmin Guo, Cuiting Fang, Xirong Tian, Zhiyong Liu, Shuai Wang, Zhili Lu, Md Mahmudul Islam, Tianyu Zhang
Summary: TB47-containing regimens have shown promising results in curing Buruli ulcer quickly and effectively, as well as preventing the emergence of drug resistance. Additionally, the discovery of double QcrB mutations could guide potential clinical molecular diagnosis of resistance and the development of new drugs.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Immunology
Joao Fevereiro, Alexandra G. Fraga, Jorge Pedrosa
Summary: Buruli ulcer, caused by Mycobacterium ulcerans, is an emerging infectious disease with an uncommon infection pattern where the host relies on a highly orchestrated genetic landscape to control the infection.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Immunology
Melanie Foulon, Marie Robbe-Saule, Lucille Esnault, Marine Malloci, Anthony Mery, Jean-Paul Saint-Andre, Anne Croue, Marie Kempf, Chadi Homedan, Estelle Marion, Laurent Marsollier
Summary: This study found that a ketogenic diet can prevent the formation of Buruli ulcer by modulating bacterial growth and host inflammatory response.
JOURNAL OF INFECTIOUS DISEASES
(2021)