Development of new vaccines and drugs for TB: limitations and potential strategic errors

Identification of Human T Cell Antigens for the Development of Vaccines against Mycobacterium tuberculosis

(2014) S. Bertholet et al.   JOURNAL OF IMMUNOLOGY

Predictors of Extensively Drug-Resistant Pulmonary Tuberculosis

(2013) Kai Kliiman   ANNALS OF INTERNAL MEDICINE

The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+and CD8+T Cells in Adults

(2010) Brian Abel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

(2010) Benjamin M. N. Kagina et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis

(2010) D. J. Ordway et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Investigating the Induction of Vaccine-Induced Th17 and Regulatory T Cells in Healthy, Mycobacterium bovis BCG-Immunized Adults Vaccinated with a New Tuberculosis Vaccine, MVA85A

(2010) S. C. de Cassan et al.   Clinical and Vaccine Immunology

Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis

(2010) M. I. Henao-Tamayo et al.   Clinical and Vaccine Immunology

Highly Persistent and Effective Prime/Boost Regimens against Tuberculosis That Use a Multivalent Modified Vaccine Virus Ankara-Based Tuberculosis Vaccine with Interleukin-15 as a Molecular Adjuvant

(2010) K. Kolibab et al.   Clinical and Vaccine Immunology

Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing

(2010) S. A. Sharpe et al.   Clinical and Vaccine Immunology

Update on Research and Development Pipeline: Tuberculosis Vaccines

(2010) Belinda Beresford et al.   CLINICAL INFECTIOUS DISEASES

CD4+Regulatory T Cells in a Cynomolgus Macaque Model ofMycobacterium tuberculosisInfection

(2010) Angela M. Green et al.   JOURNAL OF INFECTIOUS DISEASES

XDR tuberculosis in South Africa: old questions, new answers

(2010) Giovanni Battista Migliori et al.   LANCET

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

(2010) Iñaki Comas et al.   NATURE GENETICS

Multiple M. tuberculosis Phenotypes in Mouse and Guinea Pig Lung Tissue Revealed by a Dual-Staining Approach

(2010) Gavin J. Ryan et al.   PLoS One

The Population Dynamics and Control of Tuberculosis

(2010) C. Dye et al.   SCIENCE

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

A Defined Tuberculosis Vaccine Candidate Boosts BCG and Protects Against Multidrug-Resistant Mycobacterium tuberculosis

(2010) S. Bertholet et al.   Science Translational Medicine

The Achilles heel of BCG

(2010) Ian M. Orme   TUBERCULOSIS

Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts

(2009) Alexander V. Pichugin et al.   AMERICAN JOURNAL OF PATHOLOGY

Substitution of Moxifloxacin for Isoniazid during Intensive Phase Treatment of Pulmonary Tuberculosis

(2009) Susan E. Dorman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

Trends in tuberculosis incidence and their determinants in 134 countries

(2009) C Dye et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Hypoxia: a window intoMycobacterium tuberculosislatency

(2009) Tige R. Rustad et al.   CELLULAR MICROBIOLOGY

Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli

(2009) Ali Akbar Velayati et al.   CHEST

Global Burden and Epidemiology of Tuberculosis

(2009) Philippe Glaziou et al.   CLINICS IN CHEST MEDICINE

Animal models of tuberculosis

(2009) Douglas Young   EUROPEAN JOURNAL OF IMMUNOLOGY

Predictors of poor treatment outcome in multi- and extensively drug-resistant pulmonary TB

(2009) K. Kliiman et al.   EUROPEAN RESPIRATORY JOURNAL

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

Cytotoxicity and Secretion of Gamma Interferon Are Carried Out by Distinct CD8 T Cells during Mycobacterium tuberculosis Infection

(2009) T. Einarsdottir et al.   INFECTION AND IMMUNITY

Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells

(2009) T. Lindenstrom et al.   JOURNAL OF IMMUNOLOGY

Structural Basis of the CD8  /MHC Class I Interaction: Focused Recognition Orients CD8  to a T Cell Proximal Position

(2009) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance

(2009) Abigail Wright et al.   LANCET

Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

(2009) Claus Aagaard et al.   PLoS One

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

(2009) S. G. Reed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs

(2009) Gopinath S. Palanisamy et al.   TUBERCULOSIS

Evaluation of new vaccines for tuberculosis in the guinea pig model

(2009) Ann Williams et al.   TUBERCULOSIS

Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis

(2009) Ronggai Sun et al.   VACCINE

Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant

(2009) P.J. Cardona et al.   VACCINE

Intradermal immunization improves protective efficacy of a novel TB vaccine candidate

(2009) Susan L. Baldwin et al.   VACCINE

Influence of Multidrug Resistance on Tuberculosis Treatment Outcomes with Standardized Regimens

(2008) Anton Mak et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis

(2008) D. R. Hoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IL-23 and IL-17 in tuberculosis

(2008) Shabaana A. Khader et al.   CYTOKINE

Doubting the TCR Coreceptor Function of CD8αα

(2008) Hilde Cheroutre et al.   IMMUNITY

Vaccine-Elicited 10-Kilodalton Culture Filtrate Protein-Specific CD8+ T Cells Are Sufficient To Mediate Protection against Mycobacterium tuberculosis Infection

(2008) Y. Wu et al.   INFECTION AND IMMUNITY

Mycobacterium bovis BCG Immunization Induces Protective Immunity against Nine Different Mycobacterium tuberculosis Strains in Mice

(2008) B. Y. Jeon et al.   INFECTION AND IMMUNITY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Metronidazole Lacks Activity againstMycobacterium tuberculosisin an In Vivo Hypoxic Granuloma Model of Latency

(2008) Lee G. Klinkenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Multidrug‐Resistant and Extensively Drug‐Resistant Tuberculosis: The National Institute of Allergy and Infectious Diseases Research Agenda and Recommendations for Priority Research

(2008) Anthony S. Fauci et al.   JOURNAL OF INFECTIOUS DISEASES

Growth ofMycobacterium tuberculosisbiofilms containing free mycolic acids and harbouring drug-tolerant bacteria

(2008) Anil K. Ojha et al.   MOLECULAR MICROBIOLOGY

Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis

(2008) Christopher Dye   NATURE REVIEWS MICROBIOLOGY

rBCG Induces Strong Antigen-Specific T Cell Responses in Rhesus Macaques in a Prime-Boost Setting with an Adenovirus 35 Tuberculosis Vaccine Vector

(2008) Isabelle Magalhaes et al.   PLoS One

Preclinical testing of new drugs for tuberculosis: current challenges

(2008) Anne J. Lenaerts et al.   TRENDS IN MICROBIOLOGY

Disseminated disease severity as a measure of virulence of Mycobacterium tuberculosis in the guinea pig model

(2008) Gopinath S. Palanisamy et al.   TUBERCULOSIS

Experimental tuberculosis: the role of comparative pathology in the discovery of improved tuberculosis treatment strategies

(2008) Randall J. Basaraba   TUBERCULOSIS

Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning

(2008) Rhea N. Coler et al.   VACCINE

Cytokine Profiles in Primary and Secondary Pulmonary Granulomas of Guinea Pigs with Tuberculosis

(2007) Lan H. Ly et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased expression of host iron-binding proteins precedes iron accumulation and calcification of primary lung lesions in experimental tuberculosis in the guinea pig

(2007) Randall J. Basaraba et al.   TUBERCULOSIS