Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery

Semisynthetic Artemisinin, the Chemical Path to Industrial Production

(2014) Joël Turconi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling

(2013) Johann Moschner et al.   Beilstein Journal of Organic Chemistry

Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A

(2013) Daniel S. Treitler et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

(2013) Carole Sourbier et al.   CANCER CELL

Synthesis of (−)-Neothiobinupharidine

(2013) Daniel J. Jansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Catalytic Enantioselective Tandem Allylation Strategy for Rapid Terpene Construction: Application to the Synthesis of Pumilaside Aglycon

(2013) Grace E. Ferris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines

(2013) Sergey V. Pronin et al.   NATURE

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide

(2013) H. Renata et al.   SCIENCE

Dendralenes Branch Out: Cross-Conjugated Oligoenes Allow the Rapid Generation of Molecular Complexity

(2012) Henning Hopf et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Re-Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions

(2012) Gopala K. Jarugumilli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Total Synthesis of Hyperforin

(2012) Brian A. Sparling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Potent Antimalarial Amphilectene

(2012) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Synthesis of (+)-Artemisinin

(2012) Chunyin Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization

(2012) Sergey V. Pronin et al.   Nature Chemistry

Total Synthesis and Biological Evaluation of (−)-Englerin A and B: Synthesis of Analogues with Improved Activity Profile

(2011) Lea Radtke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective 1,2-Diboration of 1,3-Dienes: Versatile Reagents for Stereoselective Allylation

(2011) Laura T. Kliman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

(2011) Philipp Heretsch et al.   CHEMICAL COMMUNICATIONS

A Brief Synthesis of (−)-Englerin A

(2011) Zhenwu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable Synthesis of Cortistatin A and Related Structures

(2011) Jun Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Simple, Nontoxic Iron System for the Allylation of Zinc Enolates

(2011) Gopala K. Jarugumilli et al.   ORGANIC LETTERS

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Synthesis of (−)-Englerins A and B

(2010) Kian Molawi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric, Protecting-Group-Free Total Synthesis of (−)-Englerin A

(2010) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nuphar lutea thioalkaloids inhibit the nuclear factor κappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide

(2010) Janet Ozer et al.   CANCER BIOLOGY & THERAPY

Ring-Closing Metathesis of Allylsilanes As a Flexible Strategy toward Cyclic Terpenes. Short Syntheses of Teucladiol, Isoteucladiol, Poitediol, and Dactylol and an Attempted Synthesis of Caryophyllene

(2010) Matthew S. Dowling et al.   JOURNAL OF ORGANIC CHEMISTRY

Aiming for the Ideal Synthesis

(2010) Tanja Gaich et al.   JOURNAL OF ORGANIC CHEMISTRY

Simple Reagents for Direct Halonium-Induced Polyene Cyclizations

(2010) Scott A. Snyder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-malarial, anti-algal, anti-tubercular, anti-bacterial, anti-photosynthetic, and anti-fouling activity of diterpene and diterpene isonitriles from the tropical marine sponge Cymbastela hooperi

(2010) Anthony D. Wright et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The organocatalytic three-step total synthesis of (+)-frondosin B

(2010) Maud Reiter et al.   Chemical Science

Total Synthesis and Absolute Configuration of the Guaiane Sesquiterpene Englerin A

(2009) Matthieu Willot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Et2SBr⋅SbCl5Br: An Effective Reagent for Direct Bromonium-Induced Polyene Cyclizations

(2009) Scott A. Snyder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach

(2009) Athanassios Giannis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pt-Catalyzed Enantioselective Diboration of Terminal Alkenes with B2(pin)2

(2009) Laura T. Kliman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asymmetric Synthesis of Seven-Membered Carbocyclic Rings via a Sequential Oxyanionic 5-Exo-Dig Cyclization/Claisen Rearrangement Process. Total Synthesis of (−)-Frondosin B

(2009) Timo V. Ovaska et al.   ORGANIC LETTERS

Halogenation Strategies In Natural Product Biosynthesis

(2008) Christopher S. Neumann et al.   CHEMISTRY & BIOLOGY

Synthesis of (+)-Cortistatin A

(2008) Ryan A. Shenvi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Englerin A, a Selective Inhibitor of Renal Cancer Cell Growth, fromPhyllanthus engleri

(2008) Ranjala Ratnayake et al.   ORGANIC LETTERS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH