Article
Pharmacology & Pharmacy
Hussa Alshahwan, Bedoor Qabazard, Alyaa Mousa, Bindu Chandrasekhar, Krishna Santhosh, Mariam H. M. Yousif
Summary: The study indicates that GYY4137 may be a novel therapeutic tool to prevent diabetes-associated vascular dysfunction. This treatment significantly improves vascular constriction and dilation responses in diabetic rats, and affects the levels of nitric oxide and hydrogen sulfide.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Joshua J. Woods, Justin J. Wilson
Summary: A metal-based H2S donor has been developed for selective delivery of H2S to hypoxic cells, showing potential protective effects against ischemic reperfusion injury in rat cardiomyoblasts. These findings demonstrate the utility of redox-activated metal complexes as hypoxia-selective H2S-releasing agents for studying the role of this gas in complex biological systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Pharmacology & Pharmacy
Rose I. M. Batista, Renato C. Nogueira, Graziele C. Ferreira, Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Jose E. Tanus-Santos
Summary: Supplementation with L-arginine has been shown to have beneficial effects in hypertension by increasing nitric oxide formation and enhancing nitrate concentrations, but these effects may be prevented by antiseptic mouthwash. Alteration of the nitrate cycle in the body by mouthwash can impact endothelial dysfunction, antihypertensive effects, and antioxidant effects of L-arginine in hypertensive rats. The findings suggest a new mechanism where antibacterial mouth rinse can affect arterial blood pressure and the development of cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Natalya Dorofeyeva, Konstantin Drachuk, Rajasekaran Rajkumar, Omkar Sabnis, Vadim Sagach
Summary: The study demonstrates that exogenous hydrogen sulfide can improve heart function and endothelium-dependent relaxation in diabetic rats. Pretreatment with NaHS can prevent endothelial dysfunction in diabetes through a NOS-dependent mechanism.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Multidisciplinary
Joshua J. Sutton, Dan Preston, Philipp Traber, Johannes Steinmetzer, Xue Wu, Surajit Kayal, Xue-Z Sun, James D. Crowley, Michael W. George, Stephan Kupfer, Keith C. Gordon
Summary: The optical properties of two Re(CO)(3)(bpy)Cl complexes with different substituents were studied, revealing distinct charge transfer bands in their absorption spectra and two emissive states in their excited-state spectroscopy which are modulated by solvent. Time-resolved infrared spectroscopy identified the nature of the excited states in different solvents, with DFT calculations suggesting that the switching of properties induced by solvent is controlled by spin-orbit coupling.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Alexia Marques Silva, Laisa Bonafim Negri, Juliana Cristina Biazzotto, Sergio de Paula Machado, Jeimison Duarte Santos, Jorge Fernandes Nasser Batista, Pedro Ivo S. Maia, Victor Marcelo Deflon, Lusiane M. Bendhack, Michael R. Hamblin, Roberto S. da Silva
Summary: We synthesized cis-[Ru(bpy)2(NO2-kappa N)Ln-](n-1) and cis-[Ru(bpy)2(NO2-kappa O)L n -](n-1) by reacting cis-[Ru(bpy)2(H2O) Ln-](n-2) with sodium nitrite or conducting basic cis-[Ru(bpy)2NO(Ln-)](n-3) hydrolysis. Photolysis at the metal-ligand charge transfer band (MLCT) of the isomers released nitric oxide (NO) at different rates. We investigated endothelium-dependent vasodilation induced by cis-[Ru(bpy)2(4-pic)(NO2-kappa N)]+ and cis-[Ru (bpy)2(4-pic)(NO2-kappa O)]+ in aortic rings and found that the release of NO was three times faster for cis-[Ru(bpy)2(NO2-kappa O)Ln-](n-1) compared to cis-[Ru(bpy)2(NO2-kappa N)Ln-](n-1).
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Medicinal
Barbara Terroni, Luis Henrique Oliveira de Moraes, Aline Renata Pavan, Gerson Jhonatan Rodrigues, Jean Leandro Dos Santos
Summary: The study found that Lapdesf-4c can induce vasodilation and counteract endothelial dysfunction, showing great potential as a new drug candidate.
Article
Chemistry, Multidisciplinary
Wen Zhou, Wanxiang Yang, Keyu Fan, Wuyang Hua, Shaohua Gou
Summary: In this study, a novel hypoxia-activated NO donor (Hano) was designed and prepared, which can increase NO release, dilate blood vessels, and attenuate myocardial hypoxia injury. This drug shows great potential for the treatment of hypoxic heart diseases.
Article
Chemistry, Analytical
Yafang Gao, Ziqi Wang, Jiening Wu, Liping Lu
Summary: A dual amplification strategy based on aggregation-induced and photoelectron transfer (PET) inhibition was developed for the highly sensitive detection of nitric oxide (NO) using a designed ruthenium-based complex. The strategy achieved a sensitive detection range of NO from 1.8 x 10-10 to 1.8 x 10-5 M with a detection limit of 60 pM, and showed excellent specificity with no detectable interference from reactive nitrogen species (RNS) and metal ions. Moreover, selective detection of NO in cells was achieved using this complex.
MICROCHEMICAL JOURNAL
(2023)
Article
Engineering, Environmental
Seung-Woon Baek, Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Semi Lee, Jeong Min Park, So-Yeon Park, Duck Hyun Song, Chun Gwon Park, Dong Keun Han
Summary: A novel nanoparticle with enhanced nitric oxide (NO) generating ability was synthesized to improve the biodegradable vascular scaffold (BVS) intervention for coronary artery diseases. The BVS containing the synthesized nanoparticles demonstrated potent functional recovery ability of unhealthy vessels by inhibiting platelet adhesion and activation, increasing endothelial cell proliferation, and decreasing smooth muscle cell proliferation. The BVS also showed scavenging ability of reactive oxygen species and inhibition of toxic NO production, with suppressed inflammatory response and induced healthy blood vessel formation when implanted in mice. This offers a new tool for designing cardiovascular stents and various biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Marjan Enayati, Karl H. Schneider, Ciarra Almeria, Christian Grasl, Christoph Kaun, Barbara Messner, Sabrina Rohringer, Ingrid Walter, Johann Wojta, Lubos Budinsky, Beat H. Walpoth, Heinrich Schima, Gerd Kager, Seth Hallstroem, Bruno K. Podesser, Helga Bergmeister
Summary: This study developed a drug-eluting vascular graft that releases nitric oxide to improve graft patency. The graft showed superior mechanical properties and anti-inflammatory effects in vitro, promoting endothelial cell proliferation while limiting smooth muscle cell proliferation. These findings suggest that the engineered vascular graft may provide promising features for the long-term success of small diameter vascular grafts.
ACTA BIOMATERIALIA
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Hassan A. Baalbaki, Kudzanai Nyamayaro, Julia Shu, Chatura Goonesinghe, Hyuk-Joon Jung, Parisa Mehrkhodavandi
Summary: Aluminum, gallium, and indium complexes were studied as catalysts for the copolymerization of CO2 and cyclohexene oxide. The indium complex exhibited higher conversion and selectivity compared to the aluminum and gallium analogues. The mechanism of the reaction and an off-cycle catalytic intermediate involving indium were investigated through experiments and structural characterization.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Rafaella Rebecchi Rios, Phamilla Gracielli Sousa Rodrigues, Juliana C. Biazzotto, Sergio Emanuel Galembeck, Roberto Santana da Silva
Summary: Nitrogen oxide derivative ruthenium compounds can release nitric oxide through chemical, electrochemical, or photochemical processes. Among them, nitrosyl ruthenium complexes have been extensively studied and the properties of ligands greatly affect the structure and NO delivery mode.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Artem A. Mikhailov, Theo Woike, Axel Gansmuller, Dominik Schaniel, Gennadiy A. Kostin
Summary: Photoinduced NO-linkage isomers in a labelled trans-[Ru((NO)-N-14/15)(py(4))F](ClO4)(2) complex were investigated in the solid state using IR-spectroscopy and DFT calculations. The experimental data and calculations allowed for a complete assignment of vibrational bands and provided insights into the structural changes leading to the downshift of certain bands. Long-time irradiation may induce irreversible reactions, such as the release of NO or nitrous oxide N2O.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)