From neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs?

Development of Novel Potent Orally Bioavailable Oseltamivir Derivatives Active against Resistant Influenza A

(2014) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop

(2013) Santosh Rudrawar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Design and Synthesis of C-1- and C-4-Modified Analogs of Zanamivir as Neuraminidase Inhibitors

(2013) Enguang Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

(2013) Chien-Hung Lin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity

(2013) J.-H. Kim et al.   SCIENCE

Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors

(2013) Christopher J. Vavricka et al.   Nature Communications

Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation

(2012) Ting-Jen R. Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs

(2012) Enguang Feng et al.   ChemMedChem

Enhanced Anti-influenza Agents Conjugated with Anti-inflammatory Activity

(2012) Kung-Cheng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antivirals Targeting Influenza A Virus

(2012) Kalyan Das   JOURNAL OF MEDICINAL CHEMISTRY

Development of Oseltamivir Phosphonate Congeners as Anti-influenza Agents

(2012) Ting-Jen R. Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Increasing Oral Absorption of Polar Neuraminidase Inhibitors: A Prodrug Transporter Approach Applied to Oseltamivir Analogue

(2012) Deepak Gupta et al.   MOLECULAR PHARMACEUTICS

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility

(2012) Santosh Rudrawar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

(2012) C. M. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B

(2012) Benjamin H. Fraser et al.   MedChemComm

Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain

(2012) Helen M. Wise et al.   PLoS Pathogens

Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir

(2011) Kung-Cheng Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes

(2011) Amgad Albohy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peramivir: Another Tool for Influenza Treatment?

(2011) S. Jain et al.   CLINICAL INFECTIOUS DISEASES

Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza

(2011) Hideyuki Ikematsu et al.   Expert Review of Anti-Infective Therapy

A Practical Synthesis of Zanamivir Phosphonate Congeners with Potent Anti-influenza Activity

(2011) Jiun-Jie Shie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing the Intestinal Membrane Permeability of Zanamivir: A Carrier Mediated Prodrug Approach

(2011) Sheeba Varghese Gupta et al.   MOLECULAR PHARMACEUTICS

Biotin-, fluorescein- and ‘clickable’ conjugates of phospha-oseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase

(2011) Mathew Stanley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mechanism of 150-cavity formation in influenza neuraminidase

(2011) Rommie E. Amaro et al.   Nature Communications

Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration

(2010) S. Kubo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses

(2010) Wen-Hsien Wen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oseltamivir in Seasonal, Avian H5N1 and Pandemic 2009 A/H1N1 Influenza

(2010) Nicolas Widmer et al.   CLINICAL PHARMACOKINETICS

Clinical Pharmacokinetics of Laninamivir, a Novel Long-Acting Neuraminidase Inhibitor, After Single and Multiple Inhaled Doses of Its Prodrug, CS-8958, in Healthy Male Volunteers

(2010) Hitoshi Ishizuka et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

(2010) Sankar Mohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Attaching Zanamivir to a Polymer Markedly Enhances Its Activity Against Drug-resistant Strains of Influenza a Virus

(2010) Alisha K. Weight et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays

(2010) Hsin-Yu Liao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enabling the Intestinal Absorption of Highly Polar Antiviral Agents: Ion-Pair Facilitated Membrane Permeation of Zanamivir Heptyl Ester and Guanidino Oseltamivir

(2010) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Influenza Vaccines for the Future

(2010) Linda C. Lambert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

(2010) Stephanie Bertram et al.   REVIEWS IN MEDICAL VIROLOGY

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

(2010) Santosh Rudrawar et al.   Nature Communications

CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract

(2009) K. Koyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en

(2009) Takeshi Honda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient Synthesis of Highly Active Phospha-Isosteres of the Influenza Neuraminidase Inhibitor Oseltamivir

(2009) Benoit Carbain et al.   ChemMedChem

Synthetic and Natural Immunomodulators Acting as Interferon Inducers

(2009) Dmytro Silin et al.   CURRENT PHARMACEUTICAL DESIGN

Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: why they are needed and how they might work

(2009) David S. Fedson   Influenza and Other Respiratory Viruses

The Evolution of Influenza Resistance and Treatment

(2009) David M. Weinstock   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase

(2009) Jianghong An et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic Effect of Zanamivir−Porphyrin Conjugates on Inhibition of Neuraminidase and Inactivation of Influenza Virus

(2009) Wen-Hsien Wen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born Molecular Dynamics and End-Point Free Energy Calculations

(2009) Rommie E. Amaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prescription of anti-influenza drugs for healthy adults: a systematic review and meta-analysis

(2009) Jane Burch et al.   LANCET INFECTIOUS DISEASES

The Emergency Use Authorization of Peramivir for Treatment of 2009 H1N1 Influenza

(2009) Debra Birnkrant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Transmission of Oseltamivir-Resistant Influenza

(2009) Anne Moscona   NEW ENGLAND JOURNAL OF MEDICINE

Galactose-conjugates of the oseltamivir pharmacophore—new tools for the characterization of influenza virus neuraminidases

(2009) Benoit Carbain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bifunctional Polymeric Inhibitors of Human Influenza A Viruses

(2009) Jayanta Haldar et al.   PHARMACEUTICAL RESEARCH

Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography

(2009) Yasuaki Kimura et al.   TETRAHEDRON LETTERS

CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity

(2008) M. Yamashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol

(2008) Irina A. Leneva et al.   ANTIVIRAL RESEARCH

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

(2008) Patrick J. Collins et al.   NATURE

Phosphate coordination and movement of DNA in the Tn5 synaptic complex: role of the (R)YREK motif

(2008) Vadim A. Klenchin et al.   NUCLEIC ACIDS RESEARCH

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

(2008) B.-J. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlates of protection: Novel generations of influenza vaccines

(2008) Guus F. Rimmelzwaan et al.   VACCINE

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

(2007) Fujun Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES