Article
Engineering, Biomedical
Chunzi Shi, Xueni Huang, Dong Wang, Chengshengze Chu, Yuxin Shi, Bo Yan, Fei Shan, Jiulong Zhang, Zhiyong Zhang, Chen Peng, Ben Zhong Tang
Summary: This study selected three lipophilic aggregation-induced emission (AIE) photosensitizers to achieve real-time and non-invasive visualization of the process of mycobacteria infection. These AIEgens showed efficient antibacterial properties and can be triggered by white light to produce reactive oxygen species (ROS). The photosensitizer TTMN exhibited outstanding antibacterial efficacy and also increased the expression of pro-inflammatory cytokines.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Jiwoong Choi, In-Cheol Sun, Hee Sook Hwang, Hong Yeol Yoon, Kwangmeyung Kim
Summary: Photodynamic nanomedicines have improved the therapeutic efficacy of photosensitizers by overcoming their limitations. Functional photodynamic nanomedicines can overcome the oxygen depletion and tissue light penetration limitations of photodynamic therapy. Recent studies have shown that combining photodynamic nanomedicines with chemotherapy or immune checkpoint inhibitor therapy can treat metastatic tumors systemically by inducing antitumor immune responses.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao, Meng Meng
Summary: In this study, a tetrahedral DNA-based nanosystem was designed to load IR780, improving its solubility and stability for cancer phototherapy. The nanoformulation showed promising results in enhancing tumor targeting and anti-tumor effects of IR780, indicating potential for intravenous administration of IR780 in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Medicine, Research & Experimental
Elzbieta Ostasnka, David Aebisher, Dorota Bartusik-Aebisher
Summary: Photodynamic Therapy (PDT) is a well-known alternative cancer treatment that relies on light activation of a photosensitizer in the presence of oxygen to induce cytotoxic effects in cancer cells. Proper light delivery and the selection of an appropriate photosensitizer are crucial for the effectiveness of PDT in treating cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Eurico Lima, Andreia G. Barroso, Margarida A. Sousa, Octavio Ferreira, Renato E. Boto, R. Fernandes, Paulo Almeida, Samuel M. Silvestre, Adriana O. Santos, Lucinda V. Reis
Summary: Novel Squaraine dyes were designed and synthesized, and their interactions with human albumin, phototoxicity activity, and cellular properties were evaluated.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xueyan Feng, Lele Li, Yuliang Zhao, Mengyuan Li
Summary: By engineering enzyme-responsive units in the loop region of DNA-based PMBs, a modular design of an enzyme/microRNA dual-regulated PMB (D-PMB) is proposed to achieve cancer-cell-selective amplification of PDT efficacy. The inert photosensitizers in D-PMB could be repeatedly activated in the presence of both tumor-specific enzyme and miRNA, leading to enhanced generation of cytotoxic single oxygen species and improved PDT efficacy in vitro and in vivo. This work presents a cooperatively activated PDT strategy, which conceptualizes an approach to design smart tumor treatment modality that enhances therapeutic efficacy with tumor-specificity.
Article
Nanoscience & Nanotechnology
Zongze Wu, Quan Liu, Swelm Wageh, Zhe Sun, Omar A. Al-Hartomy, Abdullah G. Al-Sehemi, Lesen Yan, Jiaojuan Chen, Wenjian Zhang, Jilin Yang, Han Zhang, Liping Liu
Summary: A smart photosensitive NiPS3 nanosheet was developed to address the issue of low oxygen content in solid tumors, which limits the efficacy of photodynamic therapy (PDT) against cancer.
Article
Biochemistry & Molecular Biology
Desislava Staneva, Awad Said, Evgenia Vasileva-Tonkova, Ivo Grabchev
Summary: This study addresses the need for antibacterial medication that can overcome the current problems of antibiotics. It suggests using fluorescent derivatives covalently bonded to the surface of cotton fabric to achieve enhanced antimicrobial activity. The results show that these compounds exhibit stronger antibacterial activity under light irradiation.
Review
Pharmacology & Pharmacy
Marta Olszowy, Martyna Nowak-Perlak, Marta Wozniak
Summary: Photodynamic diagnostics (PDD) and photodynamic therapy (PDT) are established medical technologies for the diagnosis and treatment of malignant neoplasms, utilizing photosensitizers, light, and oxygen. This review highlights recent advancements in nanotechnology, such as using quantum dots as photosensitizers or energy donors, liposomes, and micelles. Furthermore, it explores the combination of PDT with other treatment modalities and discusses the promising enhancements in PDD and PDT in the field of oncology.
Article
Oncology
Qing Xie, Meng Su, Yang Liu, Dawei Zhang, Zhen Li, Mingfeng Bai
Summary: Photodynamic therapy (PDT) is a clinically approved therapeutic strategy that combines a specific wavelength of light and light-activated photosensitizers (PSs). The usage of PDT for cancer treatment is often hindered by the lack of tumor selectivity of PSs, but the development of novel TSPO-PSs with high affinity for TSPO may provide efficient and target-specific PDT effect in tumors associated with high-TSPO expression.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Oncology
James Yao, Emily Bergsland, Rahul Aggarwal, Ana Aparicio, Himisha Beltran, Judy S. Crabtree, Christine L. Hann, Toni Ibrahim, Lauren A. Byers, Hironobu Sasano, John Umejiego, Marianne Pavel
Summary: Neuroendocrine neoplasms (NEN) are heterogeneous malignancies classified into well-differentiated neuroendocrine tumors (NET) and poorly differentiated neuroendocrine carcinomas (NEC). Delta-like ligand 3 (DLL3) overexpression in NEN is associated with tumorigenesis. Therapeutic targeting of DLL3 has shown promising clinical activity in small-cell lung cancer (SCLC).
Article
Chemistry, Multidisciplinary
Lichao Su, Yiming Chen, Hongqi Huo, Naishun Liao, Ying Wu, Xiaoguang Ge, Zhiyong Guo, Zhongxiang Chen, Xuan Zhang, Jibin Song
Summary: A novel therapeutic monitoring platform has been developed in this study to monitor the efficacy of photodynamic therapy in real time and evaluate the treatment effect in vivo. This probe can effectively quantify and monitor the concentration and consumption of reactants using chemiluminescence and fluorescence signal changes generated by light excitation, providing strong support for achieving more precise treatment.
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes have great potential as photosensitizers for photodynamic therapy. The modular architectures of these complexes allow for tuning of various properties such as cellular uptake, subcellular targeting, solubility, and light absorption. Many studies focus on systematic variation of ligands to investigate their impact on photophysical and photobiological performance. However, comparisons between Ru(II)-based PSs and other generations of PSs are scarce. Nonetheless, quantitative models based on PDT dose metrics are available for qualitative comparisons. This review summarizes the relevant studies on Ru(II)-containing PSs and their potential efficacy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Manjunatha Ankathatti Munegowda, Angelica Manalac, Madrigal Weersink, Sherri A. McFarland, Lothar Lilge
Summary: Ruthenium(II)-based coordination complexes are promising photosensitizers for photodynamic therapy with potential in oncology and antimicrobial fields. These complexes can be tuned for different photophysical properties and studies comparing their efficacy to other PSs are limited but possible using PDT dose metrics.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Andreea Crintea, Alexandru Catalin Motofelea, Alina Simona Sovrea, Anne-Marie Constantin, Carmen-Bianca Crivii, Rahela Carpa, Alina Gabriela Dutu
Summary: Cancer is a leading cause of death worldwide, and invasive methods such as surgery, chemotherapy, and radiotherapy are commonly used for treatment. However, these methods can have severe adverse reactions. Nanomaterials, specifically dendrimers, are being increasingly explored as structures for anticancer therapies due to their unique properties. Dendrimers can be controlled to obtain compounds with desired characteristics and used for targeted distribution of pharmacological substances for cancer diagnosis and treatment. They can simultaneously achieve multiple objectives in anticancer therapy, such as targeted delivery, controlled release, and combination with other anticancer strategies. This review aims to summarize and highlight the potential uses of dendrimers in oncological conditions.
Article
Chemistry, Multidisciplinary
Karolis Norvaisa, Sophie Maguire, Claire Donohoe, John E. O'Brien, Brendan Twamley, Ligia C. Gomes-da-Silva, Mathias O. Senge
Summary: Inspired by 'picket-fence' systems, this study utilized strain to introduce intramolecular tension, leading to selective compound atropisomer conversion and the formation of distinctive supramolecular nanostructures.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Arno Wiehe, Mathias O. Senge
Summary: This review provides an overview of the research, development, and clinical applications of the photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (mTHPC, temoporfin) in photodynamic (cancer) therapy (PDT) and other medical applications. The review covers the chemistry, biochemistry, pharmacology, and clinical applications of temoporfin, including the formulation development such as liposomal formulations. The literature covered spans from 2009 to early 2022 and is connected to a previous extensive review on this photosensitizer, which traces its development, approval, and clinical application.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Organic
Claire Donohoe, Asterios Charisiadis, Sophie Maguire, Brendan Twamley, Fabio A. Schaberle, Ligia C. Gomes-da-Silva, Mathias O. Senge
Summary: The time dependence of atropisomer interconversion has hindered the development of single atropisomer drug candidates. The instability caused by moderate interconversion energy barriers is a concern for drug stability. However, there is a recent focus on developing stable atropisomer drugs with enhanced activity.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Biao Yang, Kaifeng Niu, Nan Cao, Nitika Grover, Wenchao Zhao, Alexander Riss, Jonas Bjoerk, Willi Auwaerter, Johannes V. Barth, Mathias O. Senge
Summary: In this study, the behavior of 1,3-disubstituted BCP moieties on metal surfaces was examined using low-temperature scanning tunneling microscopy/non-contact atomic force microscopy studies and density functional theory modeling. The configuration, supramolecular assembly, and thermally activated dehalogenative coupling reactions of BCP-containing precursors on Au(111) were investigated, resulting in the formation of polymeric chains. These findings provide sub-molecular insights into the behavior of BCP scaffolds on surfaces and expand the potential application of BCP derivatives in custom-designed surface architectures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Nitika Grover, Maxime Cheveau, Brendan Twamley, Christopher J. Kingsbury, Cornelia M. Mattern, Mathias O. Senge
Summary: We present a two-step method for obtaining versatile bicyclo[1.1.1]pentane (BCP) derivatives using Grignard reagents. This approach allows for the incorporation of BCP units into tetrapyrrolic macrocycles, as well as the synthesis of a novel class of calix[4]pyrrole analogues by replacing bridging methylene groups with BCP units. Moreover, electron-withdrawing substituents at the BCP bridgeheads lead to the formation of a doubly N-confused system. Single-crystal X-ray diffraction analyses and 2D NMR spectroscopy reveal that the pyrrole rings in BCP-containing macrocycles exist in 1,3-alternate or alpha beta alpha beta conformations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Irina Osadchuk, Hanna-Eliisa Luts, Karolis Norvaisa, Victor Borovkov, Mathias O. Senge
Summary: The determination of molecular stereochemistry and absolute configuration is important in chemistry, pharmacology, and biology. Electronic circular dichroism (ECD) is a widely used tool for chirality assignment, but the mechanisms of induced ECD in porphyrin complexes are not fully understood.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Crystallography
Harry C. Sample, Brendan Twamley, Mathias O. Senge
Summary: The crystal structures of three S-(pyridin-2-yl) benzothioesters with different para-phenyl substituents are reported. These compounds are used in the mono-acylation of pyrrolic species to produce multifunctional tetrapyrroles. The dominant interactions in the crystal packing vary from pi-pi stacking in compound 1 to exclusively C-H···O/N interactions in compound 3 as the para-phenyl motif changes from electron withdrawing to electron donating.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Crystallography
Harry C. Sample, Brendan Twamley, Mathias O. Senge
Summary: The crystal structure of compound 1 (C26H24Br2N4O8S2) is presented in this study. Compound 1 was obtained as a by-product in the synthesis of geminal-dimethyl hydrodipyrrins. Unexpected enantiomeric resolution was observed in both the bulk sample and crystal of 1, with distinct C-H···O (C-methyl-H···O-nitro, C-sp3-H···O-sulfonyl) interactions present in the enantiomers, along with other interactions, forming a polymer along the c-axis direction. Little data is available on the 1,3-dinitrobutane scaffold, unlike the well-documented pyrrolic fragments.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Davide Ranieri, Alberto Privitera, Fabio Santanni, Karolina Urbanska, Grant J. Strachan, Brendan Twamley, Enrico Salvadori, Yu-Kai Liao, Mario Chiesa, Mathias O. Senge, Federico Totti, Lorenzo Sorace, Roberta Sessoli
Summary: By synthesizing and studying a VIVO-CuII porphyrin dimer, we observed measurable exchange coupling and good spin coherence, making it suitable for operating two-qubit molecular spin-based quantum gates under various conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Irina Osadchuk, Hanna-Eliisa Luts, Karolis Norvaisa, Victor Borovkov
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Editorial Material
Chemistry, Multidisciplinary
Irina Osadchuk, Hanna-Eliisa Luts, Karolis Norvaisa, Victor Borovkov, Mathias O. Senge
Summary: This article features the groups of Irina Osadchuk at Tallinn University of Technology and Mathias Senge at Trinity College Dublin. The image illustrates the measurement and simulation of ECD and UV-Vis spectra of a porphyrin molecule with two guest molecules (R)-camphor sulfonic acid under UV-visible light irradiation. Read the full text of the article at 10.1002/chem.202301408.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Nan Cao, Jonas Bjoerk, Eduardo Corral-Rascon, Zhi Chen, Mario Ruben, Mathias O. Senge, Johannes V. Barth, Alexander Riss
Summary: This study investigates how aromaticity affects the reactivity of alkyne-substituted porphyrin molecules on a Au(111) surface. The experiments show that carbon atoms stabilized by aromaticity display lower reactivity, which is consistent with density functional theory calculations.
Review
Chemistry, Multidisciplinary
Tomoya Ishizuka, Nitika Grover, Christopher J. Kingsbury, Hiroaki Kotani, Mathias O. Senge, Takahiko Kojima
Summary: This article summarizes the synthetic methods and design aspects of nonplanar porphyrin formation, the key properties and functionality of the nonplanar aromatic framework, and the scope and utility of this emerging class in addressing important scientific, industrial, and environmental issues.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Karolis Norvaisa, John E. O'Brien, Irina Osadchuk, Brendan Twamley, Victor Borovkov, Mathias O. Senge
Summary: In this study, we investigated the activity and symmetry of porphyrin-based supramolecular receptors in a chiral environment through NMR analysis of atropisomeric receptors. By exploiting the hydrogen bond abilities of the exposed porphyrin inner core, we found that N-H signals in a previously underutilized region of the spectrum can detect enantiomeric compositions with three times higher sensitivity than previously reported systems.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Robby Buechner, Vinicius Vaz da Cruz, Nitika Grover, Asterios Charisiadis, Mattis Fondell, Robert Haverkamp, Mathias O. Senge, Alexander Foehlisch
Summary: Free base porphyrins, such as 5,10,15,20-tetrakis(4-carboxylatophenyl)porphyrin, are powerful photosensitizers for singlet oxygen generation and light-harvesting. The atomic level selectivity of dynamic UV pump - N K-edge probe X-ray absorption spectroscopy, combined with TD-DFT theory, provides insight into the excited molecular states within an unusual relaxation pathway. The efficient intersystem crossing is confirmed to be the result of long singlet excited state lifetime and thermal effects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
