Review
Pharmacology & Pharmacy
Sheila I. Pena-Corona, Hector Hernandez-Parra, Sergio A. Bernal-Chavez, Nestor Mendoza-Munoz, Alejandra Romero-Montero, Maria Luisa Del Prado-Audelo, Hernan Cortes, Dilek Arslan Atessahin, Solomon Habtemariam, Zainab M. Almarhoon, Ahmad Faizal Abdull Razis, Babagana Modu, Javad Sharifi-Rad, Gerardo Leyva-Gomez
Summary: Cancer is a major cause of death worldwide and poses significant clinical, social, and financial burdens. Traditional cancer chemotherapies have limitations, and there is a need for bioactive anticancer compounds. Neopeltolide, a macrolide derived from deep-water sponges, shows promise as a novel drug for cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tetiana Melnyk, Esther Masia, Oleksandr Zagorodko, Inmaculada Conejos-Sanchez, Maria J. Vicent
Summary: Brain tumors, specifically malignant gliomas, are a major cause of pediatric cancer death. In this study, we synthesized a family of polyglutamate-palbociclib conjugates to overcome limitations associated with free palbociclib in the treatment of pediatric brain tumors. We evaluated the activity of these conjugates in different types of brain tumor cells and discovered that the microenvironment and conformational changes influenced drug release kinetics and therapeutic output.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Medicinal
Lei Yu, Xiaofang Xie, Xiaoyu Cao, Junren Chen, Guanru Chen, Yan Chen, Gangmin Li, Junyuan Qin, Fu Peng, Cheng Peng
Summary: Maslinic acid and its derivatives have shown inhibitory effects on various types of cancer cells, with potential as a future anti-tumor therapeutic agent. Further studies are warranted to explore the broad prospects of MA derivatives in cancer treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Dechao Tan, Hisa Hui Ling Tseng, Zhangfeng Zhong, Shengpeng Wang, Chi Teng Vong, Yitao Wang
Summary: This article reviews the therapeutic effects and related mechanisms of glycyrrhizic acid (GL) and its derivatives in managing blood glucose levels and treating type 2 diabetes mellitus (T2DM) and its complications. It also discusses existing clinical trials and highlights the research gap in clinical research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Blazej Grodner, Mariola Napiorkowska, Dariusz Maciej Pisklak
Summary: The study investigated the effects of compounds (I) and (II) on acid phosphatase, revealing that compound (I) exhibited stronger competitive inhibition while derivative (II) showed weaker competitive inhibition. The type and strength of inhibition as well as affinity of these compounds depended on the type of substituent in the main chemical molecule.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
L. Gao, I. Miletto, C. Ivaldi, G. Paul, L. Marchese, S. Coluccia, F. Jiang, E. Gianotti, M. Pera-Titus
Summary: A new catalyst based on crystalline silicoaluminophosphate SAPO-5 with hierarchical porosity and optimized silicon content was developed for the one-pot synthesis of tetrahydrofuran derivatives. NH3-TPD and FT-IR spectroscopy were used to assess the acidity and accessibility of the catalyst, which showed potential for efficient hydrogenation reactions.
JOURNAL OF CATALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Omaima M. AboulWafa, Hoda M. G. Daabees, Ahmed H. El-Said
Summary: A novel series of benzoxazole-appended piperidine derivatives were synthesized and screened for their antiproliferative activity against breast cancer cell lines. The compounds showed potent activity against MCF-7 and MDA-MB-231 cell lines, surpassing the activity of doxorubicin. Some of the active compounds demonstrated strong EGFR inhibition and apoptosis-inducing properties. Docking studies revealed their potential as candidates for EGFR inhibition and apoptosis induction.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Lihua Huang, Zonghao Sun, Qian Shen, Zhongxi Huang, Shuangxi Wang, Naidi Yang, Gongqiang Li, Qiong Wu, Wei Wang, Lin Li, Changmin Yu
Summary: This article provides an overview of the application of mitochondria-targeted nanocarriers in function regulation and discusses the advantages and disadvantages of different strategies for nanocarrier targeting of mitochondria. The article also explores the future prospects of mitochondria-targeted delivery systems in drug-based therapeutics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yue Liu, Peng-Xiao Li, Wen-Wen Mu, Ya-Lei Sun, Ren-Min Liu, Jie Yang, Guo-Yun Liu
Summary: This work focuses on the design and synthesis of barbituric acid derivatives containing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds for the development of potent anticancer agents. The results showed that certain substitutions on the benzyl ring of barbituric acid derivatives led to increased antiproliferative activities. Mechanistic investigation revealed the potential of one derivative to induce cell cycle arrest and increase ROS levels.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Physical
Ossama Daoui, Souad Elkhattabi, Samir Chtita
Summary: Researchers conducted computational studies and simulations to investigate the potential of pyridine derivatives as MALT1 allosteric inhibitors. Two optimal candidate compounds were identified, providing valuable insights for the design of new drugs for lymphoma therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Pervaiz Ali Channar, Mubashir Aziz, Syeda Abida Ejaz, Gul-e-Saba Chaudhry, Amna Saeed, Rabail Ujan, Abbas Hasan, Syeda Rabia Ejaz, Aamer Saeed
Summary: The synthesis of compounds with a thiazolidinone pharmacophore was achieved, and their anticancer activities were evaluated. Compounds 2c and 2d exhibited significant cytotoxicity against MCF-7 and HeLa cell lines by inducing apoptosis. Molecular docking and dynamic simulations provided further support to these findings, and computational studies suggested the potential of these compounds as lead molecules for the development of novel drug candidates for specific cancers.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Medicine, Research & Experimental
Shumaila Ijaz, Javed Iqbal, Banzeer Ahsan Abbasi, Zakir Ullah, Tabassum Yaseen, Sobia Kanwal, Tariq Mahmood, Sandugash Sydykbayeva, Alibek Ydyrys, Zainab M. Almarhoon, Javad Sharifi-Rad, Christophe Hano, Daniela Calina, William C. Cho
Summary: Cancer remains a major cause of death globally, and rosmarinic acid (RA) is a bioactive compound found in plants. This review highlights the chemopreventive and chemotherapeutic effects of RA and its derivatives, providing clues for the development of complementary drugs for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Chiranjeev Sharma, Myeong A. Choi, Yoojin Song, Young Ho Seo
Summary: In this study, heterobifunctional small molecules were designed and synthesized, which combine HSF1 inhibitor and anticancer drug through E3 ligase-mediated proteolysis, selectively degrading cancerous proteins.
Review
Chemistry, Multidisciplinary
Mandira Majumder, Haneesh Saini, Ivan Dedek, Andreas Schneemann, Nilesh R. Chodankar, Viswanatha Ramarao, Mysore Sridhar Santosh, Ashok Kumar Nanjundan, Stepan Kment, Deepak Dubal, Michal Otyepka, Radek Zboril, Kolleboyina Jayaramulu
Summary: The conversion of nitrogen to ammonia is environmentally friendly, but the low efficiency and slow production of ammonia are current challenges.
Article
Biophysics
Yuta Koda, Yukio Nagasaki
Summary: In this study, novel self-assembling antioxidants based on L-cysteine were developed to reduce the adverse effects of conventional antioxidants. These antioxidants showed high stability and low toxicity in vitro and in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Analytical
Nadeem A. Khan, Sirajuddin Ahmed, Izharul Haq Farooqi, Imran Ali
Summary: The article discusses the application of various technologies in the treatment of pharmaceutical and wastewater. It highlights the need for better technologies to improve removal rates of certain elements that inhibit neurotransmitter activity and proliferation. Additionally, the combination of activated sludge and membrane filtration bioreactors shows higher removal efficiency, while ozonation enhances biodegradability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Imran Ali, Stoyanova Alyona, Kon'kova Tatiana, Gaydukova Anastasiya, Hassan M. Albishri, Wael Hamad Alshitari
Summary: A sorption-electroflotation method using carbon nanomaterials was developed to remove non-biodegradable and carcinogenic toxic metal ions. Carbon nanotubes (CNTs) and carbon nanoshells (CNSs) were used to remove Ni(II), Co(II), Zn(II), Fe(II), and Cu(II). Surface properties and composition of the nanomaterials were characterized, and different models were applied to analyze the data. The method showed excellent removal efficiency, with the highest percentage removal achieved through simultaneous sorption-electroflotation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Imran Ali, Hokman Mahmudov, Gunel Imanova, Telman Suleymanov, Ahmed M. Hameed, Ahmed Alharbi
Summary: Hydrogen production through water splitting using Al2O3 nanoparticles as a radiation catalyst with gamma rays irradiation was studied. The effects of different particle sizes, surface area, amounts of radiation catalyst, and irradiation time were investigated. It was found that smaller-sized nanoparticles resulted in higher hydrogen production.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Analytical
Valentina Greco, Marcello Locatelli, Fabio Savini, Ugo de Grazia, Ottavia Montanaro, Enrica Rosato, Miryam Perrucci, Luigi Ciriolo, Abuzar Kabir, Halil Ibrahim Ulusoy, Cristian D'Ovidio, Imran Ali, Alessandro Giuffrida
Summary: This article discusses the primary cause of poor and ambiguous results in the bioanalytical process, which is sample pre-treatment, particularly in clinical analysis. It focuses on both classical and new techniques for pre-treatment of complex sample matrices. The use of green solvents and alternative biological samples like saliva, as well as new techniques that require minimal sample pre-treatment, are explored. The article is divided into sections on clinical applications and sample preparation techniques for diagnostic purposes.
Article
Materials Science, Multidisciplinary
Imran Ali, Teymur Agayev, Gunel T. Imanova, Hokman Mahmudov, Shahla Musayeva, Omar M. L. Alharbi, Mohammad Nahid Siddiqui
Summary: The production of economic green hydrogen fuel is in high demand. In this study, hydrogen generation by water radiolysis of a hexane-water system on ZrO2 surface was investigated at different temperatures. The radiation-catalytic decomposition of hexane-water increased at high temperatures and resulted in an increase in hydrogen production. At a temperature of 673 K, a chain mode conversion of the key products of hexane-water led to molecular hydrogen. The maximum yield of hydrogen achieved was 188.5 molecule/100 eV with the n-ZrO2 + C6H14(ads)-water (0.003 g: 0.0051 g: 0.0015 g) system at 673 K.
Review
Biochemistry & Molecular Biology
Cristian D'Ovidio, Marcello Locatelli, Miryam Perrucci, Luigi Ciriolo, Kenneth G. Furton, Isil Gazioglu, Abuzar Kabir, Giuseppe Maria Merone, Ugo de Grazia, Imran Ali, Antonio Maria Catena, Michele Treglia, Luigi T. Marsella, Fabio Savini
Summary: LC-MS/MS plays a crucial role in screening and tracking pharmacotoxicological and forensic cases due to its advanced features. This review paper focuses on its applications in pharmacotoxicology and highlights its importance in the development of pharmacological and forensic research. It discusses therapeutic drug monitoring and clinical approaches as well as the determination of illicit drugs.
Review
Chemistry, Multidisciplinary
Valentina Greco, Alessandro Giuffrida, Marcello Locatelli, Fabio Savini, Ugo de Grazia, Luigi Ciriolo, Miryam Perrucci, Abuzar Kabir, Halil Ibrahim Ulusoy, Cristian D'Ovidio, Imran Ali
Summary: This review focuses on the sample preparation for forensic analysis, including elimination of interferents, specimen cleanup, and extraction of analytes of interest to reduce matrix effect. The selection of literature provides a general overview of the state-of-the-art in this field. Different biological matrices, such as blood and urine, are commonly used to investigate substances related to death, while other body fluids like bile and oral fluids are still under discussion for their usability. The review also categorizes solid matrices obtained after autopsy into conventional and unconventional matrices for better understanding, considering widely used pretreatment techniques and representative innovative techniques.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Analytical
Syed Dilshad Alam, Mirza Adil Beg, Muralidhararao Bagadi, Marcello Locatelli, Zeid A. Alothman, Mohd Mustaqeem, Imran Ali
Summary: Berberine was extracted from Berberis vulgaris, Berberis aquifolium, and Hydrastis canadensis using ethanol and water (70:30, v/v). The extracted berberine was characterized using UV-visible and Fourier-transform infrared spectroscopy. Thin-layer chromatography and high-performance liquid chromatography (HPLC) methods were both employed for the separation and identification of berberine, and showed different applications. The extracted berberine exhibited better activity in treating Leishmaniosis compared to the standard drug Amphotericin B.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Khadidja Addadi, Khaled Sekkoum, Nasser Belboukhari, Zeid A. ALOthman, Ahmed M. Aljuwayid, Mika Sillanpaa, Imran Ali
Summary: In this study, the enantio-separation of three chiral sulfoxide drugs was achieved on a Chiralpak AS-3R column using acetonitrile-water as the mobile phase. The chiral separation was validated properly with LOD and LOQ values of 9.70-14.16 and 29.39-42.91 μg/mL, respectively. The enantiomer elution order was confirmed through experimental and theoretical methods. A simple, fast, reliable, and thermodynamically stable HPLC method was developed for the separation and determination of enantiomer elution order of the chiral sulfoxide drugs.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Imran Ali, Anastasya Gaydukova, Tatiana Kon'kova, Zeid Abdullah ALOthman, Mika Sillanpaa
Summary: This study investigated the acid leaching process of grinding waste from a heat-resistant nickel alloy. Optimal conditions for acid dissolution were established to maximize the extraction of nickel, the main component of the alloy. These results are significant for industry professionals in metal recovery and environmentalists in waste treatment.
Article
Engineering, Chemical
Imran Ali, Aleksandr Shchegolkov, Aleksey Shchegolkov, Maksim Aleksandrovich Chumak, Nashchekin Alexey Viktorovich, Likhachev Kirill Vasilievich, Gunel Imanova, Tonni Agustiono Kurniawan, Mohamed A. Habila
Summary: Multi-walled carbon nanotubes (MWCNTs) synthesized by the microwave method were found to enhance the thermal and electrical conductivity of silicone elastomers. The highest thermal conductivity achieved was 0.48 W/m°C with 8.0 wt% MWCNTs, while the highest electrical conductivity reached 2.4 x 10-5 S/cm. Microwave-synthesized MWCNTs demonstrated high stability in an electrical resistance heater application, making them suitable for household appliances.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Energy & Fuels
Muhammad Sarfraz Arshad, Xavier Yangkou Mbianda, Imran Ali, Wanbing Guan, Tariq Kamal, Kimmo Kauhaniemi, Syed Zulqadar Hassan, Ghulam Yasin
Summary: This paper discusses the importance of nanomaterials in solid oxide fuel cells and the enhancement of active sites for electrode reactions through nanoengineering and composite approaches. The use of nanotechnology enables environmentally friendly and sustainable manufacturing processes for SOFCs. Additionally, the paper provides an overview of the applications of SOFCs, notable research institutions and companies, and future challenges and perspectives.
Article
Chemistry, Multidisciplinary
Imran Ali, Aicha Kraimi, Nasser Belboukhari, Khaled Sekkoum, Mouslim Messali
Summary: In order to enhance the anticoagulant activity of acenocoumarol, five new imino derivatives were synthesized and characterized. These derivatives were separated into their stereoisomers using chiral HPLC. The absolute configuration of all 20 stereoisomers was determined and their biological activities were predicted using DFT calculations.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemical Research Methods
Maha Hasni, Nasser Belboukhari, Khaled Sekkoum, Raluca-Ioana Stefan-van Staden, Zeid A. Alothman, Ersin Demir, Imran Ali
Summary: The essential oil of Heliotropium bacciferum plant has significant medicinal value, and this study extracted and analyzed its essential oil, as well as evaluated its anti-inflammatory and anti-bacterial activities. The results showed that the essential oil displayed effective anti-inflammatory and anti-bacterial properties, indicating its potential as a therapeutic agent.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Farhat Habib, Asghar Ali, Iram Irfan, Amir Azam, Mohammad Abid, Imran Ali
Summary: In this study, a series of novel 1,2,4-oxadiazole-sulfonamide conjugates were synthesized and evaluated for their antimicrobial activity. Compound 8d showed significant inhibitory activity against both Gram-positive and Gram-negative bacterial strains, and exhibited synergistic effect with some antibiotics. It also demonstrated favorable drug-like characteristics and no toxicity towards human red blood cells.
