Cholera: pathophysiology and emerging therapeutic targets

Cholera

(2012) Jason B Harris et al.   LANCET

Hydroxyxanthone as an inhibitor of cAMP-activated apical chloride channel in human intestinal epithelial cell

(2012) Wachiraporn Luerang et al.   LIFE SCIENCES

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins

(2012) Jin A. Cho et al.   Frontiers in Cellular and Infection Microbiology

A High-Throughput Screening Assay for Inhibitors of Bacterial Motility Identifies a Novel Inhibitor of the Na+-Driven Flagellar Motor and Virulence Gene Expression in Vibrio cholerae

(2011) Lynn Rasmussen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Developing novel antisecretory drugs to treat infectious diarrhea

(2011) Eugenio L de Hostos et al.   Future Medicinal Chemistry

Vibrio choleraeinfection, novel drug targets and phage therapy

(2011) Mobashar Hussain Urf Turabe Fazil et al.   Future Microbiology

Structural and Functional Interactions between the Cholera Toxin A1 Subunit and ERdj3/HEDJ, a Chaperone of the Endoplasmic Reticulum

(2011) Shane Massey et al.   INFECTION AND IMMUNITY

Protection and Attachment of Vibrio cholerae Mediated by the Toxin-Coregulated Pilus in the Infant Mouse Model

(2011) S. J. Krebs et al.   JOURNAL OF BACTERIOLOGY

The Role and Specificity of the Catalytic and Regulatory Cation-binding Sites of the Na+-pumping NADH:Quinone Oxidoreductase fromVibrio cholerae

(2011) Oscar Juárez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Action of the Chalcone Isoliquiritigenin as a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Inhibitor: Potential Therapy for Cholera and Polycystic Kidney Disease

(2011) Chatchai Muanprasat et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

New-generation vaccines against cholera

(2011) John Clemens et al.   Nature Reviews Gastroenterology & Hepatology

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

(2011) Michael Taylor et al.   PLoS One

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

TorsinA participates in endoplasmic reticulum-associated degradation

(2011) Flávia C. Nery et al.   Nature Communications

The Costs of Climate Change: A Study of Cholera in Tanzania

(2011) Sara L. M. Trærup et al.   International Journal of Environmental Research and Public Health

Contribution of Subdomain Structure to the Thermal Stability of the Cholera Toxin A1 Subunit

(2010) Tuhina Banerjee et al.   BIOCHEMISTRY

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

The active Zot domain (aa 288–293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

(2010) Simeon E. Goldblum et al.   FASEB JOURNAL

Capsaicin, a potential inhibitor of cholera toxin production inVibrio cholerae

(2010) Shruti Chatterjee et al.   FEMS MICROBIOLOGY LETTERS

H-NS Binding and Repression of the ctx Promoter in Vibrio cholerae

(2010) E. A. Stonehouse et al.   JOURNAL OF BACTERIOLOGY

Disruption of the K+Channel β-Subunit KCNE3 Reveals an Important Role in Intestinal and Tracheal Cl−Transport

(2010) Patricia Preston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 Is Required for Transfer of the Cholera Toxin A1 Subunit from the Endoplasmic Reticulum to the Cytosol

(2010) Michael Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibiotics for Both Moderate and Severe Cholera

(2010) Eric J. Nelson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Plant-Derived Hydrolysable Tannin Inhibits CFTR Chloride Channel: A Potential Treatment of Diarrhea

(2010) Nisa Wongsamitkul et al.   PHARMACEUTICAL RESEARCH

Energy transducing redox steps of the Na+-pumping NADH:quinone oxidoreductase fromVibrio cholerae

(2010) Oscar Juárez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide

(2010) Ethan A. Merritt et al.   PROTEIN SCIENCE

Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cells

(2010) Naoko Morinaga et al.   TOXICON

The Vibrio cholerae Flagellar Regulatory Hierarchy Controls Expression of Virulence Factors

(2009) K. A. Syed et al.   JOURNAL OF BACTERIOLOGY

Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication

(2009) Shane Massey et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial

(2009) Dipika Sur et al.   LANCET

The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

(2009) Kaleena M. Bernardi et al.   MOLECULAR BIOLOGY OF THE CELL

The Vibrio cholerae Cytolysin Promotes Chloride Secretion from Intact Human Intestinal Mucosa

(2009) Lucantonio Debellis et al.   PLoS One

Cholera toxin structure, gene regulation and pathophysiological and immunological aspects

(2008) J. Sánchez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nanomolar CFTR Inhibition by Pore-Occluding Divalent Polyethylene Glycol-Malonic Acid Hydrazides

(2008) N.D. Sonawane et al.   CHEMISTRY & BIOLOGY

Cholera Toxin Up-Regulates Endoplasmic Reticulum Proteins That Correlate with Sensitivity to the Toxin

(2008) Garima Dixit et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Stevioside and related compounds: Therapeutic benefits beyond sweetness

(2008) Varanuj Chatsudthipong et al.   PHARMACOLOGY & THERAPEUTICS

A Randomized, Placebo-Controlled Trial of the Bivalent Killed, Whole-Cell, Oral Cholera Vaccine in Adults and Children in a Cholera Endemic Area in Kolkata, India

(2008) Dilip Mahalanabis et al.   PLoS One

Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea

(2008) A. Y. Kots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental signatures associated with cholera epidemics

(2008) G. Constantin de Magny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derlin-1 Facilitates the Retro-Translocation of Cholera Toxin

(2007) Kaleena M. Bernardi et al.   MOLECULAR BIOLOGY OF THE CELL