5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12receptor

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

(2013) Peter Bach et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent Fibrinolysis Inhibitor Discovered by Shape and Electrostatic Complementarity to the Drug Tranexamic Acid

(2013) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of Ethyl 6-Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

(2013) Peter Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor

(2011) Peter Bach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor

(2011) Francesca Deflorian et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Part II: Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

(2010) John J. Parlow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acyl glucuronides: the good, the bad and the ugly

(2010) Sophie L. Regan et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

(2010) R. Sawamura et al.   DRUG METABOLISM AND DISPOSITION

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Piperazinyl Glutamate Pyridines as Potent Orally Bioavailable P2Y12Antagonists for Inhibition of Platelet Aggregation

(2010) John J. Parlow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization

(2010) Sarah R. Langdon et al.   Molecular Informatics

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

(2009) John J. Parlow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation

(2009) John J. Parlow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

(2009) Steven W. Kortum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydrogen Bonding, Electrostatic Potential, and Molecular Design

(2009) Peter W. Kenny   Journal of Chemical Information and Modeling

High-Affinity, Non-Nucleotide-Derived Competitive Antagonists of Platelet P2Y12Receptors

(2009) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

The pKBHXDatabase: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists

(2009) Christian Laurence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation

(2008) James G. Douglass et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in antiplatelet therapy: overview of new P2Y12 receptor antagonists in development

(2008) M. Cattaneo   EUROPEAN HEART JOURNAL SUPPLEMENTS

Lipophilic Modifications to Dinucleoside Polyphosphates and Nucleotides that Confer Antagonist Properties at the Platelet P2Y12Receptor

(2008) James G. Douglass et al.   JOURNAL OF MEDICINAL CHEMISTRY